APLS


Line plots across dimensions of each concept
Line plots across concepts
Tables

Table of contents



us-gaap:CommonStockValue

us-gaap:CommonStockSharesIssued

us-gaap:CommonStockSharesOutstanding

us-gaap:WeightedAverageNumberOfShareOutstandingBasicAndDiluted

us-gaap:AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount
us-gaap:AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecurities

us-gaap:EarningsPerShareBasic

us-gaap:EarningsPerShareDiluted

us-gaap:EarningsPerShareBasicAndDiluted

us-gaap:ComprehensiveIncomeNetOfTax

us-gaap:GeneralAndAdministrativeExpense
us-gaap:AdjustmentsForNewAccountingPronouncements
us-gaap:InterestExpense
us-gaap:LongtermDebtType
us-gaap:InterestExpenseDebt

us-gaap:InterestPaidNet

us-gaap:NetIncomeLoss
us-gaap:StatementEquityComponents

us-gaap:OperatingExpenses

us-gaap:OperatingIncomeLoss

us-gaap:OtherComprehensiveIncomeLossForeignCurrencyTransactionAndTranslationAdjustmentNetOfTax
us-gaap:StatementEquityComponents

us-gaap:OtherComprehensiveIncomeLossNetOfTax
us-gaap:StatementEquityComponents

us-gaap:OtherNonoperatingIncomeExpense

us-gaap:ProfitLoss

us-gaap:ResearchAndDevelopmentExpense

us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax

us-gaap:Assets

us-gaap:Liabilities

us-gaap:LiabilitiesAndStockholdersEquity

us-gaap:StockholdersEquity
us-gaap:CumulativeEffectPeriodOfAdoption
us-gaap:CumulativeEffectPeriodOfAdoption, us-gaap:StatementEquityComponents
us-gaap:StatementEquityComponents

us-gaap:AssetsCurrent

us-gaap:CashAndCashEquivalentsAtCarryingValue

us-gaap:CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents

us-gaap:MarketableSecuritiesCurrent

us-gaap:AccountsReceivableNetCurrent

us-gaap:InventoryNet

us-gaap:InventoryRawMaterialsAndSupplies

us-gaap:OtherAssetsCurrent

us-gaap:PropertyPlantAndEquipmentNet

us-gaap:OperatingLeaseRightOfUseAsset

us-gaap:OtherAssetsNoncurrent

us-gaap:AccountsPayableCurrent

us-gaap:AccruedLiabilitiesCurrent
us-gaap:TypeOfArrangement

us-gaap:LiabilitiesCurrent

us-gaap:OperatingLeaseLiabilityCurrent

us-gaap:OtherAccruedLiabilitiesCurrent
us-gaap:LongtermDebtType
us-gaap:LongTermDebt

us-gaap:OperatingLeaseLiabilityNoncurrent

us-gaap:LesseeOperatingLeaseLiabilityPaymentsDueYearTwo

us-gaap:LesseeOperatingLeaseLiabilityPaymentsDueYearThree

us-gaap:LesseeOperatingLeaseLiabilityPaymentsDueYearFour

us-gaap:OperatingLeaseLiability

us-gaap:LesseeOperatingLeaseLiabilityPaymentsDue
us-gaap:StatementGeographical, us-gaap:TypeOfArrangement

us-gaap:LesseeOperatingLeaseLiabilityUndiscountedExcessAmount

us-gaap:StockholdersEquity
us-gaap:CumulativeEffectPeriodOfAdoption
us-gaap:CumulativeEffectPeriodOfAdoption, us-gaap:StatementEquityComponents
us-gaap:StatementEquityComponents

us-gaap:CommonStockValue

us-gaap:AdditionalPaidInCapital

us-gaap:RetainedEarningsAccumulatedDeficit

us-gaap:AccumulatedOtherComprehensiveIncomeLossNetOfTax

us-gaap:AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue
us-gaap:StatementEquityComponents

us-gaap:NetCashProvidedByUsedInOperatingActivities

us-gaap:NetCashProvidedByUsedInInvestingActivities

us-gaap:NetCashProvidedByUsedInFinancingActivities

us-gaap:CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect
us-gaap:AdjustmentsForNewAccountingPronouncements
us-gaap:AmortizationOfFinancingCosts
us-gaap:LongtermDebtType

us-gaap:IncreaseDecreaseInAccountsPayable

us-gaap:NetCashProvidedByUsedInOperatingActivities

us-gaap:NetIncomeLoss
us-gaap:StatementEquityComponents

us-gaap:ProfitLoss

us-gaap:ShareBasedCompensation

us-gaap:NetCashProvidedByUsedInInvestingActivities

us-gaap:PaymentsToAcquirePropertyPlantAndEquipment

us-gaap:NetCashProvidedByUsedInFinancingActivities

us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePrice

us-gaap:DeferredTaxAssetsValuationAllowance
us-gaap:DebtInstrument, us-gaap:LongtermDebtType, us-gaap:TypeOfArrangement
apls:AdditionalAmountIssuedInPaymentOfIssuanceCosts

apls:AdjustmentsToAdditionalPaidInCapitalForfeitureOfAccruedInterestInExchangeOfConvertibleNotes
us-gaap:StatementEquityComponents

apls:AmortizationOfDiscountsForConvertibleNotesNetOfFinancingCosts
us-gaap:TypeOfArrangement
apls:AnnualLicenseMaintenanceFees

apls:ContraResearchAndDevelopmentExpense
us-gaap:CounterpartyName, us-gaap:TypeOfArrangement
apls:ContractResearchAndDevelopmentReimbursement

apls:CostOfResearchCollaboration
us-gaap:CounterpartyName
apls:DevelopmentCostReimbursement
us-gaap:CounterpartyName, us-gaap:AdjustmentsForNewAccountingPronouncements, us-gaap:TypeOfArrangement
us-gaap:CounterpartyName, us-gaap:SubsequentEventType, us-gaap:TypeOfArrangement
us-gaap:CounterpartyName, us-gaap:TypeOfArrangement

apls:ForfeitureOfAccruedInterestInExchangeOfConvertibleNotes
us-gaap:DebtInstrument, us-gaap:LongtermDebtType, us-gaap:TypeOfArrangement

apls:InterestExpenseNonoperating

apls:LossOnConversionOfDebt
us-gaap:DebtInstrument, us-gaap:LongtermDebtType, us-gaap:TypeOfArrangement
us-gaap:DebtInstrument, us-gaap:LongtermDebtType, us-gaap:TypeOfArrangement
apls:LossOnConversionOfDebtRelatedToAdditionalSharesIssued

apls:MinimumPaymentOfAdditionalFundingAmount
us-gaap:CounterpartyName
apls:NonRefundableUpfrontPayment

apls:OperatingLeaseRightOfUseAssetAmortization
us-gaap:TypeOfArrangement
apls:PaymentMadeUnderAgreement
us-gaap:Range
apls:PercentageOfRoyaltyFeesPayments
us-gaap:DebtInstrument
apls:PremiumPaidForCappedCallTransaction
us-gaap:CounterpartyName, us-gaap:TypeOfArrangement
apls:ProceedsFromContractResearchAndDevelopment

apls:ProceedsFromDevelopmentDerivativeLiability

apls:ProceedsFromIssuanceOfConvertibleNotesNetOfIssuanceCosts
us-gaap:CounterpartyName, us-gaap:AdjustmentsForNewAccountingPronouncements, us-gaap:TypeOfArrangement
apls:UpfrontPayment
us-gaap:CounterpartyName, us-gaap:SubsequentEventType, us-gaap:TypeOfArrangement

us-gaap:AdjustmentsToAdditionalPaidInCapitalConvertibleDebtWithConversionFeature
us-gaap:StatementEquityComponents

us-gaap:AmortizationOfDebtDiscountPremium
us-gaap:LongtermDebtType

us-gaap:DebtConversionConvertedInstrumentAmount1
us-gaap:DebtInstrument, us-gaap:LongtermDebtType, us-gaap:SubsequentEventType, us-gaap:TypeOfArrangement
us-gaap:DebtInstrument, us-gaap:LongtermDebtType, us-gaap:TypeOfArrangement
us-gaap:DebtInstrument, us-gaap:LongtermDebtType, us-gaap:TypeOfArrangement
us-gaap:DebtInstrumentConvertibleConversionRatio1
us-gaap:LongtermDebtType, us-gaap:StatementEquityComponents
us-gaap:LongtermDebtType
us-gaap:DebtInstrumentConvertibleThresholdPercentageOfStockPriceTrigger
us-gaap:AdjustmentsForNewAccountingPronouncements
us-gaap:DebtInstrumentIncreaseDecreaseForPeriodNet
us-gaap:DebtInstrument, us-gaap:LongtermDebtType, us-gaap:TypeOfArrangement

us-gaap:Depreciation

us-gaap:DerivativeGainLossOnDerivativeNet
us-gaap:TypeOfArrangement

us-gaap:EffectOfExchangeRateOnCashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents

us-gaap:IncreaseDecreaseInAccruedLiabilities

us-gaap:IncreaseDecreaseInOtherCurrentAssets

us-gaap:IncreaseDecreaseInOtherNoncurrentAssets

us-gaap:IncreaseDecreaseInPrepaidExpense
us-gaap:LongtermDebtType
us-gaap:InterestExpenseDebtExcludingAmortization

us-gaap:InvestmentIncomeNonoperating

us-gaap:LongTermPurchaseCommitmentAmount
us-gaap:SubsequentEventType, us-gaap:TypeOfArrangement
us-gaap:TypeOfArrangement

us-gaap:OperatingLeaseCost

us-gaap:OperatingLeasePayments

us-gaap:OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent

us-gaap:OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax
us-gaap:StatementEquityComponents

us-gaap:PaymentsRelatedToTaxWithholdingForShareBasedCompensation

us-gaap:PaymentsToAcquireAvailableForSaleSecurities
us-gaap:TypeOfArrangement
us-gaap:ProceedsFromCollaborators

us-gaap:ProceedsFromIssuanceOfCommonStock

us-gaap:ProceedsFromMaturitiesPrepaymentsAndCallsOfAvailableForSaleSecurities

us-gaap:ProceedsFromStockOptionsExercised

us-gaap:ProceedsFromStockPlans

us-gaap:RestrictedStockValueSharesIssuedNetOfTaxWithholdings
us-gaap:StatementEquityComponents

us-gaap:RightOfUseAssetObtainedInExchangeForOperatingLeaseLiability

us-gaap:StockIssuedDuringPeriodValueConversionOfConvertibleSecurities
us-gaap:StatementEquityComponents

us-gaap:StockIssuedDuringPeriodValueEmployeeStockPurchasePlan
us-gaap:StatementEquityComponents

us-gaap:StockIssuedDuringPeriodValueStockOptionsExercised
us-gaap:StatementEquityComponents
us-gaap:AdjustmentsForNewAccountingPronouncements
us-gaap:StockholdersEquityPeriodIncreaseDecrease
us-gaap:AdjustmentsForNewAccountingPronouncements, us-gaap:StatementEquityComponents

apls:AccruedCostOfResearchCollaborationCurrent

apls:AccruedLicenseFeesCurrent

apls:AccruedPayrollLiabilitiesCurrent

apls:AccruedResearchAndDevelopmentCurrent
us-gaap:CounterpartyName, us-gaap:Range, us-gaap:AdjustmentsForNewAccountingPronouncements, us-gaap:TypeOfArrangement
apls:AggregateMilestonePaymentsUponAchievementOfSpecifiedOneTimeRegulatoryAndCommercialMilestoneEvents
us-gaap:CounterpartyName, us-gaap:Range, us-gaap:SubsequentEventType, us-gaap:TypeOfArrangement
us-gaap:CounterpartyName, us-gaap:Range, us-gaap:TypeOfArrangement

apls:CashAndCashEquivalentsAndMarketableSecurities
us-gaap:CounterpartyName, us-gaap:TypeOfArrangement
apls:CollaborativeArrangementUpFrontPaymentInNextTwelveMonths
us-gaap:CounterpartyName, us-gaap:BalanceSheetLocation, us-gaap:TypeOfArrangement
apls:CollaborativeArrangementUpfrontNonRefundableAmountPayable
us-gaap:CounterpartyName, us-gaap:SubsequentEventType, us-gaap:TypeOfArrangement

apls:ContraResearchAndDevelopmentCurrent

apls:ContractResearchAndDevelopmentCurrent

apls:ContractResearchAndDevelopmentLongTermAssets

apls:ContractResearchAndDevelopmentOtherAssets

apls:ContractResearchAndDevelopmentReceivable
us-gaap:CounterpartyName, us-gaap:TypeOfArrangement
us-gaap:FairValueByFairValueHierarchyLevel, us-gaap:FairValueByLiabilityClass
apls:ConvertibleSeniorNotesNoncurrent

apls:DeferredTaxAssetsOrphanDrugCredits
us-gaap:IncomeTaxAuthority
apls:DeferredTaxAssetsTaxCreditCarryforwardsResearchAndDevelopment

apls:DeferredTaxLiabilitiesSection481AAdjustment

apls:DevelopmentDerivativeLiabilitiesCurrent
us-gaap:TypeOfArrangement

apls:DevelopmentDerivativeLiabilitiesGross

apls:DevelopmentDerivativeLiabilitiesNoncurrent
us-gaap:TypeOfArrangement

apls:EstimatedTerminationCostsAndOtherFees

apls:LesseeOperatingLeaseLiabilityPaymentsDueYearFiveAndThereafter

apls:LesseeOperatingLeaseLiabilityPaymentsDueYearFourAndThereafter

apls:NetDeferredTaxAssetsBeforeValuationAllowance
us-gaap:StatementGeographical, us-gaap:TypeOfArrangement
apls:OperatingLeaseArea
us-gaap:StatementGeographical, us-gaap:TypeOfArrangement
apls:OperatingLeaseSquareFeetOfOfficeSpaceLeased

apls:PrepaidResearchAndDevelopmentCostCurrent
us-gaap:BalanceSheetLocation
apls:ProductSalesReserves
us-gaap:TypeOfArrangement
apls:RoyaltyExpenseOwed

apls:ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisedInPeriodAggregateIntrinsicValue
us-gaap:CounterpartyName, us-gaap:TypeOfArrangement
apls:UnrecognizedUpfrontPayment
us-gaap:FairValueByAssetClass, us-gaap:FairValueByFairValueHierarchyLevel, us-gaap:FairValueByMeasurementFrequency
us-gaap:AssetsFairValueDisclosure
us-gaap:FairValueByAssetClass, us-gaap:FairValueByFairValueHierarchyLevel, us-gaap:FairValueByMeasurementFrequency, us-gaap:FinancialInstrument
us-gaap:FairValueByAssetClass, us-gaap:FairValueByFairValueHierarchyLevel, us-gaap:FairValueByMeasurementFrequency, us-gaap:InvestmentType
us-gaap:FairValueByAssetClass, us-gaap:FairValueByMeasurementFrequency
us-gaap:FairValueByAssetClass, us-gaap:FairValueByMeasurementFrequency, us-gaap:FinancialInstrument
us-gaap:FairValueByAssetClass, us-gaap:FairValueByMeasurementFrequency, us-gaap:InvestmentType
us-gaap:FairValueByFairValueHierarchyLevel, us-gaap:FairValueByMeasurementFrequency
us-gaap:FairValueByMeasurementFrequency
us-gaap:FinancialInstrument
us-gaap:AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax
us-gaap:FinancialInstrument
us-gaap:AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax
us-gaap:FinancialInstrument
us-gaap:AvailableForSaleDebtSecuritiesAmortizedCostBasis
us-gaap:FinancialInstrument
us-gaap:AvailableForSaleSecuritiesDebtSecurities
us-gaap:PlanName
us-gaap:CommonStockCapitalSharesReservedForFutureIssuance
us-gaap:AdjustmentsForNewAccountingPronouncements
us-gaap:ConvertibleDebt
us-gaap:AdjustmentsForNewAccountingPronouncements, us-gaap:DebtInstrument

us-gaap:ConvertibleDebtNoncurrent
us-gaap:LongtermDebtType, us-gaap:StatementEquityComponents
us-gaap:DebtInstrumentConvertibleConversionPrice1
us-gaap:LongtermDebtType
us-gaap:DebtInstrumentFaceAmount
us-gaap:LongtermDebtType
us-gaap:DeferredFinanceCostsGross
us-gaap:AdjustmentsForNewAccountingPronouncements, us-gaap:DebtInstrument
us-gaap:DeferredFinanceCostsNet
us-gaap:DebtInstrument, us-gaap:LongtermDebtType, us-gaap:TypeOfArrangement

us-gaap:DeferredIncomeTaxLiabilities

us-gaap:DeferredTaxAssetsDerivativeInstruments

us-gaap:DeferredTaxAssetsGoodwillAndIntangibleAssets

us-gaap:DeferredTaxAssetsGross

us-gaap:DeferredTaxAssetsOperatingLossCarryforwards
us-gaap:IncomeTaxAuthority
us-gaap:DeferredTaxAssetsOperatingLossCarryforwardsNotSubjectToExpiration

us-gaap:DeferredTaxAssetsOther

us-gaap:DeferredTaxAssetsTaxCreditCarryforwardsResearch

us-gaap:DeferredTaxAssetsTaxDeferredExpenseCompensationAndBenefitsShareBasedCompensationCost

us-gaap:DeferredTaxAssetsTaxDeferredExpenseReservesAndAccruals

us-gaap:DeferredTaxLiabilitiesFinancingArrangements

us-gaap:DeferredTaxLiabilitiesPropertyPlantAndEquipment

us-gaap:EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedStockOptions
us-gaap:AwardType
us-gaap:FairValueByFairValueHierarchyLevel, us-gaap:FairValueByLiabilityClass, us-gaap:FairValueByMeasurementFrequency
us-gaap:FinancialLiabilitiesFairValueDisclosure
us-gaap:FairValueByFairValueHierarchyLevel, us-gaap:FairValueByMeasurementFrequency
us-gaap:FairValueByLiabilityClass, us-gaap:FairValueByMeasurementFrequency
us-gaap:FairValueByMeasurementFrequency

us-gaap:LesseeOperatingLeaseLiabilityPaymentsDueNextTwelveMonths

us-gaap:LesseeOperatingLeaseLiabilityPaymentsRemainderOfFiscalYear

us-gaap:OperatingLeaseWeightedAverageDiscountRatePercent
us-gaap:IncomeTaxAuthority
us-gaap:OperatingLossCarryforwards

us-gaap:PrepaidExpenseCurrent

us-gaap:RestrictedCash

us-gaap:RestrictedCashCurrent
us-gaap:AwardType
us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValue

us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisableWeightedAverageExercisePrice

us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsVestedAndExpectedToVestOutstandingAggregateIntrinsicValue

us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsVestedAndExpectedToVestOutstandingWeightedAverageExercisePrice

us-gaap:SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsExercisableIntrinsicValue1

Plots across concepts


IncomeStatement
Comprehensive Income Net Of Tax
Balance Sheet
Stockholders Equity
Assets
Inventory Net
Current Assets
Accounts Receivable Net Current
NonCurrent Assets
Property Plant And Equipment Net
Liabilities
Operating Lease Liability
Current Liabilities
Operating Lease Liability Current
Stockholders Equity
Retained Earnings Accumulated Deficit
CashFlow
Net Income Loss
NetCashProvidedByUsedInOperatingActivities
Net Income Loss
NetCashProvidedByUsedInInvestingActivities
Payments To Acquire Property Plant And Equipment
OperatingLeaseLiability
Operating Lease Liability Current
LesseeOperatingLeaseLiabilityPaymentsDue
Lessee Operating Lease Liability Payments Remainder Of Fiscal Year

Tables

  2021-06-302020-12-312020-09-30
us-gaap:CommonStockValue ▄▄▄0.0080.0080.008
us-gaap:CommonStockSharesIssued NA76.13NA
us-gaap:CommonStockSharesOutstanding NA76.13NA
us-gaap:WeightedAverageNumberOfShareOutstandingBasicAndDiluted 80.654NA0.075628
us-gaap:AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount 23.974NA25.784
us-gaap:EarningsPerShareBasic NA1.03-1.79
us-gaap:EarningsPerShareDiluted NA0.93-1.79
us-gaap:EarningsPerShareBasicAndDiluted ▁█▃-2.721.0600000000000005-1.79
  2021-06-302020-12-312020-09-30
  2021-06-302020-12-312020-09-30
  2021-06-302020-12-312020-09-30
us-gaap:ComprehensiveIncomeNetOfTax ▁█▃-219.479.907-137.788
us-gaap:GeneralAndAdministrativeExpense █▅▁48.96744.49236.991
 us-gaap:InterestExpense us-gaap:AdjustmentsForNewAccountingPronouncements apls:AccountingStandardsUpdate202006NANANA
 us-gaap:InterestExpenseDebt us-gaap:LongtermDebtType apls:ConvertibleSeniorNotesDueTwoThousandTwentySix▁██3.89.69.5
us-gaap:InterestPaidNet ▁▁█0.00.09.1
us-gaap:NetIncomeLoss ▁█▃-219.19178.265-135.7
 us-gaap:NetIncomeLoss us-gaap:StatementEquityComponents us-gaap:RetainedEarnings-219.191NA-135.7
us-gaap:OperatingExpenses █▁▂194.91119.879130.198
us-gaap:OperatingIncomeLoss ▁█▂-194.287130.12-129.552
us-gaap:OtherComprehensiveIncomeLossForeignCurrencyTransactionAndTranslationAdjustmentNetOfTax ▄█▁-0.1741.772-1.658
 us-gaap:OtherComprehensiveIncomeLossForeignCurrencyTransactionAndTranslationAdjustmentNetOfTax us-gaap:StatementEquityComponents us-gaap:AccumulatedOtherComprehensiveIncome-0.174NA-1.658
us-gaap:OtherComprehensiveIncomeLossNetOfTax -0.209NA-2.088
 us-gaap:OtherComprehensiveIncomeLossNetOfTax us-gaap:StatementEquityComponents us-gaap:AccumulatedNetUnrealizedInvestmentGainLoss-0.035NA-0.43
 us-gaap:OtherComprehensiveIncomeLossNetOfTax us-gaap:StatementEquityComponents us-gaap:AccumulatedTranslationAdjustment-0.174NA-1.658
us-gaap:OtherNonoperatingIncomeExpense ▇▁█-0.061-0.505-0.016
us-gaap:ProfitLoss ▁█▃-219.19178.265-135.7
us-gaap:ResearchAndDevelopmentExpense █▁█95.94350.33793.207
us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax ▁█▁0.623250.00.646
  2021-06-302020-12-312020-09-30
  2021-06-302020-12-312020-09-30
us-gaap:Assets ▁█▃699.912960.569768.334
us-gaap:Liabilities █▅▁841.405756.012662.494
us-gaap:LiabilitiesAndStockholdersEquity ▁█▃699.912960.569768.334
us-gaap:StockholdersEquity ▁█▆-141.493204.557105.84
 us-gaap:StockholdersEquity us-gaap:CumulativeEffectPeriodOfAdoption srt:CumulativeEffectPeriodOfAdoptionAdjustmentNA-149.734NA
 us-gaap:StockholdersEquity us-gaap:CumulativeEffectPeriodOfAdoption,us-gaap:StatementEquityComponents srt:CumulativeEffectPeriodOfAdoptionAdjustment,us-gaap:AdditionalPaidInCapitalNA-165.747NA
 us-gaap:StockholdersEquity us-gaap:CumulativeEffectPeriodOfAdoption,us-gaap:StatementEquityComponents srt:CumulativeEffectPeriodOfAdoptionAdjustment,us-gaap:RetainedEarningsNA16.013NA
 us-gaap:StockholdersEquity us-gaap:StatementEquityComponents us-gaap:AccumulatedNetUnrealizedInvestmentGainLoss▃▁█0.036-0.0080.122
 us-gaap:StockholdersEquity us-gaap:StatementEquityComponents us-gaap:AccumulatedOtherComprehensiveIncome▁█▁-1.829-0.117-1.759
 us-gaap:StockholdersEquity us-gaap:StatementEquityComponents us-gaap:AccumulatedTranslationAdjustment▁█▁-1.865-0.109-1.881
 us-gaap:StockholdersEquity us-gaap:StatementEquityComponents us-gaap:AdditionalPaidInCapital█▃▁1173.5121131.0131112.203
 us-gaap:StockholdersEquity us-gaap:StatementEquityComponents us-gaap:CommonStock▄▄▄0.0080.0080.008
 us-gaap:StockholdersEquity us-gaap:StatementEquityComponents us-gaap:RetainedEarnings▁█▇-1313.184-926.347-1004.612
  2021-06-302020-12-312020-09-30
us-gaap:AssetsCurrent ▁█▃655.126917.192742.349
us-gaap:CashAndCashEquivalentsAtCarryingValue ▁█▄270.764565.779415.56
us-gaap:CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents ▁█▄272.336567.045416.815
us-gaap:MarketableSecuritiesCurrent █▁▁328.246311.869312.598
us-gaap:AccountsReceivableNetCurrent 0.719NANA
us-gaap:InventoryNet 3.731NANA
us-gaap:InventoryRawMaterialsAndSupplies 3.7NANA
us-gaap:OtherAssetsCurrent █▇▁31.22826.8781.637
  2021-06-302020-12-312020-09-30
us-gaap:PropertyPlantAndEquipmentNet ▇█▁6.756.8036.531
us-gaap:OperatingLeaseRightOfUseAsset █▁▂21.93917.71918.545
us-gaap:OtherAssetsNoncurrent ▇█▁16.09718.8550.909
  2021-06-302020-12-312020-09-30
us-gaap:AccountsPayableCurrent ▁▅█5.3398.47711.069
us-gaap:AccruedLiabilitiesCurrent █▆▁134.303111.93560.766
us-gaap:LiabilitiesCurrent █▆▁157.787128.32775.273
us-gaap:OperatingLeaseLiabilityCurrent █▄▁4.0353.6853.438
us-gaap:OtherAccruedLiabilitiesCurrent █▄▁26.69216.118.086
  2021-06-302020-12-312020-09-30
 us-gaap:LongTermDebt us-gaap:LongtermDebtType apls:ConvertibleSeniorNotesDueTwoThousandTwentySix█▂▁386.5358.8353.8
us-gaap:OperatingLeaseLiabilityNoncurrent █▁▂19.12515.21715.674
us-gaap:LesseeOperatingLeaseLiabilityPaymentsDueYearTwo █▂▁5.6274.8424.636
us-gaap:LesseeOperatingLeaseLiabilityPaymentsDueYearThree █▇▁4.8654.8264.633
us-gaap:LesseeOperatingLeaseLiabilityPaymentsDueYearFour NA4.114NA
  2021-06-302020-12-312020-09-30
us-gaap:StockholdersEquity ▁█▆-141.493204.557105.84
 us-gaap:StockholdersEquity us-gaap:CumulativeEffectPeriodOfAdoption srt:CumulativeEffectPeriodOfAdoptionAdjustmentNA-149.734NA
 us-gaap:StockholdersEquity us-gaap:CumulativeEffectPeriodOfAdoption,us-gaap:StatementEquityComponents srt:CumulativeEffectPeriodOfAdoptionAdjustment,us-gaap:AdditionalPaidInCapitalNA-165.747NA
 us-gaap:StockholdersEquity us-gaap:CumulativeEffectPeriodOfAdoption,us-gaap:StatementEquityComponents srt:CumulativeEffectPeriodOfAdoptionAdjustment,us-gaap:RetainedEarningsNA16.013NA
 us-gaap:StockholdersEquity us-gaap:StatementEquityComponents us-gaap:AccumulatedNetUnrealizedInvestmentGainLoss▃▁█0.036-0.0080.122
 us-gaap:StockholdersEquity us-gaap:StatementEquityComponents us-gaap:AccumulatedOtherComprehensiveIncome▁█▁-1.829-0.117-1.759
 us-gaap:StockholdersEquity us-gaap:StatementEquityComponents us-gaap:AccumulatedTranslationAdjustment▁█▁-1.865-0.109-1.881
 us-gaap:StockholdersEquity us-gaap:StatementEquityComponents us-gaap:AdditionalPaidInCapital█▃▁1173.5121131.0131112.203
 us-gaap:StockholdersEquity us-gaap:StatementEquityComponents us-gaap:CommonStock▄▄▄0.0080.0080.008
 us-gaap:StockholdersEquity us-gaap:StatementEquityComponents us-gaap:RetainedEarnings▁█▇-1313.184-926.347-1004.612
us-gaap:CommonStockValue ▄▄▄0.0080.0080.008
us-gaap:AdditionalPaidInCapital █▃▁1173.5121131.0131112.203
us-gaap:RetainedEarningsAccumulatedDeficit ▁█▇-1313.184-926.347-1004.612
us-gaap:AccumulatedOtherComprehensiveIncomeLossNetOfTax ▁█▁-1.829-0.117-1.759
us-gaap:AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue 17.722NA12.099
  2021-06-302020-12-312020-09-30
us-gaap:NetCashProvidedByUsedInOperatingActivities ▁█▂-128.688141.979-99.824
us-gaap:NetCashProvidedByUsedInInvestingActivities ▆▁█129.752-0.091198.763
us-gaap:NetCashProvidedByUsedInFinancingActivities ▆█▁4.5266.3170.926
us-gaap:CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect ▁█▅5.349150.2398.219
  2021-06-302020-12-312020-09-30
 us-gaap:AmortizationOfFinancingCosts us-gaap:AdjustmentsForNewAccountingPronouncements apls:AccountingStandardsUpdate202006NANANA
 us-gaap:AmortizationOfFinancingCosts us-gaap:LongtermDebtType apls:ConvertibleSeniorNotesDueTwoThousandTwentySix█▁▁0.30.10.1
us-gaap:IncreaseDecreaseInAccountsPayable █▁█0.874-2.4460.792
us-gaap:NetCashProvidedByUsedInOperatingActivities ▁█▂-128.688141.979-99.824
us-gaap:NetIncomeLoss ▁█▃-219.19178.265-135.7
 us-gaap:NetIncomeLoss us-gaap:StatementEquityComponents us-gaap:RetainedEarnings-219.191NA-135.7
us-gaap:ProfitLoss ▁█▃-219.19178.265-135.7
us-gaap:ShareBasedCompensation █▁▁17.72212.49412.099
  2021-06-302020-12-312020-09-30
us-gaap:NetCashProvidedByUsedInInvestingActivities ▆▁█129.752-0.091198.763
us-gaap:PaymentsToAcquirePropertyPlantAndEquipment ▁▂█0.2480.7113.738
  2021-06-302020-12-312020-09-30
us-gaap:NetCashProvidedByUsedInFinancingActivities ▆█▁4.5266.3170.926
  2021-06-302020-12-312020-09-30

Common Stock Value

us-gaap:CommonStockValue

us-gaap:CommonStockValue


Common
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302016-12-31
Value8000.08000.08000.08000.08000.07000.06393.06387.06367.06322.05628.05624.05615.05042.05033.0847.0843.0
Percentage of CommonStockValue100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0
Percentage of Assets0.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.0

Common Stock Shares Issued

us-gaap:CommonStockSharesIssued

us-gaap:CommonStockSharesIssued


Common
Period End2020-12-312020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302016-12-31
Value7675756363636356565650508.4729038.428366
Percentage of CommonStockSharesIssued100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0

Common Stock Shares Outstanding

us-gaap:CommonStockSharesOutstanding

us-gaap:CommonStockSharesOutstanding


Common
Period End2020-12-312020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302016-12-31
Value7675756363636356565650508.4729038.428366
Percentage of CommonStockSharesOutstanding100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0

Weighted Average Number Of Share Outstanding Basic And Diluted

us-gaap:WeightedAverageNumberOfShareOutstandingBasicAndDiluted

us-gaap:WeightedAverageNumberOfShareOutstandingBasicAndDiluted


Weighted
Period End2021-06-302021-03-312020-09-302020-06-302020-03-312019-09-302019-06-302019-03-312018-09-302018-06-302018-03-312017-09-302017-06-302017-03-312016-09-30
Value80790.0756280.075550.073726363575654508.4420728.4283668.4283668.428366
Percentage of WeightedAverageNumberOfShareOutstandingBasicAndDiluted100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0

Antidilutive Securities Excluded From Computation Of Earnings Per Share Amount

us-gaap:AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount

us-gaap:AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount


Antidilutive
Period End2021-06-302021-03-312020-09-302020-06-302020-03-312019-09-302019-06-302019-03-312018-09-302018-06-302018-03-312017-09-302017-06-302017-03-312016-09-30
Value2324252515109.108659.2050977.285197.30747.4323835316530
Percentage of AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0

us-gaap:AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount us-gaap:AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecurities

apls:ConvertibleNotes


Antidilutive
Period End2021-06-302021-03-312020-09-302020-06-302020-03-31
Value9.9819.98113135.575
Percentage of AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount41.641.051.152.036.4

us-gaap:EmployeeStockOption


Antidilutive
Period End2021-06-302021-03-312020-09-302020-06-302020-03-312019-09-302019-06-302019-03-312018-09-302018-06-302018-03-312017-09-302017-06-302017-03-312016-09-30
Value121312119.434109.0945869.1910337.2711267.2933367.4183165.1521194.6751188.6970283.831237
Percentage of AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount54.155.147.246.761.699.999.899.899.899.899.814.615.013.412.7

us-gaap:RestrictedStockUnitsRSU


Antidilutive
Period End2021-06-302021-03-312020-09-302020-06-302020-03-31
Value1.0120.9490.4330.3490.298
Percentage of AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount4.23.91.71.41.9

Earnings Per Share Basic

us-gaap:EarningsPerShareBasic

us-gaap:EarningsPerShareBasic


Earnings
Period End2020-12-312020-09-302020-06-302020-03-31
Value1.03-1.79-1.57-2.29
Percentage of EarningsPerShareBasic100.0100.0100.0100.0

Earnings Per Share Diluted

us-gaap:EarningsPerShareDiluted

us-gaap:EarningsPerShareDiluted


Earnings
Period End2020-12-312020-09-302020-06-302020-03-31
Value0.93-1.79-1.57-2.29
Percentage of EarningsPerShareDiluted100.0100.0100.0100.0

Earnings Per Share Basic And Diluted

us-gaap:EarningsPerShareBasicAndDiluted

us-gaap:EarningsPerShareBasicAndDiluted


Earnings
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302017-06-302017-03-312016-12-312016-09-302016-06-302016-03-31
Value-2.72-2.321.06-1.79-1.57-2.29-1.77-1.1-1.12-0.87-0.65-0.64-0.61-0.43-3.68-1.37-0.67-0.5-3.22-0.86-0.41-0.33
Percentage of EarningsPerShareBasicAndDiluted100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0

Comprehensive Income Net Of Tax

us-gaap:ComprehensiveIncomeNetOfTax

us-gaap:ComprehensiveIncomeNetOfTax


Comprehensive
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-30
Value-219.4-185.16279-137.788-119.298-167.658-113.165949-69.907931-71.091496-50.572205-36.922223-35.632173-33.334302-21.736304-18.255896-11.573273
Percentage of ComprehensiveIncomeNetOfTax100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax-35216.70.032.0-21329.40.00.00.00.00.00.00.00.00.00.00.00.0

General And Administrative Expense

us-gaap:GeneralAndAdministrativeExpense

us-gaap:GeneralAndAdministrativeExpense


General
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302017-06-302017-03-312016-12-312016-09-30
Value4840443628292718128.1706716.3909816.2651255.9478234.0352554.8599612.0714371.7103441.8214091.0872761.000146
Percentage of GeneralAndAdministrativeExpense100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax7859.90.017.85726.20.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.0

Interest Expense

us-gaap:InterestExpense us-gaap:AdjustmentsForNewAccountingPronouncements

us-gaap:InterestExpense

apls:AccountingStandardsUpdate202006


Interest
Period End2021-01-01
Value17
Percentage of InterestExpense100.0
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax0.0
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax apls:AccountingStandardsUpdate2020060.0

Interest Expense Debt

us-gaap:InterestExpenseDebt us-gaap:LongtermDebtType

us-gaap:InterestExpenseDebt

apls:ConvertibleSeniorNotesDueTwoThousandTwentySix


Interest
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-31
Value3.84.29.69.56.93.94.4
Percentage of InterestExpenseDebt100.0100.0100.0100.0100.0100.0100.0
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax610.00.03.81470.60.00.00.0
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax apls:ConvertibleSeniorNotesDueTwoThousandTwentySix0.00.00.00.00.00.00.0

Interest Paid Net

us-gaap:InterestPaidNet

us-gaap:InterestPaidNet


Interest
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-31
Value0.06.8930.09.10.03.8290.0283830.2305210.140.5884730.4776390.3304160.4565280.551750.0
Percentage of InterestPaidNet0.0100.00.0100.00.0100.0100.0100.0100.0100.0100.0100.0100.0100.00.0
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax0.00.00.01408.70.00.00.00.00.00.00.00.00.00.00.0

Net Income Loss

us-gaap:NetIncomeLoss

us-gaap:NetIncomeLoss


Net
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302017-06-302017-03-312016-12-312016-09-302016-06-302016-03-31
Value-219.191-183.65978-135.7-118.617-168.822-113.217423-69.824659-71.090164-50.574367-36.459475-35.972115-33.3343-21.736304-18.255896-11.573273-12.126152-9.050773-6.620102-7.210591-7.294245-5.999699
Percentage of NetIncomeLoss100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax-35183.10.031.3-21006.20.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.0

us-gaap:NetIncomeLoss us-gaap:StatementEquityComponents

us-gaap:RetainedEarnings


Net
Period End2021-06-302021-03-312020-09-302020-06-302020-03-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-31
Value-219.191-183.659-135.7-118.617-168.822-69.824659-71.090164-50.574367-36.459474-35.545924-33.334302-21.736304
Percentage of NetIncomeLoss100.0100.0100.0100.0100.0100.0100.0100.0100.098.8100.0100.0
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax-35183.10.0-21006.20.00.00.00.00.00.00.00.00.0
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax us-gaap:RetainedEarnings0.00.00.00.00.00.00.00.00.00.00.00.0

Operating Expenses

us-gaap:OperatingExpenses

us-gaap:OperatingExpenses


Operating
Period End2021-06-302020-12-312020-09-302020-06-302019-12-312019-09-30
Value19411913011510569
Percentage of OperatingExpenses100.0100.0100.0100.0100.0100.0
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax31285.748.020154.50.00.00.0

Operating Income Loss

us-gaap:OperatingIncomeLoss

us-gaap:OperatingIncomeLoss


Operating
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302017-06-302017-03-312016-12-312016-09-302016-06-302016-03-31
Value-194.287-124.591130-129.552-115.508-98.786-105.940283-69.947962-63.476438-48.65057-37.196592-35.804581-33.485442-21.438145-17.568845-11.589319-12.39449-9.214375-6.247048-7.234204-7.572638-6.228452
Percentage of OperatingIncomeLoss100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax-31185.70.052.0-20054.50.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.0

Other Comprehensive Income Loss Foreign Currency Transaction And Translation Adjustment Net Of Tax

us-gaap:OtherComprehensiveIncomeLossForeignCurrencyTransactionAndTranslationAdjustmentNetOfTax

us-gaap:OtherComprehensiveIncomeLossForeignCurrencyTransactionAndTranslationAdjustmentNetOfTax


Other
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-30
Value-174000.0-1582000.01772000.0-1658000.0161000.0-230000.051474.0-83272.0-1332.02162.0-462750.0339940.0
Percentage of OtherComprehensiveIncomeLossForeignCurrencyTransactionAndTranslationAdjustmentNetOfTax100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax-27.90.00.7-256.70.00.00.00.00.00.00.00.0

us-gaap:OtherComprehensiveIncomeLossForeignCurrencyTransactionAndTranslationAdjustmentNetOfTax us-gaap:StatementEquityComponents

us-gaap:AccumulatedOtherComprehensiveIncome


Other
Period End2021-06-302021-03-312020-09-302020-06-302020-03-312019-09-302019-06-302019-03-312018-12-312018-09-30
Value-174000.0-1582000.0-1658000.0161000.0-230000.0-83272.0-1332.02162.0-462750.0-86249.0
Percentage of OtherComprehensiveIncomeLossForeignCurrencyTransactionAndTranslationAdjustmentNetOfTax100.0100.0100.0100.0100.0100.0100.0100.0100.0-25.4
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax-27.90.0-256.70.00.00.00.00.00.00.0
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax us-gaap:AccumulatedOtherComprehensiveIncome0.00.00.00.00.00.00.00.00.00.0

Other Comprehensive Income Loss Net Of Tax

us-gaap:OtherComprehensiveIncomeLossNetOfTax

us-gaap:OtherComprehensiveIncomeLossNetOfTax


Other
Period End2021-06-302021-03-312020-09-302020-06-302020-03-312019-09-302019-06-302019-03-31
Value-209000.0-1503000.0-2088000.0-681000.01164000.0-83000.0-1000.02000.0
Percentage of OtherComprehensiveIncomeLossNetOfTax100.0100.0100.0100.0100.0100.0100.0100.0
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax-33.50.0-323.20.00.00.00.00.0

us-gaap:OtherComprehensiveIncomeLossNetOfTax us-gaap:StatementEquityComponents

us-gaap:AccumulatedNetUnrealizedInvestmentGainLoss


Other
Period End2021-06-302021-03-312020-09-302020-06-302020-03-31
Value-35000.079000.0-430000.0-842000.01394000.0
Percentage of OtherComprehensiveIncomeLossNetOfTax16.7-5.320.6123.6119.8
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax-5.60.0-66.60.00.0
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax us-gaap:AccumulatedNetUnrealizedInvestmentGainLoss0.00.00.00.00.0

us-gaap:AccumulatedTranslationAdjustment


Other
Period End2021-06-302021-03-312020-09-302020-06-302020-03-312019-09-302019-06-302019-03-31
Value-174000.0-1582000.0-1658000.0161000.0-230000.0-83000.0-1000.02000.0
Percentage of OtherComprehensiveIncomeLossNetOfTax83.3105.379.4-23.6-19.8100.0100.0100.0
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax-27.90.0-256.70.00.00.00.00.0
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax us-gaap:AccumulatedTranslationAdjustment0.00.00.00.00.00.00.00.0

Other Nonoperating Income Expense

us-gaap:OtherNonoperatingIncomeExpense

us-gaap:OtherNonoperatingIncomeExpense


Other
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302017-06-302016-12-312016-09-30
Value-61000.01544000.0-505000.0-16000.05000.014000.0-89373.0-61048.0228290.0-253180.0-24183.0-22234.0-32867.0-31473.0-12475.016046.0397.0-76563.023613.0
Percentage of OtherNonoperatingIncomeExpense100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax-9.80.0-0.2-2.50.00.00.00.00.00.00.00.00.00.00.00.00.00.00.0

Profit Loss

us-gaap:ProfitLoss

us-gaap:ProfitLoss


Profit
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-31
Value-219190000.0-183660000.078265000.0-135700000.0-118620000.0-168820000.0-113220000.0-69825000.0-71090000.0-50574000.0-36886000.0-35546000.0-33334000.0-21736000.0
Percentage of ProfitLoss100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax-35183.10.031.3-21006.20.00.00.00.00.00.00.00.00.00.0

Research And Development Expense

us-gaap:ResearchAndDevelopmentExpense

us-gaap:ResearchAndDevelopmentExpense


Research
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302017-06-302017-03-312016-12-312016-09-30
Value9584509387697851504030292717139.517882107.2310845.5915726.234058
Percentage of ResearchAndDevelopmentExpense100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax15400.20.020.114428.30.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.0

Revenue From Contract With Customer Excluding Assessed Tax

us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax

us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax


Revenue
Period End2021-06-302020-12-312020-09-30
Value0.6232500.646
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax100.0100.0100.0
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax100.0100.0100.0

Assets

us-gaap:Assets

us-gaap:Assets


Assets
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302016-12-31
Value6998109607688706883894663163182032392661631821927
Percentage of Assets100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0
Percentage of Assets100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0

Liabilities

us-gaap:Liabilities

us-gaap:Liabilities


Liabilities
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312016-12-31
Value8417587566626384293553261579342433734333.638938
Percentage of Liabilities100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0
Percentage of Assets120.293.678.786.273.362.491.270.149.829.420.918.114.020.918.213.3

Liabilities And Stockholders Equity

us-gaap:LiabilitiesAndStockholdersEquity

us-gaap:LiabilitiesAndStockholdersEquity


Liabilities
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302016-12-31
Value6998109607688706883894663163182032392661631821927
Percentage of LiabilitiesAndStockholdersEquity100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0
Percentage of Assets100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0

Stockholders Equity

us-gaap:StockholdersEquity

us-gaap:StockholdersEquity


Stockholders
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302016-12-312015-12-312014-12-31
Value-141.493512041052322583413915922416019522912914812233413
Percentage of StockholdersEquity100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0
Percentage of Assets-20.26.421.313.826.737.68.829.950.270.679.181.986.079.181.863.886.70.00.0

us-gaap:StockholdersEquity us-gaap:CumulativeEffectPeriodOfAdoption

srt:CumulativeEffectPeriodOfAdoptionAdjustment


Stockholders
Period End2020-12-31
Value-149.734
Percentage of StockholdersEquity-73.2
Percentage of Assets-15.6
Percentage of Assets srt:CumulativeEffectPeriodOfAdoptionAdjustment0.0

us-gaap:StockholdersEquity us-gaap:CumulativeEffectPeriodOfAdoption, us-gaap:StatementEquityComponents

srt:CumulativeEffectPeriodOfAdoptionAdjustment, us-gaap:AdditionalPaidInCapital


Stockholders
Period End2020-12-31
Value-165.747
Percentage of StockholdersEquity-81.0
Percentage of Assets-17.3
Percentage of Assets srt:CumulativeEffectPeriodOfAdoptionAdjustment us-gaap:AdditionalPaidInCapital0.0

srt:CumulativeEffectPeriodOfAdoptionAdjustment, us-gaap:RetainedEarnings


Stockholders
Period End2020-12-31
Value16
Percentage of StockholdersEquity7.8
Percentage of Assets1.7
Percentage of Assets srt:CumulativeEffectPeriodOfAdoptionAdjustment us-gaap:RetainedEarnings0.0

us-gaap:StockholdersEquity us-gaap:StatementEquityComponents

us-gaap:AccumulatedNetUnrealizedInvestmentGainLoss


Stockholders
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-31
Value0.0360.071-0.0080.1220.5521.394
Percentage of StockholdersEquity-0.00.1-0.00.10.20.5
Percentage of Assets0.00.0-0.00.00.10.2
Percentage of Assets us-gaap:AccumulatedNetUnrealizedInvestmentGainLoss0.00.00.00.00.00.0

us-gaap:AccumulatedOtherComprehensiveIncome


Stockholders
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-30
Value-1.829-1.62-0.117-1.7590.3291.01-0.153775-0.205249-0.121977-0.120645-0.1228070.339942
Percentage of StockholdersEquity1.3-3.1-0.1-1.70.10.4-0.4-0.1-0.1-0.1-0.10.2
Percentage of Assets-0.3-0.2-0.0-0.20.00.1-0.0-0.0-0.0-0.0-0.10.1
Percentage of Assets us-gaap:AccumulatedOtherComprehensiveIncome0.00.00.00.00.00.00.00.00.00.00.00.0

us-gaap:AccumulatedTranslationAdjustment


Stockholders
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-31
Value-1.865-1.691-0.109-1.881-0.223-0.384-0.154-0.205-0.122-0.121-0.123
Percentage of StockholdersEquity1.3-3.3-0.1-1.8-0.1-0.1-0.4-0.1-0.1-0.1-0.1
Percentage of Assets-0.3-0.2-0.0-0.2-0.0-0.1-0.0-0.0-0.0-0.0-0.1
Percentage of Assets us-gaap:AccumulatedTranslationAdjustment0.00.00.00.00.00.00.00.00.00.00.0

us-gaap:AdditionalPaidInCapital


Stockholders
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312016-12-312015-12-312014-12-31
Value11731147113111121100100861560855755243743543330029829281.974955
Percentage of StockholdersEquity-829.42220.9552.91050.8474.3389.31799.2435.7350.5245.7272.0222.5189.0232.5200.2126.182.714.9
Percentage of Assets167.7141.6117.7144.8126.5146.4158.2130.4176.1173.5215.1182.3162.6183.8163.7109.30.00.0
Percentage of Assets us-gaap:AdditionalPaidInCapital0.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.0

us-gaap:CommonStock


Stockholders
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312016-12-312015-12-312014-12-31
Value0.0080.0080.0080.0080.0080.0070.0063930.0063870.0063670.0063220.0056280.0056240.0056150.0050420.0050330.0008430.0008430.000458
Percentage of StockholdersEquity-0.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.0
Percentage of Assets0.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.0
Percentage of Assets us-gaap:CommonStock0.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.0

us-gaap:RetainedEarnings


Stockholders
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312016-12-312015-12-312014-12-31
Value-1313.184-1093.993-926.347-1004.612-868.912-750.295-581.47246-468.255037-398.430378-327.340214-276.765847-240.306373-204.334259-170.999957-149.263653-98.257559-71.132922-24.616966
Percentage of StockholdersEquity928.1-2117.8-452.9-949.2-374.4-289.7-1698.7-335.5-250.4-145.6-171.9-122.6-89.0-132.5-100.2-412.9-203.4-186.1
Percentage of Assets-187.6-135.0-96.4-130.8-99.9-108.9-149.4-100.4-125.8-102.8-136.0-100.5-76.6-104.8-82.0-358.20.00.0
Percentage of Assets us-gaap:RetainedEarnings0.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.0

Assets Current

us-gaap:AssetsCurrent

us-gaap:AssetsCurrent


Assets
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302016-12-31
Value6557739177428536723734513083102022382661631821927
Percentage of AssetsCurrent100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0
Percentage of Assets93.695.595.596.698.197.695.996.797.497.599.599.9100.099.999.999.499.8

Cash And Cash Equivalents At Carrying Value

us-gaap:CashAndCashEquivalentsAtCarryingValue

us-gaap:CashAndCashEquivalentsAtCarryingValue


Cash
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302017-06-302017-03-312016-12-312016-09-302015-12-312014-12-31
Value270265565415317417351433289288176220253152175134.9390871624313613
Percentage of CashAndCashEquivalentsAtCarryingValue100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0
Percentage of Assets38.732.858.954.136.560.790.493.191.390.586.692.395.193.796.468.60.00.090.60.00.00.0

Cash Cash Equivalents Restricted Cash And Restricted Cash Equivalents

us-gaap:CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents

us-gaap:CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents


Cash
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312016-12-312015-12-31
Value2722665674163184183514332892881762202531521752436
Percentage of CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0
Percentage of Assets38.933.059.054.236.660.890.493.191.390.586.692.395.193.796.490.60.0

Marketable Securities Current

us-gaap:MarketableSecuritiesCurrent

us-gaap:MarketableSecuritiesCurrent


Marketable
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-31
Value328458311312515228
Percentage of MarketableSecuritiesCurrent100.0100.0100.0100.0100.0100.0
Percentage of Assets46.956.632.540.759.233.2

Accounts Receivable Net Current

us-gaap:AccountsReceivableNetCurrent

us-gaap:AccountsReceivableNetCurrent


Accounts
Period End2021-06-30
Value719000.0
Percentage of AccountsReceivableNetCurrent100.0
Percentage of Assets0.1

Inventory Net

us-gaap:InventoryNet

us-gaap:InventoryNet


Inventory
Period End2021-06-30
Value3731000.0
Percentage of InventoryNet100.0
Percentage of Assets0.5

Inventory Raw Materials And Supplies

us-gaap:InventoryRawMaterialsAndSupplies

us-gaap:InventoryRawMaterialsAndSupplies


Inventory
Period End2021-06-30
Value3700000.0
Percentage of InventoryRawMaterialsAndSupplies100.0
Percentage of Assets0.5

Other Assets Current

us-gaap:OtherAssetsCurrent

us-gaap:OtherAssetsCurrent


Other
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302016-12-31
Value3131261.6371.8281.8911.3075912.457533.3559950.015570.3641130.0815320.0076950.2057130.0148233.653521.157438
Percentage of OtherAssetsCurrent100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0
Percentage of Assets4.53.92.80.20.20.30.30.51.10.00.20.00.00.10.019.14.2

Property Plant And Equipment Net

us-gaap:PropertyPlantAndEquipmentNet

us-gaap:PropertyPlantAndEquipmentNet


Property
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-31
Value6750000.07077000.06803000.06531000.02416000.01972000.01655000.01592800.01439100.01041100.0977920.0
Percentage of PropertyPlantAndEquipmentNet100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0
Percentage of Assets1.00.90.70.90.30.30.40.30.50.30.5

Operating Lease Right Of Use Asset

us-gaap:OperatingLeaseRightOfUseAsset

us-gaap:OperatingLeaseRightOfUseAsset


Operating
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312019-01-01
Value21221718121314136.66.65.511865
Percentage of OperatingLeaseRightOfUseAsset100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0
Percentage of Assets3.12.81.82.41.52.03.62.92.12.10.0

Other Assets Noncurrent

us-gaap:OtherAssetsNoncurrent

us-gaap:OtherAssetsNoncurrent


Other
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302016-12-31
Value166.909180.9090.9060.8450.3850880.2365150.2078730.1623451.0943380.2129790.116150.116150.116150.108350.064528
Percentage of OtherAssetsNoncurrent100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0
Percentage of Assets2.30.92.00.10.10.10.10.10.10.10.50.10.00.10.10.60.2

Accounts Payable Current

us-gaap:AccountsPayableCurrent

us-gaap:AccountsPayableCurrent


Accounts
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302016-12-31
Value5.3394.1588.477119.9273.0788.360527111311105.46885.1330174.5850583.6632534.0010592.547212
Percentage of AccountsPayableCurrent100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0
Percentage of Assets0.80.50.91.41.10.42.12.54.43.75.02.31.92.82.020.99.3

Accrued Liabilities Current

us-gaap:AccruedLiabilitiesCurrent

us-gaap:AccruedLiabilitiesCurrent


Accrued
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302016-12-31
Value134691116045445430207.3426015.103002105.1211782.7098012.8907052.9368851.091726
Percentage of AccruedLiabilitiesCurrent100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0
Percentage of Assets19.28.611.77.95.26.514.16.56.42.32.54.41.91.71.615.34.0

us-gaap:AccruedLiabilitiesCurrent us-gaap:TypeOfArrangement

apls:SobiAgreementAndAnotherLicensingTransaction


Accrued
Period End2020-12-31
Value25
Percentage of AccruedLiabilitiesCurrent22.3
Percentage of Assets2.6
Percentage of Assets apls:SobiAgreementAndAnotherLicensingTransaction0.0

Liabilities Current

us-gaap:LiabilitiesCurrent

us-gaap:LiabilitiesCurrent


Liabilities
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302016-12-31
Value15783128755750654435201716107.2948596.5539586.9379443.638938
Percentage of LiabilitiesCurrent100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0
Percentage of Assets22.510.313.49.86.77.416.99.611.26.48.46.73.84.53.636.213.3

Operating Lease Liability Current

us-gaap:OperatingLeaseLiabilityCurrent

us-gaap:OperatingLeaseLiabilityCurrent


Operating
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-31
Value4035000.03902000.03685000.03438000.02664000.02732000.02609000.0
Percentage of OperatingLeaseLiabilityCurrent100.0100.0100.0100.0100.0100.0100.0
Percentage of Assets0.60.50.40.40.30.40.7

Other Accrued Liabilities Current

us-gaap:OtherAccruedLiabilitiesCurrent

us-gaap:OtherAccruedLiabilitiesCurrent


Other
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302016-12-31
Value2624168.0869.9867.0026.8906764.501310.9561290.8631251.3523860.3606880.1808590.1486450.1754060.2031840.129062
Percentage of OtherAccruedLiabilitiesCurrent100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0
Percentage of Assets3.83.11.71.11.11.01.81.00.30.30.70.20.10.10.11.10.5

Long Term Debt

us-gaap:LongTermDebt us-gaap:LongtermDebtType

us-gaap:LongTermDebt

apls:ConvertibleSeniorNotesDueTwoThousandTwentySix


Long
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-30
Value386386358353348144142140
Percentage of LongTermDebt100.0100.0100.0100.0100.0100.0100.0100.0
Percentage of Assets55.247.737.446.040.121.036.630.2
Percentage of Assets apls:ConvertibleSeniorNotesDueTwoThousandTwentySix0.00.00.00.00.00.00.00.0

Operating Lease Liability Noncurrent

us-gaap:OperatingLeaseLiabilityNoncurrent

us-gaap:OperatingLeaseLiabilityNoncurrent


Operating
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-31
Value19191515101111
Percentage of OperatingLeaseLiabilityNoncurrent100.0100.0100.0100.0100.0100.0100.0
Percentage of Assets2.72.51.62.01.21.73.0

Lessee Operating Lease Liability Payments Due Year Two

us-gaap:LesseeOperatingLeaseLiabilityPaymentsDueYearTwo

us-gaap:LesseeOperatingLeaseLiabilityPaymentsDueYearTwo


Lessee
Period End2021-06-302021-03-312020-12-312020-09-30
Value5627000.05480000.04842000.04636000.0
Percentage of LesseeOperatingLeaseLiabilityPaymentsDueYearTwo100.0100.0100.0100.0
Percentage of Assets0.80.70.50.6

Lessee Operating Lease Liability Payments Due Year Three

us-gaap:LesseeOperatingLeaseLiabilityPaymentsDueYearThree

us-gaap:LesseeOperatingLeaseLiabilityPaymentsDueYearThree


Lessee
Period End2021-06-302021-03-312020-12-312020-09-30
Value4865000.04811000.04826000.04633000.0
Percentage of LesseeOperatingLeaseLiabilityPaymentsDueYearThree100.0100.0100.0100.0
Percentage of Assets0.70.60.50.6

Lessee Operating Lease Liability Payments Due Year Four

us-gaap:LesseeOperatingLeaseLiabilityPaymentsDueYearFour

us-gaap:LesseeOperatingLeaseLiabilityPaymentsDueYearFour


Lessee
Period End2020-12-31
Value4114000.0
Percentage of LesseeOperatingLeaseLiabilityPaymentsDueYearFour100.0
Percentage of Assets0.4

Operating Lease Liability

us-gaap:OperatingLeaseLiability

us-gaap:OperatingLeaseLiability


Operating
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312019-01-01
Value23231819131414136.86.6945315.511865
Percentage of OperatingLeaseLiability100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0
Percentage of Assets3.32.92.02.51.52.13.72.92.12.10.0

Lessee Operating Lease Liability Payments Due

us-gaap:LesseeOperatingLeaseLiabilityPaymentsDue

us-gaap:LesseeOperatingLeaseLiabilityPaymentsDue


Lessee
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-31
Value28292223161717
Percentage of LesseeOperatingLeaseLiabilityPaymentsDue100.0100.0100.0100.0100.0100.0100.0
Percentage of Assets4.03.62.33.01.82.54.5

us-gaap:LesseeOperatingLeaseLiabilityPaymentsDue us-gaap:StatementGeographical, us-gaap:TypeOfArrangement

apls:WalthamMassachusetts, apls:AmendedWalthamOfficeSpaceLease


Lessee
Period End2020-12-31
Value19
Percentage of LesseeOperatingLeaseLiabilityPaymentsDue86.3
Percentage of Assets2.0
Percentage of Assets apls:WalthamMassachusetts apls:AmendedWalthamOfficeSpaceLease0.0

Lessee Operating Lease Liability Undiscounted Excess Amount

us-gaap:LesseeOperatingLeaseLiabilityUndiscountedExcessAmount

us-gaap:LesseeOperatingLeaseLiabilityUndiscountedExcessAmount


Lessee
Period End2021-06-302021-03-312020-12-312020-09-30
Value5035000.05366000.03587000.03985000.0
Percentage of LesseeOperatingLeaseLiabilityUndiscountedExcessAmount100.0100.0100.0100.0
Percentage of Assets0.70.70.40.5

Stockholders Equity

us-gaap:StockholdersEquity

us-gaap:StockholdersEquity


Stockholders
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302016-12-312015-12-312014-12-31
Value-141.493512041052322583413915922416019522912914812233413
Percentage of StockholdersEquity100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0
Percentage of Assets-20.26.421.313.826.737.68.829.950.270.679.181.986.079.181.863.886.70.00.0

us-gaap:StockholdersEquity us-gaap:CumulativeEffectPeriodOfAdoption

srt:CumulativeEffectPeriodOfAdoptionAdjustment


Stockholders
Period End2020-12-31
Value-149.734
Percentage of StockholdersEquity-73.2
Percentage of Assets-15.6
Percentage of Assets srt:CumulativeEffectPeriodOfAdoptionAdjustment0.0

us-gaap:StockholdersEquity us-gaap:CumulativeEffectPeriodOfAdoption, us-gaap:StatementEquityComponents

srt:CumulativeEffectPeriodOfAdoptionAdjustment, us-gaap:AdditionalPaidInCapital


Stockholders
Period End2020-12-31
Value-165.747
Percentage of StockholdersEquity-81.0
Percentage of Assets-17.3
Percentage of Assets srt:CumulativeEffectPeriodOfAdoptionAdjustment us-gaap:AdditionalPaidInCapital0.0

srt:CumulativeEffectPeriodOfAdoptionAdjustment, us-gaap:RetainedEarnings


Stockholders
Period End2020-12-31
Value16
Percentage of StockholdersEquity7.8
Percentage of Assets1.7
Percentage of Assets srt:CumulativeEffectPeriodOfAdoptionAdjustment us-gaap:RetainedEarnings0.0

us-gaap:StockholdersEquity us-gaap:StatementEquityComponents

us-gaap:AccumulatedNetUnrealizedInvestmentGainLoss


Stockholders
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-31
Value0.0360.071-0.0080.1220.5521.394
Percentage of StockholdersEquity-0.00.1-0.00.10.20.5
Percentage of Assets0.00.0-0.00.00.10.2
Percentage of Assets us-gaap:AccumulatedNetUnrealizedInvestmentGainLoss0.00.00.00.00.00.0

us-gaap:AccumulatedOtherComprehensiveIncome


Stockholders
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-30
Value-1.829-1.62-0.117-1.7590.3291.01-0.153775-0.205249-0.121977-0.120645-0.1228070.339942
Percentage of StockholdersEquity1.3-3.1-0.1-1.70.10.4-0.4-0.1-0.1-0.1-0.10.2
Percentage of Assets-0.3-0.2-0.0-0.20.00.1-0.0-0.0-0.0-0.0-0.10.1
Percentage of Assets us-gaap:AccumulatedOtherComprehensiveIncome0.00.00.00.00.00.00.00.00.00.00.00.0

us-gaap:AccumulatedTranslationAdjustment


Stockholders
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-31
Value-1.865-1.691-0.109-1.881-0.223-0.384-0.154-0.205-0.122-0.121-0.123
Percentage of StockholdersEquity1.3-3.3-0.1-1.8-0.1-0.1-0.4-0.1-0.1-0.1-0.1
Percentage of Assets-0.3-0.2-0.0-0.2-0.0-0.1-0.0-0.0-0.0-0.0-0.1
Percentage of Assets us-gaap:AccumulatedTranslationAdjustment0.00.00.00.00.00.00.00.00.00.00.0

us-gaap:AdditionalPaidInCapital


Stockholders
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312016-12-312015-12-312014-12-31
Value11731147113111121100100861560855755243743543330029829281.974955
Percentage of StockholdersEquity-829.42220.9552.91050.8474.3389.31799.2435.7350.5245.7272.0222.5189.0232.5200.2126.182.714.9
Percentage of Assets167.7141.6117.7144.8126.5146.4158.2130.4176.1173.5215.1182.3162.6183.8163.7109.30.00.0
Percentage of Assets us-gaap:AdditionalPaidInCapital0.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.0

us-gaap:CommonStock


Stockholders
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312016-12-312015-12-312014-12-31
Value0.0080.0080.0080.0080.0080.0070.0063930.0063870.0063670.0063220.0056280.0056240.0056150.0050420.0050330.0008430.0008430.000458
Percentage of StockholdersEquity-0.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.0
Percentage of Assets0.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.0
Percentage of Assets us-gaap:CommonStock0.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.0

us-gaap:RetainedEarnings


Stockholders
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312016-12-312015-12-312014-12-31
Value-1313.184-1093.993-926.347-1004.612-868.912-750.295-581.47246-468.255037-398.430378-327.340214-276.765847-240.306373-204.334259-170.999957-149.263653-98.257559-71.132922-24.616966
Percentage of StockholdersEquity928.1-2117.8-452.9-949.2-374.4-289.7-1698.7-335.5-250.4-145.6-171.9-122.6-89.0-132.5-100.2-412.9-203.4-186.1
Percentage of Assets-187.6-135.0-96.4-130.8-99.9-108.9-149.4-100.4-125.8-102.8-136.0-100.5-76.6-104.8-82.0-358.20.00.0
Percentage of Assets us-gaap:RetainedEarnings0.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.0

Common Stock Value

us-gaap:CommonStockValue

us-gaap:CommonStockValue


Common
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302016-12-31
Value8000.08000.08000.08000.08000.07000.06393.06387.06367.06322.05628.05624.05615.05042.05033.0847.0843.0
Percentage of CommonStockValue100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0
Percentage of Assets0.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.0

Additional Paid In Capital

us-gaap:AdditionalPaidInCapital

us-gaap:AdditionalPaidInCapital


Additional
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302016-12-31
Value1173114711311112110010086156085575524374354333002983129
Percentage of AdditionalPaidInCapital100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0
Percentage of Assets167.7141.6117.7144.8126.5146.4158.2130.4176.1173.5215.1182.3162.6183.8163.7164.1109.3

Retained Earnings Accumulated Deficit

us-gaap:RetainedEarningsAccumulatedDeficit

us-gaap:RetainedEarningsAccumulatedDeficit


Retained
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302016-12-31
Value-1313200000.0-1094000000.0-926350000.0-1004600000.0-868910000.0-750300000.0-581470000.0-468260000.0-398430000.0-327340000.0-276770000.0-240310000.0-204330000.0-171000000.0-149260000.0-131010000.0-98258000.0
Percentage of RetainedEarningsAccumulatedDeficit100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0
Percentage of Assets-187.6-135.0-96.4-130.8-99.9-108.9-149.4-100.4-125.8-102.8-136.0-100.5-76.6-104.8-82.0-684.4-358.2

Accumulated Other Comprehensive Income Loss Net Of Tax

us-gaap:AccumulatedOtherComprehensiveIncomeLossNetOfTax

us-gaap:AccumulatedOtherComprehensiveIncomeLossNetOfTax


Accumulated
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-31
Value-1829000.0-1620000.0-117000.0-1759000.0329000.01010000.0-153780.0-205250.0-121980.0-120640.0-122810.0
Percentage of AccumulatedOtherComprehensiveIncomeLossNetOfTax100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0
Percentage of Assets-0.3-0.2-0.0-0.20.00.1-0.0-0.0-0.0-0.0-0.1

Adjustments To Additional Paid In Capital Sharebased Compensation Requisite Service Period Recognition Value

us-gaap:AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue

us-gaap:AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue


Adjustments
Period End2021-06-302021-03-312020-09-302020-06-302020-03-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-31
Value171612119.2945.2951524.1832214.5585881.8286172.0509242.2435271.6101884.16434
Percentage of AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0
Percentage of Assets0.00.00.00.00.00.00.00.00.00.00.00.00.0

us-gaap:AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue us-gaap:StatementEquityComponents

us-gaap:AdditionalPaidInCapital


Adjustments
Period End2021-06-302021-03-312020-09-302020-06-302020-03-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-31
Value171612119.2945.2951524.1832214.5585881.8286172.0509242.2435271.610188
Percentage of AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0
Percentage of Assets0.00.00.00.00.00.00.00.00.00.00.00.0
Percentage of Assets us-gaap:AdditionalPaidInCapital0.00.00.00.00.00.00.00.00.00.00.00.0

Net Cash Provided By Used In Operating Activities

us-gaap:NetCashProvidedByUsedInOperatingActivities

us-gaap:NetCashProvidedByUsedInOperatingActivities


Net
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-30
Value-128.688-153.314141-99.824-94.294-108.349-82.071683-53.59764-39.905638-35.560484-44.478223-33.132448-30.694877-22.935249-15.532804-11.137868
Percentage of NetCashProvidedByUsedInOperatingActivities100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax-20656.20.056.8-15452.60.00.00.00.00.00.00.00.00.00.00.00.0

Net Cash Provided By Used In Investing Activities

us-gaap:NetCashProvidedByUsedInInvestingActivities

us-gaap:NetCashProvidedByUsedInInvestingActivities


Net
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-31
Value129-146.765-0.091198-287.807-227.854-0.155-0.471-0.192-0.875
Percentage of NetCashProvidedByUsedInInvestingActivities100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax20827.00.0-0.030768.30.00.00.00.00.00.0

Net Cash Provided By Used In Financing Activities

us-gaap:NetCashProvidedByUsedInFinancingActivities

us-gaap:NetCashProvidedByUsedInFinancingActivities


Net
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-31
Value4.5261.6326.3170.9262814030.20961198401480.115657-0.0384341310.222697178
Percentage of NetCashProvidedByUsedInFinancingActivities100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax726.50.02.5143.30.00.00.00.00.00.00.00.00.00.00.0

Cash Cash Equivalents Restricted Cash And Restricted Cash Equivalents Period Increase Decrease Including Exchange Rate Effect

us-gaap:CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect

us-gaap:CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect


Cash
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-31
Value5.349-300.05815098-100.30166-82.0095591440.881863111-44.373152-33.198722100-22.712552
Percentage of CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax858.60.060.115204.20.00.00.00.00.00.00.00.00.00.0

Amortization Of Financing Costs

us-gaap:AmortizationOfFinancingCosts us-gaap:AdjustmentsForNewAccountingPronouncements

us-gaap:AmortizationOfFinancingCosts

apls:AccountingStandardsUpdate202006


Amortization
Period End2021-01-01
Value1100000.0
Percentage of AmortizationOfFinancingCosts100.0

us-gaap:AmortizationOfFinancingCosts us-gaap:LongtermDebtType

apls:ConvertibleSeniorNotesDueTwoThousandTwentySix


Amortization
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-30
Value300000.0400000.0100000.0100000.0100000.0100000.0100000.09031.0
Percentage of AmortizationOfFinancingCosts0.00.00.00.00.00.00.00.0

Increase Decrease In Accounts Payable

us-gaap:IncreaseDecreaseInAccountsPayable

us-gaap:IncreaseDecreaseInAccountsPayable


Increase
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302017-06-302017-03-312016-12-31
Value874000.0-4170000.0-2446000.0792000.06837000.0-5237000.0-3433400.0-2008300.01894400.01906500.04792600.0325080.0547960.0921800.0-521550.01396700.0237520.0-180330.0-249580.0
Percentage of IncreaseDecreaseInAccountsPayable100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0

Net Cash Provided By Used In Operating Activities

us-gaap:NetCashProvidedByUsedInOperatingActivities

us-gaap:NetCashProvidedByUsedInOperatingActivities


Net
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-30
Value-128.688-153.314141-99.824-94.294-108.349-82.071683-53.59764-39.905638-35.560484-44.478223-33.132448-30.694877-22.935249-15.532804-11.137868
Percentage of NetCashProvidedByUsedInOperatingActivities100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax-20656.20.056.8-15452.60.00.00.00.00.00.00.00.00.00.00.00.0

Net Income Loss

us-gaap:NetIncomeLoss

us-gaap:NetIncomeLoss


Net
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302017-06-302017-03-312016-12-312016-09-302016-06-302016-03-31
Value-219.191-183.65978-135.7-118.617-168.822-113.217423-69.824659-71.090164-50.574367-36.459475-35.972115-33.3343-21.736304-18.255896-11.573273-12.126152-9.050773-6.620102-7.210591-7.294245-5.999699
Percentage of NetIncomeLoss100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax-35183.10.031.3-21006.20.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.0

us-gaap:NetIncomeLoss us-gaap:StatementEquityComponents

us-gaap:RetainedEarnings


Net
Period End2021-06-302021-03-312020-09-302020-06-302020-03-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-31
Value-219.191-183.659-135.7-118.617-168.822-69.824659-71.090164-50.574367-36.459474-35.545924-33.334302-21.736304
Percentage of NetIncomeLoss100.0100.0100.0100.0100.0100.0100.0100.0100.098.8100.0100.0
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax-35183.10.0-21006.20.00.00.00.00.00.00.00.00.0
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax us-gaap:RetainedEarnings0.00.00.00.00.00.00.00.00.00.00.00.0

Profit Loss

us-gaap:ProfitLoss

us-gaap:ProfitLoss


Profit
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-31
Value-219.191-183.65978-135.7-118.617-168.822-113.217423-69.824659-71.090164-50.574367-36.885665-35.545923-33.334302-21.736304
Percentage of ProfitLoss100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax-35183.10.031.3-21006.20.00.00.00.00.00.00.00.00.00.0

Share Based Compensation

us-gaap:ShareBasedCompensation

us-gaap:ShareBasedCompensation


Share
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302017-06-302017-03-312016-12-31
Value17161212119.2947.1070685.2951524.1832214.5585881.8286172.0509242.2435271.6101884.164340.5455370.3809240.3279090.316559
Percentage of ShareBasedCompensation100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0

Net Cash Provided By Used In Investing Activities

us-gaap:NetCashProvidedByUsedInInvestingActivities

us-gaap:NetCashProvidedByUsedInInvestingActivities


Net
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-31
Value129-146.765-0.091198-287.807-227.854-0.155-0.471-0.192-0.875
Percentage of NetCashProvidedByUsedInInvestingActivities100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax20827.00.0-0.030768.30.00.00.00.00.00.0

Payments To Acquire Property Plant And Equipment

us-gaap:PaymentsToAcquirePropertyPlantAndEquipment

us-gaap:PaymentsToAcquirePropertyPlantAndEquipment


Payments
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-31
Value248000.0484000.0711000.03738000.0538000.0435000.0155000.0471000.0192000.0875000.0
Percentage of PaymentsToAcquirePropertyPlantAndEquipment100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0

Net Cash Provided By Used In Financing Activities

us-gaap:NetCashProvidedByUsedInFinancingActivities

us-gaap:NetCashProvidedByUsedInFinancingActivities


Net
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-31
Value4.5261.6326.3170.9262814030.20961198401480.115657-0.0384341310.222697178
Percentage of NetCashProvidedByUsedInFinancingActivities100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax726.50.02.5143.30.00.00.00.00.00.00.00.00.00.00.0

Share Based Compensation Arrangement By Share Based Payment Award Options Outstanding Weighted Average Exercise Price

us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePrice

us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePrice


Share
Period End2020-12-312019-12-312018-12-312017-12-312017-09-302016-12-312015-12-312014-12-31
Value19.1313.528.094.783.042.842.712.5
Percentage of ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePrice100.0100.0100.0100.0100.0100.0100.0100.0

Deferred Tax Assets Valuation Allowance

us-gaap:DeferredTaxAssetsValuationAllowance

us-gaap:DeferredTaxAssetsValuationAllowance


Deferred
Period End2020-12-312019-12-312018-12-312017-12-312016-12-31
Value397156794130
Percentage of DeferredTaxAssetsValuationAllowance100.0100.0100.0100.0100.0

apls:AdditionalAmountIssuedInPaymentOfIssuanceCosts us-gaap:DebtInstrument, us-gaap:LongtermDebtType, us-gaap:TypeOfArrangement

apls:AdditionalAmountIssuedInPaymentOfIssuanceCosts

apls:TwoThousandNineteenConvertibleNotes, apls:ConvertibleSeniorNotesDueTwoThousandTwentySix, apls:ExchangeAgreements


Additional
Period End2021-01-31
Value3100000.0
Percentage of AdditionalAmountIssuedInPaymentOfIssuanceCosts100.0

apls:AdjustmentsToAdditionalPaidInCapitalForfeitureOfAccruedInterestInExchangeOfConvertibleNotes

apls:AdjustmentsToAdditionalPaidInCapitalForfeitureOfAccruedInterestInExchangeOfConvertibleNotes


Adjustments
Period End2021-03-31
Value1668000.0
Percentage of AdjustmentsToAdditionalPaidInCapitalForfeitureOfAccruedInterestInExchangeOfConvertibleNotes100.0

apls:AdjustmentsToAdditionalPaidInCapitalForfeitureOfAccruedInterestInExchangeOfConvertibleNotes us-gaap:StatementEquityComponents

us-gaap:AdditionalPaidInCapital


Adjustments
Period End2021-03-31
Value1668000.0
Percentage of AdjustmentsToAdditionalPaidInCapitalForfeitureOfAccruedInterestInExchangeOfConvertibleNotes100.0

apls:AmortizationOfDiscountsForConvertibleNotesNetOfFinancingCosts

apls:AmortizationOfDiscountsForConvertibleNotesNetOfFinancingCosts


Amortization
Period End2020-12-312020-09-302020-06-302020-03-312019-12-31
Value5.064.9283.5541.9941.952
Percentage of AmortizationOfDiscountsForConvertibleNotesNetOfFinancingCosts100.0100.0100.0100.0100.0

apls:AnnualLicenseMaintenanceFees us-gaap:TypeOfArrangement

apls:AnnualLicenseMaintenanceFees

apls:TwoThousandTenLicenseAgreement


Annual
Period End2021-06-302021-03-31
Value0100000.0
Percentage of AnnualLicenseMaintenanceFees0.0100.0

apls:ContraResearchAndDevelopmentExpense

apls:ContraResearchAndDevelopmentExpense


Contra
Period End2021-06-302021-03-31
Value9.18.1
Percentage of ContraResearchAndDevelopmentExpense100.0100.0

apls:ContractResearchAndDevelopmentReimbursement us-gaap:CounterpartyName, us-gaap:TypeOfArrangement

apls:ContractResearchAndDevelopmentReimbursement

apls:SwedishOrphanBiovitrumABPubl, apls:CollaborationAndLicenseAgreement


Contract
Period End2021-06-302021-03-31
Value0.080
Percentage of ContractResearchAndDevelopmentReimbursement0.0100.0

apls:CostOfResearchCollaboration

apls:CostOfResearchCollaboration


Cost
Period End2021-06-30
Value50
Percentage of CostOfResearchCollaboration100.0

apls:DevelopmentCostReimbursement us-gaap:CounterpartyName

apls:DevelopmentCostReimbursement

apls:SwedishOrphanBiovitrumABPubl


Development
Period End2020-10-27
Value80
Percentage of DevelopmentCostReimbursement100.0

apls:DevelopmentCostReimbursement us-gaap:CounterpartyName, us-gaap:AdjustmentsForNewAccountingPronouncements, us-gaap:TypeOfArrangement

apls:SwedishOrphanBiovitrumABPubl, us-gaap:AccountingStandardsUpdate201818, apls:CollaborationAndLicenseAgreement


Development
Period End2020-10-27
Value80
Percentage of DevelopmentCostReimbursement100.0

apls:DevelopmentCostReimbursement us-gaap:CounterpartyName, us-gaap:SubsequentEventType, us-gaap:TypeOfArrangement

apls:SwedishOrphanBiovitrumABPubl, us-gaap:SubsequentEvent, apls:CollaborationAndLicenseAgreement


Development
Period End2020-10-27
Value80
Percentage of DevelopmentCostReimbursement100.0

apls:DevelopmentCostReimbursement us-gaap:CounterpartyName, us-gaap:TypeOfArrangement

apls:SwedishOrphanBiovitrumABPubl, apls:CollaborationAndLicenseAgreement


Development
Period End2020-10-27
Value80
Percentage of DevelopmentCostReimbursement100.0

apls:ForfeitureOfAccruedInterestInExchangeOfConvertibleNotes

apls:ForfeitureOfAccruedInterestInExchangeOfConvertibleNotes


Forfeiture
Period End2021-06-302021-03-31
Value01668000.0
Percentage of ForfeitureOfAccruedInterestInExchangeOfConvertibleNotes0.0100.0

apls:ForfeitureOfAccruedInterestInExchangeOfConvertibleNotes us-gaap:DebtInstrument, us-gaap:LongtermDebtType, us-gaap:TypeOfArrangement

apls:TwoThousandNineteenConvertibleNotes, apls:ConvertibleSeniorNotesDueTwoThousandTwentySix, apls:ExchangeAgreements


Forfeiture
Period End2021-01-31
Value1700000.0
Percentage of ForfeitureOfAccruedInterestInExchangeOfConvertibleNotes0.0

apls:InterestExpenseNonoperating

apls:InterestExpenseNonoperating


Interest
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-31
Value3.7674.1759.619.4996.9093.9193.9302310.6013770.1594970.5935051.2422130.5775340.6036560.667087
Percentage of InterestExpenseNonoperating100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0

apls:LossOnConversionOfDebt

apls:LossOnConversionOfDebt


Loss
Period End2021-06-302021-03-31
Value0.039
Percentage of LossOnConversionOfDebt0.0100.0

apls:LossOnConversionOfDebt us-gaap:DebtInstrument, us-gaap:LongtermDebtType, us-gaap:TypeOfArrangement

apls:TwoThousandNineteenConvertibleNotes, apls:ConvertibleSeniorNotesDueTwoThousandTwentySix, apls:ExchangeAgreements


Loss
Period End2021-01-31
Value39
Percentage of LossOnConversionOfDebt0.0

apls:LossOnConversionOfDebtRelatedToAdditionalSharesIssued us-gaap:DebtInstrument, us-gaap:LongtermDebtType, us-gaap:TypeOfArrangement

apls:LossOnConversionOfDebtRelatedToAdditionalSharesIssued

apls:TwoThousandNineteenConvertibleNotes, apls:ConvertibleSeniorNotesDueTwoThousandTwentySix, apls:ExchangeAgreements


Loss
Period End2021-01-31
Value36
Percentage of LossOnConversionOfDebtRelatedToAdditionalSharesIssued100.0

apls:MinimumPaymentOfAdditionalFundingAmount

apls:MinimumPaymentOfAdditionalFundingAmount


Minimum
Period End2021-06-302020-03-312019-09-302019-06-302019-03-31
Value-4.020204060
Percentage of MinimumPaymentOfAdditionalFundingAmount100.0100.0100.0100.0100.0

apls:NonRefundableUpfrontPayment us-gaap:CounterpartyName

apls:NonRefundableUpfrontPayment

apls:SwedishOrphanBiovitrumABPubl


Non
Period End2020-10-27
Value250
Percentage of NonRefundableUpfrontPayment100.0

apls:OperatingLeaseRightOfUseAssetAmortization

apls:OperatingLeaseRightOfUseAssetAmortization


Operating
Period End2021-06-302021-03-312020-09-302020-06-302020-03-312019-09-302019-06-302019-03-31
Value6000.0112000.0125000.027000.057000.078000.076000.073000.0
Percentage of OperatingLeaseRightOfUseAssetAmortization100.0100.0100.0100.0100.0100.0100.0100.0

apls:PaymentMadeUnderAgreement us-gaap:TypeOfArrangement

apls:PaymentMadeUnderAgreement

apls:SFJAgreement


Payment
Period End2021-06-30
Value4000000.0
Percentage of PaymentMadeUnderAgreement100.0

apls:PercentageOfRoyaltyFeesPayments us-gaap:Range

apls:PercentageOfRoyaltyFeesPayments

srt:Maximum


Percentage
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-31
Value06.005.9400.060
Percentage of PercentageOfRoyaltyFeesPayments0.0100.00.0100.00.0100.00.0

srt:Minimum


Percentage
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-31
Value03.002.9700.030
Percentage of PercentageOfRoyaltyFeesPayments0.050.00.050.00.050.00.0

apls:PremiumPaidForCappedCallTransaction us-gaap:DebtInstrument

apls:PremiumPaidForCappedCallTransaction

apls:TwoThousandNineteenConvertibleNotes


Premium
Period End2021-06-302021-03-312020-12-312020-09-30
Value0.0280.00.0
Percentage of PremiumPaidForCappedCallTransaction0.0100.00.00.0

apls:TwoThousandTwentyConvertibleNotes


Premium
Period End2021-06-302021-03-312020-12-312020-09-30
Value0.0430.00.0
Percentage of PremiumPaidForCappedCallTransaction0.0151.80.00.0

apls:ProceedsFromContractResearchAndDevelopment us-gaap:CounterpartyName, us-gaap:TypeOfArrangement

apls:ProceedsFromContractResearchAndDevelopment

apls:SwedishOrphanBiovitrumABPubl, apls:CollaborationAndLicenseAgreement


Proceeds
Period End2021-01-31
Value25
Percentage of ProceedsFromContractResearchAndDevelopment100.0

apls:ProceedsFromDevelopmentDerivativeLiability

apls:ProceedsFromDevelopmentDerivativeLiability


Proceeds
Period End2020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-31
Value0.00.00.0200.0204060
Percentage of ProceedsFromDevelopmentDerivativeLiability0.00.00.0100.00.0100.0100.0100.0

apls:ProceedsFromIssuanceOfConvertibleNotesNetOfIssuanceCosts

apls:ProceedsFromIssuanceOfConvertibleNotesNetOfIssuanceCosts


Proceeds
Period End2020-12-312020-09-302019-12-31
Value0.0-0.2-0.488
Percentage of ProceedsFromIssuanceOfConvertibleNotesNetOfIssuanceCosts0.0100.0100.0

apls:UpfrontPayment us-gaap:CounterpartyName, us-gaap:AdjustmentsForNewAccountingPronouncements, us-gaap:TypeOfArrangement

apls:UpfrontPayment

apls:SwedishOrphanBiovitrumABPubl, us-gaap:AccountingStandardsUpdate201818, apls:CollaborationAndLicenseAgreement


Upfront
Period End2020-11-30
Value250
Percentage of UpfrontPayment100.0

apls:UpfrontPayment us-gaap:CounterpartyName, us-gaap:SubsequentEventType, us-gaap:TypeOfArrangement

apls:BeamTherapeuticsInc, us-gaap:SubsequentEvent, apls:CollaborationAndLicenseAgreement


Upfront
Period End2021-07-31
Value50
Percentage of UpfrontPayment0.0

apls:BeamTherapeuticsIncorporation, us-gaap:SubsequentEvent, apls:ResearchCollaborationAgreement


Upfront
Period End2021-07-31
Value50
Percentage of UpfrontPayment0.0

us-gaap:AdjustmentsToAdditionalPaidInCapitalConvertibleDebtWithConversionFeature

us-gaap:AdjustmentsToAdditionalPaidInCapitalConvertibleDebtWithConversionFeature


Adjustments
Period End2020-09-302020-06-302019-09-30
Value-1.66212272
Percentage of AdjustmentsToAdditionalPaidInCapitalConvertibleDebtWithConversionFeature100.0100.0100.0

us-gaap:AdjustmentsToAdditionalPaidInCapitalConvertibleDebtWithConversionFeature us-gaap:StatementEquityComponents

us-gaap:AdditionalPaidInCapital


Adjustments
Period End2020-09-302020-06-302019-09-30
Value-1.66212272
Percentage of AdjustmentsToAdditionalPaidInCapitalConvertibleDebtWithConversionFeature100.0100.0100.0

us-gaap:AmortizationOfDebtDiscountPremium

us-gaap:AmortizationOfDebtDiscountPremium


Amortization
Period End2021-03-312019-12-312019-09-302019-06-302019-03-31
Value0.360.00.0137250.0190.019
Percentage of AmortizationOfDebtDiscountPremium100.00.0100.0100.0100.0

us-gaap:AmortizationOfDebtDiscountPremium us-gaap:LongtermDebtType

apls:ConvertibleSeniorNotesDueTwoThousandTwentySix


Amortization
Period End2020-12-312020-09-302020-06-302020-03-312019-12-312019-09-30
Value4.94.83.41.92.0893680.224655
Percentage of AmortizationOfDebtDiscountPremium0.00.00.00.00.01636.8

us-gaap:DebtConversionConvertedInstrumentAmount1

us-gaap:DebtConversionConvertedInstrumentAmount1


Debt
Period End2021-06-302021-03-31
Value0.0126
Percentage of DebtConversionConvertedInstrumentAmount10.0100.0

us-gaap:DebtConversionConvertedInstrumentAmount1 us-gaap:DebtInstrument, us-gaap:LongtermDebtType, us-gaap:SubsequentEventType, us-gaap:TypeOfArrangement

apls:TwoThousandNineteenAndTwoThousandTwentyConvertibleNotes, apls:ConvertibleSeniorNotesDueTwoThousandTwentySix, us-gaap:SubsequentEvent, apls:ExchangeAgreements


Debt
Period End2021-07-31
Value201
Percentage of DebtConversionConvertedInstrumentAmount10.0

apls:TwoThousandNineteenConvertibleNotes, apls:ConvertibleSeniorNotesDueTwoThousandTwentySix, us-gaap:SubsequentEvent, apls:ExchangeAgreements


Debt
Period End2021-01-06
Value126
Percentage of DebtConversionConvertedInstrumentAmount10.0

us-gaap:DebtConversionConvertedInstrumentAmount1 us-gaap:DebtInstrument, us-gaap:LongtermDebtType, us-gaap:TypeOfArrangement

apls:TwoThousandNineteenConvertibleNotes, apls:ConvertibleSeniorNotesDueTwoThousandTwentySix, apls:ExchangeAgreements


Debt
Period End2021-06-302021-03-312021-01-31
Value0.0126126
Percentage of DebtConversionConvertedInstrumentAmount10.0100.00.0

us-gaap:DebtInstrumentConvertibleConversionRatio1 us-gaap:DebtInstrument, us-gaap:LongtermDebtType, us-gaap:TypeOfArrangement

us-gaap:DebtInstrumentConvertibleConversionRatio1

apls:TwoThousandNineteenConvertibleNotes, apls:ConvertibleSeniorNotesDueTwoThousandTwentySix, apls:ExchangeAgreements


Debt
Period End2021-01-31
Value25.34
Percentage of DebtInstrumentConvertibleConversionRatio1100.0

us-gaap:DebtInstrumentConvertibleConversionRatio1 us-gaap:LongtermDebtType, us-gaap:StatementEquityComponents

apls:ConvertibleSeniorNotesDueTwoThousandTwentySix, us-gaap:CommonStock


Debt
Period End2021-06-302021-03-312020-12-31
Value025.340
Percentage of DebtInstrumentConvertibleConversionRatio10.00.00.0

us-gaap:DebtInstrumentConvertibleThresholdPercentageOfStockPriceTrigger us-gaap:LongtermDebtType

us-gaap:DebtInstrumentConvertibleThresholdPercentageOfStockPriceTrigger

apls:ConvertibleSeniorNotesDueTwoThousandTwentySix


Debt
Period End2021-06-302021-03-312020-12-31
Value0130.00
Percentage of DebtInstrumentConvertibleThresholdPercentageOfStockPriceTrigger0.0100.00.0

us-gaap:DebtInstrumentIncreaseDecreaseForPeriodNet us-gaap:AdjustmentsForNewAccountingPronouncements

us-gaap:DebtInstrumentIncreaseDecreaseForPeriodNet

apls:AccountingStandardsUpdate202006


Debt
Period End2021-01-01
Value149
Percentage of DebtInstrumentIncreaseDecreaseForPeriodNet100.0

us-gaap:DebtInstrumentIncreaseDecreaseForPeriodNet us-gaap:DebtInstrument, us-gaap:LongtermDebtType, us-gaap:TypeOfArrangement

apls:TwoThousandNineteenConvertibleNotes, apls:ConvertibleSeniorNotesDueTwoThousandTwentySix, apls:ExchangeAgreements


Debt
Period End2021-01-31
Value-122.8
Percentage of DebtInstrumentIncreaseDecreaseForPeriodNet0.0

us-gaap:Depreciation

us-gaap:Depreciation


Depreciation
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-31
Value442000.0282000.0267000.0190000.095000.085000.087000.066000.046000.041000.0
Percentage of Depreciation100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0

us-gaap:DerivativeGainLossOnDerivativeNet

us-gaap:DerivativeGainLossOnDerivativeNet


Derivative
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-31
Value-21180000.0-17084000.0-40090000.02697000.02770000.0-68406000.0-4736000.0-263000.0-9104000.0-736000.0
Percentage of DerivativeGainLossOnDerivativeNet100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0

us-gaap:DerivativeGainLossOnDerivativeNet us-gaap:TypeOfArrangement

apls:SFJAgreement


Derivative
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-31
Value-21200000.0-17100000.0-40100000.02700000.02800000.0-68400000.0-4739000.0-263000.0-9104000.0-736000.0
Percentage of DerivativeGainLossOnDerivativeNet100.1100.1100.0100.1101.1100.0100.1100.0100.0100.0

us-gaap:EffectOfExchangeRateOnCashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents

us-gaap:EffectOfExchangeRateOnCashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents


Effect
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-31
Value-241000.0-1611000.02025000.0-1646000.0132000.0-152000.08300.0-15598.016000.0-4000.0-10586.0
Percentage of EffectOfExchangeRateOnCashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0

us-gaap:IncreaseDecreaseInAccruedLiabilities

us-gaap:IncreaseDecreaseInAccruedLiabilities


Increase
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302017-06-302017-03-312016-12-31
Value65-42.80250130.421-9.9912410122.764408-5.4615045.4650512.411377-0.180904-0.04618-0.5770862.0674730.354772-0.823502
Percentage of IncreaseDecreaseInAccruedLiabilities100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0

us-gaap:IncreaseDecreaseInOtherCurrentAssets

us-gaap:IncreaseDecreaseInOtherCurrentAssets


Increase
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-03-31
Value0.0694.24225-0.1970.1530.671-1.171628-2.1557863.064915-0.0248540.296210.020279-0.1953540.188226-1.936041-0.217759
Percentage of IncreaseDecreaseInOtherCurrentAssets100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0

us-gaap:IncreaseDecreaseInOtherNoncurrentAssets

us-gaap:IncreaseDecreaseInOtherNoncurrentAssets


Increase
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312017-12-312016-12-31
Value9.188-11.946170.0010.0580.460.2027710.0290180.0450.0460.8813590.0078-0.065336
Percentage of IncreaseDecreaseInOtherNoncurrentAssets100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0

us-gaap:IncreaseDecreaseInPrepaidExpense

us-gaap:IncreaseDecreaseInPrepaidExpense


Increase
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-30
Value1.6545.819-0.235-6.626-4.8813.0045.0597190.765742-6.532304-3.8241967.4787565.9986682.7356853.0620092.1897680.279691
Percentage of IncreaseDecreaseInPrepaidExpense100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0

us-gaap:InterestExpenseDebtExcludingAmortization us-gaap:LongtermDebtType

us-gaap:InterestExpenseDebtExcludingAmortization

apls:ConvertibleSeniorNotesDueTwoThousandTwentySix


Interest
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-31
Value3.43.84.64.63.41.9
Percentage of InterestExpenseDebtExcludingAmortization100.0100.0100.0100.0100.0100.0

us-gaap:InvestmentIncomeNonoperating

us-gaap:InvestmentIncomeNonoperating


Investment
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-31
Value104000.0134000.0194000.0670000.01025000.02275000.01478500.01341800.01421500.0867020.01491800.0858420.0787660.0400400.0
Percentage of InvestmentIncomeNonoperating100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0

us-gaap:LongTermPurchaseCommitmentAmount

us-gaap:LongTermPurchaseCommitmentAmount


Long
Period End2020-12-31
Value10
Percentage of LongTermPurchaseCommitmentAmount100.0

us-gaap:LongTermPurchaseCommitmentAmount us-gaap:SubsequentEventType, us-gaap:TypeOfArrangement

us-gaap:SubsequentEvent, apls:BachemAmericasIncAndBachemAG


Long
Period End2021-04-01
Value2.9
Percentage of LongTermPurchaseCommitmentAmount0.0

us-gaap:SubsequentEvent, apls:NOFCorporationAndNOFAmericaCorporation


Long
Period End2021-04-01
Value6.4
Percentage of LongTermPurchaseCommitmentAmount0.0

us-gaap:SubsequentEvent, apls:PurchaseCommitmentsThroughJuneTwoThousandAndTwentyThree


Long
Period End2021-07-01
Value5.0
Percentage of LongTermPurchaseCommitmentAmount0.0

us-gaap:SubsequentEvent, apls:PurchaseCommitmentsThroughJuneTwoThousandAndTwentyTwo


Long
Period End2021-07-01
Value9.6
Percentage of LongTermPurchaseCommitmentAmount0.0

us-gaap:LongTermPurchaseCommitmentAmount us-gaap:TypeOfArrangement

apls:BachemAmericasIncAndBachemAG


Long
Period End2021-03-31
Value16
Percentage of LongTermPurchaseCommitmentAmount0.0

apls:NOFCorporationAndNOFAmericaCorporation


Long
Period End2021-03-31
Value32
Percentage of LongTermPurchaseCommitmentAmount0.0

us-gaap:OperatingLeaseCost

us-gaap:OperatingLeaseCost


Operating
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-31
Value1400000.01300000.01300000.01100000.01000000.01000000.0951870.0561750.0482830.0400000.0
Percentage of OperatingLeaseCost100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0

us-gaap:OperatingLeasePayments

us-gaap:OperatingLeasePayments


Operating
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-31
Value1357000.01588000.01410000.01266000.01088000.0968000.0790000.0510000.0382000.0331000.0
Percentage of OperatingLeasePayments100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0

us-gaap:OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent

us-gaap:OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent


Other
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-30
Value-209000.0-1503000.01642000.0-2088000.0-681000.01164000.051474.0-83272.0-1332.02000.0-36558.0-86249.0
Percentage of OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0

us-gaap:OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax

us-gaap:OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax


Other
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-31
Value-35000.079000.0-130000.0-430000.0-842000.01394000.0
Percentage of OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax100.0100.0100.0100.0100.0100.0

us-gaap:OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax us-gaap:StatementEquityComponents

us-gaap:AccumulatedOtherComprehensiveIncome


Other
Period End2021-06-302021-03-312020-09-302020-06-302020-03-31
Value-35000.079000.0-430000.0-842000.01394000.0
Percentage of OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax100.0100.0100.0100.0100.0

us-gaap:PaymentsRelatedToTaxWithholdingForShareBasedCompensation

us-gaap:PaymentsRelatedToTaxWithholdingForShareBasedCompensation


Payments
Period End2021-06-302021-03-31
Value234000.0956000.0
Percentage of PaymentsRelatedToTaxWithholdingForShareBasedCompensation100.0100.0

us-gaap:PaymentsToAcquireAvailableForSaleSecurities

us-gaap:PaymentsToAcquireAvailableForSaleSecurities


Payments
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-31
Value0.0171311-0.001339227
Percentage of PaymentsToAcquireAvailableForSaleSecurities0.0100.0100.0100.0100.0100.0

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us-gaap:ProceedsFromCollaborators

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Proceeds
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312020-01-312019-12-312019-09-302019-06-272019-06-302019-02-282019-03-31
Value0.01400.00.00.02020-60.02020406060
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us-gaap:ProceedsFromIssuanceOfCommonStock

us-gaap:ProceedsFromIssuanceOfCommonStock


Proceeds
Period End2020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-30
Value0.00.0-0.17381-0.6581520.0-0.022741100.0-0.130997
Percentage of ProceedsFromIssuanceOfCommonStock0.00.0100.0100.0100.00.0100.0100.00.0100.0

us-gaap:ProceedsFromMaturitiesPrepaymentsAndCallsOfAvailableForSaleSecurities

us-gaap:ProceedsFromMaturitiesPrepaymentsAndCallsOfAvailableForSaleSecurities


Proceeds
Period End2021-06-302021-03-312020-12-312020-09-30
Value13025312202
Percentage of ProceedsFromMaturitiesPrepaymentsAndCallsOfAvailableForSaleSecurities100.0100.0100.0100.0

us-gaap:ProceedsFromStockOptionsExercised

us-gaap:ProceedsFromStockOptionsExercised


Proceeds
Period End2021-06-302021-03-312020-09-302020-06-302020-03-312019-09-302019-06-302019-03-312018-09-302018-06-302018-03-31
Value7062000.02588000.01126000.01355000.01674000.0929710.01262200.0192000.0114990.0275750.0225360.0
Percentage of ProceedsFromStockOptionsExercised100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0

us-gaap:ProceedsFromStockPlans

us-gaap:ProceedsFromStockPlans


Proceeds
Period End2020-12-312020-09-30
Value1054000.00
Percentage of ProceedsFromStockPlans100.00.0

us-gaap:RestrictedStockValueSharesIssuedNetOfTaxWithholdings

us-gaap:RestrictedStockValueSharesIssuedNetOfTaxWithholdings


Restricted
Period End2021-06-302021-03-31
Value-233000.0-956000.0
Percentage of RestrictedStockValueSharesIssuedNetOfTaxWithholdings100.0100.0

us-gaap:RestrictedStockValueSharesIssuedNetOfTaxWithholdings us-gaap:StatementEquityComponents

us-gaap:AdditionalPaidInCapital


Restricted
Period End2021-06-302021-03-31
Value-233000.0-956000.0
Percentage of RestrictedStockValueSharesIssuedNetOfTaxWithholdings100.0100.0

us-gaap:RightOfUseAssetObtainedInExchangeForOperatingLeaseLiability

us-gaap:RightOfUseAssetObtainedInExchangeForOperatingLeaseLiability


Right
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-31
Value0.05.6750.5736.330.00.334-4.0957.0090.3476.94
Percentage of RightOfUseAssetObtainedInExchangeForOperatingLeaseLiability0.0100.0100.0100.00.0100.0100.0100.0100.0100.0

us-gaap:StockIssuedDuringPeriodValueConversionOfConvertibleSecurities

us-gaap:StockIssuedDuringPeriodValueConversionOfConvertibleSecurities


Stock
Period End2021-03-31
Value162
Percentage of StockIssuedDuringPeriodValueConversionOfConvertibleSecurities100.0

us-gaap:StockIssuedDuringPeriodValueConversionOfConvertibleSecurities us-gaap:StatementEquityComponents

us-gaap:AdditionalPaidInCapital


Stock
Period End2021-03-31
Value162
Percentage of StockIssuedDuringPeriodValueConversionOfConvertibleSecurities100.0

us-gaap:StockIssuedDuringPeriodValueEmployeeStockPurchasePlan

us-gaap:StockIssuedDuringPeriodValueEmployeeStockPurchasePlan


Stock
Period End2021-06-302020-06-30
Value1698000.0521000.0
Percentage of StockIssuedDuringPeriodValueEmployeeStockPurchasePlan100.0100.0

us-gaap:StockIssuedDuringPeriodValueEmployeeStockPurchasePlan us-gaap:StatementEquityComponents

us-gaap:AdditionalPaidInCapital


Stock
Period End2021-06-302020-06-30
Value1698000.0521000.0
Percentage of StockIssuedDuringPeriodValueEmployeeStockPurchasePlan100.0100.0

us-gaap:StockIssuedDuringPeriodValueStockOptionsExercised

us-gaap:StockIssuedDuringPeriodValueStockOptionsExercised


Stock
Period End2021-06-302021-03-312020-09-302020-06-302020-03-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-31
Value7062000.02588000.01127000.01355000.01674000.0954390.01262200.0192000.0111410.0114990.0275750.0225360.07501.0
Percentage of StockIssuedDuringPeriodValueStockOptionsExercised100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0

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us-gaap:AdditionalPaidInCapital


Stock
Period End2021-06-302021-03-312020-09-302020-06-302020-03-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-31
Value7062000.02588000.01127000.01354000.01674000.0954370.01262100.0192000.0111410.0114980.0275730.0225350.0
Percentage of StockIssuedDuringPeriodValueStockOptionsExercised100.0100.0100.099.9100.0100.0100.0100.0100.0100.0100.0100.0

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us-gaap:StockholdersEquityPeriodIncreaseDecrease

apls:AccountingStandardsUpdate202006


Stockholders
Period End2021-01-01
Value-149700000.0
Percentage of StockholdersEquityPeriodIncreaseDecrease100.0

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apls:AccountingStandardsUpdate202006, us-gaap:RetainedEarnings


Stockholders
Period End2021-01-01
Value-16000000.0
Percentage of StockholdersEquityPeriodIncreaseDecrease10.7

apls:AccruedCostOfResearchCollaborationCurrent

apls:AccruedCostOfResearchCollaborationCurrent


Accrued
Period End2021-06-30
Value50
Percentage of AccruedCostOfResearchCollaborationCurrent100.0

apls:AccruedLicenseFeesCurrent

apls:AccruedLicenseFeesCurrent


Accrued
Period End2020-12-31
Value25
Percentage of AccruedLicenseFeesCurrent100.0

apls:AccruedPayrollLiabilitiesCurrent

apls:AccruedPayrollLiabilitiesCurrent


Accrued
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302016-12-31
Value17112217117.898117.5861986.126121.7772440.2690462.3498451.4619190.7031860.2514911.0727510.091598
Percentage of AccruedPayrollLiabilitiesCurrent100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0

apls:AccruedResearchAndDevelopmentCurrent

apls:AccruedResearchAndDevelopmentCurrent


Accrued
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302016-12-31
Value3932473523303618134.7022323.481577.8551073.47841.857972.4638081.660950.871066
Percentage of AccruedResearchAndDevelopmentCurrent100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0

apls:AggregateMilestonePaymentsUponAchievementOfSpecifiedOneTimeRegulatoryAndCommercialMilestoneEvents us-gaap:CounterpartyName, us-gaap:Range, us-gaap:AdjustmentsForNewAccountingPronouncements, us-gaap:TypeOfArrangement

apls:AggregateMilestonePaymentsUponAchievementOfSpecifiedOneTimeRegulatoryAndCommercialMilestoneEvents

apls:SwedishOrphanBiovitrumABPubl, srt:Maximum, us-gaap:AccountingStandardsUpdate201818, apls:CollaborationAndLicenseAgreement


Aggregate
Period End2020-10-27
Value915
Percentage of AggregateMilestonePaymentsUponAchievementOfSpecifiedOneTimeRegulatoryAndCommercialMilestoneEvents100.0

apls:AggregateMilestonePaymentsUponAchievementOfSpecifiedOneTimeRegulatoryAndCommercialMilestoneEvents us-gaap:CounterpartyName, us-gaap:Range, us-gaap:SubsequentEventType, us-gaap:TypeOfArrangement

apls:SwedishOrphanBiovitrumABPubl, srt:Maximum, us-gaap:SubsequentEvent, apls:CollaborationAndLicenseAgreement


Aggregate
Period End2020-10-27
Value915
Percentage of AggregateMilestonePaymentsUponAchievementOfSpecifiedOneTimeRegulatoryAndCommercialMilestoneEvents100.0

apls:AggregateMilestonePaymentsUponAchievementOfSpecifiedOneTimeRegulatoryAndCommercialMilestoneEvents us-gaap:CounterpartyName, us-gaap:Range, us-gaap:TypeOfArrangement

apls:SwedishOrphanBiovitrumABPubl, srt:Maximum, apls:CollaborationAndLicenseAgreement


Aggregate
Period End2020-10-27
Value915
Percentage of AggregateMilestonePaymentsUponAchievementOfSpecifiedOneTimeRegulatoryAndCommercialMilestoneEvents100.0

apls:CashAndCashEquivalentsAndMarketableSecurities

apls:CashAndCashEquivalentsAndMarketableSecurities


Cash
Period End2020-12-31
Value877
Percentage of CashAndCashEquivalentsAndMarketableSecurities100.0

apls:CollaborativeArrangementUpFrontPaymentInNextTwelveMonths us-gaap:CounterpartyName, us-gaap:TypeOfArrangement

apls:CollaborativeArrangementUpFrontPaymentInNextTwelveMonths

apls:BeamTherapeuticsIncorporation, apls:ResearchCollaborationAgreement


Collaborative
Period End2021-06-30
Value25
Percentage of CollaborativeArrangementUpFrontPaymentInNextTwelveMonths100.0

apls:CollaborativeArrangementUpfrontNonRefundableAmountPayable us-gaap:CounterpartyName, us-gaap:BalanceSheetLocation, us-gaap:TypeOfArrangement

apls:CollaborativeArrangementUpfrontNonRefundableAmountPayable

apls:BeamTherapeuticsIncorporation, apls:AccruedLiabilitiesCurrent, apls:ResearchCollaborationAgreement


Collaborative
Period End2021-06-30
Value50
Percentage of CollaborativeArrangementUpfrontNonRefundableAmountPayable100.0

apls:CollaborativeArrangementUpfrontNonRefundableAmountPayable us-gaap:CounterpartyName, us-gaap:SubsequentEventType, us-gaap:TypeOfArrangement

apls:BeamTherapeuticsIncorporation, us-gaap:SubsequentEvent, apls:ResearchCollaborationAgreement


Collaborative
Period End2021-07-31
Value50
Percentage of CollaborativeArrangementUpfrontNonRefundableAmountPayable0.0

apls:ContraResearchAndDevelopmentCurrent

apls:ContraResearchAndDevelopmentCurrent


Contra
Period End2020-12-31
Value25
Percentage of ContraResearchAndDevelopmentCurrent100.0

apls:ContractResearchAndDevelopmentCurrent

apls:ContractResearchAndDevelopmentCurrent


Contract
Period End2021-06-302021-03-312020-12-31
Value202025
Percentage of ContractResearchAndDevelopmentCurrent100.0100.0100.0

apls:ContractResearchAndDevelopmentLongTermAssets

apls:ContractResearchAndDevelopmentLongTermAssets


Contract
Period End2020-12-31
Value18
Percentage of ContractResearchAndDevelopmentLongTermAssets100.0

apls:ContractResearchAndDevelopmentOtherAssets

apls:ContractResearchAndDevelopmentOtherAssets


Contract
Period End2021-06-302021-03-31
Value156.1
Percentage of ContractResearchAndDevelopmentOtherAssets100.0100.0

apls:ContractResearchAndDevelopmentReceivable

apls:ContractResearchAndDevelopmentReceivable


Contract
Period End2020-12-31
Value43
Percentage of ContractResearchAndDevelopmentReceivable100.0

apls:ContractResearchAndDevelopmentReceivable us-gaap:CounterpartyName, us-gaap:TypeOfArrangement

apls:SwedishOrphanBiovitrumABPubl, apls:CollaborationAndLicenseAgreement


Contract
Period End2021-06-302021-03-31
Value3526
Percentage of ContractResearchAndDevelopmentReceivable0.00.0

apls:ConvertibleSeniorNotesNoncurrent us-gaap:FairValueByFairValueHierarchyLevel, us-gaap:FairValueByLiabilityClass

apls:ConvertibleSeniorNotesNoncurrent

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Convertible
Period End2021-06-302021-03-31
Value739547
Percentage of ConvertibleSeniorNotesNoncurrent100.0100.0

us-gaap:FairValueInputsLevel2, apls:ConvertibleSeniorNotes


Convertible
Period End2020-12-31
Value676
Percentage of ConvertibleSeniorNotesNoncurrent0.0

us-gaap:FairValueInputsLevel3, apls:ConvertibleSeniorNotes


Convertible
Period End2020-12-312020-09-302020-06-302020-03-312019-12-31
Value676371378155149
Percentage of ConvertibleSeniorNotesNoncurrent0.00.00.00.00.0

apls:DeferredTaxAssetsOrphanDrugCredits

apls:DeferredTaxAssetsOrphanDrugCredits


Deferred
Period End2020-12-312019-12-312018-12-312017-12-312016-12-31
Value149.3804757.1653544.9286663.502686
Percentage of DeferredTaxAssetsOrphanDrugCredits100.0100.0100.0100.0100.0

apls:DeferredTaxAssetsTaxCreditCarryforwardsResearchAndDevelopment us-gaap:IncomeTaxAuthority

apls:DeferredTaxAssetsTaxCreditCarryforwardsResearchAndDevelopment

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Deferred
Period End2020-12-312019-12-312018-12-31
Value342414
Percentage of DeferredTaxAssetsTaxCreditCarryforwardsResearchAndDevelopment100.0100.0100.0

us-gaap:StateAndLocalJurisdiction


Deferred
Period End2020-12-31
Value6.5
Percentage of DeferredTaxAssetsTaxCreditCarryforwardsResearchAndDevelopment19.0

apls:DeferredTaxLiabilitiesSection481AAdjustment

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Deferred
Period End2020-12-312019-12-31
Value1935000.02891000.0
Percentage of DeferredTaxLiabilitiesSection481AAdjustment100.0100.0

apls:DevelopmentDerivativeLiabilitiesCurrent

apls:DevelopmentDerivativeLiabilitiesCurrent


Development
Period End2021-06-302021-03-312020-12-31
Value146.2124.23
Percentage of DevelopmentDerivativeLiabilitiesCurrent100.0100.0100.0

apls:DevelopmentDerivativeLiabilitiesCurrent us-gaap:TypeOfArrangement

apls:SFJAgreement


Development
Period End2021-06-302021-03-312020-12-31
Value146.24.2
Percentage of DevelopmentDerivativeLiabilitiesCurrent99.999.899.3

apls:DevelopmentDerivativeLiabilitiesGross

apls:DevelopmentDerivativeLiabilitiesGross


Development
Period End2021-06-302021-03-312020-12-312020-06-302020-03-312019-12-31
Value292274257220223134
Percentage of DevelopmentDerivativeLiabilitiesGross100.0100.0100.0100.0100.0100.0

apls:DevelopmentDerivativeLiabilitiesNoncurrent

apls:DevelopmentDerivativeLiabilitiesNoncurrent


Development
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-31
Value27826825321722022313413010960
Percentage of DevelopmentDerivativeLiabilitiesNoncurrent100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0

apls:DevelopmentDerivativeLiabilitiesNoncurrent us-gaap:TypeOfArrangement

apls:SFJAgreement


Development
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-30
Value292275257217220223134130
Percentage of DevelopmentDerivativeLiabilitiesNoncurrent105.1102.3101.7100.0100.0100.0100.0100.0

apls:EstimatedTerminationCostsAndOtherFees

apls:EstimatedTerminationCostsAndOtherFees


Estimated
Period End2021-06-302021-03-312020-12-312020-09-30
Value4300000.03200000.02800000.02100000.0
Percentage of EstimatedTerminationCostsAndOtherFees100.0100.0100.0100.0

apls:LesseeOperatingLeaseLiabilityPaymentsDueYearFiveAndThereafter

apls:LesseeOperatingLeaseLiabilityPaymentsDueYearFiveAndThereafter


Lessee
Period End2020-12-31
Value3745000.0
Percentage of LesseeOperatingLeaseLiabilityPaymentsDueYearFiveAndThereafter100.0

apls:LesseeOperatingLeaseLiabilityPaymentsDueYearFourAndThereafter

apls:LesseeOperatingLeaseLiabilityPaymentsDueYearFourAndThereafter


Lessee
Period End2021-06-302021-03-312020-09-30
Value9267000.09267000.07846000.0
Percentage of LesseeOperatingLeaseLiabilityPaymentsDueYearFourAndThereafter100.0100.0100.0

apls:NetDeferredTaxAssetsBeforeValuationAllowance

apls:NetDeferredTaxAssetsBeforeValuationAllowance


Net
Period End2020-12-312019-12-312018-12-312017-12-31
Value3971567941
Percentage of NetDeferredTaxAssetsBeforeValuationAllowance100.0100.0100.0100.0

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apls:OperatingLeaseArea

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Operating
Period End2020-12-31
Value16401.0
Percentage of OperatingLeaseArea100.0

apls:OperatingLeaseSquareFeetOfOfficeSpaceLeased us-gaap:StatementGeographical, us-gaap:TypeOfArrangement

apls:OperatingLeaseSquareFeetOfOfficeSpaceLeased

apls:WalthamMassachusetts, apls:AmendedWalthamOfficeSpaceLease


Operating
Period End2020-12-31
Value77818.0
Percentage of OperatingLeaseSquareFeetOfOfficeSpaceLeased100.0

apls:PrepaidResearchAndDevelopmentCostCurrent

apls:PrepaidResearchAndDevelopmentCostCurrent


Prepaid
Period End2021-06-302021-03-312020-12-312019-12-312018-12-312017-12-31
Value14148.018234.1
Percentage of PrepaidResearchAndDevelopmentCostCurrent100.0100.0100.0100.0100.0100.0

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apls:ProductSalesReserves

apls:AccruedLiabilitiesCurrent


Product
Period End2021-06-30
Value100000.0
Percentage of ProductSalesReserves100.0

apls:RoyaltyExpenseOwed us-gaap:TypeOfArrangement

apls:RoyaltyExpenseOwed

apls:SobiAgreementAndAnotherLicensingTransaction


Royalty
Period End2020-12-31
Value25
Percentage of RoyaltyExpenseOwed100.0

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apls:ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisedInPeriodAggregateIntrinsicValue


Share
Period End2020-12-312019-12-312018-12-31
Value38155.0
Percentage of ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisedInPeriodAggregateIntrinsicValue100.0100.0100.0

apls:UnrecognizedUpfrontPayment us-gaap:CounterpartyName, us-gaap:TypeOfArrangement

apls:UnrecognizedUpfrontPayment

apls:BeamTherapeuticsIncorporation, apls:ResearchCollaborationAgreement


Unrecognized
Period End2021-06-30
Value25
Percentage of UnrecognizedUpfrontPayment100.0

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Assets
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-31
Value434343404040
Percentage of AssetsFairValueDisclosure100.0100.0100.0100.0100.0100.0

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Assets
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312018-12-31
Value21421342727127325628192
Percentage of AssetsFairValueDisclosure492.5489.1981.1664.3670.0627.50.00.0

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Assets
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-31
Value328458311292495228
Percentage of AssetsFairValueDisclosure753.11051.4715.7716.81214.0560.7

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Assets
Period End2020-12-312020-03-31
Value89117
Percentage of AssetsFairValueDisclosure206.5287.1

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Assets
Period End2020-09-302020-06-30
Value1919
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Assets
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-31
Value434343404040
Percentage of AssetsFairValueDisclosure100.0100.0100.0100.0100.0100.0

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Assets
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312018-12-31
Value21421342727127325628192
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Assets
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-31
Value328458311292495228
Percentage of AssetsFairValueDisclosure753.11051.4715.7716.81214.0560.7

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Assets
Period End2020-12-312020-03-31
Value89117
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Assets
Period End2020-09-302020-06-30
Value1919
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Assets
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312018-12-31
Value25825647131131429628192
Percentage of AssetsFairValueDisclosure592.5589.11081.1764.3770.0727.50.00.0

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Assets
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-31
Value328458401312515345
Percentage of AssetsFairValueDisclosure753.11051.4922.2765.81262.9847.8

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Assets
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312018-12-31
Value25825647131131429628192
Percentage of AssetsFairValueDisclosure592.5589.11081.1764.3770.0727.50.00.0

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Assets
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-31
Value328458401312515345
Percentage of AssetsFairValueDisclosure753.11051.4922.2765.81262.9847.8

us-gaap:AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax us-gaap:FinancialInstrument

us-gaap:AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax

us-gaap:USGovernmentAgenciesDebtSecurities


Available
Period End2021-06-302021-03-312020-12-312020-09-30
Value36000.079000.011000.0122000.0
Percentage of AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax100.0100.0100.0100.0

us-gaap:AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax us-gaap:FinancialInstrument

us-gaap:AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax

us-gaap:USGovernmentAgenciesDebtSecurities


Available
Period End2020-12-31
Value19000.0
Percentage of AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax100.0

us-gaap:AvailableForSaleDebtSecuritiesAmortizedCostBasis us-gaap:FinancialInstrument

us-gaap:AvailableForSaleDebtSecuritiesAmortizedCostBasis

us-gaap:USGovernmentAgenciesDebtSecurities


Available
Period End2021-06-302021-03-312020-12-312020-09-30
Value328458311312
Percentage of AvailableForSaleDebtSecuritiesAmortizedCostBasis100.0100.0100.0100.0

us-gaap:AvailableForSaleSecuritiesDebtSecurities us-gaap:FinancialInstrument

us-gaap:AvailableForSaleSecuritiesDebtSecurities

us-gaap:USGovernmentAgenciesDebtSecurities


Available
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-31
Value328458311312515228
Percentage of AvailableForSaleSecuritiesDebtSecurities100.0100.0100.0100.0100.0100.0

us-gaap:CommonStockCapitalSharesReservedForFutureIssuance us-gaap:PlanName

us-gaap:CommonStockCapitalSharesReservedForFutureIssuance

apls:TwoThousandSeventeenStockIncentivePlan


Common
Period End2020-12-312019-12-312018-12-312017-12-31
Value8.6136.3190014.032391.682596
Percentage of CommonStockCapitalSharesReservedForFutureIssuance100.0100.0100.0100.0

us-gaap:ConvertibleDebt us-gaap:AdjustmentsForNewAccountingPronouncements

us-gaap:ConvertibleDebt

apls:AccountingStandardsUpdate202006


Convertible
Period End2021-01-01
Value149
Percentage of ConvertibleDebt100.0

us-gaap:ConvertibleDebt us-gaap:AdjustmentsForNewAccountingPronouncements, us-gaap:DebtInstrument

apls:AccountingStandardsUpdate202006, apls:TwoThousandNineteenConvertibleNotes


Convertible
Period End2021-01-01
Value74
Percentage of ConvertibleDebt50.0

apls:AccountingStandardsUpdate202006, apls:TwoThousandTwentyConvertibleNotes


Convertible
Period End2021-01-01
Value95
Percentage of ConvertibleDebt63.8

us-gaap:ConvertibleDebtNoncurrent

us-gaap:ConvertibleDebtNoncurrent


Convertible
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-31
Value386386358353348144142
Percentage of ConvertibleDebtNoncurrent100.0100.0100.0100.0100.0100.0100.0

us-gaap:DebtInstrumentConvertibleConversionPrice1 us-gaap:LongtermDebtType, us-gaap:StatementEquityComponents

us-gaap:DebtInstrumentConvertibleConversionPrice1

apls:ConvertibleSeniorNotesDueTwoThousandTwentySix, us-gaap:CommonStock


Debt
Period End2021-06-302021-03-312020-12-312020-09-30
Value39.46239.46239.46239.46
Percentage of DebtInstrumentConvertibleConversionPrice1100.0100.0100.0100.0

us-gaap:DebtInstrumentFaceAmount us-gaap:LongtermDebtType

us-gaap:DebtInstrumentFaceAmount

apls:ConvertibleSeniorNotesDueTwoThousandTwentySix


Debt
Period End2020-12-312020-09-302020-06-302020-03-312019-12-31
Value520353348220220
Percentage of DebtInstrumentFaceAmount100.0100.0100.0100.0100.0

us-gaap:DeferredFinanceCostsGross us-gaap:LongtermDebtType

us-gaap:DeferredFinanceCostsGross

apls:ConvertibleSeniorNotesDueTwoThousandTwentySix


Deferred
Period End2021-06-302021-03-312020-12-312020-09-30
Value7400000.07700000.07800000.08000000.0
Percentage of DeferredFinanceCostsGross100.0100.0100.0100.0

us-gaap:DeferredFinanceCostsNet us-gaap:AdjustmentsForNewAccountingPronouncements, us-gaap:DebtInstrument

us-gaap:DeferredFinanceCostsNet

apls:AccountingStandardsUpdate202006, apls:TwoThousandNineteenConvertibleNotes


Deferred
Period End2021-01-01
Value2400000.0
Percentage of DeferredFinanceCostsNet100.0

apls:AccountingStandardsUpdate202006, apls:TwoThousandTwentyConvertibleNotes


Deferred
Period End2021-01-01
Value2300000.0
Percentage of DeferredFinanceCostsNet95.8

us-gaap:DeferredFinanceCostsNet us-gaap:DebtInstrument, us-gaap:LongtermDebtType, us-gaap:TypeOfArrangement

apls:TwoThousandNineteenConvertibleNotes, apls:ConvertibleSeniorNotesDueTwoThousandTwentySix, apls:ExchangeAgreements


Deferred
Period End2021-01-31
Value3300000.0
Percentage of DeferredFinanceCostsNet0.0

us-gaap:DeferredIncomeTaxLiabilities

us-gaap:DeferredIncomeTaxLiabilities


Deferred
Period End2020-12-312019-12-312018-12-31
Value12142.475809
Percentage of DeferredIncomeTaxLiabilities100.0100.0100.0

us-gaap:DeferredTaxAssetsDerivativeInstruments

us-gaap:DeferredTaxAssetsDerivativeInstruments


Deferred
Period End2020-12-312019-12-31
Value6835
Percentage of DeferredTaxAssetsDerivativeInstruments100.0100.0

us-gaap:DeferredTaxAssetsGoodwillAndIntangibleAssets

us-gaap:DeferredTaxAssetsGoodwillAndIntangibleAssets


Deferred
Period End2020-12-312019-12-312018-12-312017-12-312016-12-31
Value1620.0155190.0196160.0235430.041166
Percentage of DeferredTaxAssetsGoodwillAndIntangibleAssets100.0100.0100.0100.0100.0

us-gaap:DeferredTaxAssetsGross

us-gaap:DeferredTaxAssetsGross


Deferred
Period End2020-12-312019-12-312018-12-312017-12-312016-12-31
Value409171814130
Percentage of DeferredTaxAssetsGross100.0100.0100.0100.0100.0

us-gaap:DeferredTaxAssetsOperatingLossCarryforwards

us-gaap:DeferredTaxAssetsOperatingLossCarryforwards


Deferred
Period End2020-12-312019-12-312018-12-312018-03-312017-12-312016-12-31
Value12210264363022
Percentage of DeferredTaxAssetsOperatingLossCarryforwards100.0100.0100.0100.0100.0100.0

us-gaap:DeferredTaxAssetsOperatingLossCarryforwardsNotSubjectToExpiration us-gaap:IncomeTaxAuthority

us-gaap:DeferredTaxAssetsOperatingLossCarryforwardsNotSubjectToExpiration

us-gaap:DomesticCountry


Deferred
Period End2020-12-31
Value276
Percentage of DeferredTaxAssetsOperatingLossCarryforwardsNotSubjectToExpiration100.0

us-gaap:DeferredTaxAssetsOther

us-gaap:DeferredTaxAssetsOther


Deferred
Period End2020-12-312019-12-31
Value207000.011000.0
Percentage of DeferredTaxAssetsOther100.0100.0

us-gaap:DeferredTaxAssetsTaxCreditCarryforwardsResearch

us-gaap:DeferredTaxAssetsTaxCreditCarryforwardsResearch


Deferred
Period End2020-12-312019-12-312018-12-312018-03-312017-12-312017-09-302016-12-31
Value24147.2696249.553513.3572912.2435651.347804
Percentage of DeferredTaxAssetsTaxCreditCarryforwardsResearch100.0100.0100.0100.0100.0100.0100.0

us-gaap:DeferredTaxAssetsTaxDeferredExpenseCompensationAndBenefitsShareBasedCompensationCost

us-gaap:DeferredTaxAssetsTaxDeferredExpenseCompensationAndBenefitsShareBasedCompensationCost


Deferred
Period End2020-12-312019-12-312018-12-312017-12-312016-12-31
Value116.6246382.9145831.8263721.000887
Percentage of DeferredTaxAssetsTaxDeferredExpenseCompensationAndBenefitsShareBasedCompensationCost100.0100.0100.0100.0100.0

us-gaap:DeferredTaxAssetsTaxDeferredExpenseReservesAndAccruals

us-gaap:DeferredTaxAssetsTaxDeferredExpenseReservesAndAccruals


Deferred
Period End2020-12-312019-12-312017-12-312016-12-31
Value4520000.02259000.0345620.0914630.0
Percentage of DeferredTaxAssetsTaxDeferredExpenseReservesAndAccruals100.0100.0100.0100.0

us-gaap:DeferredTaxLiabilitiesFinancingArrangements

us-gaap:DeferredTaxLiabilitiesFinancingArrangements


Deferred
Period End2020-12-312019-12-31
Value1011
Percentage of DeferredTaxLiabilitiesFinancingArrangements100.0100.0

us-gaap:DeferredTaxLiabilitiesPropertyPlantAndEquipment

us-gaap:DeferredTaxLiabilitiesPropertyPlantAndEquipment


Deferred
Period End2020-12-31
Value23000.0
Percentage of DeferredTaxLiabilitiesPropertyPlantAndEquipment100.0

us-gaap:EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedStockOptions

us-gaap:EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedStockOptions


Employee
Period End2020-12-312019-12-312018-12-312017-12-312016-12-312015-12-31
Value1007927102.910871.67311
Percentage of EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedStockOptions100.0100.0100.0100.0100.0100.0

us-gaap:EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedStockOptions us-gaap:AwardType

us-gaap:RestrictedStockUnitsRSU


Employee
Period End2020-12-31
Value16
Percentage of EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedStockOptions16.2

us-gaap:FinancialLiabilitiesFairValueDisclosure us-gaap:FairValueByFairValueHierarchyLevel, us-gaap:FairValueByLiabilityClass, us-gaap:FairValueByMeasurementFrequency

us-gaap:FinancialLiabilitiesFairValueDisclosure

us-gaap:FairValueInputsLevel3, apls:ConvertibleSeniorNotes, us-gaap:FairValueMeasurementsNonrecurring


Financial
Period End2020-09-302020-06-302020-03-312019-12-31
Value370378155149
Percentage of FinancialLiabilitiesFairValueDisclosure100.0100.0100.0100.0

us-gaap:FairValueInputsLevel3, apls:DevelopmentDerivativeLiability, us-gaap:FairValueMeasurementsRecurring


Financial
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-31
Value292274257217220223134
Percentage of FinancialLiabilitiesFairValueDisclosure0.00.00.058.758.2144.090.2

us-gaap:FinancialLiabilitiesFairValueDisclosure us-gaap:FairValueByFairValueHierarchyLevel, us-gaap:FairValueByMeasurementFrequency

us-gaap:FairValueInputsLevel3, us-gaap:FairValueMeasurementsNonrecurring


Financial
Period End2020-09-302020-06-302020-03-312019-12-31
Value370378155149
Percentage of FinancialLiabilitiesFairValueDisclosure100.0100.0100.0100.0

us-gaap:FairValueInputsLevel3, us-gaap:FairValueMeasurementsRecurring


Financial
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-31
Value292274257217220223134
Percentage of FinancialLiabilitiesFairValueDisclosure0.00.00.058.758.2144.090.2

us-gaap:FinancialLiabilitiesFairValueDisclosure us-gaap:FairValueByLiabilityClass, us-gaap:FairValueByMeasurementFrequency

apls:ConvertibleSeniorNotes, us-gaap:FairValueMeasurementsNonrecurring


Financial
Period End2020-09-302020-06-302020-03-312019-12-31
Value370378155149
Percentage of FinancialLiabilitiesFairValueDisclosure100.0100.0100.0100.0

apls:DevelopmentDerivativeLiability, us-gaap:FairValueMeasurementsRecurring


Financial
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-31
Value292274257217220223134
Percentage of FinancialLiabilitiesFairValueDisclosure0.00.00.058.758.2144.090.2

us-gaap:FinancialLiabilitiesFairValueDisclosure us-gaap:FairValueByMeasurementFrequency

us-gaap:FairValueMeasurementsNonrecurring


Financial
Period End2020-09-302020-06-302020-03-312019-12-312018-12-31
Value37037815514926
Percentage of FinancialLiabilitiesFairValueDisclosure100.0100.0100.0100.00.0

us-gaap:FairValueMeasurementsRecurring


Financial
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312018-12-31
Value2922742572172202231340.158783
Percentage of FinancialLiabilitiesFairValueDisclosure0.00.00.058.758.2144.090.20.0

us-gaap:LesseeOperatingLeaseLiabilityPaymentsDueNextTwelveMonths

us-gaap:LesseeOperatingLeaseLiabilityPaymentsDueNextTwelveMonths


Lessee
Period End2021-06-302021-03-312020-12-312020-09-30
Value5562000.05415000.04962000.04759000.0
Percentage of LesseeOperatingLeaseLiabilityPaymentsDueNextTwelveMonths100.0100.0100.0100.0

us-gaap:LesseeOperatingLeaseLiabilityPaymentsRemainderOfFiscalYear

us-gaap:LesseeOperatingLeaseLiabilityPaymentsRemainderOfFiscalYear


Lessee
Period End2021-06-302021-03-312020-09-30
Value2874000.04204000.01223000.0
Percentage of LesseeOperatingLeaseLiabilityPaymentsRemainderOfFiscalYear100.0100.0100.0

us-gaap:OperatingLeaseWeightedAverageDiscountRatePercent

us-gaap:OperatingLeaseWeightedAverageDiscountRatePercent


Operating
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-31
Value7.717.767.747.840.0830.08320.0819
Percentage of OperatingLeaseWeightedAverageDiscountRatePercent100.0100.0100.0100.0100.0100.0100.0

us-gaap:OperatingLossCarryforwards us-gaap:IncomeTaxAuthority

us-gaap:OperatingLossCarryforwards

us-gaap:DomesticCountry


Operating
Period End2020-12-312019-12-312018-12-312017-12-31
Value358392251118
Percentage of OperatingLossCarryforwards100.0100.0100.0100.0

us-gaap:ForeignCountry


Operating
Period End2020-12-31
Value240
Percentage of OperatingLossCarryforwards67.3

us-gaap:StateAndLocalJurisdiction


Operating
Period End2020-12-312019-12-312018-12-312017-12-31
Value405358254118
Percentage of OperatingLossCarryforwards113.191.2101.3100.0

us-gaap:PrepaidExpenseCurrent

us-gaap:PrepaidExpenseCurrent


Prepaid
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312016-12-31
Value181711111722191413202416108.1216025.0595931.132438
Percentage of PrepaidExpenseCurrent100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0

us-gaap:RestrictedCash

us-gaap:RestrictedCash


Restricted
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-31
Value1572000.01552000.01266000.01255000.01248000.01016000.0
Percentage of RestrictedCash100.0100.0100.0100.0100.0100.0

us-gaap:RestrictedCashCurrent

us-gaap:RestrictedCashCurrent


Restricted
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-31
Value1572000.01552000.01266000.01255000.01248000.01016000.0
Percentage of RestrictedCashCurrent100.0100.0100.0100.0100.0100.0

us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValue us-gaap:AwardType

us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValue

us-gaap:RestrictedStockUnitsRSU


Share
Period End2020-12-31
Value38.84
Percentage of ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValue100.0

us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisableWeightedAverageExercisePrice

us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisableWeightedAverageExercisePrice


Share
Period End2020-12-312017-12-312017-09-302016-12-312015-12-31
Value10.963.672.72.562.43
Percentage of ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisableWeightedAverageExercisePrice100.0100.0100.0100.0100.0

us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsVestedAndExpectedToVestOutstandingAggregateIntrinsicValue

us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsVestedAndExpectedToVestOutstandingAggregateIntrinsicValue


Share
Period End2020-12-312017-12-312015-12-31
Value166500.812365
Percentage of ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsVestedAndExpectedToVestOutstandingAggregateIntrinsicValue100.0100.0100.0

us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsVestedAndExpectedToVestOutstandingWeightedAverageExercisePrice

us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsVestedAndExpectedToVestOutstandingWeightedAverageExercisePrice


Share
Period End2020-12-312017-12-312016-12-312015-12-31
Value27.855.883.163.16
Percentage of ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsVestedAndExpectedToVestOutstandingWeightedAverageExercisePrice100.0100.0100.0100.0

us-gaap:SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsExercisableIntrinsicValue1

us-gaap:SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsExercisableIntrinsicValue1


Sharebased
Period End2020-12-312017-12-312016-12-312015-12-31
Value280560.2432.058419
Percentage of SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsExercisableIntrinsicValue1100.0100.0100.0100.0

Line plots across dimensions of each concept


us-gaap:AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount
us-gaap:AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecurities
(None,)
Antidilutive Securities Excluded From Computation Of Earnings Per Share Amountus-gaap: Antidilutive Securities Excluded From Computation Of Earnings Per Share By Antidilutive Securities
TTM Greenblatt ROC
_
(None,)
T T M  Greenblatt  R O C_
us-gaap:OtherComprehensiveIncomeLossNetOfTax
us-gaap:StatementEquityComponents
(None,)
Other Comprehensive Income Loss Net Of Taxus-gaap: Statement Equity Components
us-gaap:StockholdersEquity
us-gaap:StatementEquityComponents
(None,)
Stockholders Equityus-gaap: Statement Equity Components
us-gaap:StockholdersEquity
us-gaap:StatementEquityComponents
(None,)
Stockholders Equityus-gaap: Statement Equity Components