IONS


Line plots across dimensions of each concept
Line plots across concepts
Tables

Table of contents



us-gaap:CommonStockValue
us-gaap:StatementEquityComponents
us-gaap:SharesIssued

us-gaap:CommonStockSharesIssued
us-gaap:StatementClassOfStock

us-gaap:CommonStockSharesAuthorized
us-gaap:StatementClassOfStock
us-gaap:StatementClassOfStock
us-gaap:PreferredStockSharesAuthorized

us-gaap:CommonStockSharesOutstanding
us-gaap:StatementClassOfStock

us-gaap:WeightedAverageNumberOfDilutedSharesOutstanding

us-gaap:WeightedAverageNumberOfSharesOutstandingBasic

us-gaap:EarningsPerShareBasic
us-gaap:Ownership
us-gaap:Ownership, us-gaap:StatementClassOfStock

us-gaap:EarningsPerShareDiluted

us-gaap:AllocatedShareBasedCompensationExpense
us-gaap:ConsolidatedEntities
us-gaap:IncomeStatementLocation

us-gaap:ComprehensiveIncomeNetOfTax

us-gaap:ComprehensiveIncomeNetOfTaxAttributableToNoncontrollingInterest

us-gaap:ComprehensiveIncomeNetOfTaxIncludingPortionAttributableToNoncontrollingInterest

us-gaap:CostOfGoodsAndServicesSold

us-gaap:CostsAndExpenses
us-gaap:ConsolidationItems
us-gaap:ConsolidationItems, us-gaap:StatementBusinessSegments

us-gaap:GainLossOnInvestments

us-gaap:GainsLossesOnExtinguishmentOfDebt
us-gaap:DebtInstrument

us-gaap:IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest

us-gaap:IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments

us-gaap:IncomeTaxExpenseBenefit

us-gaap:IncomeTaxesPaid

us-gaap:InterestExpense

us-gaap:InterestPaidNet

us-gaap:NetIncomeLoss
us-gaap:ConsolidatedEntities
us-gaap:Ownership
us-gaap:Ownership, us-gaap:StatementClassOfStock
us-gaap:StatementBusinessSegments
us-gaap:StatementEquityComponents

us-gaap:NetIncomeLossAttributableToNoncontrollingInterest

us-gaap:NetIncomeLossAvailableToCommonStockholdersBasic

us-gaap:OperatingIncomeLoss
us-gaap:ConsolidationItems
us-gaap:ConsolidationItems, us-gaap:StatementBusinessSegments

us-gaap:OtherNonoperatingIncomeExpense

us-gaap:ProfitLoss

us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax
us-gaap:ConsolidationItems
us-gaap:ConsolidationItems, us-gaap:ProductOrService
us-gaap:ConsolidationItems, us-gaap:ProductOrService, us-gaap:StatementBusinessSegments
us-gaap:ConsolidationItems, us-gaap:StatementBusinessSegments
us-gaap:ProductOrService
us-gaap:ProductOrService, us-gaap:SubsequentEventType, us-gaap:TypeOfArrangement
us-gaap:ProductOrService, us-gaap:TypeOfArrangement
us-gaap:TypeOfArrangement

us-gaap:Revenues

us-gaap:SellingGeneralAndAdministrativeExpense

us-gaap:Assets
us-gaap:ConsolidationItems
us-gaap:ConsolidationItems, us-gaap:StatementBusinessSegments

us-gaap:Liabilities

us-gaap:LiabilitiesAndStockholdersEquity

us-gaap:StockholdersEquity

us-gaap:AssetsCurrent

us-gaap:CashAndCashEquivalentsAtCarryingValue

us-gaap:CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents

us-gaap:InventoryNet

us-gaap:InventoryFinishedGoods

us-gaap:OtherAssetsCurrent
us-gaap:PropertyPlantAndEquipmentByType
us-gaap:PropertyPlantAndEquipmentGross

us-gaap:AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment

us-gaap:AmortizationOfIntangibleAssets

us-gaap:PropertyPlantAndEquipmentNet
us-gaap:PropertyPlantAndEquipmentByType

us-gaap:FiniteLivedIntangibleAssetsNet

us-gaap:OperatingLeaseRightOfUseAsset

us-gaap:OtherAssetsNoncurrent
us-gaap:FairValueByFairValueHierarchyLevel, us-gaap:FairValueByMeasurementFrequency
us-gaap:EquitySecuritiesFvNi
us-gaap:FairValueByMeasurementFrequency
us-gaap:FinancialInstrument
us-gaap:InvestmentType

us-gaap:AccountsPayableCurrent

us-gaap:AccruedIncomeTaxesCurrent

us-gaap:AccruedLiabilitiesCurrent

us-gaap:ContractWithCustomerLiabilityCurrent

us-gaap:LiabilitiesCurrent

us-gaap:OperatingLeaseLiabilityCurrent

us-gaap:OtherAccruedLiabilitiesCurrent

us-gaap:DebtAndCapitalLeaseObligations

us-gaap:LongTermDebtAndCapitalLeaseObligations

us-gaap:MinorityInterest

us-gaap:LesseeOperatingLeaseLiabilityPaymentsDueYearTwo

us-gaap:LesseeOperatingLeaseLiabilityPaymentsDueYearThree

us-gaap:LesseeOperatingLeaseLiabilityPaymentsDueYearFour

us-gaap:LesseeOperatingLeaseLiabilityPaymentsDueYearFive

us-gaap:LesseeOperatingLeaseLiabilityPaymentsDueAfterYearFive

us-gaap:OperatingLeaseLiability

us-gaap:LesseeOperatingLeaseLiabilityPaymentsDue

us-gaap:LesseeOperatingLeaseLiabilityUndiscountedExcessAmount

us-gaap:StockholdersEquity

us-gaap:StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest
us-gaap:Restatement
us-gaap:Restatement, us-gaap:AdjustmentsForNewAccountingPronouncements
us-gaap:Restatement, us-gaap:AdjustmentsForNewAccountingPronouncements, us-gaap:StatementEquityComponents
us-gaap:Restatement, us-gaap:StatementEquityComponents
us-gaap:StatementEquityComponents

us-gaap:CommonStockValue

us-gaap:AdditionalPaidInCapitalCommonStock
us-gaap:Restatement
us-gaap:Restatement, us-gaap:AdjustmentsForNewAccountingPronouncements

us-gaap:RetainedEarningsAccumulatedDeficit
us-gaap:Restatement
us-gaap:Restatement, us-gaap:AdjustmentsForNewAccountingPronouncements

us-gaap:AccumulatedOtherComprehensiveIncomeLossNetOfTax

us-gaap:MinorityInterest

us-gaap:AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue
us-gaap:StatementEquityComponents

us-gaap:NetCashProvidedByUsedInOperatingActivities

us-gaap:NetCashProvidedByUsedInInvestingActivities

us-gaap:NetCashProvidedByUsedInFinancingActivities

us-gaap:CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect

us-gaap:AmortizationOfFinancingCosts

us-gaap:DeferredIncomeTaxExpenseBenefit

us-gaap:IncreaseDecreaseInAccountsPayable

us-gaap:IncreaseDecreaseInInventories

us-gaap:NetCashProvidedByUsedInOperatingActivities

us-gaap:NetIncomeLoss
us-gaap:ConsolidatedEntities
us-gaap:Ownership
us-gaap:Ownership, us-gaap:StatementClassOfStock
us-gaap:StatementBusinessSegments
us-gaap:StatementEquityComponents

us-gaap:ProfitLoss

us-gaap:ShareBasedCompensation

us-gaap:NetCashProvidedByUsedInInvestingActivities

us-gaap:PaymentsToAcquirePropertyPlantAndEquipment

us-gaap:NetCashProvidedByUsedInFinancingActivities

us-gaap:PaymentsForRepurchaseOfCommonStock
us-gaap:DebtInstrument
us-gaap:DebtInstrumentInterestRateStatedPercentage
us-gaap:DebtInstrument, us-gaap:SubsequentEventType

us-gaap:EffectiveIncomeTaxRateContinuingOperations
us-gaap:AwardType
us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber
us-gaap:PlanName
us-gaap:AwardType
us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePrice

us-gaap:UnrecognizedTaxBenefits

us-gaap:DeferredTaxAssetsValuationAllowance

ions:AssetImpairmentChargesIncludingOtherThanTemporaryImpairmentInCostMethodInvestments

ions:CallSpread
us-gaap:SubsequentEventType

ions:CashPurchasePriceOfEquityAwards
us-gaap:Ownership
us-gaap:Ownership
ions:ConsolidationLessThanWhollyOwnedSubsidiaryParentOwnershipInterestChangesPurchaseOfInterestByParentPricePerShare
us-gaap:Ownership
ions:ConsolidationLessThanWhollyOwnedSubsidiaryParentOwnershipInterestChangesPurchaseOfInterestByParentShares
us-gaap:ConsolidatedEntities
ions:CoronavirusAidReliefAndEconomicSecurityActIncomeTaxExpenseBenefit
us-gaap:DebtInstrument
ions:DebtInstrumentConvertiblePercentageOfPrincipalAmountUsedAsPurchasePriceUponOccurrenceOfFundamentalChange
us-gaap:DebtInstrument, us-gaap:SubsequentEventType
us-gaap:ProductOrService, us-gaap:SubsequentEventType, us-gaap:TypeOfArrangement
ions:MilestonePaymentAchieved
us-gaap:ProductOrService, us-gaap:TypeOfArrangement
us-gaap:SubsequentEventType, us-gaap:TypeOfArrangement
us-gaap:TypeOfArrangement
us-gaap:SubsequentEventType, us-gaap:TypeOfArrangement
ions:MilestonePaymentEarned
us-gaap:ProductOrService, us-gaap:TypeOfArrangement
ions:MilestonePaymentsAchievedAndIncludedInTransactionPriceForPerformanceObligation

ions:NonCashCapitalAndPatentExpenditures

ions:OperatingLeaseRightOfUseAssetAmortization
us-gaap:Ownership
ions:PaymentsForCancelledEquityAwards

ions:PaymentsToAcquireLicensesAndOtherAssets
us-gaap:ProductOrService, us-gaap:SubsequentEventType, us-gaap:TypeOfArrangement
ions:PercentageEnrollmentInPhase3Study

ions:ResearchDevelopmentAndPatentExpense
us-gaap:IncomeStatementLocation, us-gaap:RestructuringCostAndReserve
ions:RestructuringReserveNetExpense
us-gaap:RestructuringCostAndReserve
us-gaap:IncomeStatementLocation, us-gaap:RestructuringCostAndReserve
ions:RestructuringReserveRestructuringChargesNetOfReserveAdjustments
us-gaap:RestructuringCostAndReserve
us-gaap:TypeOfArrangement
ions:RevenueFromContractWithCustomerTransactionPriceAdditions
us-gaap:Range, us-gaap:AwardType, us-gaap:GranteeStatus
ions:ShareBasedCompensationArrangementByShareBasedPaymentAwardPercentageOfUnitsGuaranteedToVest
us-gaap:Ownership
ions:WeightedAverageNumberOfSharesOwnedInSubsidiary
us-gaap:Ownership, us-gaap:StatementClassOfStock

us-gaap:AccretionAmortizationOfDiscountsAndPremiumsInvestments

us-gaap:AdjustmentsRelatedToTaxWithholdingForShareBasedCompensation
us-gaap:StatementEquityComponents

us-gaap:AdjustmentsToAdditionalPaidInCapitalOther
us-gaap:StatementEquityComponents

us-gaap:AdjustmentsToAdditionalPaidInCapitalWarrantIssued
us-gaap:StatementEquityComponents

us-gaap:AmortizationOfDebtDiscountPremium
us-gaap:ConcentrationRiskByBenchmark, us-gaap:ConcentrationRiskByType, us-gaap:TypeOfArrangement
us-gaap:ConcentrationRiskPercentage1
us-gaap:MajorCustomers, us-gaap:ConcentrationRiskByBenchmark, us-gaap:ConcentrationRiskByType
us-gaap:Ownership
us-gaap:ConsolidationLessThanWhollyOwnedSubsidiaryParentOwnershipInterestChangesPurchaseOfInterestByParent

us-gaap:ContractWithCustomerLiabilityRevenueRecognized

us-gaap:Depreciation

us-gaap:EffectOfExchangeRateOnCashAndCashEquivalents

us-gaap:EffectiveIncomeTaxRateReconciliationAtFederalStatutoryIncomeTaxRate
us-gaap:InvestmentType
us-gaap:EquitySecuritiesFvNiUnrealizedGain
us-gaap:InvestmentType
us-gaap:EquitySecuritiesFvNiUnrealizedLoss

us-gaap:ImpairmentOfIntangibleAssetsFinitelived

us-gaap:IncreaseDecreaseInAccruedIncomeTaxesPayable

us-gaap:IncreaseDecreaseInContractWithCustomerAsset

us-gaap:IncreaseDecreaseInContractWithCustomerLiability

us-gaap:IncreaseDecreaseInOtherCurrentLiabilities

us-gaap:IncreaseDecreaseInOtherEmployeeRelatedLiabilities

us-gaap:IncreaseDecreaseInOtherOperatingAssets

us-gaap:InvestmentIncomeNet
us-gaap:TypeOfArrangement
us-gaap:LitigationSettlementAmountAwardedFromOtherParty

us-gaap:MinorityInterestPeriodIncreaseDecrease
us-gaap:StatementEquityComponents

us-gaap:OperatingLeaseRightOfUseAssetAmortizationExpense

us-gaap:OtherComprehensiveIncomeAvailableforsaleSecuritiesAdjustmentNetOfTaxPortionAttributableToParent
us-gaap:StatementEquityComponents

us-gaap:OtherComprehensiveIncomeForeignCurrencyTransactionAndTranslationGainLossArisingDuringPeriodNetOfTax
us-gaap:StatementEquityComponents

us-gaap:OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax

us-gaap:PaymentsForHedgeFinancingActivities
us-gaap:SubsequentEventType
us-gaap:RestructuringCostAndReserve
us-gaap:PaymentsForRestructuring

us-gaap:PaymentsRelatedToTaxWithholdingForShareBasedCompensation

us-gaap:PaymentsToAcquireAvailableForSaleSecuritiesDebt

us-gaap:PaymentsToAcquireOtherProductiveAssets

us-gaap:ProceedsFromIssuanceOfSharesUnderIncentiveAndShareBasedCompensationPlansIncludingStockOptions

us-gaap:ProceedsFromIssuanceOfWarrants
us-gaap:SubsequentEventType

us-gaap:ProceedsFromSaleAndMaturityOfAvailableForSaleSecurities
us-gaap:DebtInstrument
us-gaap:RepaymentsOfConvertibleDebt
us-gaap:DebtInstrument, us-gaap:SubsequentEventType
us-gaap:IncomeStatementLocation, us-gaap:RestructuringCostAndReserve
us-gaap:RestructuringCharges
us-gaap:RestructuringCostAndReserve
us-gaap:RestructuringCostAndReserve
us-gaap:RestructuringReserveAccrualAdjustment1
us-gaap:AwardType
us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRate
us-gaap:AwardType, us-gaap:GranteeStatus
us-gaap:ConsolidatedEntities, us-gaap:AwardType
us-gaap:AwardType
us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsWeightedAverageVolatilityRate
us-gaap:AwardType, us-gaap:GranteeStatus
us-gaap:ConsolidatedEntities, us-gaap:AwardType
us-gaap:AwardType, us-gaap:GranteeStatus
us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageGrantDateFairValue
us-gaap:AwardType, us-gaap:GranteeStatus, us-gaap:Vesting
us-gaap:SharebasedCompensationArrangementBySharebasedPaymentAwardAwardVestingRightsPercentage
us-gaap:StatementEquityComponents
us-gaap:SharesPaidForTaxWithholdingForShareBasedCompensation
us-gaap:StatementEquityComponents
us-gaap:StockIssuedDuringPeriodSharesShareBasedCompensation

us-gaap:StockIssuedDuringPeriodValueShareBasedCompensationGross
us-gaap:StatementEquityComponents
us-gaap:StatementEquityComponents
us-gaap:StockRepurchasedAndRetiredDuringPeriodShares

us-gaap:StockRepurchasedAndRetiredDuringPeriodValue
us-gaap:StatementEquityComponents

us-gaap:ValuationAllowancesAndReservesPeriodIncreaseDecrease

ions:AccruedClinicalExpenses

ions:AccruedCommercialExpensesCurrent

ions:AccruedInLicensingFeesCurrent

ions:AvailableForSaleSecuritiesDebtMaturitiesAfterOneThroughTwoYearsPercentage

ions:AvailableForSaleSecuritiesDebtMaturitiesAfterTwoThroughThreeAndOneHalfYearsPercentage

ions:AvailableForSaleSecuritiesDebtMaturitiesAfterTwoThroughThreeYearsPercentage

ions:AvailableForSaleSecuritiesDebtMaturitiesWithinOneYearPercentage

ions:AvailableForSaleSecuritiesDebtMaturitiesWithinTwoYearsPercentage
us-gaap:ProductOrService, us-gaap:TypeOfArrangement
ions:CumulativePaymentsIncludedInTransactionPriceForPerformanceObligation
us-gaap:TypeOfArrangement
us-gaap:Range, us-gaap:TypeOfArrangement
ions:CumulativePaymentsReceived
us-gaap:TypeOfArrangement
us-gaap:ProductOrService, us-gaap:Range, us-gaap:TypeOfArrangement
ions:CumulativeRevenueFromContractWithCustomerExcludingAssessedTax
us-gaap:Range, us-gaap:TypeOfArrangement
us-gaap:DebtInstrument
ions:DebtInstrumentConvertibleConversionPriceIncludingCallSpread
us-gaap:DebtInstrument, us-gaap:SubsequentEventType
us-gaap:DebtInstrument
ions:DebtInstrumentConvertibleSharesSubjectToConversion
us-gaap:DebtInstrument, us-gaap:SubsequentEventType

ions:DebtSecuritiesAvailableForSaleAndEquitySecuritiesFvNi

ions:DebtSecuritiesAvailableForSaleAndEquitySecuritiesFvNiCost

ions:DebtSecuritiesAvailableForSaleAndEquitySecuritiesFvNiGrossUnrealizedGain

ions:DebtSecuritiesAvailableForSaleAndEquitySecuritiesFvNiGrossUnrealizedLoss

ions:DeferredTaxAssetsLiabilitiesNetBeforeValuationAllowance
us-gaap:PlanName
ions:EmployeeStockPurchasePlanSharesAvailableForPurchase
us-gaap:PlanName
ions:IncreaseDecreaseInFungibleShareReserveForEachShareIssuedPursuantToFullValueAward
us-gaap:PlanName
ions:IncreaseDecreaseInFungibleShareReserveForEachShareReturningFromFullValueAward

ions:LeasesAndOtherObligations
us-gaap:ConsolidatedEntities, us-gaap:GeographicDistribution
ions:LesseeOperatingLeaseAllowanceForTenantImprovements
us-gaap:ConsolidatedEntities, us-gaap:GeographicDistribution
ions:LesseeOperatingLeaseInitialLetterOfCreditToSecureLeaseObligation
us-gaap:ConsolidatedEntities, us-gaap:GeographicDistribution
ions:LesseeOperatingLeaseLetterOfCreditToSecureLeaseObligationOnFifthAnniversaryOfRentCommencementDate
us-gaap:ConsolidatedEntities, us-gaap:GeographicDistribution
ions:LesseeOperatingLeaseLetterOfCreditToSecureLeaseObligationOnThirdAnniversaryOfRentCommencementDate

ions:LongTermDebtAndLeaseObligationCurrentAndOtherCurrentLiabilities

ions:LongTermObligationsCurrent

ions:LongTermObligationsNoncurrent
us-gaap:TypeOfArrangement
ions:MaximumAmountOfPaymentReceivableForEachAdditionalDrugDeveloped
us-gaap:TypeOfArrangement
ions:MaximumAmountOfPaymentsReceivableForCommercializationMilestones
us-gaap:TypeOfArrangement
ions:MaximumAmountOfPaymentsReceivableForDevelopmentMilestones
us-gaap:TypeOfArrangement
ions:MaximumAmountOfPaymentsReceivableForDevelopmentRegulatoryAndSalesMilestones
us-gaap:TypeOfArrangement
ions:MaximumAmountOfPaymentsReceivableForLicenseFeesAndMilestones
us-gaap:TypeOfArrangement
ions:MaximumAmountOfPaymentsReceivableForMilestones
us-gaap:TypeOfArrangement
ions:MaximumAmountOfPaymentsReceivableForRegulatoryMilestones
us-gaap:TypeOfArrangement
ions:MaximumAmountOfPaymentsReceivableForSalesMilestones
us-gaap:TypeOfArrangement
ions:MaximumAmountOfPaymentsReceivablePerDrugForSubstantiveMilestonePayments
us-gaap:TypeOfArrangement
ions:MaximumPaymentReceivableUnderLicenseAgreement
us-gaap:TypeOfArrangement
ions:MinimumAmountOfPaymentsReceivableForLicenseFeesAndSubstantiveMilestones
us-gaap:Range, us-gaap:StatementScenario, us-gaap:TypeOfArrangement
ions:NextPotentialMilestonePayment
us-gaap:SubsequentEventType, us-gaap:TypeOfArrangement
us-gaap:ProductOrService, us-gaap:Range, us-gaap:SubsequentEventType, us-gaap:TypeOfArrangement
ions:NextPotentialPayment
us-gaap:Range, us-gaap:SubsequentEventType, us-gaap:TypeOfArrangement
us-gaap:Range, us-gaap:TypeOfArrangement
us-gaap:StatementScenario, us-gaap:TypeOfArrangement
us-gaap:SubsequentEventType, us-gaap:TypeOfArrangement
us-gaap:TypeOfArrangement
us-gaap:Range, us-gaap:TypeOfArrangement
ions:NumberOfCountriesWhereDrugIsApprovedForUse
us-gaap:StatementScenario
ions:PercentageOfTaxableIncomeThatCanBeOffsetWithFederalNetOperatingLosses
us-gaap:ConsolidatedEntities
ions:RemainingPortionOfAvailableEquitySharePool
us-gaap:SubsequentEventType, us-gaap:TypeOfArrangement
ions:UpfrontPayments
us-gaap:FairValueByFairValueHierarchyLevel, us-gaap:FairValueByMeasurementFrequency
us-gaap:AssetsFairValueDisclosure
us-gaap:FairValueByMeasurementFrequency
us-gaap:FinancialInstrument
us-gaap:AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax
us-gaap:FinancialInstrument, us-gaap:InvestmentSecondaryCategorization
us-gaap:InvestmentSecondaryCategorization, us-gaap:InvestmentType
us-gaap:InvestmentType
us-gaap:FinancialInstrument
us-gaap:AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax
us-gaap:FinancialInstrument, us-gaap:InvestmentSecondaryCategorization
us-gaap:InvestmentSecondaryCategorization, us-gaap:InvestmentType
us-gaap:InvestmentType
us-gaap:FinancialInstrument
us-gaap:AvailableForSaleDebtSecuritiesAmortizedCostBasis
us-gaap:FinancialInstrument, us-gaap:InvestmentSecondaryCategorization
us-gaap:InvestmentSecondaryCategorization, us-gaap:InvestmentType
us-gaap:InvestmentType
us-gaap:BalanceSheetLocation, us-gaap:FairValueByMeasurementFrequency, us-gaap:FinancialInstrument
us-gaap:AvailableForSaleSecurities
us-gaap:FairValueByFairValueHierarchyLevel, us-gaap:FairValueByMeasurementFrequency, us-gaap:FinancialInstrument
us-gaap:FairValueByMeasurementFrequency, us-gaap:FinancialInstrument

us-gaap:AvailableForSaleSecuritiesContinuousUnrealizedLossPositionAccumulatedLoss
us-gaap:InvestmentType

us-gaap:AvailableForSaleSecuritiesContinuousUnrealizedLossPositionFairValue
us-gaap:InvestmentType

us-gaap:AvailableForSaleSecuritiesContinuousUnrealizedLossPositionLessThan12MonthsAccumulatedLoss
us-gaap:InvestmentType

us-gaap:AvailableForSaleSecuritiesContinuousUnrealizedLossPositionLessThanTwelveMonthsFairValue
us-gaap:InvestmentType

us-gaap:AvailableForSaleSecuritiesContinuousUnrealizedLossPositionTwelveMonthsOrLongerFairValue
us-gaap:InvestmentType
us-gaap:BalanceSheetLocation, us-gaap:FairValueByMeasurementFrequency, us-gaap:FinancialInstrument
us-gaap:AvailableForSaleSecuritiesDebtSecurities
us-gaap:FairValueByFairValueHierarchyLevel, us-gaap:FairValueByMeasurementFrequency, us-gaap:FinancialInstrument
us-gaap:FairValueByMeasurementFrequency, us-gaap:FinancialInstrument
us-gaap:FinancialInstrument
us-gaap:FinancialInstrument, us-gaap:InvestmentSecondaryCategorization
us-gaap:InvestmentSecondaryCategorization, us-gaap:InvestmentType
us-gaap:InvestmentType

us-gaap:AvailableForSaleSecuritiesDebtSecuritiesCurrent

us-gaap:AvailableforsaleSecuritiesInUnrealizedLossPositionsQualitativeDisclosureNumberOfPositions1
us-gaap:InvestmentType
us-gaap:Ownership
us-gaap:BusinessAcquisitionCostOfAcquiredEntityTransactionCosts
us-gaap:FairValueByFairValueHierarchyLevel, us-gaap:FairValueByMeasurementFrequency
us-gaap:CashAndCashEquivalentsFairValueDisclosure
us-gaap:FairValueByMeasurementFrequency
us-gaap:StatementClassOfStock
us-gaap:CommonStockCapitalSharesReservedForFutureIssuance

us-gaap:ContractWithCustomerAssetNetCurrent
us-gaap:TypeOfArrangement
us-gaap:ContractWithCustomerLiability

us-gaap:ContractWithCustomerLiabilityNoncurrent

us-gaap:ContractualObligation

us-gaap:ContractualObligationDueAfterFifthYear

us-gaap:ContractualObligationDueInFifthYear

us-gaap:ContractualObligationDueInFourthYear

us-gaap:ContractualObligationDueInNextTwelveMonths

us-gaap:ContractualObligationDueInSecondYear

us-gaap:ContractualObligationDueInThirdYear
us-gaap:DebtInstrument
us-gaap:ConvertibleDebt

us-gaap:ConvertibleDebtCurrent
us-gaap:DebtInstrument
us-gaap:Restatement
us-gaap:Restatement, us-gaap:AdjustmentsForNewAccountingPronouncements
us-gaap:DebtInstrument
us-gaap:ConvertibleDebtNoncurrent
us-gaap:Restatement, us-gaap:AdjustmentsForNewAccountingPronouncements, us-gaap:DebtInstrument
us-gaap:Restatement, us-gaap:DebtInstrument
us-gaap:DebtInstrument
us-gaap:DebtInstrumentCarryingAmount
us-gaap:DebtInstrument, us-gaap:SubsequentEventType
us-gaap:DebtInstrument
us-gaap:DebtInstrumentConvertibleCarryingAmountOfTheEquityComponent
us-gaap:DebtInstrument
us-gaap:DebtInstrumentConvertibleConversionPrice1
us-gaap:DebtInstrument, us-gaap:SubsequentEventType
us-gaap:DebtInstrument
us-gaap:DebtInstrumentFaceAmount
us-gaap:DebtInstrument, us-gaap:SubsequentEventType
us-gaap:DebtInstrument
us-gaap:DebtInstrumentInterestRateEffectivePercentage
us-gaap:DebtInstrument, us-gaap:MeasurementInputType
us-gaap:DebtInstrumentMeasurementInput
us-gaap:DebtInstrument
us-gaap:DebtInstrumentRepurchasedFaceAmount
us-gaap:DebtInstrument, us-gaap:SubsequentEventType

us-gaap:DebtInstrumentUnamortizedDiscount
us-gaap:DebtInstrument
us-gaap:DebtInstrumentUnamortizedDiscountPremiumNet

us-gaap:DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPositionLessThan12Months
us-gaap:FinancialInstrument

us-gaap:DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPositionLessThan12MonthsAccumulatedLoss
us-gaap:FinancialInstrument

us-gaap:DebtSecuritiesAvailableForSaleContinuousUnrealizedLossPositionLessThan12MonthsNumberOfPositions
us-gaap:FinancialInstrument

us-gaap:DeferredFinanceCostsNet
us-gaap:DebtInstrument

us-gaap:DeferredIncomeTaxAssetsNet

us-gaap:DeferredRentCredit

us-gaap:DeferredTaxAssetsDeferredIncome

us-gaap:DeferredTaxAssetsGoodwillAndIntangibleAssets

us-gaap:DeferredTaxAssetsGross

us-gaap:DeferredTaxAssetsOperatingLossCarryforwards

us-gaap:DeferredTaxAssetsOther

us-gaap:DeferredTaxAssetsTaxCreditCarryforwards

us-gaap:DeferredTaxAssetsTaxDeferredExpenseCompensationAndBenefitsShareBasedCompensationCost

us-gaap:DeferredTaxLiabilitiesFinancingArrangements

us-gaap:DeferredTaxLiabilitiesOther

us-gaap:DeferredTaxLiabilitiesPropertyPlantAndEquipment

us-gaap:EmployeeRelatedLiabilitiesCurrent
us-gaap:ConsolidatedEntities
us-gaap:EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognized
us-gaap:AwardType
us-gaap:EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedShareBasedAwardsOtherThanOptions
us-gaap:ConsolidatedEntities
us-gaap:Ownership
us-gaap:AwardType
us-gaap:EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedStockOptions
us-gaap:InvestmentType
us-gaap:EquitySecuritiesFvNiCost
us-gaap:FiniteLivedIntangibleAssetsByMajorClass
us-gaap:FiniteLivedIntangibleAssetsAccumulatedAmortization
us-gaap:FiniteLivedIntangibleAssetsByMajorClass
us-gaap:FiniteLivedIntangibleAssetsAmortizationExpenseNextTwelveMonths
us-gaap:FiniteLivedIntangibleAssetsByMajorClass
us-gaap:FiniteLivedIntangibleAssetsAmortizationExpenseYearFive
us-gaap:FiniteLivedIntangibleAssetsByMajorClass
us-gaap:FiniteLivedIntangibleAssetsAmortizationExpenseYearFour
us-gaap:FiniteLivedIntangibleAssetsByMajorClass
us-gaap:FiniteLivedIntangibleAssetsAmortizationExpenseYearThree
us-gaap:FiniteLivedIntangibleAssetsByMajorClass
us-gaap:FiniteLivedIntangibleAssetsAmortizationExpenseYearTwo
us-gaap:FiniteLivedIntangibleAssetsByMajorClass
us-gaap:FiniteLivedIntangibleAssetsGross

us-gaap:InterestPayableCurrentAndNoncurrent

us-gaap:InventoryRawMaterials
us-gaap:PublicUtilitiesInventory

us-gaap:InventoryWorkInProcess

us-gaap:LesseeOperatingLeaseLiabilityPaymentsDueNextTwelveMonths
us-gaap:CreditFacility, us-gaap:LineOfCreditFacility
us-gaap:LineOfCreditFacilityMaximumBorrowingCapacity

us-gaap:LoansPayableToBank

us-gaap:LongTermDebtAndCapitalLeaseObligationsCurrent
us-gaap:DebtInstrument, us-gaap:FairValueByFairValueHierarchyLevel
us-gaap:LongTermDebtFairValue

us-gaap:LongTermLoansFromBank
us-gaap:Ownership
us-gaap:MinorityInterestOwnershipPercentageByParent
us-gaap:Ownership, us-gaap:Range
us-gaap:DebtInstrument, us-gaap:FairValueByFairValueHierarchyLevel
us-gaap:NotesPayableFairValueDisclosure

us-gaap:OperatingLeaseWeightedAverageDiscountRatePercent
us-gaap:IncomeTaxAuthorityName
us-gaap:OperatingLossCarryforwards
us-gaap:RestructuringCostAndReserve
us-gaap:RestructuringAndRelatedCostCostIncurredToDate1
us-gaap:Range, us-gaap:RestructuringCostAndReserve
us-gaap:RestructuringAndRelatedCostExpectedCost1
us-gaap:RestructuringCostAndReserve
us-gaap:RestructuringAndRelatedCostExpectedCostRemaining1
us-gaap:BalanceSheetLocation, us-gaap:RestructuringCostAndReserve
us-gaap:RestructuringReserve
us-gaap:RestructuringCostAndReserve
us-gaap:AwardType
us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedNumber
us-gaap:AwardType
us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValue
us-gaap:PlanName
us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardMaximumEmployeeSubscriptionRate
us-gaap:AwardType, us-gaap:PlanName
us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsOutstandingNumber
us-gaap:PlanName
us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAuthorized
us-gaap:PlanName
us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAvailableForGrant
us-gaap:AwardType
us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisableNumber
us-gaap:PlanName
us-gaap:AwardType
us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisableWeightedAverageExercisePrice
us-gaap:AwardType
us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingIntrinsicValue
us-gaap:AwardType
us-gaap:SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsExercisableIntrinsicValue1
us-gaap:IncomeTaxAuthorityName, us-gaap:TaxCreditCarryforward
us-gaap:TaxCreditCarryforwardAmount

us-gaap:UnrecognizedTaxBenefitsThatWouldImpactEffectiveTaxRate

Plots across concepts


IncomeStatement
Comprehensive Income Net Of Tax
Expenses
Other Nonoperating Income Expense
Balance Sheet
Operating Lease Right Of Use Asset
Assets
Operating Lease Right Of Use Asset
Current Assets
Inventory Net
NonCurrent Assets
Operating Lease Right Of Use Asset
PropertyPlantAndEquipmentNet
Accumulated Depreciation Depletion And Amortization Property Plant And Equipment
Liabilities
Operating Lease Liability
Current Liabilities
Accrued Income Taxes Current
Noncurrent Liabilities
Minority Interest
Stockholders Equity
Retained Earnings Accumulated Deficit
CashFlow
Net Cash Provided By Used In Investing Activities
NetCashProvidedByUsedInOperatingActivities
Net Income Loss
NetCashProvidedByUsedInInvestingActivities
Net Cash Provided By Used In Investing Activities
NetCashProvidedByUsedInFinancingActivities
Payments For Repurchase Of Common Stock
Shares
Weighted Average Number Of Diluted Shares Outstanding
OperatingLeaseLiability
Operating Lease Liability Current
LesseeOperatingLeaseLiabilityPaymentsDue
Lessee Operating Lease Liability Payments Due Year Four
InventoryNet
Inventory Finished Goods

Tables

  2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302017-06-302017-03-312016-12-312016-09-302016-06-302016-03-312015-12-312015-09-302015-06-302015-05-312015-03-312014-12-312014-09-302014-06-302014-03-312013-12-312013-09-302013-06-302013-03-312012-12-312012-09-302012-06-302012-03-312011-12-312011-09-302011-06-302011-03-312010-12-312010-09-302010-06-302010-03-31
us-gaap:CommonStockValue ████▇▇████▇▇▇▃▃▃▂▂▂▁▁▁▁▁▁0.1410.1410.140.140.1390.1390.140.1410.140.140.1380.1380.1370.1250.1250.1250.1240.1240.1220.1210.1210.1210.120.120.12NA0.120.1180.1180.1180.1180.1160.1160.1140.1030.1020.1020.10.10.10.10.10.10.099NANANA
 us-gaap:SharesIssued us-gaap:StatementEquityComponents us-gaap:CommonStock███▇▇▇███▇▇▆▆▁▁141.022140.924140.366139.794139.489139.282140.34140.637140.393139.624137.929137.507137.157125.449124.976NANANA121.636NANANA120.351NANANANA118.443NANANA116.471NANANA101.481NANANA100.043NANANA99.394NANANA
us-gaap:CommonStockSharesIssued ████▇▇████▇▇▇▃▃▃▂▂▂▁▁▁▁▁▁141.021583140.924356140.365594139.793901139.489405139.282168140.339615140.636397140.393074139.623937137.928828137.506203137.156361125.448746124.976373124.619363124.146356123.880559121.636273121.147433120.85272120.71781120.35148120.028312119.881615NA119.602322118.442726117.990371117.669618117.54186116.471371115.998221114.291999102.6952101.481134101.193132100.320445100.183182100.04297699.72331799.61852599.58009399.39378NANANA
us-gaap:CommonStockSharesAuthorized ▄▄▄▄▄▄▄▄▄▄▄▄▄▄▄▄▄▄▄▄▄▄▄▄▄300.0300.0300.0300.0300.0300.0300.0300.0300.0300.0300.0300.0300.0300.0300.0300.0300.0300.0300.0300.0300.0300.0300.0300.0300.0NA300.0300.0NA300.0200.0200.0200.0200.0200.0200.0200.0200.0200.0200.0200.0200.0200.0200.0NANANA
 us-gaap:PreferredStockSharesAuthorized us-gaap:StatementClassOfStock us-gaap:PreferredStockNANA15.0NANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANA
us-gaap:CommonStockSharesOutstanding ████▇▇████▇▇▇▃▃▃▂▂▂▁▁▁▁▁▁141.021583140.924356140.365594139.793901139.489405139.282168140.339615140.636397140.393074139.623937137.928828137.506203137.156361125.448746124.976373124.619363124.146356123.880559121.636273121.147433120.85272120.71781120.35148120.028312119.881615NA119.602322118.442726117.990371117.669618117.54186116.471371115.998221114.291999102.6952101.481134101.193132100.320445100.183182100.04297699.72331799.61852599.58009399.39378NANANA
us-gaap:WeightedAverageNumberOfDilutedSharesOutstanding █▁140.962140.77NA139.708139.352139.429153.303143.408140.247141.537149.856143.314128.712125.33126.862124.37123.989124.972123.953123.378120.798120.598NA119.979127.779NANA122.839NA117.588NANA115.263108.539101.875NA100.68100.213100.157NA99.68799.60299.569NA99.19699.09199.013
us-gaap:WeightedAverageNumberOfSharesOutstandingBasic ▇▇▇▇▇▇▇▇▇▇▆█▄▂▂▂▂▂▁▁▁▁140.962140.77139.956139.708139.352139.429140.583140.551140.247138.582137.699143.314128.712125.33124.818124.37123.989122.861121.34120.989120.798120.598NA119.979119.742NANA118.223NA117.588NANA115.263108.539101.875NA100.68100.213100.157NA99.68799.60299.569NA99.19699.09199.013
us-gaap:EarningsPerShareBasic ▄▄▁▄▄▄▇▅▅▆█▅▄▅▅▅▄▅▅▅▄▄▄▄▅-0.57-0.64-2.44-0.22-0.23-0.351.310.19-0.010.632.32-0.03-0.29-0.010.020.0-0.090.030.210.06-0.47-0.52-0.59-0.30.3NA-0.140.26-0.23-0.1-0.27NANANANANANANANA-0.19999999999999996-0.27-0.18-0.2-0.14-0.13-0.25-0.1
 us-gaap:EarningsPerShareBasic us-gaap:Ownership ions:AkceaTherapeuticsIncNANA-0.05NANANA0.87-0.34-0.40.35-0.79-0.73-0.72-0.44NANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANA
 us-gaap:EarningsPerShareBasic us-gaap:Ownership,us-gaap:StatementClassOfStock ions:AkceaTherapeuticsInc,us-gaap:CommonStockNANANA-0.49-0.49-0.42NA-0.34-0.40.35-0.79-0.73-0.72-0.44-0.35-0.27NANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANA
us-gaap:EarningsPerShareDiluted ▄▄▁▄▄▄▇▅▅▆█▅▄▅▅▅▅▅▅▅▄▄▄▄▅-0.57-0.64-2.44-0.22-0.23-0.351.280.18-0.010.622.21-0.03-0.29-0.010.020.0-0.090.030.210.06-0.47-0.52-0.59-0.30.29NA-0.140.25-0.23-0.1-0.27NANANANA-0.03-0.37-0.01-0.24-0.2-0.27-0.18-0.2-0.14-0.13-0.25-0.1
  2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302017-06-302017-03-312016-12-312016-09-302016-06-302016-03-312015-12-312015-09-302015-06-302015-05-312015-03-312014-12-312014-09-302014-06-302014-03-312013-12-312013-09-302013-06-302013-03-312012-12-312012-09-302012-06-302012-03-312011-12-312011-09-302011-06-302011-03-312010-12-312010-09-302010-06-302010-03-31
 Cost Ratio us-gaap:ConsolidationItems us-gaap:IntersegmentEliminationNANA-38.456-0.846-5.893-0.804-127.583-5.515-3.0-88.492-50.001-51.907NA-5.229NANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANA
 Cost Ratio us-gaap:ConsolidationItems,us-gaap:StatementBusinessSegments us-gaap:OperatingSegments,ions:AkceaTherapeuticsNANA94.419.4722.37716.074277.4820.62426.624163.81610.19719.24118.32117.108NANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANA
 Cost Ratio us-gaap:ConsolidationItems,us-gaap:StatementBusinessSegments us-gaap:OperatingSegments,ions:IonisCoreNANA234.337141.455129.053118.097343.784152.783140.189221.89231.919178.06199.426132.54NANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANA
 Operating Margin us-gaap:ConsolidationItems us-gaap:IntersegmentEliminationNANA-38.456-0.846-5.893-0.804-127.583-5.515-3.0-88.492-50.001-51.907NA-5.229NANA-2.93-51.477-8.8-3.848NANA-1.062-3.186NANANANANANANANANANANANANANANANANANANANANANANA
 Operating Margin us-gaap:ConsolidationItems,us-gaap:StatementBusinessSegments us-gaap:OperatingSegments,ions:IonisCoreNANA234.337141.455129.053118.097343.784152.783140.189221.89231.919178.06199.426132.54146.103108.408109.49161.183NANANANANANANANANANANANANANANANANANANANANANANANANANANANANA
  2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302017-06-302017-03-312016-12-312016-09-302016-06-302016-03-312015-12-312015-09-302015-06-302015-05-312015-03-312014-12-312014-09-302014-06-302014-03-312013-12-312013-09-302013-06-302013-03-312012-12-312012-09-302012-06-302012-03-312011-12-312011-09-302011-06-302011-03-312010-12-312010-09-302010-06-302010-03-31
  2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302017-06-302017-03-312016-12-312016-09-302016-06-302016-03-312015-12-312015-09-302015-06-302015-05-312015-03-312014-12-312014-09-302014-06-302014-03-312013-12-312013-09-302013-06-302013-03-312012-12-312012-09-302012-06-302012-03-312011-12-312011-09-302011-06-302011-03-312010-12-312010-09-302010-06-302010-03-31
us-gaap:AllocatedShareBasedCompensationExpense ▂▃█▄▄▃▃▂▃▄▃▃▃▂▂▂▂▂▁▁▁▂▁▁▁30.02237.86195.0445.84548.44240.7935.0124.12641.93345.50534.10234.88333.87628.45122.33321.47221.25820.91215.15817.58619.2620.10317.40714.99713.605NA13.3058.4898.1187.7087.0693.12.8122.6362.8691.812.0342.462.2672.2492.3642.52.7322.7122.963.132NA
us-gaap:ComprehensiveIncomeNetOfTax ▄▄▁▄▄▄▇▅▅▆█▅▄▅▅▅▄▅▅▅▄▄▄▄▅-82.468-93.001-341.77-34.076-21.05-50.171184.50225.0382.4888.85320.574-4.463-39.736-2.8641.281-0.715-11.1183.35422.0057.706-67.593-65.467-67.041-72.1446.945NA-9.3553.906-34.501-16.362-23.36-32.217-22.535-0.9243.6328.997-37.7610.003-23.467-19.653-28.434NANANANANANA
us-gaap:ComprehensiveIncomeNetOfTaxAttributableToNoncontrollingInterest NANA-1.597-12.188-11.441-10.25419.541-7.729-9.1366.442-17.326-15.797-16.237-9.423-7.469-3.9520.00.00.00.0NANANANANANANANANANANANANANANANANANANANANANANANANANANA
us-gaap:ComprehensiveIncomeNetOfTaxIncludingPortionAttributableToNoncontrollingInterest ▄▄▁▄▄▄▇▅▅▆█▄▄▅▅▅▅▅▅▅-82.468-93.001-343.367-46.264-32.491-60.425204.04317.309-6.65695.292303.248-20.26-55.973-12.287-6.188-4.667-2.9978.8522.0057.706NANANANANANANANANANANANANANANANANANANA-19.653-28.434-18.179NA-14.199-12.233-25.591NA
us-gaap:CostOfGoodsAndServicesSold ▇▆██▇▆▃▃▄▃▅▁▁▁2.9582.5783.3013.0863.0122.5481.0110.9671.3641.0411.820.00.00.0NANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANA
us-gaap:CostsAndExpenses ▃▃█▃▃▃▅▂▂▂▂▂▂▁198.719203.578312.945196.616197.291194.494233.028165.369182.64175.679181.331163.967168.028147.72NANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANA
us-gaap:GainLossOnInvestments ▂▁▅▂█▁0.860.0135.8180.8359.6250.246NANA0.0NANANANANANANANANANANANANANANA0.001NA0.00.5810.538-0.260.3970.3050.1750.841.0581.4460.00.0020.0174.4490.0180.034-0.3180.449-0.015-0.136-1.01
us-gaap:GainsLossesOnExtinguishmentOfDebt -8.627NANANANANANANANANANANANANA7.689-7.689NANA-3.9830.0NANANANANANANANANANANANANANANA0.0-4.77NANANANANANANANANANA
 us-gaap:GainsLossesOnExtinguishmentOfDebt us-gaap:DebtInstrument ions:ConvertibleSeniorNotes1PercentNANANANANANA21.9NANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANA
us-gaap:IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest -80.548NANANA-35.476NANANANANANANANANANA-3.935-10.9843.46828.7987.351-57.086-62.685-71.061-35.77636.437NA-17.50615.644-25.278-11.2-33.556-23.753-29.763-11.307-1.736-11.042-38.345-1.207-23.993-20.036-26.882-17.88-19.992-13.896-12.454NANA
us-gaap:IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments NA-89.739-23.645-40.443-44.208-61.737238.2613.517-16.939121.93110.767-19.913-56.215-10.797-22.844-6.532-2.8638.964NANANANANANANANANANANANANANANANANANANANANANANANANANANANANA
us-gaap:IncomeTaxExpenseBenefit ▄▄█▄▄▄▅▄▄▅▁▄▄▄▄▄▄▄▄▄▄▄▄▄▄0.3270.13317.7812.648-0.439-3.25734.303-14.915-6.92731.047-291.9650.4520.3580.015-7.1640.9610.2220.02.9330.0-0.2310.2320.3720.00.789NA-0.789-15.4091.3980.881-2.276NANANANA-8.405-0.7060.00.0020.00.00.0090.0020.090.00.002NA
us-gaap:IncomeTaxesPaid NA0.002NA23.4830.0460.003NA9.0370.00.0NANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANA
us-gaap:InterestExpense ▁▁▇▇▇▆█▇▇▇▇▇▇▆▆▆▇▇▆▆▆▆▅▅▅2.3572.41411.50611.32111.17310.9913.36412.00211.80211.59911.45711.28211.11310.93810.78610.82511.77811.3639.9349.7469.6259.499.3519.2339.127NA9.0217.3074.9984.9614.9434.8854.8674.8084.7954.8175.9375.2195.1795.1084.7733.4373.4153.3973.3383.2613.237
us-gaap:InterestPaidNet ▅▂▅▂▅▂█▂█▂█▂█▂▇▂▇▁▆▂2.2720.5942.5470.6072.4920.6014.3960.6984.1090.6674.1580.6814.1090.6444.0150.4133.5010.1063.0180.881NANANANANANANANANANANANANANANANANANANANANA0.1232.275NANA0.1322.281
us-gaap:NetIncomeLoss ▄▄▁▄▄▄▇▅▅▆█▅▄▅▅▅▄▅▅▅▄▄▄▄▅-80.875-89.869-340.271-30.944-31.845-48.226184.41526.163-0.87684.443320.078-4.559-40.358-1.422.744-0.976-11.2063.46825.8657.351-56.855-62.917-71.433-35.77635.648NA-16.71731.053-26.676-12.081-31.28NANANANANANANANANANA-17.889-19.994NANA-25.154-9.658
 us-gaap:NetIncomeLoss us-gaap:ConsolidatedEntities ions:AkceaTherapeuticsIncNANA-85.987NANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANA
 us-gaap:NetIncomeLoss us-gaap:Ownership ions:AkceaTherapeuticsIncNANA-85.987-37.822-37.665-32.67462.243-23.772-28.24423.846-53.219-47.843-43.814-19.997-15.955-9.587NANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANA
 us-gaap:NetIncomeLoss us-gaap:Ownership,us-gaap:StatementClassOfStock ions:AkceaTherapeuticsInc,us-gaap:CommonStockNANANA-37.822-37.665-32.674NA-23.772-28.24423.846-53.219-47.843-43.814-19.997-15.955-9.87NANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANA
 us-gaap:NetIncomeLoss us-gaap:StatementBusinessSegments ions:IonisCoreNANA-250.6826.7745.807-15.63121.55249.9327.31163.697372.91343.2265.88218.78518.6729.168NANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANA
 us-gaap:NetIncomeLoss us-gaap:StatementEquityComponents us-gaap:Parent▄▄▁▄▄▄▇▅▅▆█▅▄▅-80.875-89.869-340.271-30.944-31.845-48.226184.41626.163-0.87684.443320.076-4.559-40.355-1.42NANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANA
 us-gaap:NetIncomeLoss us-gaap:StatementEquityComponents us-gaap:RetainedEarnings▄▄▁▄▄▄▇▅▅▆█▅▄▅-80.875-89.869-340.271-30.944-31.845-48.226184.41626.163-0.87684.443320.076-4.559-40.355-1.42NANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANA
us-gaap:NetIncomeLossAttributableToNoncontrollingInterest NANA-1.155-12.147-11.924-10.25419.542-7.732-9.1366.441-17.344-15.806-16.215-9.392-7.406-3.920.00.00.00.0NANANANANANANANANANANANANANANANANANANANANANANANANANANA
us-gaap:NetIncomeLossAvailableToCommonStockholdersBasic NANA-340.272-31.048-31.858-48.304183.79526.158-0.93387.543319.694-4.616-37.932-1.2122.717-0.4192.413.46825.8657.351NANANANA35.648NA-16.71731.053-26.676-12.081-31.28-24.276-24.57-10.126-1.672-2.637-37.639-1.207-23.995-20.036-26.882-17.889-19.994-13.985-12.454-25.154-9.658
us-gaap:OperatingIncomeLoss ▁▁▂▂▂▂█▃▂▅▃▂▂▃▃▃▃▃▄▃▂▂▂▂▄-72.969-91.971-22.664-36.537-51.754-61.127260.6522.523-18.827121.53510.782-18.572-50.281-3.301-1.69313.909-1.67113.98941.15516.108-48.927-54.652-62.94-48.13844.646NA-9.3310.08-21.493-6.65-29.667-19.858-25.505-7.9281.625-26.119-28.0463.696-18.455-18.616-22.316-14.06-16.108-15.857-8.947-18.672-4.88
 us-gaap:OperatingIncomeLoss us-gaap:ConsolidationItems us-gaap:IntersegmentEliminationNANA1.4761.4781.4611.4621.4771.4781.462-12.046-47.948-43.961-0.4090.030.030.030.030.03-0.090.030.03-0.0360.00.00.03NANANANANANANANANANANANANANANANANANANANANANA
 us-gaap:OperatingIncomeLoss us-gaap:ConsolidationItems,us-gaap:StatementBusinessSegments us-gaap:OperatingSegments,ions:AkceaTherapeuticsNANA-91.091-49.813-51.091-45.2683.163-32.591-38.70426.206-72.058-65.008-63.423-30.327-24.951-12.564-11.274-59.873-32.416-20.25-14.805-16.049-25.33-13.101-8.919NA-7.005NANANANANANANANANANANANANANANANANANANANA
 us-gaap:OperatingIncomeLoss us-gaap:ConsolidationItems,us-gaap:StatementBusinessSegments us-gaap:OperatingSegments,ions:IonisCoreNANA66.94911.798-2.124-17.329176.01433.63618.415107.375130.79190.39713.55126.99623.22826.4439.57373.83273.66136.328-34.152-38.567-37.701-35.06753.535NA-2.325NANANANANANANANANANANANANANANANANANANANA
us-gaap:OtherNonoperatingIncomeExpense ▇███▇▇▇▇▇▇▇██▇█▁█-0.1890.0030.060.126-0.149-0.099-0.354-0.14-0.045-0.147-0.037-0.0220.045-0.168-0.02-2.1410.0NANANANANANANANANANANANANANANANANANANANANANANANANANANANANANA
us-gaap:ProfitLoss ▄▄▁▄▄▄▇▅▅▆█▄▄▅▅▅▅▅▅▅▄▄-80.875-89.869-341.426-43.091-43.769-58.48203.95718.432-10.01290.884302.735-20.365-56.573-10.812-4.662-4.896-11.2063.46825.8657.351-56.855-62.917NANANANA-16.71731.053-26.676-12.081-31.28-24.276-24.57-10.126-1.672NANANANANANANANANANANANA
us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax ▃▂▅▃▃▃█▃▃▅▄▃▃▃▃▃▂▃▃▂▁▁▂▂▃▂▂▂▁▂▁▁▁▁▁▁▁▂▁▁▁▁▁▁▁▁▁125.75111.607290.281160.079145.537133.367493.68167.892163.813297.214192.113145.395117.747144.419172.299118.314112.273115.8160.349110.92738.4736.87451.57149.121120.42891.262.58384.86144.06357.07628.16142.24823.58538.09243.3619.87311.60147.3423.23532.40320.71324.82321.14726.4228.62423.50329.926
us-gaap:Revenues ▃▂▅▃▃▃█▃▃▅▄▃▃▃▃▃▂▂▃▂▁▁▂▂▃▂▂▂▁▂▁▁▁▁▁▁▁▂▁▁▁▁▁▁▁▁▁125.75111.607290.281160.079145.537133.367493.68167.892163.813297.214192.113145.395117.747144.419172.299120.911104.152110.304160.349110.92738.4736.87451.57149.121120.42891.262.58384.86144.06357.07628.16142.24823.58538.09243.3619.87311.60147.3423.23532.40320.71324.82321.14726.4228.62423.50329.926
us-gaap:SellingGeneralAndAdministrativeExpense ▄▄█▄▄▅▅▄▅▄▄▄▄▃▃▂▂▁▁▁▁▁56.45561.199138.86768.44772.01574.99483.27660.03675.11168.22166.05968.71266.19843.65345.70626.78822.31713.67718.04210.1889.82410.562NANANANANANANANANANANANANANANANANANANANANANANANANA
  2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302017-06-302017-03-312016-12-312016-09-302016-06-302016-03-312015-12-312015-09-302015-06-302015-05-312015-03-312014-12-312014-09-302014-06-302014-03-312013-12-312013-09-302013-06-302013-03-312012-12-312012-09-302012-06-302012-03-312011-12-312011-09-302011-06-302011-03-312010-12-312010-09-302010-06-302010-03-31
  2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302017-06-302017-03-312016-12-312016-09-302016-06-302016-03-312015-12-312015-09-302015-06-302015-05-312015-03-312014-12-312014-09-302014-06-302014-03-312013-12-312013-09-302013-06-302013-03-312012-12-312012-09-302012-06-302012-03-312011-12-312011-09-302011-06-302011-03-312010-12-312010-09-302010-06-302010-03-31
us-gaap:Assets ▆▅▆████▇▇▇▆▅▅▂▂▂▂▂▁▁▁▁▁▂▁2497.0692248.5512389.7553095.7013078.953090.9133233.1122894.9892877.7652835.8892667.7842247.9132247.3151299.561322.0241252.5611090.8311083.996912.467843.586811.109875.819956.105988.005976.258NA955.433955.809793.803817.777834.616847.156881.916788.651552.961545.686485.681472.394470.807484.894505.785529.572505.942550.477NANANA
us-gaap:Liabilities █▆▆▆▆▆▆▅▅▅▆▅▅▂▂▂▂▂▂▁▁▁▁▁▁1914.3951567.9871546.4081489.3171484.1551520.5021548.5651397.0231420.5631448.4691480.6241407.7691429.879912.459903.305854.893875.26882.19812.902703.947699.896717.657755.315742.591675.938NA679.582698.029449.031450.917460.514468.766480.47387.57351.87362.92315.404318.08319.935313.46318.96317.355278.239305.935NANANA
us-gaap:LiabilitiesAndStockholdersEquity ▆▅▆████▇▇▇▆▅▅▂▂▂▂▂▁▁▁▁▁▂▁2497.0692248.5512389.7553095.7013078.953090.9133233.1122894.9892877.7652835.8892667.7842247.9132247.3151299.561322.0241252.5611090.8311083.996912.467843.586811.109875.819956.105988.005976.258NA955.433955.809793.803817.777834.616847.156881.916788.651552.961545.686485.681472.394470.807484.894505.785529.572505.942550.477NANANA
us-gaap:StockholdersEquity ▃▄▅██▇█▇▇▇▆▄▄▂▂▂▂▂▁▁▁▁▂▂▂582.674680.564843.3471383.1491377.1751360.2391471.0941336.2931269.3841207.6511048.079710.55696.255301.391330.872307.968215.571201.80699.565139.639111.213158.162200.79245.414300.32NA275.851257.78344.772366.86374.102378.39401.446401.081201.091182.766170.277154.314150.872171.434186.825NANA244.542NANANA
  2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302017-06-302017-03-312016-12-312016-09-302016-06-302016-03-312015-12-312015-09-302015-06-302015-05-312015-03-312014-12-312014-09-302014-06-302014-03-312013-12-312013-09-302013-06-302013-03-312012-12-312012-09-302012-06-302012-03-312011-12-312011-09-302011-06-302011-03-312010-12-312010-09-302010-06-302010-03-31
us-gaap:AssetsCurrent ▆▅▆▇▇▇█▇▇▇▆▆▆▃▃▂▂▂▁▁▁▁▁▂▂2238.4181989.4182130.7072536.9812531.1872558.0452720.5972408.0912414.2222373.9492207.8862079.2242083.2721143.2831167.9841111.113964.359962.372797.932730.329697.971763.91837.003868.261855.452NA835.427836.597681.163705.797722.053735.51763.304669.061431.829423.438361.586350.419347.613360.139377.089410.72437.395483.137NANANA
us-gaap:CashAndCashEquivalentsAtCarryingValue ▆▄▄▆▅▅▇▃▃▄▃▅█▂▁▂▁▁▁▁▁▁▁▁▁565.119414.155397.664633.059530.181486.195683.287247.939272.523375.811278.82479.891805.49227.505129.63159.184132.991114.22184.68584.275112.53493.337128.797126.593119.487NA148.348142.99873.2294.081161.778159.973256.408296.54107.65124.48284.56385.64556.39165.47755.26385.02286.270.052100.12246.03898.59
us-gaap:CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents ▆▄▄▆▅▅▇▂▂▄▃▅█▂▁565.119414.155397.664633.059530.181486.195683.287247.939272.523375.811278.82479.891805.49227.505129.63NANANA84.685NANANANANANANANANANANANANANANANANANANANANANANANANANANANA
us-gaap:InventoryNet █▇▇▇█▇▅▆▆▂▁▁24.09922.19921.96522.17223.72222.88518.1819.37518.50511.0578.5828.378NANA9.982NANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANA
us-gaap:InventoryFinishedGoods ▄▅█▃▂▂▁1.5591.9063.0050.950.7410.6020.258NANANA0.085NANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANA
us-gaap:OtherAssetsCurrent ▇▇██▇▇█▇▆▅▆▅▄▄▄▃▃▂▁▁▁▁▁▂▂131.045123.827140.163146.628131.015122.468139.839118.809102.07198.686102.47397.12576.99462.06472.33248.9351.53125.93314.76315.23617.2517.40314.77329.06629.868NA13.15415.6918.3538.5679.8147.5187.3725.7868.0748.7277.85.7247.4175.4157.5537.6137.3767.058NANANA
  2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302017-06-302017-03-312016-12-312016-09-302016-06-302016-03-312015-12-312015-09-302015-06-302015-05-312015-03-312014-12-312014-09-302014-06-302014-03-312013-12-312013-09-302013-06-302013-03-312012-12-312012-09-302012-06-302012-03-312011-12-312011-09-302011-06-302011-03-312010-12-312010-09-302010-06-302010-03-31
 us-gaap:PropertyPlantAndEquipmentGross us-gaap:PropertyPlantAndEquipmentByType ions:EquipmentAndComputerSoftwareNANA68.99NANANA60.965NANANA53.496NANANA66.558NANANA63.287NANANA56.822NANANANA49.772NANANANANANANANANANANANANANANANANANANA
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 us-gaap:PropertyPlantAndEquipmentGross us-gaap:PropertyPlantAndEquipmentByType us-gaap:FurnitureAndFixturesNANA12.871NANANA7.354NANANA6.283NANANA6.161NANANA5.937NANANA5.842NANANANA5.732NANANANANANANANANANANANANANANANANANANA
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us-gaap:AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment NANA87.379NANANA74.013NANANA61.474NANANA87.676NANANA80.075NANANA72.706NANANANA66.053NANANA60.431NANANA54.465NANANA47.42NANANA40.826NANANA
us-gaap:AmortizationOfIntangibleAssets ▆▅▅▅▅▅█▁▄▄▄▄▄▄0.5930.5440.5380.5270.5130.4860.7730.1910.4780.470.4660.4610.4520.443NANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANA
us-gaap:PropertyPlantAndEquipmentNet ████▇▇▆▆▄▄▄▄▄▄▃▃▂▁▁▁▁▁▁▁▁179.316180.413181.077181.518172.618163.952153.651148.717135.349133.519132.16132.003127.94123.188121.907116.62499.67795.43992.84590.9790.60290.36590.23389.24389.692NA89.04788.95888.06886.32186.64186.19887.27388.31289.69491.08492.59894.00895.13296.61598.01988.0137.6835.703NANANA
us-gaap:FiniteLivedIntangibleAssetsNet █▇▇▇▆▆▄▆▅▄▃▃▂▂▁29.37328.79527.93728.27427.726.7525.67426.98526.05625.2224.03224.02723.45222.91422.004NANANA20.365NANANANANANANANANANANANANANANANANANANANANANANANANANANANA
us-gaap:OperatingLeaseRightOfUseAsset NANA13.1NANANA12.613.012.913.1NANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANA
us-gaap:OtherAssetsNoncurrent ███▇▇▅▅▄▄▄▂▂▂▂▂▁▁49.96249.92550.03441.19141.46532.55227.63326.19925.77825.95412.9112.65912.65110.17510.1292.9165.433NA1.325NANANANANANANANANANANANANANANANANANANANANANANANANANANANA
 us-gaap:EquitySecuritiesFvNi us-gaap:FairValueByFairValueHierarchyLevel,us-gaap:FairValueByMeasurementFrequency us-gaap:FairValueInputsLevel1,us-gaap:FairValueMeasurementsRecurring██▅▂▂▂▁▁▁▁▁3.2613.1982.0310.5390.6840.6170.00.00.00.00.0NANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANA
 us-gaap:EquitySecuritiesFvNi us-gaap:FairValueByFairValueHierarchyLevel,us-gaap:FairValueByMeasurementFrequency us-gaap:FairValueInputsLevel3,us-gaap:FairValueMeasurementsRecurringNANANA1.6081.7061.4724.5060.6060.8960.9681.349NANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANA
 us-gaap:EquitySecuritiesFvNi us-gaap:FairValueByMeasurementFrequency us-gaap:FairValueMeasurementsRecurring▆▆▄▄▄▄█▁▂▂▂3.2613.1982.0312.1472.392.0894.5060.6060.8960.9681.349NANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANA
 us-gaap:EquitySecuritiesFvNi us-gaap:FinancialInstrument ions:EquitySecuritiesPrivateCompanies31.769NA31.0NANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANA
 us-gaap:EquitySecuritiesFvNi us-gaap:FinancialInstrument ions:EquitySecuritiesPubliclyTradedCompanies3.261NA2.031NANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANA
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 us-gaap:EquitySecuritiesFvNi us-gaap:InvestmentType ions:EquitySecuritiesPrivateCompaniesNA31.031.024.34924.337NA10.0NANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANA
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  2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302017-06-302017-03-312016-12-312016-09-302016-06-302016-03-312015-12-312015-09-302015-06-302015-05-312015-03-312014-12-312014-09-302014-06-302014-03-312013-12-312013-09-302013-06-302013-03-312012-12-312012-09-302012-06-302012-03-312011-12-312011-09-302011-06-302011-03-312010-12-312010-09-302010-06-302010-03-31
us-gaap:AccountsPayableCurrent ▃▂▄▄▁▆▄▃▄▃█▃▃▃▇▆▃▆▆▄▄▅█▅▂14.6589.50617.19916.2227.40721.17416.06713.14615.62813.33228.6613.57613.29113.83324.88623.52513.26823.23721.1215.6817.58319.46428.35519.29410.954NA16.48717.98415.62713.4539.86911.0098.7819.4615.38510.2395.2566.1945.3448.36.6533.0714.6526.523NANANA
us-gaap:AccruedIncomeTaxesCurrent ▁▁▁▃▇██▁▂▅▁1.8751.3261.3248.92927.94332.94632.5141.9454.03518.4010.858NANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANA
us-gaap:AccruedLiabilitiesCurrent ▇▇█▇▆▅▆▄▄▄▄▄▅▆▆▂▃▂▃▁▁▂▂▂▁75.1578.76690.16180.7567.80262.50766.76952.61549.68145.1348.36150.78658.48666.4766.61833.96335.87830.8736.01323.61618.97626.17228.10524.48723.753NA23.74630.45129.1425.16627.90322.09222.28316.51417.75815.40111.915.61915.618.65515.07110.8738.13412.389NANANA
us-gaap:ContractWithCustomerLiabilityCurrent ▁▂▂▁▁▃▃▅▅▆███▃▄102.072106.74108.376104.431100.401120.811118.272137.607137.388144.846160.256157.145160.589120.127125.336NANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANA
us-gaap:LiabilitiesCurrent ▄▄█▃▃▃▃▃▃▃▄▃▃▃▃▂▂▂▁▁▁▁▂▁▁293.825295.105583.25244.571231.341258.025273.005231.777241.213252.473280.294260.238248.619212.643224.741177.647191.76170.58133.784106.892111.081124.495148.876122.198102.132NA100.288115.332107.325100.816100.83697.812103.27886.99570.29574.32251.60155.06361.70776.11283.54291.9894.399105.89NANANA
us-gaap:OperatingLeaseLiabilityCurrent NANA2.0NANANA2.02.11.92.0NANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANA
us-gaap:OtherAccruedLiabilitiesCurrent NANA30.861NANANA32.019NANANA13.938NANANA16.481NANANA6.155NANANANANANANANANANANANANANANANANANANANANANANANANANANANA
  2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302017-06-302017-03-312016-12-312016-09-302016-06-302016-03-312015-12-312015-09-302015-06-302015-05-312015-03-312014-12-312014-09-302014-06-302014-03-312013-12-312013-09-302013-06-302013-03-312012-12-312012-09-302012-06-302012-03-312011-12-312011-09-302011-06-302011-03-312010-12-312010-09-302010-06-302010-03-31
us-gaap:DebtAndCapitalLeaseObligations NANA839.574NANANA787.526NANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANA
us-gaap:LongTermDebtAndCapitalLeaseObligations NANA539.112NANANA785.5NANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANA145.5734.7245.4654.9385.72NANANA
us-gaap:MinorityInterest NANANA223.235217.62210.172213.453161.673187.818179.769139.081129.594121.18185.7187.84789.7NANA0.0NANANANANANANANANANANANANANANANANANANANANANANANANANANANA
us-gaap:LesseeOperatingLeaseLiabilityPaymentsDueYearTwo NANA2.968NANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANA
us-gaap:LesseeOperatingLeaseLiabilityPaymentsDueYearThree NANA2.707NANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANA
us-gaap:LesseeOperatingLeaseLiabilityPaymentsDueYearFour NANA2.583NANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANA
us-gaap:LesseeOperatingLeaseLiabilityPaymentsDueYearFive NANA2.442NANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANA
us-gaap:LesseeOperatingLeaseLiabilityPaymentsDueAfterYearFive NANA7.038NANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANA
  2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302017-06-302017-03-312016-12-312016-09-302016-06-302016-03-312015-12-312015-09-302015-06-302015-05-312015-03-312014-12-312014-09-302014-06-302014-03-312013-12-312013-09-302013-06-302013-03-312012-12-312012-09-302012-06-302012-03-312011-12-312011-09-302011-06-302011-03-312010-12-312010-09-302010-06-302010-03-31
us-gaap:StockholdersEquity ▃▄▅██▇█▇▇▇▆▄▄▂▂▂▂▂▁▁▁▁▂▂▂582.674680.564843.3471383.1491377.1751360.2391471.0941336.2931269.3841207.6511048.079710.55696.255301.391330.872307.968215.571201.80699.565139.639111.213158.162200.79245.414300.32NA275.851257.78344.772366.86374.102378.39401.446401.081201.091182.766170.277154.314150.872171.434186.825NANA244.542NANANA
us-gaap:StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest ▂▃▃██▇█▇▇▆▅▃▃▁▁▁582.674680.564843.3471606.3841594.7951570.4111684.5471497.9661457.2021387.421187.16840.144817.436387.101418.719397.668NANA99.565NANANA200.79NANANANA257.78NANANA378.39NANANA182.766NANANA171.434NA212.217227.703244.542NANANA
us-gaap:CommonStockValue ████▇▇████▇▇▇▃▃▃▂▂▂▁▁▁▁▁▁0.1410.1410.140.140.1390.1390.140.1410.140.140.1380.1380.1370.1250.1250.1250.1240.1240.1220.1210.1210.1210.120.120.12NA0.120.1180.1180.1180.1180.1160.1160.1140.1030.1020.1020.10.10.10.10.10.10.099NANANA
us-gaap:AdditionalPaidInCapitalCommonStock ▅▅▇██▇▇▇▇▇▆▆▆▃▃▃▂▂▁▂▂▁▁▁▁1910.3791925.8012113.6462311.6792271.632233.6442203.7782219.092177.2222117.9692047.252030.3132011.5611576.9541549.9041528.1861434.9861410.1021311.2291373.3091352.5891331.9451309.1071286.691269.452NA1251.9281224.5091365.4071352.9941343.8741324.8041315.6431292.7451091.8421077.151073.6581019.9361016.4971013.5921009.331006.2881003.5951000.181NANANA
us-gaap:RetainedEarningsAccumulatedDeficit ▁▂▂▆▆▆█▆▆▆▅▁▁▂▂▂▂▂▂▂▂▃▃▄▅-1302.05-1221.175-1249.368-909.098-878.154-846.309-707.534-857.563-883.726-882.85-967.293-1287.369-1282.809-1242.454-1187.398-1190.144-1189.167-1177.96-1181.428-1207.293-1214.644-1157.789-1094.872-1023.439-987.663NA-1023.311-1006.594-1037.647-1010.971-998.89-967.61-943.334-918.764-908.638-906.966-904.329-866.69-865.483-841.488-821.452-794.57-776.681-756.687NANANA
 us-gaap:RetainedEarningsAccumulatedDeficit us-gaap:Restatement srt:ScenarioPreviouslyReportedNANA-1249.368NANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANA
 us-gaap:RetainedEarningsAccumulatedDeficit us-gaap:Restatement,us-gaap:AdjustmentsForNewAccountingPronouncements srt:RevisionOfPriorPeriodAccountingStandardsUpdateAdjustment,ions:AccountingStandardsUpdate202006NANA118.062NANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANA
 us-gaap:RetainedEarningsAccumulatedDeficit us-gaap:Restatement,us-gaap:AdjustmentsForNewAccountingPronouncements srt:RevisionOfPriorPeriodAccountingStandardsUpdateAdjustment,us-gaap:AccountingStandardsUpdate202006NANA118.062NANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANA
us-gaap:AccumulatedOtherComprehensiveIncomeLossNetOfTax ▂▂▃▃▃▂▂▂▂▂▁▁▁▁▁▁▁▁▁▂▂▃▄▃█-25.796-24.203-21.071-19.572-16.44-27.235-25.29-25.375-24.252-27.608-32.016-32.532-32.634-33.234-31.759-30.199-30.372-30.46-30.358-26.498-26.853-16.115-13.565-17.95718.411NA47.11439.74716.89424.71929.021.0829.02126.98617.78412.480.8460.968-0.242-0.77-1.1530.3990.6890.949NANANA
us-gaap:MinorityInterest NANANA223.235217.62210.172213.453161.673187.818179.769139.081129.594121.18185.7187.84789.7NANA0.0NANANANANANANANANANANANANANANANANANANANANANANANANANANANA
us-gaap:AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue ▂▂█▃▃▃▂▁▃▃▂▂▂▁30.02237.86195.0445.84548.44240.7935.0124.12641.93345.50534.10234.88333.87628.451NANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANA
  2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302017-06-302017-03-312016-12-312016-09-302016-06-302016-03-312015-12-312015-09-302015-06-302015-05-312015-03-312014-12-312014-09-302014-06-302014-03-312013-12-312013-09-302013-06-302013-03-312012-12-312012-09-302012-06-302012-03-312011-12-312011-09-302011-06-302011-03-312010-12-312010-09-302010-06-302010-03-31
us-gaap:NetCashProvidedByUsedInOperatingActivities ▁▁▃▂▁▂▅▂▁▃▃▁█▂▂▂▂▃▁▂-62.652-54.66297.977-10.357-44.144-7.584277.932-12.806-27.111107.705115.49-26.004500.23713.16520.40128.722.363122.665-26.83924.286NANANANANANANANANANANANANANANANA-24.871-2.577-6.711-24.334-24.448-26.177-39.842-25.503-21.4295.03-21.691
us-gaap:NetCashProvidedByUsedInInvestingActivities ▄▇█▇▇▄▇▆▄▅▂▂▁▇▅▄▆▄▆▅-101.0378.856187.849101.9479.695-95.007138.1911.396-110.687-70.174-326.207-307.671-375.17179.486-54.212-150.09914.695-168.67520.801-57.088NANANANANANANANANANANANANANANANA-10.60824.094-0.52233.963-4.42324.6456.718-7.24275.914-59.93614.958
us-gaap:NetCashProvidedByUsedInFinancingActivities ▇▅▁▅▅▄▅▅▅▅▅▅█▅▅▆▅▅▅▅314.542-7.577-521.4810.9378.435-94.50119.225-13.17434.5159.469.6468.076452.9195.2244.257147.5721.71275.5466.4484.543NANANANANANANANANANANANANANANANA34.3977.737-1.8530.585-0.8880.359-0.7282.675-0.4012.3540.068
us-gaap:CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect ▅▄▁▅▄▁█150.96416.491-235.395102.87843.986-197.092435.348NANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANA
  2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302017-06-302017-03-312016-12-312016-09-302016-06-302016-03-312015-12-312015-09-302015-06-302015-05-312015-03-312014-12-312014-09-302014-06-302014-03-312013-12-312013-09-302013-06-302013-03-312012-12-312012-09-302012-06-302012-03-312011-12-312011-09-302011-06-302011-03-312010-12-312010-09-302010-06-302010-03-31
us-gaap:AmortizationOfFinancingCosts █▅▄▃▃▃▂▂▂▂▂▂▂▂▂▂▂▂▁▁▁▁▁▁▁1.3330.860.6940.6480.6410.5950.4940.4910.4830.4740.4670.490.4120.4410.4140.4050.4010.3960.3150.3090.3030.2980.2920.2860.28NA0.2750.1830.140.1370.1350.1070.1060.1020.1NANANANANANANANANANANANA
us-gaap:DeferredIncomeTaxExpenseBenefit NANA316.746-0.9620.924-3.437-11.199-10.3330.88713.549-290.5110.00.00.0NANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANA
us-gaap:IncreaseDecreaseInAccountsPayable ▇▃▇▆▁▅▆▄▅▁█▅▅▂▆▇▃▅▆▄▅▂▇▇▄6.75-9.5698.2153.969-15.350.4112.421-2.661.087-17.19112.9510.633-1.095-13.1443.4918.323-10.5020.4724.523-2.764-1.019-11.4178.3499.059-5.502NA-2.6953.41-0.5774.637-2.6462.359-0.463.736-5.569NANANANANANANANANANANANA
us-gaap:IncreaseDecreaseInInventories ▆▄▃▁▅▇▂▅█▇▄▃▄▂▆▆▃▃▁▆▅▃▄▃▃1.90.234-0.207-1.550.8372.181-1.1950.873.2612.4750.204-0.6890.007-0.9221.5311.947-0.297-0.688-1.831.6511.148-0.3790.316-0.199-0.057NA0.549-0.795-0.6910.239-0.4960.648-0.9242.5-0.312NANANANANANANANANANANANA
us-gaap:NetCashProvidedByUsedInOperatingActivities ▁▁▃▂▁▂▅▂▁▃▃▁█▂▂▂▂▃▁▂-62.652-54.66297.977-10.357-44.144-7.584277.932-12.806-27.111107.705115.49-26.004500.23713.16520.40128.722.363122.665-26.83924.286NANANANANANANANANANANANANANANANA-24.871-2.577-6.711-24.334-24.448-26.177-39.842-25.503-21.4295.03-21.691
us-gaap:NetIncomeLoss ▄▄▁▄▄▄▇▅▅▆█▅▄▅▅▅▄▅▅▅▄▄▄▄▅-80.875-89.869-340.271-30.944-31.845-48.226184.41526.163-0.87684.443320.078-4.559-40.358-1.422.744-0.976-11.2063.46825.8657.351-56.855-62.917-71.433-35.77635.648NA-16.71731.053-26.676-12.081-31.28NANANANANANANANANANA-17.889-19.994NANA-25.154-9.658
 us-gaap:NetIncomeLoss us-gaap:ConsolidatedEntities ions:AkceaTherapeuticsIncNANA-85.987NANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANA
 us-gaap:NetIncomeLoss us-gaap:Ownership ions:AkceaTherapeuticsIncNANA-85.987-37.822-37.665-32.67462.243-23.772-28.24423.846-53.219-47.843-43.814-19.997-15.955-9.587NANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANA
 us-gaap:NetIncomeLoss us-gaap:Ownership,us-gaap:StatementClassOfStock ions:AkceaTherapeuticsInc,us-gaap:CommonStockNANANA-37.822-37.665-32.674NA-23.772-28.24423.846-53.219-47.843-43.814-19.997-15.955-9.87NANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANA
 us-gaap:NetIncomeLoss us-gaap:StatementBusinessSegments ions:IonisCoreNANA-250.6826.7745.807-15.63121.55249.9327.31163.697372.91343.2265.88218.78518.6729.168NANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANA
 us-gaap:NetIncomeLoss us-gaap:StatementEquityComponents us-gaap:Parent▄▄▁▄▄▄▇▅▅▆█▅▄▅-80.875-89.869-340.271-30.944-31.845-48.226184.41626.163-0.87684.443320.076-4.559-40.355-1.42NANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANA
 us-gaap:NetIncomeLoss us-gaap:StatementEquityComponents us-gaap:RetainedEarnings▄▄▁▄▄▄▇▅▅▆█▅▄▅-80.875-89.869-340.271-30.944-31.845-48.226184.41626.163-0.87684.443320.076-4.559-40.355-1.42NANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANA
us-gaap:ProfitLoss ▄▄▁▄▄▄▇▅▅▆█▄▄▅▅▅▅▅▅▅▄▄-80.875-89.869-341.426-43.091-43.769-58.48203.95718.432-10.01290.884302.735-20.365-56.573-10.812-4.662-4.896-11.2063.46825.8657.351-56.855-62.917NANANANA-16.71731.053-26.676-12.081-31.28-24.276-24.57-10.126-1.672NANANANANANANANANANANANA
us-gaap:ShareBasedCompensation ▂▃█▄▄▃▃▂▃▄▃▃▃▂▂▂▂▂▁▁▁▂▁▁▁30.02137.86195.0445.84448.44340.7935.0124.12741.93245.50534.10234.88333.87628.45122.33321.47221.25820.91215.15817.58619.26120.10317.40714.99713.605NA13.3058.4898.1187.7077.0693.12.8132.6362.869NANANANANANANANANANANANA
  2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302017-06-302017-03-312016-12-312016-09-302016-06-302016-03-312015-12-312015-09-302015-06-302015-05-312015-03-312014-12-312014-09-302014-06-302014-03-312013-12-312013-09-302013-06-302013-03-312012-12-312012-09-302012-06-302012-03-312011-12-312011-09-302011-06-302011-03-312010-12-312010-09-302010-06-302010-03-31
us-gaap:NetCashProvidedByUsedInInvestingActivities ▄▇█▇▇▄▇▆▄▅▂▂▁▇▅▄▆▄▆▅-101.0378.856187.849101.9479.695-95.007138.1911.396-110.687-70.174-326.207-307.671-375.17179.486-54.212-150.09914.695-168.67520.801-57.088NANANANANANANANANANANANANANANANA-10.60824.094-0.52233.963-4.42324.6456.718-7.24275.914-59.93614.958
us-gaap:PaymentsToAcquirePropertyPlantAndEquipment ▃▁▃▆▅▅▄█▂▂▁▂▄▂▄█▃▂▂▁▂▁▂▁▂4.3581.7725.14911.7939.0989.087.76215.94.0143.2291.3873.2446.6342.3438.26217.0496.2163.2372.7941.052.6350.6282.4111.3413.062NA0.8783.5490.8691.6971.4030.4390.5220.3690.2220.4460.1690.7510.113-0.3241.6733.4062.5760.4970.8460.88511.009
  2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302017-06-302017-03-312016-12-312016-09-302016-06-302016-03-312015-12-312015-09-302015-06-302015-05-312015-03-312014-12-312014-09-302014-06-302014-03-312013-12-312013-09-302013-06-302013-03-312012-12-312012-09-302012-06-302012-03-312011-12-312011-09-302011-06-302011-03-312010-12-312010-09-302010-06-302010-03-31
us-gaap:NetCashProvidedByUsedInFinancingActivities ▇▅▁▅▅▄▅▅▅▅▅▅█▅▅▆▅▅▅▅314.542-7.577-521.4810.9378.435-94.50119.225-13.17434.5159.469.6468.076452.9195.2244.257147.5721.71275.5466.4484.543NANANANANANANANANANANANANANANANA34.3977.737-1.8530.585-0.8880.359-0.7282.675-0.4012.3540.068
us-gaap:PaymentsForRepurchaseOfCommonStock NANA0.00.0-0.00290.5534.4NA0.00.0NANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANA
  2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302017-06-302017-03-312016-12-312016-09-302016-06-302016-03-312015-12-312015-09-302015-06-302015-05-312015-03-312014-12-312014-09-302014-06-302014-03-312013-12-312013-09-302013-06-302013-03-312012-12-312012-09-302012-06-302012-03-312011-12-312011-09-302011-06-302011-03-312010-12-312010-09-302010-06-302010-03-31
 us-gaap:DebtInstrumentInterestRateStatedPercentage us-gaap:DebtInstrument ions:ConvertibleSeniorNotes0125Percent████▁▁▁1.25e-071.25e-071.25e-071.25e-071.25e-091.25e-091.25e-09NANANA1.25e-09NANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANA
 us-gaap:DebtInstrumentInterestRateStatedPercentage us-gaap:DebtInstrument ions:ConvertibleSeniorNotes1Percent████▁▁▁▁▁▁▁▁▁▁▁▁▁▁▁▁▁▁▁▁▁1e-061e-061e-061e-061e-081e-081e-081e-081e-081e-081e-081e-081e-081e-081e-081e-081e-081e-081e-081e-081e-081e-081e-081e-081e-08NANA1e-08NANANANANANANANANANANANANANANANANANANA
 us-gaap:DebtInstrumentInterestRateStatedPercentage us-gaap:DebtInstrument,us-gaap:SubsequentEventType ions:ConvertibleSeniorNotes0Percent,us-gaap:SubsequentEventNANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANANA

Common Stock Value

us-gaap:CommonStockValue

us-gaap:CommonStockValue


Common
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302017-06-302017-03-312016-12-312016-09-302016-06-302016-03-312015-12-312015-09-302015-06-302015-03-312014-12-312014-09-302014-06-302014-03-312013-12-312013-09-302013-06-302013-03-312012-12-312012-09-302012-06-302012-03-312011-12-312011-09-302011-06-302011-03-312010-12-312009-12-31
Value141000.0141000.0140000.0140000.0139000.0139000.0140000.0141000.0140000.0140000.0138000.0138000.0137000.0125000.0125000.0125000.0124000.0124000.0122000.0121000.0121000.0121000.0120000.0120000.0120000.0120000.0118000.0118000.0118000.0118000.0116000.0116000.0114000.0103000.0102000.0102000.0100000.0100000.0100000.0100000.0100000.0100000.099000.099000.0
Percentage of CommonStockValue100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0
Percentage of Assets0.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.0

Shares Issued

us-gaap:SharesIssued us-gaap:StatementEquityComponents

us-gaap:SharesIssued

us-gaap:CommonStock


Shares
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312016-12-312015-12-312014-12-312013-12-312012-12-312011-12-312010-12-312009-12-312008-12-312007-12-31
Value14114014013913913914014014013913713713712512412112011811610110099989787
Percentage of SharesIssued100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0

Common Stock Shares Issued

us-gaap:CommonStockSharesIssued

us-gaap:CommonStockSharesIssued


Common
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302017-06-302017-03-312016-12-312016-09-302016-06-302016-03-312015-12-312015-09-302015-06-302015-03-312014-12-312014-09-302014-06-302014-03-312013-12-312013-09-302013-06-302013-03-312012-12-312012-09-302012-06-302012-03-312011-12-312011-09-302011-06-302011-03-312010-12-312009-12-31
Value1411401401391391391401401401391371371371251241241241231211211201201201201191191181171171171161151141021011011001001009999999998
Percentage of CommonStockSharesIssued100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0

us-gaap:CommonStockSharesIssued us-gaap:StatementClassOfStock

us-gaap:CommonStock


Common
Period End2020-12-312019-12-312018-12-312017-12-312016-12-312015-12-312014-12-312013-12-312012-12-312011-12-312010-12-31
Value14014013712412112011811610110099
Percentage of CommonStockSharesIssued100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0

Common Stock Shares Authorized

us-gaap:CommonStockSharesAuthorized

us-gaap:CommonStockSharesAuthorized


Common
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302017-06-302017-03-312016-12-312016-09-302016-06-302016-03-312015-12-312015-09-302015-06-302015-03-312014-12-312014-06-302014-03-312013-12-312013-09-302013-06-302013-03-312012-12-312012-09-302012-06-302012-03-312011-12-312011-09-302011-06-302011-03-312010-12-312009-12-31
Value300300300300300300300300300300300300300300300300300300300300300300300300300300300300200200200200200200200200200200200200200200200
Percentage of CommonStockSharesAuthorized100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0

us-gaap:CommonStockSharesAuthorized us-gaap:StatementClassOfStock

us-gaap:CommonStock


Common
Period End2020-12-312019-12-312018-12-312017-12-312016-12-312015-12-312014-12-312013-12-312012-12-312011-12-312010-12-31
Value300300300300300300300200200200200
Percentage of CommonStockSharesAuthorized100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0

Preferred Stock Shares Authorized

us-gaap:PreferredStockSharesAuthorized us-gaap:StatementClassOfStock

us-gaap:PreferredStockSharesAuthorized

us-gaap:PreferredStock


Preferred
Period End2020-12-31
Value15
Percentage of PreferredStockSharesAuthorized100.0

Common Stock Shares Outstanding

us-gaap:CommonStockSharesOutstanding

us-gaap:CommonStockSharesOutstanding


Common
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302017-06-302017-03-312016-12-312016-09-302016-06-302016-03-312015-12-312015-09-302015-06-302015-03-312014-12-312014-09-302014-06-302014-03-312013-12-312013-09-302013-06-302013-03-312012-12-312012-09-302012-06-302012-03-312011-12-312011-09-302011-06-302011-03-312010-12-312009-12-31
Value1411401401391391391401401401391371371371251241241241231211211201201201201191191181171171171161151141021011011001001009999999998
Percentage of CommonStockSharesOutstanding100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0

us-gaap:CommonStockSharesOutstanding us-gaap:StatementClassOfStock

us-gaap:CommonStock


Common
Period End2020-12-312019-12-312018-12-312017-12-312016-12-312015-12-312014-12-312013-12-312012-12-312011-12-312010-12-31
Value14014013712412112011811610110099
Percentage of CommonStockSharesOutstanding100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0

Weighted Average Number Of Diluted Shares Outstanding

us-gaap:WeightedAverageNumberOfDilutedSharesOutstanding

us-gaap:WeightedAverageNumberOfDilutedSharesOutstanding


Weighted
Period End2021-06-302021-03-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302017-06-302017-03-312016-12-312016-09-302016-06-302016-03-312015-09-302015-06-302014-12-312014-06-302013-09-302013-06-302013-03-312012-09-302012-06-302012-03-312011-09-302011-06-302011-03-312010-09-302010-06-302010-03-31
Value140140139139139153143140141149143128125126124123124123123120120119127122117115108101100100100999999999999
Percentage of WeightedAverageNumberOfDilutedSharesOutstanding100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0

Weighted Average Number Of Shares Outstanding Basic

us-gaap:WeightedAverageNumberOfSharesOutstandingBasic

us-gaap:WeightedAverageNumberOfSharesOutstandingBasic


Weighted
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302017-06-302017-03-312016-12-312016-09-302016-06-302016-03-312015-09-302015-06-302014-12-312014-06-302013-09-302013-06-302013-03-312012-09-302012-06-302012-03-312011-09-302011-06-302011-03-312010-09-302010-06-302010-03-31
Value140140139139139139140140140138137143128125124124123122121120120120119119118117115108101100100100999999999999
Percentage of WeightedAverageNumberOfSharesOutstandingBasic100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0

Earnings Per Share Basic

us-gaap:EarningsPerShareBasic

us-gaap:EarningsPerShareBasic


Earnings
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302017-06-302017-03-312016-12-312016-09-302016-06-302016-03-312015-12-312015-09-302015-06-302015-03-312014-12-312014-09-302014-06-302014-03-312011-12-312011-09-302011-06-302011-03-312010-12-312010-09-302010-06-302010-03-31
Value-0.57-0.64-2.44-0.22-0.23-0.351.310.19-0.010.632.32-0.03-0.29-0.010.020-0.090.030.210.06-0.47-0.52-0.59-0.30.3-0.140.26-0.23-0.1-0.27-0.2-0.27-0.18-0.2-0.14-0.13-0.25-0.1
Percentage of EarningsPerShareBasic100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.00.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0

us-gaap:EarningsPerShareBasic us-gaap:Ownership

ions:AkceaTherapeuticsInc


Earnings
Period End2020-12-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-31
Value-0.050.87-0.34-0.40.35-0.79-0.73-0.72-0.44
Percentage of EarningsPerShareBasic2.066.4-178.94000.055.6-34.12433.3248.34400.0

us-gaap:EarningsPerShareBasic us-gaap:Ownership, us-gaap:StatementClassOfStock

ions:AkceaTherapeuticsInc, us-gaap:CommonStock


Earnings
Period End2020-09-302020-06-302020-03-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-30
Value-0.49-0.49-0.42-0.34-0.40.35-0.79-0.73-0.72-0.44-0.35-0.27
Percentage of EarningsPerShareBasic222.7213.0120.0-178.94000.055.6-34.12433.3248.34400.0-1750.00.0

Earnings Per Share Diluted

us-gaap:EarningsPerShareDiluted

us-gaap:EarningsPerShareDiluted


Earnings
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302017-06-302017-03-312016-12-312016-09-302016-06-302016-03-312015-12-312015-09-302015-06-302015-03-312014-12-312014-09-302014-06-302014-03-312012-12-312012-09-302012-06-302012-03-312011-12-312011-09-302011-06-302011-03-312010-12-312010-09-302010-06-302010-03-31
Value-0.57-0.64-2.44-0.22-0.23-0.351.280.18-0.010.622.21-0.03-0.29-0.010.020-0.090.030.210.06-0.47-0.52-0.59-0.30.29-0.140.25-0.23-0.1-0.27-0.03-0.37-0.01-0.24-0.2-0.27-0.18-0.2-0.14-0.13-0.25-0.1
Percentage of EarningsPerShareDiluted100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.00.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0

Allocated Share Based Compensation Expense

us-gaap:AllocatedShareBasedCompensationExpense

us-gaap:AllocatedShareBasedCompensationExpense


Allocated
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302017-06-302017-03-312016-12-312016-09-302016-06-302016-03-312015-12-312015-09-302015-06-302015-03-312014-12-312014-09-302014-06-302014-03-312013-12-312013-09-302013-06-302013-03-312012-12-312012-09-302012-06-302012-03-312011-12-312011-09-302011-06-302011-03-312010-12-312010-09-302010-06-30
Value30379545484035244145343433282221212015171920171413138.4898.1187.7087.0693.12.8122.6362.8691.812.0342.462.2672.2492.3642.52.7322.7122.963.132
Percentage of AllocatedShareBasedCompensationExpense100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax23.933.932.728.633.330.67.114.425.615.317.824.028.819.713.018.118.918.19.515.950.154.533.830.511.321.310.018.413.525.17.311.96.96.69.117.55.29.86.911.410.112.910.310.313.3

us-gaap:AllocatedShareBasedCompensationExpense us-gaap:ConsolidatedEntities

ions:AkceaTherapeuticsInc


Allocated
Period End2020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302017-06-30
Value5713167.37.6-19.114181312126.45.74.73.9
Percentage of AllocatedShareBasedCompensationExpense60.630.133.217.921.7-79.234.340.938.436.435.722.525.521.918.3
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax19.88.611.15.51.5-11.48.86.36.88.710.34.43.34.03.5
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax ions:AkceaTherapeuticsInc0.00.00.00.00.00.00.00.00.00.00.00.00.00.00.0

us-gaap:AllocatedShareBasedCompensationExpense us-gaap:IncomeStatementLocation

ions:ResearchDevelopmentAndPatent


Allocated
Period End2020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302017-06-302017-03-312016-12-312016-09-302016-06-302016-03-31
Value3825262523232324181819191616161612131414
Percentage of AllocatedShareBasedCompensationExpense40.755.353.762.766.998.456.753.755.353.856.869.272.075.475.977.182.875.575.273.5
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax13.315.817.919.24.714.114.58.29.812.916.313.69.313.714.413.97.812.037.740.1
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax ions:ResearchDevelopmentAndPatent0.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.0

ions:ResearchDevelopmentAndPatentExpense


Allocated
Period End2021-03-312020-03-31
Value2525
Percentage of AllocatedShareBasedCompensationExpense68.462.7
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax23.219.2
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax ions:ResearchDevelopmentAndPatentExpense0.00.0

ions:ResearchDevelopmentAndPatentExpenses


Allocated
Period End2021-06-302020-06-30
Value2226
Percentage of AllocatedShareBasedCompensationExpense75.853.7
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax18.117.9
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax ions:ResearchDevelopmentAndPatentExpenses0.00.0

us-gaap:CostOfSales


Allocated
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-31
Value0.00.1821.0890.3150.350.2370.0550.1270.1370.1180.160.00.00.0
Percentage of AllocatedShareBasedCompensationExpense0.00.51.10.70.70.60.20.50.30.30.50.00.00.0
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax0.00.20.40.20.20.20.00.10.10.00.10.00.00.0
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax us-gaap:CostOfSales0.00.00.00.00.00.00.00.00.00.00.00.00.00.0

us-gaap:SellingGeneralAndAdministrativeExpenses


Allocated
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302017-06-302017-03-312016-12-312016-09-302016-06-302016-03-31
Value7.2741155202214110.25518201516148.7696.2555.2915.1184.792.64.3074.7685.333
Percentage of AllocatedShareBasedCompensationExpense24.231.158.244.045.636.833.01.143.046.044.246.243.230.828.024.624.122.917.224.524.826.5
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax5.810.619.012.615.211.22.30.211.07.07.911.112.46.13.64.54.64.11.63.912.414.5
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax us-gaap:SellingGeneralAndAdministrativeExpenses0.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.0

Comprehensive Income Net Of Tax

us-gaap:ComprehensiveIncomeNetOfTax

us-gaap:ComprehensiveIncomeNetOfTax


Comprehensive
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302017-06-302017-03-312016-12-312016-09-302016-06-302016-03-312015-12-312015-09-302015-06-302015-03-312014-12-312014-09-302014-06-302014-03-312013-12-312013-09-302013-06-302013-03-312012-12-312012-09-302012-06-302012-03-312011-12-312011-09-30
Value-82.468-93.001-341.77-34.076-21.05-50.171184252.4888320-4.463-39.736-2.8641.281-0.715-11.1183.354227.706-67.593-65.467-67.041-72.1446.945-9.3553-34.501-16.362-23.36-32.217-22.535-0.9243.6328.997-37.7610.003-23.467-19.653-28.434
Percentage of ComprehensiveIncomeNetOfTax100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax-65.6-83.3-117.7-21.3-14.5-37.637.414.91.529.9166.9-3.1-33.7-2.00.7-0.6-9.92.913.76.9-175.7-177.5-130.0-146.95.8-14.963.5-78.3-28.7-83.0-76.3-95.5-2.48.445.3-325.50.0-101.0-60.7-137.3

Comprehensive Income Net Of Tax Attributable To Noncontrolling Interest

us-gaap:ComprehensiveIncomeNetOfTaxAttributableToNoncontrollingInterest

us-gaap:ComprehensiveIncomeNetOfTaxAttributableToNoncontrollingInterest


Comprehensive
Period End2020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302017-06-302017-03-312016-12-312016-09-30
Value-1.597-12.188-11.441-10.25419-7.729-9.1366.442-17.326-15.797-16.237-9.423-7.469-3.9520.00.00.00.0
Percentage of ComprehensiveIncomeNetOfTaxAttributableToNoncontrollingInterest100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.00.00.00.00.0
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax-0.6-7.6-7.9-7.74.0-4.6-5.62.2-9.0-10.9-13.8-6.5-4.3-3.30.00.00.00.0

Comprehensive Income Net Of Tax Including Portion Attributable To Noncontrolling Interest

us-gaap:ComprehensiveIncomeNetOfTaxIncludingPortionAttributableToNoncontrollingInterest

us-gaap:ComprehensiveIncomeNetOfTaxIncludingPortionAttributableToNoncontrollingInterest


Comprehensive
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302017-06-302017-03-312016-12-312016-09-302011-12-312011-09-302011-06-302010-12-312010-09-302010-06-30
Value-82.468-93.001-343.367-46.264-32.491-60.42520417-6.65695303-20.26-55.973-12.287-6.188-4.667-2.9978.85227.706-19.653-28.434-18.179-14.199-12.233-25.591
Percentage of ComprehensiveIncomeNetOfTaxIncludingPortionAttributableToNoncontrollingInterest100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax-65.6-83.3-118.3-28.9-22.3-45.341.310.3-4.132.1157.8-13.9-47.5-8.5-3.6-3.9-2.77.613.76.9-60.7-137.3-73.2-53.7-42.7-108.9

Cost Of Goods And Services Sold

us-gaap:CostOfGoodsAndServicesSold

us-gaap:CostOfGoodsAndServicesSold


Cost
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-31
Value2.9582.5783.3013.0863.0122.5481.0110.9671.3641.0411.820.00.00.0
Percentage of CostOfGoodsAndServicesSold100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.00.00.00.0
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax2.42.31.11.92.11.90.20.60.80.40.90.00.00.0

Costs And Expenses

us-gaap:CostsAndExpenses

us-gaap:CostsAndExpenses


Costs
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-31
Value198203312196197194233165182175181163168147
Percentage of CostsAndExpenses100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax158.0182.4107.8122.8135.6145.847.298.5111.559.194.4112.8142.7102.3

us-gaap:CostsAndExpenses us-gaap:ConsolidationItems

us-gaap:IntersegmentElimination


Costs
Period End2020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-31
Value-39.932-2.324-7.354-2.266-129.06-6.993-4.462-76.446-2.053-7.9460.409-5.259
Percentage of CostsAndExpenses-12.8-1.2-3.7-1.2-55.4-4.2-2.4-43.5-1.1-4.80.2-3.6
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax-13.8-1.5-5.1-1.7-26.1-4.2-2.7-25.7-1.1-5.50.3-3.6
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax us-gaap:IntersegmentElimination0.0274.7124.8281.80.0126.8148.786.40.015.30.0100.6

us-gaap:CostsAndExpenses us-gaap:ConsolidationItems, us-gaap:StatementBusinessSegments

us-gaap:OperatingSegments, ions:AkceaTherapeutics


Costs
Period End2020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-31
Value185697361194536513782848147
Percentage of CostsAndExpenses59.335.237.231.583.432.235.878.345.451.448.632.1
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax63.943.350.546.039.431.739.946.342.857.969.432.8
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax us-gaap:OperatingSegments ions:AkceaTherapeutics0.0355.8328.3381.60.0258.0245.484.00.0437.9446.2277.3

us-gaap:OperatingSegments, ions:IonisCore


Costs
Period End2020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-31
Value1671291311351671191211141018785105
Percentage of CostsAndExpenses53.565.966.569.672.072.066.765.255.853.551.171.4
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax57.781.090.1101.534.071.074.338.552.660.372.973.1
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax us-gaap:OperatingSegments ions:IonisCore0.091.7101.6114.70.078.086.951.60.049.286.479.6

Gain Loss On Investments

us-gaap:GainLossOnInvestments

us-gaap:GainLossOnInvestments


Gain
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-06-302015-06-302015-03-312014-12-312014-09-302014-06-302014-03-312013-12-312013-09-302013-06-302013-03-312012-12-312012-09-302012-06-302012-03-312011-12-312011-09-302011-06-302011-03-312010-12-312010-09-302010-06-302010-03-31
Value0.860.0135.8180.8359.6250.2460.00.0010.00.5810.538-0.260.3970.3050.1750.841.0581.4460.00.0020.0174.4490.0180.034-0.3180.449-0.015-0.136-1.01
Percentage of GainLossOnInvestments100.0100.0100.0100.0100.0100.00.0100.00.0100.0100.0100.0100.0100.0100.0100.0100.0100.00.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax0.70.02.00.56.60.20.00.00.00.71.2-0.51.40.70.72.22.47.30.00.00.113.70.10.1-1.51.7-0.1-0.6-3.4

Gains Losses On Extinguishment Of Debt

us-gaap:GainsLossesOnExtinguishmentOfDebt

us-gaap:GainsLossesOnExtinguishmentOfDebt


Gains
Period End2021-06-302017-12-312017-09-302016-12-312016-09-302012-12-312012-09-30
Value-8.6277.689-7.689-3.9830.00.0-4.77
Percentage of GainsLossesOnExtinguishmentOfDebt100.0100.0100.0100.00.00.0100.0
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax-6.94.5-6.5-2.50.00.0-41.1

us-gaap:GainsLossesOnExtinguishmentOfDebt us-gaap:DebtInstrument

ions:ConvertibleSeniorNotes1Percent


Gains
Period End2021-04-302019-12-31
Value8.621
Percentage of GainsLossesOnExtinguishmentOfDebt0.00.0
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax0.00.0
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax ions:ConvertibleSeniorNotes1Percent0.00.0

Income Loss From Continuing Operations Before Income Taxes Extraordinary Items Noncontrolling Interest

us-gaap:IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest

us-gaap:IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest


Income
Period End2021-06-302020-06-302017-09-302017-06-302017-03-312016-12-312016-09-302016-06-302016-03-312015-12-312015-09-302015-06-302015-03-312014-12-312014-09-302014-06-302014-03-312013-12-312013-09-302013-06-302013-03-312012-12-312012-09-302012-06-302012-03-312011-12-312011-09-302011-06-302011-03-312010-12-312010-09-30
Value-80.548-35.476-3.935-10.9843.468287.351-57.086-62.685-71.061-35.77636-17.50615-25.278-11.2-33.556-23.753-29.763-11.307-1.736-11.042-38.345-1.207-23.993-20.036-26.882-17.88-19.992-13.896-12.454
Percentage of IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax-64.1-24.4-3.3-9.83.018.06.6-148.4-170.0-137.8-72.830.3-28.018.4-57.4-19.6-119.2-56.2-126.2-29.7-4.0-55.6-330.5-2.5-103.3-61.8-129.8-72.0-94.5-52.6-43.5

Income Loss From Continuing Operations Before Income Taxes Minority Interest And Income Loss From Equity Method Investments

us-gaap:IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments

us-gaap:IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments


Income
Period End2021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302017-06-302017-03-31
Value-89.739-23.645-40.443-44.208-61.7372383.517-16.93912110-19.913-56.215-10.797-22.844-6.532-2.8638.964
Percentage of IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax-80.4-8.1-25.3-30.4-46.348.32.1-10.341.05.6-13.7-47.7-7.5-13.3-5.5-2.67.7

Income Tax Expense Benefit

us-gaap:IncomeTaxExpenseBenefit

us-gaap:IncomeTaxExpenseBenefit


Income
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302017-06-302017-03-312016-12-312016-09-302016-06-302016-03-312015-12-312015-09-302015-06-302015-03-312014-12-312014-09-302014-06-302014-03-312012-12-312012-09-302012-06-302012-03-312011-12-312011-09-302011-06-302011-03-312010-12-312010-09-302010-06-30
Value0.3270.133172.648-0.439-3.25734-14.915-6.92731-291.9650.4520.3580.015-7.1640.9610.2220.02.9330.0-0.2310.2320.3720.00.789-0.789-15.4091.3980.881-2.276-8.405-0.7060.00.0020.00.00.0090.0020.090.00.002
Percentage of IncomeTaxExpenseBenefit100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.00.0100.00.0100.0100.0100.00.0100.0100.0100.0100.0100.0100.0100.0100.00.0100.00.00.0100.0100.0100.00.0100.0
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax0.30.1109.51.7-0.3-2.46.9-8.9-4.210.4-152.00.30.30.0-4.20.80.20.01.80.0-0.60.60.70.00.7-1.3-18.23.21.5-8.1-42.3-6.10.00.00.00.00.00.00.30.00.0

Income Taxes Paid

us-gaap:IncomeTaxesPaid

us-gaap:IncomeTaxesPaid


Income
Period End2021-03-312020-09-302020-06-302020-03-312019-09-302019-06-302019-03-31
Value0.002230.0460.0039.0370.00.0
Percentage of IncomeTaxesPaid100.0100.0100.0100.0100.00.00.0
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax0.014.70.00.05.40.00.0

Interest Expense

us-gaap:InterestExpense

us-gaap:InterestExpense


Interest
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302017-06-302017-03-312016-12-312016-09-302016-06-302016-03-312015-12-312015-09-302015-06-302015-03-312014-12-312014-09-302014-06-302014-03-312013-12-312013-09-302013-06-302013-03-312012-12-312012-09-302012-06-302012-03-312011-12-312011-09-302011-06-302011-03-312010-12-312010-09-302010-06-302010-03-31
Value2.3572.414111111101312111111111110101011119.9349.7469.6259.499.3519.2339.1279.0217.3074.9984.9614.9434.8854.8674.8084.7954.8175.9375.2195.1795.1084.7733.4373.4153.3973.3383.2613.237
Percentage of InterestExpense100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax1.92.24.07.17.78.22.77.17.23.96.07.89.47.66.39.110.59.86.28.825.025.718.118.87.614.48.611.38.717.611.620.612.611.124.251.211.022.315.823.013.816.112.911.713.910.8

Interest Paid Net

us-gaap:InterestPaidNet

us-gaap:InterestPaidNet


Interest
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302017-06-302017-03-312016-12-312016-09-302011-06-302011-03-312010-06-302010-03-31
Value2272000.0594000.02547000.0607000.02492000.0601000.04396000.0698000.04109000.0667000.04158000.0681000.04109000.0644000.04015000.0413000.03501000.0106000.03018000.0881000.0123000.02275000.0132000.02281000.0
Percentage of InterestPaidNet100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax1.80.50.90.41.70.50.90.42.50.22.20.53.50.42.30.33.10.11.90.80.510.80.67.6

Net Income Loss

us-gaap:NetIncomeLoss

us-gaap:NetIncomeLoss


Net
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302017-06-302017-03-312016-12-312016-09-302016-06-302016-03-312015-12-312015-09-302015-06-302015-03-312014-12-312014-09-302014-06-302014-03-312011-06-302011-03-312010-06-302010-03-31
Value-80.875-89.869-340.271-30.944-31.845-48.22618426-0.87684320-4.559-40.358-1.422.744-0.976-11.2063.468257.351-56.855-62.917-71.433-35.77635-16.71731-26.676-12.081-31.28-17.889-19.994-25.154-9.658
Percentage of NetIncomeLoss100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax-64.3-80.5-117.2-19.3-21.9-36.237.415.6-0.528.4166.6-3.1-34.3-1.01.6-0.8-10.03.016.16.6-147.8-170.6-138.5-72.829.6-26.736.6-60.5-21.2-111.1-72.1-94.5-107.0-32.3

us-gaap:NetIncomeLoss us-gaap:ConsolidatedEntities

ions:AkceaTherapeuticsInc


Net
Period End2020-12-31
Value-85.987
Percentage of NetIncomeLoss25.3
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax0.0
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax ions:AkceaTherapeuticsInc0.0

us-gaap:NetIncomeLoss us-gaap:Ownership

ions:AkceaTherapeuticsInc


Net
Period End2020-12-312020-10-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-30
Value-85.987-3.603-37.822-37.665-32.67462-23.772-28.24423-53.219-47.843-43.814-19.997-15.955-9.587
Percentage of NetIncomeLoss25.30.0122.2118.367.833.8-90.93224.228.2-16.61049.4108.61408.2-581.5982.3
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax0.00.0-23.6-25.9-24.512.6-14.2-17.28.0-27.7-32.9-37.2-13.8-9.3-8.1
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax ions:AkceaTherapeuticsInc0.00.00.00.00.00.00.00.00.00.00.00.00.00.00.0

us-gaap:NetIncomeLoss us-gaap:Ownership, us-gaap:StatementClassOfStock

ions:AkceaTherapeuticsInc, us-gaap:CommonStock


Net
Period End2020-09-302020-06-302020-03-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-30
Value-37.822-37.665-32.674-23.772-28.24423-53.219-47.843-43.814-19.997-15.955-9.87
Percentage of NetIncomeLoss122.2118.367.8-90.93224.228.2-16.61049.4108.61408.2-581.51011.3
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax-23.6-25.9-24.5-14.2-17.28.0-27.7-32.9-37.2-13.8-9.3-8.3
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax ions:AkceaTherapeuticsInc us-gaap:CommonStock0.00.00.00.00.00.00.00.00.00.00.00.0

us-gaap:NetIncomeLoss us-gaap:StatementBusinessSegments

ions:IonisCore


Net
Period End2020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-30
Value-250.6826.7745.807-15.63121492763372435.88218189.168
Percentage of NetIncomeLoss73.7-21.9-18.232.465.9190.8-3117.775.4116.5-948.1-14.6-1322.9680.5-939.3
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax-86.44.24.0-11.724.629.716.721.4194.129.75.013.010.87.7
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax ions:IonisCore0.00.00.00.00.00.00.00.00.00.00.00.00.00.0

us-gaap:NetIncomeLoss us-gaap:StatementEquityComponents

us-gaap:Parent


Net
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-31
Value-80.875-89.869-340.271-30.944-31.845-48.22618426-0.87684320-4.559-40.355-1.42
Percentage of NetIncomeLoss100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax-64.3-80.5-117.2-19.3-21.9-36.237.415.6-0.528.4166.6-3.1-34.3-1.0
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax us-gaap:Parent0.00.00.00.00.00.00.00.00.00.00.00.00.00.0

us-gaap:RetainedEarnings


Net
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-31
Value-80.875-89.869-340.271-30.944-31.845-48.22618426-0.87684320-4.559-40.355-1.42
Percentage of NetIncomeLoss100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax-64.3-80.5-117.2-19.3-21.9-36.237.415.6-0.528.4166.6-3.1-34.3-1.0
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax us-gaap:RetainedEarnings0.00.00.00.00.00.00.00.00.00.00.00.00.00.0

Net Income Loss Attributable To Noncontrolling Interest

us-gaap:NetIncomeLossAttributableToNoncontrollingInterest

us-gaap:NetIncomeLossAttributableToNoncontrollingInterest


Net
Period End2020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302017-06-302017-03-312016-12-312016-09-30
Value-1155000.0-12147000.0-11924000.0-10254000.019542000.0-7732000.0-9136000.06441000.0-17344000.0-15806000.0-16215000.0-9392000.0-7406000.0-3920000.00000
Percentage of NetIncomeLossAttributableToNoncontrollingInterest100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.00.00.00.00.0
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax-0.4-7.6-8.2-7.74.0-4.6-5.62.2-9.0-10.9-13.8-6.5-4.3-3.30.00.00.00.0

Net Income Loss Available To Common Stockholders Basic

us-gaap:NetIncomeLossAvailableToCommonStockholdersBasic

us-gaap:NetIncomeLossAvailableToCommonStockholdersBasic


Net
Period End2020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302017-06-302017-03-312016-12-312016-09-302015-06-302015-03-312014-12-312014-09-302014-06-302014-03-312013-12-312013-09-302013-06-302013-03-312012-12-312012-09-302012-06-302012-03-312011-12-312011-09-302011-06-302011-03-312010-12-312010-09-302010-06-302010-03-31
Value-340.272-31.048-31.858-48.30418326-0.93387319-4.616-37.932-1.2122.717-0.4192.413.468257.35135-16.71731-26.676-12.081-31.28-24.276-24.57-10.126-1.672-2.637-37.639-1.207-23.995-20.036-26.882-17.889-19.994-13.985-12.454-25.154-9.658
Percentage of NetIncomeLossAvailableToCommonStockholdersBasic100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax-117.2-19.4-21.9-36.237.215.6-0.629.5166.4-3.2-32.2-0.81.6-0.42.13.016.16.629.6-26.736.6-60.5-21.2-111.1-57.5-104.2-26.6-3.9-13.3-324.4-2.5-103.3-61.8-129.8-72.1-94.5-52.9-43.5-107.0-32.3

Operating Income Loss

us-gaap:OperatingIncomeLoss

us-gaap:OperatingIncomeLoss


Operating
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302017-06-302017-03-312016-12-312016-09-302016-06-302016-03-312015-12-312015-09-302015-06-302015-03-312014-12-312014-09-302014-06-302014-03-312013-12-312013-09-302013-06-302013-03-312012-12-312012-09-302012-06-302012-03-312011-12-312011-09-302011-06-302011-03-312010-12-312010-09-302010-06-302010-03-31
Value-72.969-91.971-22.664-36.537-51.754-61.1272602.523-18.82712110-18.572-50.281-3.301-1.69313-1.671134116-48.927-54.652-62.94-48.13844-9.3310-21.493-6.65-29.667-19.858-25.505-7.9281.625-26.119-28.0463.696-18.455-18.616-22.316-14.06-16.108-15.857-8.947-18.672-4.88
Percentage of OperatingIncomeLoss100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax-58.0-82.4-7.8-22.8-35.6-45.852.81.5-11.540.95.6-12.8-42.7-2.3-1.011.8-1.512.125.714.5-127.2-148.2-122.0-98.037.1-14.911.9-48.8-11.7-105.3-47.0-108.1-20.83.7-131.4-241.87.8-79.4-57.5-107.7-56.6-76.2-60.0-31.3-79.4-16.3

us-gaap:OperatingIncomeLoss us-gaap:ConsolidationItems

us-gaap:IntersegmentElimination


Operating
Period End2020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302017-06-302017-03-312016-12-312016-09-302016-06-302016-03-312015-12-312015-09-302015-06-30
Value1.4761.4781.4611.4621.4771.4781.462-12.046-47.948-43.961-0.4090.030.030.030.030.03-0.090.030.03-0.0360.00.00.03
Percentage of OperatingIncomeLoss-6.5-4.0-2.8-2.40.658.6-7.8-9.9-444.7236.70.8-0.9-1.80.2-1.80.2-0.20.2-0.10.1-0.0-0.00.1
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax0.50.91.01.10.30.90.9-4.1-25.0-30.2-0.30.00.00.00.00.0-0.10.00.1-0.10.00.00.0
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax us-gaap:IntersegmentElimination0.0-174.7-24.8-181.80.0-26.8-48.713.60.084.70.0-0.60.00.0-1.0-0.10.0-0.80.00.00.0-0.00.0

us-gaap:OperatingIncomeLoss us-gaap:ConsolidationItems, us-gaap:StatementBusinessSegments

us-gaap:OperatingSegments, ions:AkceaTherapeutics


Operating
Period End2020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302017-06-302017-03-312016-12-312016-09-302016-06-302016-03-312015-12-312015-09-302015-06-302015-03-31
Value-91.091-49.813-51.091-45.2683-32.591-38.70426-72.058-65.008-63.423-30.327-24.951-12.564-11.274-59.873-32.416-20.25-14.805-16.049-25.33-13.101-8.919-7.005
Percentage of OperatingIncomeLoss401.9136.398.774.031.9-1291.8205.621.6-668.3350.0126.1918.71473.8-90.3674.7-428.0-78.8-125.730.329.440.227.2-20.075.1
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax-31.4-31.1-35.1-33.916.8-19.4-23.68.8-37.5-44.7-53.9-21.0-14.5-10.6-10.0-51.7-20.2-18.3-38.5-43.5-49.1-26.7-7.4-11.2
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax us-gaap:OperatingSegments ions:AkceaTherapeutics0.0-255.8-228.3-281.60.0-158.0-145.416.00.0-337.9-346.2-177.30.0-126.8-197.3-982.50.00.00.00.00.00.00.00.0

us-gaap:OperatingSegments, ions:IonisCore


Operating
Period End2020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302017-06-302017-03-312016-12-312016-09-302016-06-302016-03-312015-12-312015-09-302015-06-302015-03-31
Value6611-2.124-17.329176331810713090132623269.573737336-34.152-38.567-37.701-35.06753-2.325
Percentage of OperatingIncomeLoss-295.4-32.34.128.367.51333.2-97.888.31213.0-486.7-27.0-817.8-1372.0190.1-572.9527.8179.0225.569.870.659.972.8119.924.9
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax23.17.4-1.5-13.035.720.011.236.168.162.211.518.713.522.38.563.845.932.7-88.8-104.6-73.1-71.444.5-3.7
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax us-gaap:OperatingSegments ions:IonisCore0.08.3-1.6-14.70.022.013.148.40.050.813.620.40.024.48.745.80.00.00.00.00.00.00.00.0

Other Nonoperating Income Expense

us-gaap:OtherNonoperatingIncomeExpense

us-gaap:OtherNonoperatingIncomeExpense


Other
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302017-06-30
Value-189000.03000.060000.0126000.0-149000.0-99000.0-354000.0-140000.0-45000.0-147000.0-37000.0-22000.045000.0-168000.0-20000.0-2141000.00
Percentage of OtherNonoperatingIncomeExpense100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.00.0
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax-0.20.00.00.1-0.1-0.1-0.1-0.1-0.0-0.0-0.0-0.00.0-0.1-0.0-1.80.0

Profit Loss

us-gaap:ProfitLoss

us-gaap:ProfitLoss


Profit
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302017-06-302017-03-312016-12-312016-09-302016-06-302016-03-312015-03-312014-12-312014-09-302014-06-302014-03-312013-12-312013-09-302013-06-302013-03-31
Value-80.875-89.869-341.426-43.091-43.769-58.4820318-10.01290302-20.365-56.573-10.812-4.662-4.896-11.2063.468257.351-56.855-62.917-16.71731-26.676-12.081-31.28-24.276-24.57-10.126-1.672
Percentage of ProfitLoss100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax-64.3-80.5-117.6-26.9-30.1-43.841.311.0-6.130.6157.6-14.0-48.0-7.5-2.7-4.1-10.03.016.16.6-147.8-170.6-26.736.6-60.5-21.2-111.1-57.5-104.2-26.6-3.9

Revenue From Contract With Customer Excluding Assessed Tax

us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax

us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax


Revenue
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302017-06-302017-03-312016-12-312016-09-302016-06-302016-03-312015-12-312015-09-302015-05-312015-06-302015-03-312014-12-312014-09-302014-06-302014-03-312013-12-312013-09-302013-06-302013-03-312012-12-312012-09-302012-06-302012-03-312011-12-312011-09-302011-06-302011-03-312010-12-312010-09-302010-06-302010-03-31
Value1251112901601451334931671632971921451171441721181121151601103836514991120628444572842233843191147233220242126282329
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0

us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax us-gaap:ConsolidationItems

us-gaap:IntersegmentElimination


Revenue
Period End2020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302017-06-302017-03-312016-12-312016-09-302016-06-302016-03-312015-12-312015-09-302015-06-30
Value-38.456-0.846-5.893-0.804-127.583-5.515-3.0-88.492-50.001-51.9070.0-5.2290.00.0-2.93-51.477-8.8-3.8480.00.0-1.062-3.1860.0
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax-13.2-0.5-4.0-0.6-25.8-3.3-1.8-29.8-26.0-35.70.0-3.60.00.0-2.6-44.5-5.5-3.50.00.0-2.1-6.50.0
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax-13.2-0.5-4.0-0.6-25.8-3.3-1.8-29.8-26.0-35.70.0-3.60.00.0-2.6-44.5-5.5-3.50.00.0-2.1-6.50.0
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax us-gaap:IntersegmentElimination100.0100.0100.0100.0100.0100.0100.0100.0100.0100.00.0100.00.00.0100.0100.0100.0100.00.00.0100.0100.00.0

us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax us-gaap:ConsolidationItems, us-gaap:ProductOrService

us-gaap:IntersegmentElimination, ions:Commercial


Revenue
Period End2020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302017-06-302017-03-31
Value-0.956-0.846-0.613-0.804-2.5830.0-3.00.07.2-7.20.00.00.00.00.00.0
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax-0.3-0.5-0.4-0.6-0.50.0-1.80.03.7-5.00.00.00.00.00.00.0
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax-0.3-0.5-0.4-0.6-0.50.0-1.80.03.7-5.00.00.00.00.00.00.0
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax us-gaap:IntersegmentElimination ions:Commercial100.0100.0100.0100.0100.00.0100.00.0100.0100.00.00.00.00.00.00.0

us-gaap:IntersegmentElimination, ions:LicensingAndOtherRoyalties


Revenue
Period End2020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302017-06-302017-03-31
Value-0.956-0.846-0.613-0.804-2.5830.0-3.00.07.2-7.20.00.00.00.00.00.0
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax-0.3-0.5-0.4-0.6-0.50.0-1.80.03.7-5.00.00.00.00.00.00.0
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax-0.3-0.5-0.4-0.6-0.50.0-1.80.03.7-5.00.00.00.00.00.00.0
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax us-gaap:IntersegmentElimination ions:LicensingAndOtherRoyalties100.0100.0100.0100.0100.00.0100.00.0100.0100.00.00.00.00.00.00.0

us-gaap:IntersegmentElimination, ions:ResearchAndDevelopmentRevenueUnderCollaborativeAgreements


Revenue
Period End2020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302017-06-30
Value-37.50.0-5.280.0-125.0-5.5150.0-88.492-57.201-44.7070.0-5.2290.00.0-2.93
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax-12.90.0-3.60.0-25.3-3.30.0-29.8-29.8-30.70.0-3.60.00.0-2.6
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax-12.90.0-3.60.0-25.3-3.30.0-29.8-29.8-30.70.0-3.60.00.0-2.6
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax us-gaap:IntersegmentElimination ions:ResearchAndDevelopmentRevenueUnderCollaborativeAgreements100.00.0100.00.0100.0100.00.0100.0100.0100.00.0100.00.00.0100.0

us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax us-gaap:ConsolidationItems, us-gaap:ProductOrService, us-gaap:StatementBusinessSegments

us-gaap:OperatingSegments, ions:Commercial, ions:AkceaTherapeutics


Revenue
Period End2020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302017-06-302017-03-31
Value191916151712156.7542.237120.00.00.00.00.00.0
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax6.711.911.211.43.67.29.72.31.28.30.00.00.00.00.00.0
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax6.711.911.211.43.67.29.72.31.28.30.00.00.00.00.00.0
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax us-gaap:OperatingSegments ions:Commercial ions:AkceaTherapeutics100.0100.0100.0100.0100.0100.0100.0100.0100.0100.00.00.00.00.00.00.0

us-gaap:OperatingSegments, ions:Commercial, ions:IonisCore


Revenue
Period End2020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302017-06-302017-03-31
Value7777736985837561637757425334237.801
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax26.648.250.852.217.349.846.020.633.153.648.629.131.329.321.16.7
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax26.648.250.852.217.349.846.020.633.153.648.629.131.329.321.16.7
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax us-gaap:OperatingSegments ions:Commercial ions:IonisCore100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0

us-gaap:OperatingSegments, ions:LicensingAndOtherRoyalties, ions:IonisCore


Revenue
Period End2020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302017-06-302017-03-31
Value2.5252.9752.2373.5984.151.9464.8961.623-6.6777.9460.5450.9421.8351.7271.3222.59
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax0.91.91.52.70.81.23.00.5-3.55.50.50.71.11.51.22.2
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax0.91.91.52.70.81.23.00.5-3.55.50.50.71.11.51.22.2
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax us-gaap:OperatingSegments ions:LicensingAndOtherRoyalties ions:IonisCore100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0

us-gaap:OperatingSegments, ions:ResearchAndDevelopmentRevenueUnderCollaborativeAgreements, ions:AkceaTherapeutics


Revenue
Period End2020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302017-06-30
Value740.436.0130.9152598.543101577.967.2411817219.9065.713
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax25.80.34.10.752.65.16.552.84.15.015.611.812.68.45.1
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax25.80.34.10.752.65.16.552.84.15.015.611.812.68.45.1
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax us-gaap:OperatingSegments ions:ResearchAndDevelopmentRevenueUnderCollaborativeAgreements ions:AkceaTherapeutics100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0

us-gaap:OperatingSegments, ions:ResearchAndDevelopmentRevenueUnderCollaborativeAgreements, ions:IonisCore


Revenue
Period End2020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302017-06-30
Value15764554825869641601681004290927385
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax54.140.237.836.452.441.239.654.087.768.935.962.753.562.476.4
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax54.140.237.836.452.441.239.654.087.768.935.962.753.562.476.4
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax us-gaap:OperatingSegments ions:ResearchAndDevelopmentRevenueUnderCollaborativeAgreements ions:IonisCore100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0

us-gaap:OperatingSegments, ions:SpinrazaRoyalties, ions:IonisCore


Revenue
Period End2020-12-312020-09-302020-06-302019-12-312019-09-302019-06-30
Value747471818170
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax25.746.349.316.448.643.0
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax25.746.349.316.448.643.0
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax us-gaap:OperatingSegments ions:SpinrazaRoyalties ions:IonisCore100.0100.0100.0100.0100.0100.0

us-gaap:OperatingSegments, us-gaap:Product, ions:AkceaTherapeutics


Revenue
Period End2020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-31
Value1919161513119.8656.754
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax6.711.911.211.42.87.16.02.3
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax6.711.911.211.42.87.16.02.3
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax us-gaap:OperatingSegments us-gaap:Product ions:AkceaTherapeutics100.0100.0100.0100.0100.0100.0100.0100.0

us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax us-gaap:ConsolidationItems, us-gaap:StatementBusinessSegments

us-gaap:OperatingSegments, ions:AkceaTherapeutics


Revenue
Period End2020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302017-06-302017-03-312016-12-312016-09-302016-06-302016-03-312015-12-312015-09-302015-06-302015-03-31
Value94192216277202616310191817219.9065.7136.0940.00.00.00.00.00.00.00.0
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax32.512.215.412.156.212.316.355.15.313.215.611.812.68.45.15.30.00.00.00.00.00.00.00.0
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax32.512.215.412.156.212.316.355.15.313.215.611.812.68.45.15.30.00.00.00.00.00.00.00.0
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax us-gaap:OperatingSegments ions:AkceaTherapeutics100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.00.00.00.00.00.00.00.00.0

us-gaap:OperatingSegments, ions:IonisCore


Revenue
Period End2020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302017-06-302017-03-31
Value23414112911834315214022123117899132146108109161
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax80.788.488.788.669.691.085.674.7120.7122.584.491.884.891.697.5139.2
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax80.788.488.788.669.691.085.674.7120.7122.584.491.884.891.697.5139.2
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax us-gaap:OperatingSegments ions:IonisCore100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0

us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax us-gaap:ProductOrService

ions:Commercial


Revenue
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302017-06-302017-03-31
Value858495958983100958868728257425334237.801
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax68.375.733.059.661.763.020.357.053.922.938.056.948.629.131.329.321.16.7
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax68.375.733.059.661.763.020.357.053.922.938.056.948.629.131.329.321.16.7
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax ions:Commercial100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0

ions:LicensingAndOtherRoyalties


Revenue
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302017-06-302017-03-31
Value2.1494.6241.5692.1291.6242.7945.5672.0827.9321.6230.523120.5450.9421.8351.7271.3222.59
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax1.74.10.51.31.12.11.11.24.80.50.38.80.50.71.11.51.22.2
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax1.74.10.51.31.12.11.11.24.80.50.38.80.50.71.11.51.22.2
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax ions:LicensingAndOtherRoyalties100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0

ions:ResearchAndDevelopmentRevenueUnderCollaborativeAgreements


Revenue
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302017-06-30
Value3927194645549393727522911962601021138388
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax31.724.367.040.438.337.079.743.046.177.162.043.151.470.966.170.778.9
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax31.724.367.040.438.337.079.743.046.177.162.043.151.470.966.170.778.9
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax ions:ResearchAndDevelopmentRevenueUnderCollaborativeAgreements100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0

ions:SpinrazaRoyalties


Revenue
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-30
Value725974747166818170
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax57.453.725.746.349.349.516.448.643.0
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax57.453.725.746.349.349.516.448.643.0
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax ions:SpinrazaRoyalties100.0100.0100.0100.0100.0100.0100.0100.0100.0

us-gaap:Product


Revenue
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-03-31
Value11191919161513119.8656.7542.2370.00.0
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax9.217.86.711.911.211.42.87.16.02.31.20.00.0
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax9.217.86.711.911.211.42.87.16.02.31.20.00.0
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax us-gaap:Product100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.00.00.0

us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax us-gaap:ProductOrService, us-gaap:SubsequentEventType, us-gaap:TypeOfArrangement

ions:Pelacarsen, us-gaap:SubsequentEvent, ions:CollaborativeArrangementAndLicensingAgreementEnteredIntoInJanuary2017WithNovartis


Revenue
Period End2021-08-04
Value25
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax0.0
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax0.0
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax ions:Pelacarsen us-gaap:SubsequentEvent ions:CollaborativeArrangementAndLicensingAgreementEnteredIntoInJanuary2017WithNovartis100.0

us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax us-gaap:ProductOrService, us-gaap:TypeOfArrangement

ions:Ion449, ions:CollaborativeArrangementAndLicensingAgreementEnteredIntoInJuly2015WithAstrazeneca


Revenue
Period End2020-12-312018-09-30
Value2010.0
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax6.96.9
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax6.96.9
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax ions:Ion449 ions:CollaborativeArrangementAndLicensingAgreementEnteredIntoInJuly2015WithAstrazeneca100.0100.0

ions:Ion455, ions:CollaborativeArrangementAndLicensingAgreementEnteredIntoInJuly2015WithAstrazeneca


Revenue
Period End2020-12-31
Value30
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax10.3
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax10.3
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax ions:Ion455 ions:CollaborativeArrangementAndLicensingAgreementEnteredIntoInJuly2015WithAstrazeneca100.0

ions:Ion464, ions:CollaborativeArrangementAndLicensingAgreementEnteredIntoInSeptember2013WithBiogen


Revenue
Period End2020-09-30
Value18
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax11.2
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax11.2
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax ions:Ion464 ions:CollaborativeArrangementAndLicensingAgreementEnteredIntoInSeptember2013WithBiogen100.0

ions:ResearchAndDevelopmentRevenueUnderCollaborativeAgreements, ions:CollaborativeArrangementAndLicensingAgreementEnteredIntoInDecember2014WithJanssenBiotechInc


Revenue
Period End2020-12-312020-09-302018-12-312018-09-302018-06-302017-12-312017-09-302017-06-30
Value0.05.00.00.95.5173.412
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax0.03.10.00.64.710.42.910.9
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax0.03.10.00.64.710.42.910.9
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax ions:ResearchAndDevelopmentRevenueUnderCollaborativeAgreements ions:CollaborativeArrangementAndLicensingAgreementEnteredIntoInDecember2014WithJanssenBiotechInc0.0100.00.0100.0100.0100.0100.0100.0

ions:ResearchAndDevelopmentRevenueUnderCollaborativeAgreements, ions:CollaborativeArrangementsAndLicensingAgreementsAstrazeneca


Revenue
Period End2020-12-312020-09-302020-06-302019-12-312019-09-302019-06-30
Value533.816136.63.8
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax18.52.411.52.83.92.3
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax18.52.411.52.83.92.3
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax ions:ResearchAndDevelopmentRevenueUnderCollaborativeAgreements ions:CollaborativeArrangementsAndLicensingAgreementsAstrazeneca100.0100.0100.0100.0100.0100.0

ions:ResearchAndDevelopmentRevenueUnderCollaborativeAgreements, ions:CollaborativeArrangementsAndLicensingAgreementsBiogen


Revenue
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302017-06-30
Value2718235126219825312470342110135458
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax22.116.28.132.017.916.020.015.219.58.236.523.918.17.57.846.452.4
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax22.116.28.132.017.916.020.015.219.58.236.523.918.17.57.846.452.4
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax ions:ResearchAndDevelopmentRevenueUnderCollaborativeAgreements ions:CollaborativeArrangementsAndLicensingAgreementsBiogen100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0

ions:SpinrazaRoyalties, ions:CollaborativeArrangementsAndLicensingAgreementsBiogen


Revenue
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-30
Value726074747166818170
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax57.453.825.746.449.349.516.448.743.0
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax57.453.825.746.449.349.516.448.743.0
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax ions:SpinrazaRoyalties ions:CollaborativeArrangementsAndLicensingAgreementsBiogen100.0100.0100.0100.0100.0100.0100.0100.0100.0

us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax us-gaap:TypeOfArrangement

ions:CollaborativeArrangementAndLicensingAgreementEnteredIntoInDecember2014WithJanssenBiotechInc


Revenue
Period End2020-09-30
Value5.0
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax3.1
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax3.1
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax ions:CollaborativeArrangementAndLicensingAgreementEnteredIntoInDecember2014WithJanssenBiotechInc100.0

ions:CollaborativeArrangementAndLicensingAgreementEnteredIntoInJuly2015WithAstrazeneca


Revenue
Period End2020-12-312020-03-31
Value2010.0
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax6.97.5
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax6.97.5
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax ions:CollaborativeArrangementAndLicensingAgreementEnteredIntoInJuly2015WithAstrazeneca100.0100.0

ions:CollaborativeArrangementAndLicensingAgreementEnteredIntoInMarch2004WithAlnylamPharmaceuticalsInc


Revenue
Period End2020-12-31
Value41
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax14.2
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax14.2
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax ions:CollaborativeArrangementAndLicensingAgreementEnteredIntoInMarch2004WithAlnylamPharmaceuticalsInc100.0

ions:CollaborativeArrangementAndLicensingAgreementEnteredIntoInOctober2018WithRoche


Revenue
Period End2020-12-31
Value-9.2
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax-3.2
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax-3.2
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax ions:CollaborativeArrangementAndLicensingAgreementEnteredIntoInOctober2018WithRoche100.0

ions:CollaborativeArrangementAndLicensingAgreementEnteredIntoInOctober2019WithPfizer


Revenue
Period End2020-12-312019-12-31
Value75246
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax25.849.8
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax25.849.8
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax ions:CollaborativeArrangementAndLicensingAgreementEnteredIntoInOctober2019WithPfizer100.0100.0

ions:CollaborativeArrangementAndLicensingAgreementEnteredIntoInSeptember2013WithBiogen


Revenue
Period End2020-09-302019-09-302018-09-30
Value18-16.510.0
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax11.2-9.86.9
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax11.2-9.86.9
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax ions:CollaborativeArrangementAndLicensingAgreementEnteredIntoInSeptember2013WithBiogen100.0100.0100.0

ions:CollaborativeArrangementsAndLicensingAgreementsBiogen


Revenue
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302017-06-302017-03-31
Value1007898125978717910710284140104785165878128
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax79.570.033.878.367.165.536.463.962.528.373.172.166.235.938.074.272.324.8
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax79.570.033.878.367.165.536.463.962.528.373.172.166.235.938.074.272.324.8
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax ions:CollaborativeArrangementsAndLicensingAgreementsBiogen100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0

Revenues

us-gaap:Revenues

us-gaap:Revenues


Revenues
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302017-06-302017-03-312016-12-312016-09-302016-06-302016-03-312015-12-312015-09-302015-05-312015-06-302015-03-312014-12-312014-09-302014-06-302014-03-312013-12-312013-09-302013-06-302013-03-312012-12-312012-09-302012-06-302012-03-312011-12-312011-09-302011-06-302011-03-312010-12-312010-09-302010-06-302010-03-31
Value1251112901601451334931671632971921451171441721201041101601103836514991120628444572842233843191147233220242126282329
Percentage of Revenues100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0102.292.895.3100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0

Selling General And Administrative Expense

us-gaap:SellingGeneralAndAdministrativeExpense

us-gaap:SellingGeneralAndAdministrativeExpense


Selling
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302017-06-302017-03-312016-12-312016-09-302016-06-302016-03-31
Value566113868727483607568666866434526221318109.82410
Percentage of SellingGeneralAndAdministrativeExpense100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax44.954.847.842.849.556.216.935.845.923.034.447.356.230.226.522.619.911.811.39.225.528.6

Assets

us-gaap:Assets

us-gaap:Assets


Assets
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302017-06-302017-03-312016-12-312016-09-302016-06-302016-03-312015-12-312015-09-302015-06-302015-03-312014-12-312014-09-302014-06-302014-03-312013-12-312013-09-302013-06-302013-03-312012-12-312012-09-302012-06-302012-03-312011-12-312011-09-302011-06-302011-03-312010-12-312009-12-31
Value249722482389309530783090323328942877283526672247224712991322125210901083912843811875956988976955955793817834847881788552545485472470484505529505550657
Percentage of Assets100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0
Percentage of Assets100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0

us-gaap:Assets us-gaap:ConsolidationItems

us-gaap:IntersegmentElimination


Assetsus-gaap:
Period End2020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302017-06-302017-03-312016-12-312016-09-302016-06-302016-03-312015-12-31
Value-838.291-849.266-846.591-845.177-844.219-721.353-730.107-735.063-672.968-577.641-498.788-301.95-288.608-283.774-260.323-251.15-165.987-149.654-136.138-126.215-103.399
Percentage of Assets-35.1-27.4-27.5-27.3-26.1-24.9-25.4-25.9-25.2-25.7-22.2-23.2-21.8-22.7-23.9-23.2-18.2-17.7-16.8-14.4-10.8
Percentage of Assets-35.1-27.4-27.5-27.3-26.1-24.9-25.4-25.9-25.2-25.7-22.2-23.2-21.8-22.7-23.9-23.2-18.2-17.7-16.8-14.4-10.8
Percentage of Assets us-gaap:IntersegmentElimination100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0

us-gaap:Assets us-gaap:ConsolidationItems, us-gaap:StatementBusinessSegments

us-gaap:OperatingSegments, ions:AkceaTherapeutics


Assetsus-gaap:
Period End2020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302017-06-302017-03-312016-12-312016-09-302016-06-302016-03-312015-12-31
Value4355075275595993834344583653793952522682891241321062636555
Percentage of Assets18.216.417.118.118.513.215.116.213.716.917.619.420.323.111.412.31.27.47.97.45.8
Percentage of Assets18.216.417.118.118.513.215.116.213.716.917.619.420.323.111.412.31.27.47.97.45.8
Percentage of Assets us-gaap:OperatingSegments ions:AkceaTherapeutics100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0

us-gaap:OperatingSegments, ions:IonisCore


Assetsus-gaap:
Period End2020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302017-06-302017-03-312016-12-312016-09-302016-06-302016-03-312015-12-31
Value279234363397337634783233317331122975244623511349134112461227120210679318839361004
Percentage of Assets116.8111.0110.3109.2107.6111.7110.3109.7111.5108.8104.6103.8101.599.6112.5110.9117.0110.4108.9107.0105.0
Percentage of Assets116.8111.0110.3109.2107.6111.7110.3109.7111.5108.8104.6103.8101.599.6112.5110.9117.0110.4108.9107.0105.0
Percentage of Assets us-gaap:OperatingSegments ions:IonisCore100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0

Liabilities

us-gaap:Liabilities

us-gaap:Liabilities


Liabilities
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302017-06-302017-03-312016-12-312016-09-302016-06-302016-03-312015-12-312015-09-302015-06-302015-03-312014-12-312014-09-302014-06-302014-03-312013-12-312013-09-302013-06-302013-03-312012-12-312012-09-302012-06-302012-03-312011-12-312011-09-302011-06-302011-03-312010-12-312009-12-31
Value1914156715461489148415201548139714201448148014071429912903854875882812703699717755742675679698449450460468480387351362315318319313318317278305355
Percentage of Liabilities100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0
Percentage of Assets76.769.764.748.148.249.247.948.349.451.155.562.663.670.268.368.380.281.489.183.486.381.979.075.269.271.173.056.655.155.255.354.549.163.666.564.967.368.064.663.159.955.055.654.0

Liabilities And Stockholders Equity

us-gaap:LiabilitiesAndStockholdersEquity

us-gaap:LiabilitiesAndStockholdersEquity


Liabilities
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302017-06-302017-03-312016-12-312016-09-302016-06-302016-03-312015-12-312015-09-302015-06-302015-03-312014-12-312014-09-302014-06-302014-03-312013-12-312013-09-302013-06-302013-03-312012-12-312012-09-302012-06-302012-03-312011-12-312011-09-302011-06-302011-03-312010-12-312009-12-31
Value249722482389309530783090323328942877283526672247224712991322125210901083912843811875956988976955955793817834847881788552545485472470484505529505550657
Percentage of LiabilitiesAndStockholdersEquity100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0
Percentage of Assets100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0

Stockholders Equity

us-gaap:StockholdersEquity

us-gaap:StockholdersEquity


Stockholders
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302017-06-302017-03-312016-12-312016-09-302016-06-302016-03-312015-12-312015-09-302015-06-302015-03-312014-12-312014-09-302014-06-302014-03-312013-12-312013-09-302013-06-302013-03-312012-12-312012-09-302012-06-302012-03-312011-12-312011-09-302010-12-312009-12-31
Value5826808431383137713601471133612691207104871069630133030721520199139111158200245300275257344366374378401401201182170154150171186244291
Percentage of StockholdersEquity100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0
Percentage of Assets23.330.335.344.744.744.045.546.244.142.639.331.631.023.225.024.619.818.610.916.613.718.121.024.830.828.927.043.444.944.844.745.550.936.433.535.132.732.035.436.944.444.4

Assets Current

us-gaap:AssetsCurrent

us-gaap:AssetsCurrent


Assets
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302017-06-302017-03-312016-12-312016-09-302016-06-302016-03-312015-12-312015-09-302015-06-302015-03-312014-12-312014-09-302014-06-302014-03-312013-12-312013-09-302013-06-302013-03-312012-12-312012-09-302012-06-302012-03-312011-12-312011-09-302011-06-302011-03-312010-12-312009-12-31
Value2238198921302536253125582720240824142373220720792083114311671111964962797730697763837868855835836681705722735763669431423361350347360377410437483596
Percentage of AssetsCurrent100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0
Percentage of Assets89.688.589.282.082.282.884.183.283.983.782.892.592.788.088.388.788.488.887.486.686.187.287.587.987.687.487.585.886.386.586.886.684.878.177.674.474.273.874.374.677.686.587.890.7

Cash And Cash Equivalents At Carrying Value

us-gaap:CashAndCashEquivalentsAtCarryingValue

us-gaap:CashAndCashEquivalentsAtCarryingValue


Cash
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302017-06-302017-03-312016-12-312016-09-302016-06-302016-03-312015-12-312015-09-302015-06-302015-03-312014-12-312014-09-302014-06-302014-03-312013-12-312013-09-302013-06-302013-03-312012-12-312012-09-302012-06-302012-03-312011-12-312011-09-302011-06-302011-03-312010-12-312010-09-302010-06-302010-03-312009-12-312008-12-312007-12-31
Value565414397633530486683247272375278479805227129159132114848411293128126119148142739416115925629610712484855665558586701004698105223138
Percentage of CashAndCashEquivalentsAtCarryingValue100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0
Percentage of Assets22.618.416.620.417.215.721.18.69.513.310.521.335.817.59.812.712.210.59.310.013.910.713.512.812.215.515.09.211.519.418.929.137.619.522.817.418.112.013.510.916.117.012.70.00.00.016.00.00.0

Cash Cash Equivalents Restricted Cash And Restricted Cash Equivalents

us-gaap:CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents

us-gaap:CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents


Cash
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312016-12-31
Value56541439763353048668324727237527847980522712984
Percentage of CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0
Percentage of Assets22.618.416.620.417.215.721.18.69.513.310.521.335.817.59.89.3

Inventory Net

us-gaap:InventoryNet

us-gaap:InventoryNet


Inventory
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302017-12-31
Value242221222322181918118.5828.3789.982
Percentage of InventoryNet100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0
Percentage of Assets1.01.00.90.70.80.70.60.70.60.40.30.40.8

Inventory Finished Goods

us-gaap:InventoryFinishedGoods

us-gaap:InventoryFinishedGoods


Inventory
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312018-12-31
Value1559000.01906000.03005000.0950000.0741000.0602000.0258000.085000.0
Percentage of InventoryFinishedGoods100.0100.0100.0100.0100.0100.0100.0100.0
Percentage of Assets0.10.10.10.00.00.00.00.0

Other Assets Current

us-gaap:OtherAssetsCurrent

us-gaap:OtherAssetsCurrent


Other
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302017-06-302017-03-312016-12-312016-09-302016-06-302016-03-312015-12-312015-09-302015-06-302015-03-312014-12-312014-09-302014-06-302014-03-312013-12-312013-09-302013-06-302013-03-312012-12-312012-09-302012-06-302012-03-312011-12-312011-09-302011-06-302011-03-312010-12-312009-12-31
Value13112314014613112213911810298102977662724851251415171714292913158.3538.5679.8147.5187.3725.7868.0748.7277.85.7247.4175.4157.5537.6137.3767.0588.147
Percentage of OtherAssetsCurrent100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0
Percentage of Assets5.25.55.94.74.34.04.34.13.53.53.84.33.44.85.53.94.72.41.61.82.12.01.52.93.11.41.61.11.01.20.90.80.71.51.61.61.21.61.11.51.41.51.31.2

Property Plant And Equipment Gross

us-gaap:PropertyPlantAndEquipmentGross us-gaap:PropertyPlantAndEquipmentByType

us-gaap:PropertyPlantAndEquipmentGross

ions:EquipmentAndComputerSoftware


Property
Period End2020-12-312019-12-312018-12-312017-12-312016-12-312015-12-312014-12-31
Value68605366635649
Percentage of PropertyPlantAndEquipmentGross100.0100.0100.0100.0100.0100.0100.0
Percentage of Assets2.91.92.05.06.95.95.2
Percentage of Assets ions:EquipmentAndComputerSoftware0.00.00.00.00.00.00.0

ions:PropertyPlantAndEquipmentExcludingLand


Property
Period End2020-12-312019-12-312018-12-312017-12-312016-12-312015-12-312014-12-31
Value245204179195162152144
Percentage of PropertyPlantAndEquipmentGross355.7335.6334.9293.1257.1268.8291.0
Percentage of Assets10.36.36.714.817.816.015.2
Percentage of Assets ions:PropertyPlantAndEquipmentExcludingLand0.00.00.00.00.00.00.0

us-gaap:BuildingAndBuildingImprovements


Property
Period End2020-12-312019-12-312018-12-312017-12-312016-12-312015-12-312014-12-31
Value1371199792484848
Percentage of PropertyPlantAndEquipmentGross199.9196.6182.3139.477.384.897.5
Percentage of Assets5.83.73.77.05.45.05.1
Percentage of Assets us-gaap:BuildingAndBuildingImprovements0.00.00.00.00.00.00.0

us-gaap:FurnitureAndFixtures


Property
Period End2020-12-312019-12-312018-12-312017-12-312016-12-312015-12-312014-12-31
Value127.3546.2836.1615.9375.8425.732
Percentage of PropertyPlantAndEquipmentGross18.712.111.79.39.410.311.5
Percentage of Assets0.50.20.20.50.70.60.6
Percentage of Assets us-gaap:FurnitureAndFixtures0.00.00.00.00.00.00.0

us-gaap:Land


Property
Period End2020-12-312019-12-312018-12-312017-12-312016-12-312015-12-312014-12-31
Value23231414101010
Percentage of PropertyPlantAndEquipmentGross33.437.827.121.816.117.920.5
Percentage of Assets1.00.70.51.11.11.11.1
Percentage of Assets us-gaap:Land0.00.00.00.00.00.00.0

us-gaap:LandImprovements


Property
Period End2020-12-312019-12-312018-12-312017-12-312016-12-312015-12-312014-12-31
Value8.3912.8532.8532.8532.8532.8532.853
Percentage of PropertyPlantAndEquipmentGross12.24.75.34.34.55.05.7
Percentage of Assets0.40.10.10.20.30.30.3
Percentage of Assets us-gaap:LandImprovements0.00.00.00.00.00.00.0

us-gaap:LeaseholdImprovements


Property
Period End2020-12-312019-12-312018-12-312017-12-312016-12-312015-12-312014-12-31
Value17131826413937
Percentage of PropertyPlantAndEquipmentGross25.022.335.540.265.968.776.2
Percentage of Assets0.70.40.72.04.64.14.0
Percentage of Assets us-gaap:LeaseholdImprovements0.00.00.00.00.00.00.0

Accumulated Depreciation Depletion And Amortization Property Plant And Equipment

us-gaap:AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment

us-gaap:AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment


Accumulated
Period End2020-12-312019-12-312018-12-312017-12-312016-12-312015-12-312014-12-312013-12-312012-12-312011-12-312010-12-31
Value8774618780726660544740
Percentage of AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0
Percentage of Assets3.72.32.36.68.87.66.97.110.09.87.4

Amortization Of Intangible Assets

us-gaap:AmortizationOfIntangibleAssets

us-gaap:AmortizationOfIntangibleAssets


Amortization
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-31
Value593000.0544000.0538000.0527000.0513000.0486000.0773000.0191000.0478000.0470000.0466000.0461000.0452000.0443000.0
Percentage of AmortizationOfIntangibleAssets100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0
Percentage of Assets0.00.00.00.00.00.00.00.00.00.00.00.00.00.0

Property Plant And Equipment Net

us-gaap:PropertyPlantAndEquipmentNet

us-gaap:PropertyPlantAndEquipmentNet


Property
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302017-06-302017-03-312016-12-312016-09-302016-06-302016-03-312015-12-312015-09-302015-06-302015-03-312014-12-312014-09-302014-06-302014-03-312013-12-312013-09-302013-06-302013-03-312012-12-312012-09-302012-06-302012-03-312011-12-312011-09-302011-06-302011-03-312010-12-312009-12-31
Value17918018118117216315314813513313213212712312111699959290909090898989888886868687888991929495969888373527
Percentage of PropertyPlantAndEquipmentNet100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0
Percentage of Assets7.28.07.65.95.65.34.85.14.74.75.05.95.79.59.29.39.18.810.210.811.210.39.49.09.29.39.311.110.610.410.29.911.216.216.719.119.920.219.919.416.67.46.54.2

us-gaap:PropertyPlantAndEquipmentNet us-gaap:PropertyPlantAndEquipmentByType

ions:PropertyPlantAndEquipmentExcludingLand


Property
Period End2020-12-312019-12-312018-12-312017-12-312016-12-312015-12-312014-12-31
Value158130117107828078
Percentage of PropertyPlantAndEquipmentNet87.385.089.088.189.088.788.5
Percentage of Assets6.64.04.48.19.18.48.2
Percentage of Assets ions:PropertyPlantAndEquipmentExcludingLand0.00.00.00.00.00.00.0

Finite Lived Intangible Assets Net

us-gaap:FiniteLivedIntangibleAssetsNet

us-gaap:FiniteLivedIntangibleAssetsNet


Finite
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312016-12-31
Value29282728272625262625242423222220
Percentage of FiniteLivedIntangibleAssetsNet100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0
Percentage of Assets1.21.31.20.90.90.90.80.90.90.90.91.11.01.81.72.2

Operating Lease Right Of Use Asset

us-gaap:OperatingLeaseRightOfUseAsset

us-gaap:OperatingLeaseRightOfUseAsset


Operating
Period End2020-12-312019-12-312019-09-302019-06-302019-03-31
Value1312131213
Percentage of OperatingLeaseRightOfUseAsset100.0100.0100.0100.0100.0
Percentage of Assets0.50.40.40.40.5

Other Assets Noncurrent

us-gaap:OtherAssetsNoncurrent

us-gaap:OtherAssetsNoncurrent


Other
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302017-06-302016-12-31
Value4949504141322726252512121210102.9165.4331.325
Percentage of OtherAssetsNoncurrent100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0
Percentage of Assets2.02.22.11.31.31.10.90.90.90.90.50.60.60.80.80.20.50.1

Equity Securities Fv Ni

us-gaap:EquitySecuritiesFvNi us-gaap:FairValueByFairValueHierarchyLevel, us-gaap:FairValueByMeasurementFrequency

us-gaap:EquitySecuritiesFvNi

us-gaap:FairValueInputsLevel1, us-gaap:FairValueMeasurementsRecurring


Equity
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-31
Value3.2613.1982.0310.5390.6840.6170.00.00.00.00.0
Percentage of EquitySecuritiesFvNi100.0100.0100.0100.0100.0100.00.00.00.00.00.0
Percentage of Assets0.10.10.10.00.00.00.00.00.00.00.0
Percentage of Assets us-gaap:FairValueInputsLevel1 us-gaap:FairValueMeasurementsRecurring0.00.00.00.00.00.00.00.00.00.00.0

us-gaap:FairValueInputsLevel3, us-gaap:FairValueMeasurementsRecurring


Equity
Period End2020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-31
Value1.6081.7061.4724.5060.6060.8960.9681.349
Percentage of EquitySecuritiesFvNi298.3249.4238.60.00.00.00.00.0
Percentage of Assets0.10.10.00.10.00.00.00.1
Percentage of Assets us-gaap:FairValueInputsLevel3 us-gaap:FairValueMeasurementsRecurring0.00.00.00.00.00.00.00.0

us-gaap:EquitySecuritiesFvNi us-gaap:FairValueByMeasurementFrequency

us-gaap:FairValueMeasurementsRecurring


Equity
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-31
Value3.2613.1982.0312.1472.392.0894.5060.6060.8960.9681.349
Percentage of EquitySecuritiesFvNi100.0100.0100.0398.3349.4338.60.00.00.00.00.0
Percentage of Assets0.10.10.10.10.10.10.10.00.00.00.1
Percentage of Assets us-gaap:FairValueMeasurementsRecurring0.00.00.00.00.00.00.00.00.00.00.0

us-gaap:EquitySecuritiesFvNi us-gaap:FinancialInstrument

ions:EquitySecuritiesPrivateCompanies


Equity
Period End2021-06-302020-12-31
Value3131
Percentage of EquitySecuritiesFvNi974.21526.3
Percentage of Assets1.31.3
Percentage of Assets ions:EquitySecuritiesPrivateCompanies0.00.0

ions:EquitySecuritiesPubliclyTradedCompanies


Equity
Period End2021-06-302020-12-31
Value3.2612.031
Percentage of EquitySecuritiesFvNi100.0100.0
Percentage of Assets0.10.1
Percentage of Assets ions:EquitySecuritiesPubliclyTradedCompanies0.00.0

us-gaap:EquitySecurities


Equity
Period End2021-06-302020-12-31
Value3533
Percentage of EquitySecuritiesFvNi1074.21626.3
Percentage of Assets1.41.4
Percentage of Assets us-gaap:EquitySecurities0.00.0

us-gaap:EquitySecuritiesFvNi us-gaap:InvestmentType

ions:EquitySecuritiesPrivateCompanies


Equity
Period End2021-03-312020-12-312020-09-302020-06-302019-12-31
Value3131242410.0
Percentage of EquitySecuritiesFvNi969.41526.34517.43558.00.0
Percentage of Assets1.41.30.80.80.3
Percentage of Assets ions:EquitySecuritiesPrivateCompanies0.00.00.00.00.0

ions:EquitySecuritiesPublicCompanies


Equity
Period End2020-09-302020-06-302019-12-31
Value2.1472.393.842
Percentage of EquitySecuritiesFvNi398.3349.40.0
Percentage of Assets0.10.10.1
Percentage of Assets ions:EquitySecuritiesPublicCompanies0.00.00.0

ions:EquitySecuritiesPubliclyTradedCompanies


Equity
Period End2021-03-312020-12-312019-12-31
Value3.1982.0313.842
Percentage of EquitySecuritiesFvNi100.0100.00.0
Percentage of Assets0.10.10.1
Percentage of Assets ions:EquitySecuritiesPubliclyTradedCompanies0.00.00.0

us-gaap:EquitySecurities


Equity
Period End2021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312018-12-31
Value3433262617131.349
Percentage of EquitySecuritiesFvNi1069.41626.34915.83907.52772.80.00.0
Percentage of Assets1.51.40.90.90.60.40.1
Percentage of Assets us-gaap:EquitySecurities0.00.00.00.00.00.00.0

Accounts Payable Current

us-gaap:AccountsPayableCurrent

us-gaap:AccountsPayableCurrent


Accounts
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302017-06-302017-03-312016-12-312016-09-302016-06-302016-03-312015-12-312015-09-302015-06-302015-03-312014-12-312014-09-302014-06-302014-03-312013-12-312013-09-302013-06-302013-03-312012-12-312012-09-302012-06-302012-03-312011-12-312011-09-302011-06-302011-03-312010-12-312009-12-31
Value149.50617167.4072116131513281313132423132321151719281910161715139.869118.7819.4615.385105.2566.1945.3448.36.6533.0714.6526.5234.696
Percentage of AccountsPayableCurrent100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0
Percentage of Assets0.60.40.70.50.20.70.50.50.50.51.10.60.61.11.91.91.22.12.31.92.22.23.02.01.11.71.92.01.61.21.31.01.21.01.91.11.31.11.71.30.60.91.20.7

Accrued Income Taxes Current

us-gaap:AccruedIncomeTaxesCurrent

us-gaap:AccruedIncomeTaxesCurrent


Accrued
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-31
Value1.8751.3261.3248.9292732321.9454.035180.858
Percentage of AccruedIncomeTaxesCurrent100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0
Percentage of Assets0.10.10.10.30.91.11.00.10.10.60.0

Accrued Liabilities Current

us-gaap:AccruedLiabilitiesCurrent

us-gaap:AccruedLiabilitiesCurrent


Accrued
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302017-06-302017-03-312016-12-312016-09-302016-06-302016-03-312015-12-312015-09-302015-06-302015-03-312014-12-312014-09-302014-06-302014-03-312013-12-312013-09-302013-06-302013-03-312012-12-312012-09-302012-06-302012-03-312011-12-312011-09-302011-06-302011-03-312010-12-312009-12-31
Value75789080676266524945485058666633353036231826282423233029252722221617151115151815108.1341212
Percentage of AccruedLiabilitiesCurrent100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0
Percentage of Assets3.03.53.82.62.22.02.11.81.71.61.82.32.65.15.02.73.32.83.92.82.33.02.92.52.42.53.23.73.13.32.62.52.13.22.82.53.33.33.83.02.11.62.31.9

Contract With Customer Liability Current

us-gaap:ContractWithCustomerLiabilityCurrent

us-gaap:ContractWithCustomerLiabilityCurrent


Contract
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-31
Value102106108104100120118137137144160157160120125
Percentage of ContractWithCustomerLiabilityCurrent100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0
Percentage of Assets4.14.74.53.43.33.93.74.84.85.16.07.07.19.29.5

Liabilities Current

us-gaap:LiabilitiesCurrent

us-gaap:LiabilitiesCurrent


Liabilities
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302017-06-302017-03-312016-12-312016-09-302016-06-302016-03-312015-12-312015-09-302015-06-302015-03-312014-12-312014-09-302014-06-302014-03-312013-12-312013-09-302013-06-302013-03-312012-12-312012-09-302012-06-302012-03-312011-12-312011-09-302011-06-302011-03-312010-12-312009-12-31
Value2932955832442312582732312412522802602482122241771911701331061111241481221021001151071001009710386707451556176839194105111
Percentage of LiabilitiesCurrent100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0
Percentage of Assets11.813.124.47.97.58.38.48.08.48.910.511.611.116.417.014.217.615.714.712.713.714.215.612.410.510.512.113.512.312.111.511.711.012.713.610.611.713.115.716.517.418.719.217.0

Operating Lease Liability Current

us-gaap:OperatingLeaseLiabilityCurrent

us-gaap:OperatingLeaseLiabilityCurrent


Operating
Period End2020-12-312019-12-312019-09-302019-06-302019-03-31
Value2000000.02000000.02100000.01900000.02000000.0
Percentage of OperatingLeaseLiabilityCurrent100.0100.0100.0100.0100.0
Percentage of Assets0.10.10.10.10.1

Other Accrued Liabilities Current

us-gaap:OtherAccruedLiabilitiesCurrent

us-gaap:OtherAccruedLiabilitiesCurrent


Other
Period End2020-12-312019-12-312018-12-312017-12-312016-12-31
Value303213166.155
Percentage of OtherAccruedLiabilitiesCurrent100.0100.0100.0100.0100.0
Percentage of Assets1.31.00.51.20.7

Debt And Capital Lease Obligations

us-gaap:DebtAndCapitalLeaseObligations

us-gaap:DebtAndCapitalLeaseObligations


Debt
Period End2020-12-312019-12-31
Value839787
Percentage of DebtAndCapitalLeaseObligations100.0100.0
Percentage of Assets35.124.4

Long Term Debt And Capital Lease Obligations

us-gaap:LongTermDebtAndCapitalLeaseObligations

us-gaap:LongTermDebtAndCapitalLeaseObligations


Long
Period End2020-12-312019-12-312011-12-312011-09-302011-06-302011-03-312010-12-312009-12-31
Value5397851454.7245.4654.9385.7211
Percentage of LongTermDebtAndCapitalLeaseObligations100.0100.0100.0100.0100.0100.0100.0100.0
Percentage of Assets22.624.330.00.91.01.01.01.7

Minority Interest

us-gaap:MinorityInterest

us-gaap:MinorityInterest


Minority
Period End2020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302016-12-31
Value2232172102131611871791391291218587890.0
Percentage of MinorityInterest100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.00.0
Percentage of Assets7.27.16.86.65.66.56.35.25.85.46.66.67.20.0

Lessee Operating Lease Liability Payments Due Year Two

us-gaap:LesseeOperatingLeaseLiabilityPaymentsDueYearTwo

us-gaap:LesseeOperatingLeaseLiabilityPaymentsDueYearTwo


Lessee
Period End2020-12-31
Value2968000.0
Percentage of LesseeOperatingLeaseLiabilityPaymentsDueYearTwo100.0
Percentage of Assets0.1

Lessee Operating Lease Liability Payments Due Year Three

us-gaap:LesseeOperatingLeaseLiabilityPaymentsDueYearThree

us-gaap:LesseeOperatingLeaseLiabilityPaymentsDueYearThree


Lessee
Period End2020-12-31
Value2707000.0
Percentage of LesseeOperatingLeaseLiabilityPaymentsDueYearThree100.0
Percentage of Assets0.1

Lessee Operating Lease Liability Payments Due Year Four

us-gaap:LesseeOperatingLeaseLiabilityPaymentsDueYearFour

us-gaap:LesseeOperatingLeaseLiabilityPaymentsDueYearFour


Lessee
Period End2020-12-31
Value2583000.0
Percentage of LesseeOperatingLeaseLiabilityPaymentsDueYearFour100.0
Percentage of Assets0.1

Lessee Operating Lease Liability Payments Due Year Five

us-gaap:LesseeOperatingLeaseLiabilityPaymentsDueYearFive

us-gaap:LesseeOperatingLeaseLiabilityPaymentsDueYearFive


Lessee
Period End2020-12-31
Value2442000.0
Percentage of LesseeOperatingLeaseLiabilityPaymentsDueYearFive100.0
Percentage of Assets0.1

Lessee Operating Lease Liability Payments Due After Year Five

us-gaap:LesseeOperatingLeaseLiabilityPaymentsDueAfterYearFive

us-gaap:LesseeOperatingLeaseLiabilityPaymentsDueAfterYearFive


Lessee
Period End2020-12-31
Value7038000.0
Percentage of LesseeOperatingLeaseLiabilityPaymentsDueAfterYearFive100.0
Percentage of Assets0.3

Operating Lease Liability

us-gaap:OperatingLeaseLiability

us-gaap:OperatingLeaseLiability


Operating
Period End2020-12-312019-12-312019-09-302019-06-302019-03-31
Value1717171717
Percentage of OperatingLeaseLiability100.0100.0100.0100.0100.0
Percentage of Assets0.70.50.60.60.6

Lessee Operating Lease Liability Payments Due

us-gaap:LesseeOperatingLeaseLiabilityPaymentsDue

us-gaap:LesseeOperatingLeaseLiabilityPaymentsDue


Lessee
Period End2020-12-31
Value20
Percentage of LesseeOperatingLeaseLiabilityPaymentsDue100.0
Percentage of Assets0.9

Lessee Operating Lease Liability Undiscounted Excess Amount

us-gaap:LesseeOperatingLeaseLiabilityUndiscountedExcessAmount

us-gaap:LesseeOperatingLeaseLiabilityUndiscountedExcessAmount


Lessee
Period End2020-12-31
Value3621000.0
Percentage of LesseeOperatingLeaseLiabilityUndiscountedExcessAmount100.0
Percentage of Assets0.2

Stockholders Equity

us-gaap:StockholdersEquity

us-gaap:StockholdersEquity


Stockholders
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302017-06-302017-03-312016-12-312016-09-302016-06-302016-03-312015-12-312015-09-302015-06-302015-03-312014-12-312014-09-302014-06-302014-03-312013-12-312013-09-302013-06-302013-03-312012-12-312012-09-302012-06-302012-03-312011-12-312011-09-302010-12-312009-12-31
Value5826808431383137713601471133612691207104871069630133030721520199139111158200245300275257344366374378401401201182170154150171186244291
Percentage of StockholdersEquity100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0
Percentage of Assets23.330.335.344.744.744.045.546.244.142.639.331.631.023.225.024.619.818.610.916.613.718.121.024.830.828.927.043.444.944.844.745.550.936.433.535.132.732.035.436.944.444.4

Stockholders Equity Including Portion Attributable To Noncontrolling Interest

us-gaap:StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest

us-gaap:StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest


Stockholders
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302016-12-312015-12-312014-12-312013-12-312012-12-312011-12-312011-06-302011-03-312010-12-312009-12-312008-12-312007-12-31
Value582680843160615941570168414971457138711878408173874183979920025737818217121222724430214759
Percentage of StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0
Percentage of Assets23.330.335.351.951.850.852.151.750.648.944.537.436.429.831.731.710.921.027.044.733.535.440.145.044.446.00.00.0

us-gaap:StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest us-gaap:Restatement

srt:ScenarioPreviouslyReported


Stockholders
Period End2020-12-312019-12-31
Value8431684
Percentage of StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest100.0100.0
Percentage of Assets35.352.1
Percentage of Assets srt:ScenarioPreviouslyReported0.00.0

us-gaap:StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest us-gaap:Restatement, us-gaap:AdjustmentsForNewAccountingPronouncements

srt:RevisionOfPriorPeriodAccountingStandardsUpdateAdjustment, ions:AccountingStandardsUpdate202006


Stockholders
Period End2020-12-312019-12-31
Value-100.065-107.089
Percentage of StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest-11.9-6.4
Percentage of Assets-4.2-3.3
Percentage of Assets srt:RevisionOfPriorPeriodAccountingStandardsUpdateAdjustment ions:AccountingStandardsUpdate2020060.00.0

srt:RevisionOfPriorPeriodAccountingStandardsUpdateAdjustment, us-gaap:AccountingStandardsUpdate202006


Stockholders
Period End2020-12-312019-12-31
Value-100.065-107.089
Percentage of StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest-11.9-6.4
Percentage of Assets-4.2-3.3
Percentage of Assets srt:RevisionOfPriorPeriodAccountingStandardsUpdateAdjustment us-gaap:AccountingStandardsUpdate2020060.00.0

us-gaap:StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest us-gaap:Restatement, us-gaap:AdjustmentsForNewAccountingPronouncements, us-gaap:StatementEquityComponents

srt:RevisionOfPriorPeriodAccountingStandardsUpdateAdjustment, ions:AccountingStandardsUpdate202006, us-gaap:AdditionalPaidInCapital


Stockholders
Period End2020-12-312019-12-31
Value-218.127-218.128
Percentage of StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest-25.9-12.9
Percentage of Assets-9.1-6.7
Percentage of Assets srt:RevisionOfPriorPeriodAccountingStandardsUpdateAdjustment ions:AccountingStandardsUpdate202006 us-gaap:AdditionalPaidInCapital0.00.0

srt:RevisionOfPriorPeriodAccountingStandardsUpdateAdjustment, ions:AccountingStandardsUpdate202006, us-gaap:RetainedEarnings


Stockholders
Period End2020-12-312019-12-31
Value118111
Percentage of StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest14.06.6
Percentage of Assets4.93.4
Percentage of Assets srt:RevisionOfPriorPeriodAccountingStandardsUpdateAdjustment ions:AccountingStandardsUpdate202006 us-gaap:RetainedEarnings0.00.0

srt:RevisionOfPriorPeriodAccountingStandardsUpdateAdjustment, us-gaap:AccountingStandardsUpdate202006, us-gaap:AdditionalPaidInCapital


Stockholders
Period End2020-12-312019-12-31
Value-218.127-218.128
Percentage of StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest-25.9-12.9
Percentage of Assets-9.1-6.7
Percentage of Assets srt:RevisionOfPriorPeriodAccountingStandardsUpdateAdjustment us-gaap:AccountingStandardsUpdate202006 us-gaap:AdditionalPaidInCapital0.00.0

srt:RevisionOfPriorPeriodAccountingStandardsUpdateAdjustment, us-gaap:AccountingStandardsUpdate202006, us-gaap:RetainedEarnings


Stockholders
Period End2020-12-312019-12-31
Value118111
Percentage of StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest14.06.6
Percentage of Assets4.93.4
Percentage of Assets srt:RevisionOfPriorPeriodAccountingStandardsUpdateAdjustment us-gaap:AccountingStandardsUpdate202006 us-gaap:RetainedEarnings0.00.0

us-gaap:StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest us-gaap:Restatement, us-gaap:StatementEquityComponents

srt:ScenarioPreviouslyReported, us-gaap:AdditionalPaidInCapital


Stockholders
Period End2020-12-312019-12-31
Value21132203
Percentage of StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest250.6130.8
Percentage of Assets88.468.2
Percentage of Assets srt:ScenarioPreviouslyReported us-gaap:AdditionalPaidInCapital0.00.0

srt:ScenarioPreviouslyReported, us-gaap:RetainedEarnings


Stockholders
Period End2020-12-312019-12-31
Value-1249.368-707.534
Percentage of StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest-148.1-42.0
Percentage of Assets-52.3-21.9
Percentage of Assets srt:ScenarioPreviouslyReported us-gaap:RetainedEarnings0.00.0

us-gaap:StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest us-gaap:StatementEquityComponents

us-gaap:AccumulatedOtherComprehensiveIncome


Stockholders
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302016-12-312016-09-302015-12-312014-12-312013-12-312012-12-312011-12-312010-12-312009-12-312008-12-312007-12-31
Value-25.796-24.203-21.071-19.572-16.44-27.235-25.29-25.375-24.252-27.608-32.016-32.532-32.634-33.234-31.759-30.199-30.358-26.498-13.565392112-0.770.9492.1530.9820.538
Percentage of StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest-4.4-3.6-2.5-1.2-1.0-1.7-1.5-1.7-1.7-2.0-2.7-3.9-4.0-8.6-7.6-7.6-30.50.0-6.815.45.66.8-0.40.40.70.70.9
Percentage of Assets-1.0-1.1-0.9-0.6-0.5-0.9-0.8-0.9-0.8-1.0-1.2-1.4-1.5-2.6-2.4-2.4-3.3-3.1-1.44.22.52.3-0.20.20.30.00.0
Percentage of Assets us-gaap:AccumulatedOtherComprehensiveIncome0.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.0

us-gaap:AdditionalPaidInCapital


Stockholders
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312016-12-312015-12-312014-12-312013-12-312012-12-312011-12-312010-12-312009-12-312008-12-312007-12-31
Value1910192521132311227122332203221921772117204720302011157615491311130912241324107710131000985960882
Percentage of StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest327.9283.0250.6143.9142.4142.2130.8148.1149.4152.7172.4241.7246.1407.4370.21317.0652.0475.0350.1589.4591.2409.0326.3651.61481.3
Percentage of Assets76.585.688.474.773.872.368.276.775.774.776.790.389.5121.3117.2143.7136.9128.1156.4197.4209.0181.7150.00.00.0
Percentage of Assets us-gaap:AdditionalPaidInCapital0.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.0

us-gaap:AociIncludingPortionAttributableToNoncontrollingInterest


Stockholders
Period End2020-12-312019-12-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302017-06-302017-03-312016-12-312016-09-302016-06-302015-12-312014-12-31
Value-21.071-25.29-32.016-32.532-32.634-33.234-31.759-30.231-30.46-30.46-30.358-26.498-26.853-13.56539
Percentage of StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest-2.5-1.5-2.7-3.9-4.0-8.6-7.6-7.60.00.0-30.50.00.0-6.815.4
Percentage of Assets-0.9-0.8-1.2-1.4-1.5-2.6-2.4-2.4-2.8-2.8-3.3-3.1-3.3-1.44.2
Percentage of Assets us-gaap:AociIncludingPortionAttributableToNoncontrollingInterest0.00.00.00.00.00.00.00.00.00.00.00.00.00.00.0

us-gaap:CommonStock


Stockholders
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312016-12-312015-12-312014-12-312013-12-312012-12-312011-12-312010-12-312009-12-312008-12-312007-12-31
Value0.1410.1410.140.140.1390.1390.140.1410.140.140.1380.1380.1370.1250.1250.1220.120.1180.1160.1020.10.0990.0990.0970.087
Percentage of StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest0.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.10.10.00.00.10.10.00.00.10.1
Percentage of Assets0.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.0
Percentage of Assets us-gaap:CommonStock0.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.0

us-gaap:NoncontrollingInterest


Stockholders
Period End2020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312016-12-312015-12-312014-12-312009-12-31
Value22321721021316118717913912912185870.00.00.010
Percentage of StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest13.913.613.412.710.812.913.011.715.414.822.121.00.00.00.03.4
Percentage of Assets7.27.16.86.65.66.56.35.25.85.46.66.60.00.00.01.6
Percentage of Assets us-gaap:NoncontrollingInterest0.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.0

us-gaap:Parent


Stockholders
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312016-12-312015-12-312014-12-31
Value5826808431383137713601471133612691207104871069630133099200257
Percentage of StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest100.0100.0100.086.186.486.687.389.287.187.088.384.685.277.979.0100.0100.0100.0
Percentage of Assets23.330.335.344.744.744.045.546.244.142.639.331.631.023.225.010.921.027.0
Percentage of Assets us-gaap:Parent0.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.0

us-gaap:RetainedEarnings


Stockholders
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312016-12-312015-12-312014-12-312013-12-312012-12-312011-12-312010-12-312009-12-312008-12-312007-12-31
Value-1302.05-1221.175-1249.368-909.098-878.154-846.309-707.534-857.563-883.726-882.85-967.293-1287.369-1282.809-1242.454-1187.398-1181.428-1094.872-1006.594-967.61-906.966-841.488-756.687-696.15-851.216-833.044
Percentage of StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest-223.5-179.4-148.1-56.6-55.1-53.9-42.0-57.2-60.6-63.6-81.5-153.2-156.9-321.0-283.6-1186.6-545.3-390.5-255.7-496.2-490.9-309.4-230.5-577.6-1398.1
Percentage of Assets-52.1-54.3-52.3-29.4-28.5-27.4-21.9-29.6-30.7-31.1-36.3-57.3-57.1-95.6-89.8-129.5-114.5-105.3-114.2-166.2-173.5-137.5-105.90.00.0
Percentage of Assets us-gaap:RetainedEarnings0.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.0

Common Stock Value

us-gaap:CommonStockValue

us-gaap:CommonStockValue


Common
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302017-06-302017-03-312016-12-312016-09-302016-06-302016-03-312015-12-312015-09-302015-06-302015-03-312014-12-312014-09-302014-06-302014-03-312013-12-312013-09-302013-06-302013-03-312012-12-312012-09-302012-06-302012-03-312011-12-312011-09-302011-06-302011-03-312010-12-312009-12-31
Value141000.0141000.0140000.0140000.0139000.0139000.0140000.0141000.0140000.0140000.0138000.0138000.0137000.0125000.0125000.0125000.0124000.0124000.0122000.0121000.0121000.0121000.0120000.0120000.0120000.0120000.0118000.0118000.0118000.0118000.0116000.0116000.0114000.0103000.0102000.0102000.0100000.0100000.0100000.0100000.0100000.0100000.099000.099000.0
Percentage of CommonStockValue100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0
Percentage of Assets0.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.0

Additional Paid In Capital Common Stock

us-gaap:AdditionalPaidInCapitalCommonStock

us-gaap:AdditionalPaidInCapitalCommonStock


Additional
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302017-06-302017-03-312016-12-312016-09-302016-06-302016-03-312015-12-312015-09-302015-06-302015-03-312014-12-312014-09-302014-06-302014-03-312013-12-312013-09-302013-06-302013-03-312012-12-312012-09-302012-06-302012-03-312011-12-312011-09-302011-06-302011-03-312010-12-312009-12-31
Value1910192521132311227122332203221921772117204720302011157615491528143414101311137313521331130912861269125112241365135213431324131512921091107710731019101610131009100610031000985
Percentage of AdditionalPaidInCapitalCommonStock100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0
Percentage of Assets76.585.688.474.773.872.368.276.775.774.776.790.389.5121.3117.2122.0131.5130.1143.7162.8166.8152.1136.9130.2130.0131.0128.1172.0165.4161.0156.4149.2163.9197.5197.4221.1215.9215.9209.0199.6190.0198.4181.7150.0

us-gaap:AdditionalPaidInCapitalCommonStock us-gaap:Restatement

srt:ScenarioPreviouslyReported


Additional
Period End2020-12-31
Value2113
Percentage of AdditionalPaidInCapitalCommonStock100.0
Percentage of Assets88.4
Percentage of Assets srt:ScenarioPreviouslyReported0.0

us-gaap:AdditionalPaidInCapitalCommonStock us-gaap:Restatement, us-gaap:AdjustmentsForNewAccountingPronouncements

srt:RevisionOfPriorPeriodAccountingStandardsUpdateAdjustment, ions:AccountingStandardsUpdate202006


Additional
Period End2020-12-31
Value-218.127
Percentage of AdditionalPaidInCapitalCommonStock-10.3
Percentage of Assets-9.1
Percentage of Assets srt:RevisionOfPriorPeriodAccountingStandardsUpdateAdjustment ions:AccountingStandardsUpdate2020060.0

srt:RevisionOfPriorPeriodAccountingStandardsUpdateAdjustment, us-gaap:AccountingStandardsUpdate202006


Additional
Period End2020-12-31
Value-218.127
Percentage of AdditionalPaidInCapitalCommonStock-10.3
Percentage of Assets-9.1
Percentage of Assets srt:RevisionOfPriorPeriodAccountingStandardsUpdateAdjustment us-gaap:AccountingStandardsUpdate2020060.0

Retained Earnings Accumulated Deficit

us-gaap:RetainedEarningsAccumulatedDeficit

us-gaap:RetainedEarningsAccumulatedDeficit


Retained
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302017-06-302017-03-312016-12-312016-09-302016-06-302016-03-312015-12-312015-09-302015-06-302015-03-312014-12-312014-09-302014-06-302014-03-312013-12-312013-09-302013-06-302013-03-312012-12-312012-09-302012-06-302012-03-312011-12-312011-09-302011-06-302011-03-312010-12-312009-12-31
Value-1302.05-1221.175-1249.368-909.098-878.154-846.309-707.534-857.563-883.726-882.85-967.293-1287.369-1282.809-1242.454-1187.398-1190.144-1189.167-1177.96-1181.428-1207.293-1214.644-1157.789-1094.872-1023.439-987.663-1023.311-1006.594-1037.647-1010.971-998.89-967.61-943.334-918.764-908.638-906.966-904.329-866.69-865.483-841.488-821.452-794.57-776.681-756.687-696.15
Percentage of RetainedEarningsAccumulatedDeficit100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0
Percentage of Assets-52.1-54.3-52.3-29.4-28.5-27.4-21.9-29.6-30.7-31.1-36.3-57.3-57.1-95.6-89.8-95.0-109.0-108.7-129.5-143.1-149.8-132.2-114.5-103.6-101.2-107.1-105.3-130.7-123.6-119.7-114.2-107.0-116.5-164.3-166.2-186.2-183.5-183.8-173.5-162.4-150.0-153.5-137.5-105.9

us-gaap:RetainedEarningsAccumulatedDeficit us-gaap:Restatement

srt:ScenarioPreviouslyReported


Retained
Period End2020-12-31
Value-1249.368
Percentage of RetainedEarningsAccumulatedDeficit100.0
Percentage of Assets-52.3
Percentage of Assets srt:ScenarioPreviouslyReported0.0

us-gaap:RetainedEarningsAccumulatedDeficit us-gaap:Restatement, us-gaap:AdjustmentsForNewAccountingPronouncements

srt:RevisionOfPriorPeriodAccountingStandardsUpdateAdjustment, ions:AccountingStandardsUpdate202006


Retained
Period End2020-12-31
Value118
Percentage of RetainedEarningsAccumulatedDeficit-9.4
Percentage of Assets4.9
Percentage of Assets srt:RevisionOfPriorPeriodAccountingStandardsUpdateAdjustment ions:AccountingStandardsUpdate2020060.0

srt:RevisionOfPriorPeriodAccountingStandardsUpdateAdjustment, us-gaap:AccountingStandardsUpdate202006


Retained
Period End2020-12-31
Value118
Percentage of RetainedEarningsAccumulatedDeficit-9.4
Percentage of Assets4.9
Percentage of Assets srt:RevisionOfPriorPeriodAccountingStandardsUpdateAdjustment us-gaap:AccountingStandardsUpdate2020060.0

Accumulated Other Comprehensive Income Loss Net Of Tax

us-gaap:AccumulatedOtherComprehensiveIncomeLossNetOfTax

us-gaap:AccumulatedOtherComprehensiveIncomeLossNetOfTax


Accumulated
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302017-06-302017-03-312016-12-312016-09-302016-06-302016-03-312015-12-312015-09-302015-06-302015-03-312014-12-312014-09-302014-06-302014-03-312013-12-312013-09-302013-06-302013-03-312012-12-312012-09-302012-06-302012-03-312011-12-312011-09-302011-06-302011-03-312010-12-312009-12-31
Value-25.796-24.203-21.071-19.572-16.44-27.235-25.29-25.375-24.252-27.608-32.016-32.532-32.634-33.234-31.759-30.199-30.372-30.46-30.358-26.498-26.853-16.115-13.565-17.95718473916242921292617120.8460.968-0.242-0.77-1.1530.3990.6890.9492.153
Percentage of AccumulatedOtherComprehensiveIncomeLossNetOfTax100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0
Percentage of Assets-1.0-1.1-0.9-0.6-0.5-0.9-0.8-0.9-0.8-1.0-1.2-1.4-1.5-2.6-2.4-2.4-2.8-2.8-3.3-3.1-3.3-1.8-1.4-1.81.94.94.22.13.03.52.53.33.43.22.30.20.2-0.1-0.2-0.20.10.10.20.3

Minority Interest

us-gaap:MinorityInterest

us-gaap:MinorityInterest


Minority
Period End2020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302016-12-31
Value2232172102131611871791391291218587890.0
Percentage of MinorityInterest100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.00.0
Percentage of Assets7.27.16.86.65.66.56.35.25.85.46.66.67.20.0

Adjustments To Additional Paid In Capital Sharebased Compensation Requisite Service Period Recognition Value

us-gaap:AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue

us-gaap:AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue


Adjustments
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-31
Value3037954548403524414534343328
Percentage of AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0
Percentage of Assets0.00.00.00.00.00.00.00.00.00.00.00.00.00.0

us-gaap:AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue us-gaap:StatementEquityComponents

us-gaap:AdditionalPaidInCapital


Adjustments
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-31
Value3037954548403524414534343328
Percentage of AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0
Percentage of Assets0.00.00.00.00.00.00.00.00.00.00.00.00.00.0
Percentage of Assets us-gaap:AdditionalPaidInCapital0.00.00.00.00.00.00.00.00.00.00.00.00.00.0

us-gaap:Parent


Adjustments
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-31
Value3037954548403524414534343328
Percentage of AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0
Percentage of Assets0.00.00.00.00.00.00.00.00.00.00.00.00.00.0
Percentage of Assets us-gaap:Parent0.00.00.00.00.00.00.00.00.00.00.00.00.00.0

Net Cash Provided By Used In Operating Activities

us-gaap:NetCashProvidedByUsedInOperatingActivities

us-gaap:NetCashProvidedByUsedInOperatingActivities


Net
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302017-06-302017-03-312016-12-312016-09-302012-09-302012-06-302012-03-312011-12-312011-09-302011-06-302011-03-312010-12-312010-09-302010-06-302010-03-31
Value-62.652-54.66297-10.357-44.144-7.584277-12.806-27.111107115-26.0045001320282.363122-26.83924-24.871-2.577-6.711-24.334-24.448-26.177-39.842-25.503-21.4295.03-21.691
Percentage of NetCashProvidedByUsedInOperatingActivities100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax-49.8-49.033.8-6.5-30.3-5.756.3-7.6-16.536.260.1-17.9424.89.111.824.32.1105.9-16.721.9-214.4-5.4-28.9-75.1-118.0-105.5-188.4-96.5-74.921.4-72.5

Net Cash Provided By Used In Investing Activities

us-gaap:NetCashProvidedByUsedInInvestingActivities

us-gaap:NetCashProvidedByUsedInInvestingActivities


Net
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302017-06-302017-03-312016-12-312016-09-302012-09-302012-06-302012-03-312011-12-312011-09-302011-06-302011-03-312010-12-312010-09-302010-06-302010-03-31
Value-101.037818710179-95.0071381.396-110.687-70.174-326.207-307.671-375.17179-54.212-150.09914-168.67520-57.088-10.60824-0.52233-4.4232456-7.24275-59.93614
Percentage of NetCashProvidedByUsedInInvestingActivities100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax-80.370.764.763.754.8-71.228.00.8-67.6-23.6-169.8-211.6-318.655.0-31.5-126.913.1-145.713.0-51.5-91.450.9-2.2104.8-21.499.3268.2-27.4265.2-255.050.0

Net Cash Provided By Used In Financing Activities

us-gaap:NetCashProvidedByUsedInFinancingActivities

us-gaap:NetCashProvidedByUsedInFinancingActivities


Net
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302017-06-302017-03-312016-12-312016-09-302012-09-302012-06-302012-03-312011-12-312011-09-302011-06-302011-03-312010-12-312010-09-302010-06-302010-03-31
Value314-7.577-521.48108.435-94.50119-13.17434599.6468.0764525.2244.2571471.712756.4484.543347.737-1.8530.585-0.8880.359-0.7282.675-0.4012.3540.068
Percentage of NetCashProvidedByUsedInFinancingActivities100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax250.1-6.8-179.66.85.8-70.93.9-7.821.120.05.05.6384.73.62.5124.71.565.24.04.1296.516.3-8.01.8-4.31.4-3.410.1-1.410.00.2

Cash Cash Equivalents Restricted Cash And Restricted Cash Equivalents Period Increase Decrease Including Exchange Rate Effect

us-gaap:CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect

us-gaap:CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect


Cash
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-31
Value15016-235.39510243-197.092435
Percentage of CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect100.0100.0100.0100.0100.0100.0100.0
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax120.114.8-81.164.330.2-147.888.2

Amortization Of Financing Costs

us-gaap:AmortizationOfFinancingCosts

us-gaap:AmortizationOfFinancingCosts


Amortization
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302017-06-302017-03-312016-12-312016-09-302016-06-302016-03-312015-12-312015-09-302015-06-302015-03-312014-12-312014-09-302014-06-302014-03-312013-12-312013-09-302013-06-302013-03-31
Value1333000.0860000.0694000.0648000.0641000.0595000.0494000.0491000.0483000.0474000.0467000.0490000.0412000.0441000.0414000.0405000.0401000.0396000.0315000.0309000.0303000.0298000.0292000.0286000.0280000.0275000.0183000.0140000.0137000.0135000.0107000.0106000.0102000.0100000.0
Percentage of AmortizationOfFinancingCosts100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0

Deferred Income Tax Expense Benefit

us-gaap:DeferredIncomeTaxExpenseBenefit

us-gaap:DeferredIncomeTaxExpenseBenefit


Deferred
Period End2020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-31
Value316-0.9620.924-3.437-11.199-10.3330.88713-290.5110.00.00.0
Percentage of DeferredIncomeTaxExpenseBenefit100.0100.0100.0100.0100.0100.0100.0100.0100.00.00.00.0

Increase Decrease In Accounts Payable

us-gaap:IncreaseDecreaseInAccountsPayable

us-gaap:IncreaseDecreaseInAccountsPayable


Increase
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302017-06-302017-03-312016-12-312016-09-302016-06-302016-03-312015-12-312015-09-302015-06-302015-03-312014-12-312014-09-302014-06-302014-03-312013-12-312013-09-302013-06-302013-03-31
Value6.75-9.5698.2153.969-15.350.4112.421-2.661.087-17.191120.633-1.095-13.1443.4918.323-10.5020.4724.523-2.764-1.019-11.4178.3499.059-5.502-2.6953.41-0.5774.637-2.6462.359-0.463.736-5.569
Percentage of IncreaseDecreaseInAccountsPayable100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0

Increase Decrease In Inventories

us-gaap:IncreaseDecreaseInInventories

us-gaap:IncreaseDecreaseInInventories


Increase
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302017-06-302017-03-312016-12-312016-09-302016-06-302016-03-312015-12-312015-09-302015-06-302015-03-312014-12-312014-09-302014-06-302014-03-312013-12-312013-09-302013-06-302013-03-31
Value1900000.0234000.0-207000.0-1550000.0837000.02181000.0-1195000.0870000.03261000.02475000.0204000.0-689000.07000.0-922000.01531000.01947000.0-297000.0-688000.0-1830000.01651000.01148000.0-379000.0316000.0-199000.0-57000.0549000.0-795000.0-691000.0239000.0-496000.0648000.0-924000.02500000.0-312000.0
Percentage of IncreaseDecreaseInInventories100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0

Net Cash Provided By Used In Operating Activities

us-gaap:NetCashProvidedByUsedInOperatingActivities

us-gaap:NetCashProvidedByUsedInOperatingActivities


Net
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302017-06-302017-03-312016-12-312016-09-302012-09-302012-06-302012-03-312011-12-312011-09-302011-06-302011-03-312010-12-312010-09-302010-06-302010-03-31
Value-62.652-54.66297-10.357-44.144-7.584277-12.806-27.111107115-26.0045001320282.363122-26.83924-24.871-2.577-6.711-24.334-24.448-26.177-39.842-25.503-21.4295.03-21.691
Percentage of NetCashProvidedByUsedInOperatingActivities100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax-49.8-49.033.8-6.5-30.3-5.756.3-7.6-16.536.260.1-17.9424.89.111.824.32.1105.9-16.721.9-214.4-5.4-28.9-75.1-118.0-105.5-188.4-96.5-74.921.4-72.5

Net Income Loss

us-gaap:NetIncomeLoss

us-gaap:NetIncomeLoss


Net
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302017-06-302017-03-312016-12-312016-09-302016-06-302016-03-312015-12-312015-09-302015-06-302015-03-312014-12-312014-09-302014-06-302014-03-312011-06-302011-03-312010-06-302010-03-31
Value-80.875-89.869-340.271-30.944-31.845-48.22618426-0.87684320-4.559-40.358-1.422.744-0.976-11.2063.468257.351-56.855-62.917-71.433-35.77635-16.71731-26.676-12.081-31.28-17.889-19.994-25.154-9.658
Percentage of NetIncomeLoss100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax-64.3-80.5-117.2-19.3-21.9-36.237.415.6-0.528.4166.6-3.1-34.3-1.01.6-0.8-10.03.016.16.6-147.8-170.6-138.5-72.829.6-26.736.6-60.5-21.2-111.1-72.1-94.5-107.0-32.3

us-gaap:NetIncomeLoss us-gaap:ConsolidatedEntities

ions:AkceaTherapeuticsInc


Net
Period End2020-12-31
Value-85.987
Percentage of NetIncomeLoss25.3
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax0.0
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax ions:AkceaTherapeuticsInc0.0

us-gaap:NetIncomeLoss us-gaap:Ownership

ions:AkceaTherapeuticsInc


Net
Period End2020-12-312020-10-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-30
Value-85.987-3.603-37.822-37.665-32.67462-23.772-28.24423-53.219-47.843-43.814-19.997-15.955-9.587
Percentage of NetIncomeLoss25.30.0122.2118.367.833.8-90.93224.228.2-16.61049.4108.61408.2-581.5982.3
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax0.00.0-23.6-25.9-24.512.6-14.2-17.28.0-27.7-32.9-37.2-13.8-9.3-8.1
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax ions:AkceaTherapeuticsInc0.00.00.00.00.00.00.00.00.00.00.00.00.00.00.0

us-gaap:NetIncomeLoss us-gaap:Ownership, us-gaap:StatementClassOfStock

ions:AkceaTherapeuticsInc, us-gaap:CommonStock


Net
Period End2020-09-302020-06-302020-03-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-30
Value-37.822-37.665-32.674-23.772-28.24423-53.219-47.843-43.814-19.997-15.955-9.87
Percentage of NetIncomeLoss122.2118.367.8-90.93224.228.2-16.61049.4108.61408.2-581.51011.3
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax-23.6-25.9-24.5-14.2-17.28.0-27.7-32.9-37.2-13.8-9.3-8.3
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax ions:AkceaTherapeuticsInc us-gaap:CommonStock0.00.00.00.00.00.00.00.00.00.00.00.0

us-gaap:NetIncomeLoss us-gaap:StatementBusinessSegments

ions:IonisCore


Net
Period End2020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-30
Value-250.6826.7745.807-15.63121492763372435.88218189.168
Percentage of NetIncomeLoss73.7-21.9-18.232.465.9190.8-3117.775.4116.5-948.1-14.6-1322.9680.5-939.3
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax-86.44.24.0-11.724.629.716.721.4194.129.75.013.010.87.7
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax ions:IonisCore0.00.00.00.00.00.00.00.00.00.00.00.00.00.0

us-gaap:NetIncomeLoss us-gaap:StatementEquityComponents

us-gaap:Parent


Net
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-31
Value-80.875-89.869-340.271-30.944-31.845-48.22618426-0.87684320-4.559-40.355-1.42
Percentage of NetIncomeLoss100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax-64.3-80.5-117.2-19.3-21.9-36.237.415.6-0.528.4166.6-3.1-34.3-1.0
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax us-gaap:Parent0.00.00.00.00.00.00.00.00.00.00.00.00.00.0

us-gaap:RetainedEarnings


Net
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-31
Value-80.875-89.869-340.271-30.944-31.845-48.22618426-0.87684320-4.559-40.355-1.42
Percentage of NetIncomeLoss100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax-64.3-80.5-117.2-19.3-21.9-36.237.415.6-0.528.4166.6-3.1-34.3-1.0
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax us-gaap:RetainedEarnings0.00.00.00.00.00.00.00.00.00.00.00.00.00.0

Profit Loss

us-gaap:ProfitLoss

us-gaap:ProfitLoss


Profit
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302017-06-302017-03-312016-12-312016-09-302016-06-302016-03-312015-03-312014-12-312014-09-302014-06-302014-03-312013-12-312013-09-302013-06-302013-03-31
Value-80.875-89.869-341.426-43.091-43.769-58.4820318-10.01290302-20.365-56.573-10.812-4.662-4.896-11.2063.468257.351-56.855-62.917-16.71731-26.676-12.081-31.28-24.276-24.57-10.126-1.672
Percentage of ProfitLoss100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax-64.3-80.5-117.6-26.9-30.1-43.841.311.0-6.130.6157.6-14.0-48.0-7.5-2.7-4.1-10.03.016.16.6-147.8-170.6-26.736.6-60.5-21.2-111.1-57.5-104.2-26.6-3.9

Share Based Compensation

us-gaap:ShareBasedCompensation

us-gaap:ShareBasedCompensation


Share
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302017-06-302017-03-312016-12-312016-09-302016-06-302016-03-312015-12-312015-09-302015-06-302015-03-312014-12-312014-09-302014-06-302014-03-312013-12-312013-09-302013-06-302013-03-31
Value30379545484035244145343433282221212015171920171413138.4898.1187.7077.0693.12.8132.6362.869
Percentage of ShareBasedCompensation100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0

Net Cash Provided By Used In Investing Activities

us-gaap:NetCashProvidedByUsedInInvestingActivities

us-gaap:NetCashProvidedByUsedInInvestingActivities


Net
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302017-06-302017-03-312016-12-312016-09-302012-09-302012-06-302012-03-312011-12-312011-09-302011-06-302011-03-312010-12-312010-09-302010-06-302010-03-31
Value-101.037818710179-95.0071381.396-110.687-70.174-326.207-307.671-375.17179-54.212-150.09914-168.67520-57.088-10.60824-0.52233-4.4232456-7.24275-59.93614
Percentage of NetCashProvidedByUsedInInvestingActivities100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax-80.370.764.763.754.8-71.228.00.8-67.6-23.6-169.8-211.6-318.655.0-31.5-126.913.1-145.713.0-51.5-91.450.9-2.2104.8-21.499.3268.2-27.4265.2-255.050.0

Payments To Acquire Property Plant And Equipment

us-gaap:PaymentsToAcquirePropertyPlantAndEquipment

us-gaap:PaymentsToAcquirePropertyPlantAndEquipment


Payments
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302017-06-302017-03-312016-12-312016-09-302016-06-302016-03-312015-12-312015-09-302015-06-302015-03-312014-12-312014-09-302014-06-302014-03-312013-12-312013-09-302013-06-302013-03-312012-12-312012-09-302012-06-302012-03-312011-12-312011-09-302011-06-302011-03-312010-12-312010-09-302010-06-302010-03-31
Value4.3581.7725.149119.0989.087.762154.0143.2291.3873.2446.6342.3438.262176.2163.2372.7941.052.6350.6282.4111.3413.0620.8783.5490.8691.6971.4030.4390.5220.3690.2220.4460.1690.7510.113-0.3241.6733.4062.5760.4970.8460.88511
Percentage of PaymentsToAcquirePropertyPlantAndEquipment100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0

Net Cash Provided By Used In Financing Activities

us-gaap:NetCashProvidedByUsedInFinancingActivities

us-gaap:NetCashProvidedByUsedInFinancingActivities


Net
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302017-06-302017-03-312016-12-312016-09-302012-09-302012-06-302012-03-312011-12-312011-09-302011-06-302011-03-312010-12-312010-09-302010-06-302010-03-31
Value314-7.577-521.48108.435-94.50119-13.17434599.6468.0764525.2244.2571471.712756.4484.543347.737-1.8530.585-0.8880.359-0.7282.675-0.4012.3540.068
Percentage of NetCashProvidedByUsedInFinancingActivities100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax250.1-6.8-179.66.85.8-70.93.9-7.821.120.05.05.6384.73.62.5124.71.565.24.04.1296.516.3-8.01.8-4.31.4-3.410.1-1.410.00.2

Payments For Repurchase Of Common Stock

us-gaap:PaymentsForRepurchaseOfCommonStock

us-gaap:PaymentsForRepurchaseOfCommonStock


Payments
Period End2020-12-312020-09-302020-06-302020-03-312019-12-312019-06-302019-03-31
Value0.00.0-0.00290340.00.0
Percentage of PaymentsForRepurchaseOfCommonStock0.00.0100.0100.0100.00.00.0

Debt Instrument Interest Rate Stated Percentage

us-gaap:DebtInstrumentInterestRateStatedPercentage us-gaap:DebtInstrument

us-gaap:DebtInstrumentInterestRateStatedPercentage

ions:ConvertibleSeniorNotes0125Percent


Debt
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312018-12-31
Value0.1250.1250.1250.1250.001250.001250.001250.00125
Percentage of DebtInstrumentInterestRateStatedPercentage100.0100.0100.0100.0100.0100.0100.0100.0
Percentage of LongTermDebtAndCapitalLeaseObligations0.00.00.00.00.00.00.00.0
Percentage of LongTermDebtAndCapitalLeaseObligations ions:ConvertibleSeniorNotes0125Percent0.00.00.00.00.00.00.00.0

ions:ConvertibleSeniorNotes1Percent


Debt
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302017-06-302017-03-312016-12-312016-09-302016-06-302016-03-312015-12-312015-09-302015-06-302014-12-31
Value1.01.01.01.00.010.010.010.010.010.010.010.010.010.010.010.010.010.010.010.010.010.010.010.010.010.01
Percentage of DebtInstrumentInterestRateStatedPercentage800.0800.0800.0800.0800.0800.0800.00.00.00.0800.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.0
Percentage of LongTermDebtAndCapitalLeaseObligations0.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.0
Percentage of LongTermDebtAndCapitalLeaseObligations ions:ConvertibleSeniorNotes1Percent0.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.0

us-gaap:DebtInstrumentInterestRateStatedPercentage us-gaap:DebtInstrument, us-gaap:SubsequentEventType

ions:ConvertibleSeniorNotes0Percent, us-gaap:SubsequentEvent


Debt
Period End2021-04-30
Value0
Percentage of DebtInstrumentInterestRateStatedPercentage0.0
Percentage of LongTermDebtAndCapitalLeaseObligations0.0
Percentage of LongTermDebtAndCapitalLeaseObligations ions:ConvertibleSeniorNotes0Percent us-gaap:SubsequentEvent0.0

Effective Income Tax Rate Continuing Operations

us-gaap:EffectiveIncomeTaxRateContinuingOperations

us-gaap:EffectiveIncomeTaxRateContinuingOperations


Effective
Period End2020-12-31
Value-187.1
Percentage of EffectiveIncomeTaxRateContinuingOperations100.0

Share Based Compensation Arrangement By Share Based Payment Award Options Outstanding Number

us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber us-gaap:AwardType

us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber

us-gaap:StockOption


Share
Period End2020-12-312019-12-312018-12-312017-12-312016-12-312015-12-312014-12-312013-12-312012-12-312011-12-31
Value1211119.3979.1788.0417.3790.0072790.0108230.010722
Percentage of ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0

us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber us-gaap:PlanName

ions:EquityIncentivePlan2011


Share
Period End2020-12-312019-12-312018-12-312017-12-312016-12-312015-12-31
Value1110.09.7054417.1206435.8300783.832225
Percentage of ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber92.490.985.875.863.547.7

ions:EquityIncentivePlan2020


Share
Period End2020-12-31
Value0.01
Percentage of ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber0.1

ions:NonemployeeDirectorsStockOptionPlan2002


Share
Period End2020-12-312019-12-312018-12-312017-12-312016-12-312015-12-31
Value1.00.90.757750.672750.6158120.544812
Percentage of ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber8.18.26.77.26.76.8

ions:StockOptionPlan1989


Share
Period End2020-12-312019-12-312018-12-312017-12-312016-12-312015-12-31
Value0.030.10.8487531.6034032.7320893.619716
Percentage of ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber0.20.97.517.129.845.0

Share Based Compensation Arrangement By Share Based Payment Award Options Outstanding Weighted Average Exercise Price

us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePrice us-gaap:AwardType

us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePrice

us-gaap:StockOption


Share
Period End2020-12-312019-12-312018-12-312017-12-312016-12-312015-12-312014-12-312013-12-312012-12-312011-12-31
Value54.1451.4847.8544.5240.4833.2119.5212.0811.311.39
Percentage of ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePrice100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0

Unrecognized Tax Benefits

us-gaap:UnrecognizedTaxBenefits

us-gaap:UnrecognizedTaxBenefits


Unrecognized
Period End2020-12-312019-12-312018-12-312017-12-312016-12-312015-12-312014-12-312013-12-312012-12-312011-12-312010-12-31
Value5469687866512723109.8348.968
Percentage of UnrecognizedTaxBenefits100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0

Deferred Tax Assets Valuation Allowance

us-gaap:DeferredTaxAssetsValuationAllowance

us-gaap:DeferredTaxAssetsValuationAllowance


Deferred
Period End2020-12-312019-12-312018-12-312017-12-312016-12-312015-12-312014-12-312013-12-312012-12-312011-12-312010-12-31
Value633196234456452404315342-313.405307265
Percentage of DeferredTaxAssetsValuationAllowance100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0

ions:AssetImpairmentChargesIncludingOtherThanTemporaryImpairmentInCostMethodInvestments

ions:AssetImpairmentChargesIncludingOtherThanTemporaryImpairmentInCostMethodInvestments


Asset
Period End2020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-31
Value405000.0298000.0-87000.01818000.013000.0189000.014000.0
Percentage of AssetImpairmentChargesIncludingOtherThanTemporaryImpairmentInCostMethodInvestments100.0100.0100.0100.0100.0100.0100.0

ions:CallSpread

ions:CallSpread


Call
Period End2021-04-302019-12-31
Value4652
Percentage of CallSpread100.0100.0

ions:CallSpread us-gaap:SubsequentEventType

us-gaap:SubsequentEvent


Call
Period End2021-04-30
Value46
Percentage of CallSpread100.0

ions:CashPurchasePriceOfEquityAwards

ions:CashPurchasePriceOfEquityAwards


Cash
Period End2020-10-31
Value18.15
Percentage of CashPurchasePriceOfEquityAwards100.0

ions:CashPurchasePriceOfEquityAwards us-gaap:Ownership

ions:AkceaTherapeuticsInc


Cash
Period End2020-12-31
Value18.15
Percentage of CashPurchasePriceOfEquityAwards0.0

ions:ConsolidationLessThanWhollyOwnedSubsidiaryParentOwnershipInterestChangesPurchaseOfInterestByParentPricePerShare us-gaap:Ownership

ions:ConsolidationLessThanWhollyOwnedSubsidiaryParentOwnershipInterestChangesPurchaseOfInterestByParentPricePerShare

ions:AkceaTherapeuticsInc


Consolidation
Period End2020-10-31
Value18.15
Percentage of ConsolidationLessThanWhollyOwnedSubsidiaryParentOwnershipInterestChangesPurchaseOfInterestByParentPricePerShare100.0

ions:ConsolidationLessThanWhollyOwnedSubsidiaryParentOwnershipInterestChangesPurchaseOfInterestByParentShares us-gaap:Ownership

ions:ConsolidationLessThanWhollyOwnedSubsidiaryParentOwnershipInterestChangesPurchaseOfInterestByParentShares

ions:AkceaTherapeuticsInc


Consolidation
Period End2020-10-31
Value24
Percentage of ConsolidationLessThanWhollyOwnedSubsidiaryParentOwnershipInterestChangesPurchaseOfInterestByParentShares100.0

ions:CoronavirusAidReliefAndEconomicSecurityActIncomeTaxExpenseBenefit us-gaap:ConsolidatedEntities

ions:CoronavirusAidReliefAndEconomicSecurityActIncomeTaxExpenseBenefit

ions:AkceaTherapeuticsInc


Coronavirus
Period End2020-09-302020-06-302020-03-31
Value00-1700000.0
Percentage of CoronavirusAidReliefAndEconomicSecurityActIncomeTaxExpenseBenefit0.00.0100.0

ions:DebtInstrumentConvertiblePercentageOfPrincipalAmountUsedAsPurchasePriceUponOccurrenceOfFundamentalChange us-gaap:DebtInstrument

ions:DebtInstrumentConvertiblePercentageOfPrincipalAmountUsedAsPurchasePriceUponOccurrenceOfFundamentalChange

ions:ConvertibleSeniorNotes0125Percent


Debt
Period End2021-06-302021-03-31
Value0100.0
Percentage of DebtInstrumentConvertiblePercentageOfPrincipalAmountUsedAsPurchasePriceUponOccurrenceOfFundamentalChange0.0100.0

ions:ConvertibleSeniorNotes1Percent


Debt
Period End2021-06-302021-03-31
Value0100.0
Percentage of DebtInstrumentConvertiblePercentageOfPrincipalAmountUsedAsPurchasePriceUponOccurrenceOfFundamentalChange0.0100.0

ions:DebtInstrumentConvertiblePercentageOfPrincipalAmountUsedAsPurchasePriceUponOccurrenceOfFundamentalChange us-gaap:DebtInstrument, us-gaap:SubsequentEventType

ions:ConvertibleSeniorNotes0Percent, us-gaap:SubsequentEvent


Debt
Period End2021-04-30
Value100.0
Percentage of DebtInstrumentConvertiblePercentageOfPrincipalAmountUsedAsPurchasePriceUponOccurrenceOfFundamentalChange0.0

ions:MilestonePaymentAchieved us-gaap:ProductOrService, us-gaap:SubsequentEventType, us-gaap:TypeOfArrangement

ions:MilestonePaymentAchieved

ions:Ion464, us-gaap:SubsequentEvent, ions:CollaborativeArrangementAndLicensingAgreementEnteredIntoInSeptember2013WithBiogen


Milestone
Period End2020-07-31
Value18
Percentage of MilestonePaymentAchieved100.0

ions:Ion541, us-gaap:SubsequentEvent, ions:CollaborativeArrangementAndLicensingAgreementEnteredIntoInSeptember2013WithBiogen


Milestone
Period End2021-04-30
Value10.0
Percentage of MilestonePaymentAchieved0.0

ions:IonisMapt, us-gaap:SubsequentEvent, ions:CollaborativeArrangementAndLicensingAgreementEnteredIntoInDecember2012WithBiogen


Milestone
Period End2020-08-05
Value12
Percentage of MilestonePaymentAchieved0.0

ions:MilestonePaymentAchieved us-gaap:ProductOrService, us-gaap:TypeOfArrangement

ions:IonisMapt, ions:CollaborativeArrangementAndLicensingAgreementEnteredIntoInDecember2012WithBiogen


Milestone
Period End2020-09-302020-03-31
Value127.5
Percentage of MilestonePaymentAchieved0.00.0

ions:MilestonePaymentAchieved us-gaap:SubsequentEventType, us-gaap:TypeOfArrangement

us-gaap:SubsequentEvent, ions:CollaborativeArrangementAndLicensingAgreementEnteredIntoInDecember2014WithJanssenBiotechInc


Milestone
Period End2020-07-31
Value5.0
Percentage of MilestonePaymentAchieved27.8

ions:MilestonePaymentAchieved us-gaap:TypeOfArrangement

ions:CollaborativeArrangementAndLicensingAgreementEnteredIntoInDecember2014WithJanssenBiotechInc


Milestone
Period End2020-09-30
Value5.0
Percentage of MilestonePaymentAchieved0.0

ions:MilestonePaymentEarned us-gaap:SubsequentEventType, us-gaap:TypeOfArrangement

ions:MilestonePaymentEarned

us-gaap:SubsequentEvent, ions:CollaborativeArrangementAndLicensingAgreementEnteredIntoInOctober2019WithPfizer


Milestone
Period End2020-10-31
Value75
Percentage of MilestonePaymentEarned100.0

ions:MilestonePaymentsAchievedAndIncludedInTransactionPriceForPerformanceObligation us-gaap:ProductOrService, us-gaap:TypeOfArrangement

ions:MilestonePaymentsAchievedAndIncludedInTransactionPriceForPerformanceObligation

ions:IonisMapt, ions:CollaborativeArrangementAndLicensingAgreementEnteredIntoInDecember2012WithBiogen


Milestone
Period End2020-09-302020-03-312019-12-312019-06-30
Value127.5127.5
Percentage of MilestonePaymentsAchievedAndIncludedInTransactionPriceForPerformanceObligation100.0100.0100.0100.0

ions:NonCashCapitalAndPatentExpenditures

ions:NonCashCapitalAndPatentExpenditures


Non
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302017-06-302017-03-312016-12-312016-09-302016-06-302016-03-312015-12-312015-09-302015-06-302015-03-31
Value-1598000.01876000.0-2517000.0115000.01558000.04903000.0-125000.0178000.01209000.01864000.02132000.0-349000.0554000.02091000.0-1492000.01770000.057000.01648000.0918000.0859000.0-862000.02524000.0715000.0-719000.0-32000.01198000.0
Percentage of NonCashCapitalAndPatentExpenditures100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0

ions:OperatingLeaseRightOfUseAssetAmortization

ions:OperatingLeaseRightOfUseAssetAmortization


Operating
Period End2020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-30
Value572000.0391000.0393000.0109000.0398000.0559000.0476000.000
Percentage of OperatingLeaseRightOfUseAssetAmortization100.0100.0100.0100.0100.0100.0100.00.00.0

ions:PaymentsForCancelledEquityAwards us-gaap:Ownership

ions:PaymentsForCancelledEquityAwards

ions:AkceaTherapeuticsInc


Payments
Period End2020-12-31
Value53
Percentage of PaymentsForCancelledEquityAwards100.0

ions:PaymentsToAcquireLicensesAndOtherAssets

ions:PaymentsToAcquireLicensesAndOtherAssets


Payments
Period End2020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302017-06-302017-03-312016-12-312016-09-302016-06-302016-03-312015-12-312015-09-302015-06-302015-03-31
Value1180000.02119000.0904000.01181000.01886000.01278000.01032000.0727000.01463000.01116000.0738000.0804000.0696000.0610000.0983000.01047000.01179000.01813000.0382000.0722000.01585000.01030000.0719000.0
Percentage of PaymentsToAcquireLicensesAndOtherAssets100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0

ions:PercentageEnrollmentInPhase3Study us-gaap:ProductOrService, us-gaap:SubsequentEventType, us-gaap:TypeOfArrangement

ions:PercentageEnrollmentInPhase3Study

ions:Pelacarsen, us-gaap:SubsequentEvent, ions:CollaborativeArrangementAndLicensingAgreementEnteredIntoInJanuary2017WithNovartis


Percentage
Period End2021-08-04
Value50.0
Percentage of PercentageEnrollmentInPhase3Study100.0

ions:ResearchDevelopmentAndPatentExpense

ions:ResearchDevelopmentAndPatentExpense


Research
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302017-06-302017-03-312016-12-312016-09-302016-06-302016-03-312015-12-312015-09-302015-06-302015-03-31
Value13913917012512211614810410610611395101104128808382101847780101886864
Percentage of ResearchDevelopmentAndPatentExpense100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0

ions:RestructuringReserveNetExpense us-gaap:IncomeStatementLocation, us-gaap:RestructuringCostAndReserve

ions:RestructuringReserveNetExpense

ions:ResearchAndDevelopmentExpenses, ions:AkceaAcquisition


Restructuring
Period End2021-03-31
Value2.5
Percentage of RestructuringReserveNetExpense100.0

ions:ResearchAndDevelopmentExpenses, ions:RestructuredEuropeanOperations


Restructuring
Period End2021-03-31
Value0.1
Percentage of RestructuringReserveNetExpense4.0

us-gaap:SellingGeneralAndAdministrativeExpenses, ions:AkceaAcquisition


Restructuring
Period End2021-03-31
Value2.9
Percentage of RestructuringReserveNetExpense116.0

us-gaap:SellingGeneralAndAdministrativeExpenses, ions:RestructuredEuropeanOperations


Restructuring
Period End2021-03-31
Value0.6
Percentage of RestructuringReserveNetExpense24.0

ions:RestructuringReserveNetExpense us-gaap:RestructuringCostAndReserve

ions:AkceaAcquisition


Restructuring
Period End2021-03-312020-12-31
Value5.415
Percentage of RestructuringReserveNetExpense216.00.0

ions:RestructuredEuropeanOperations


Restructuring
Period End2021-03-312020-12-31
Value0.712
Percentage of RestructuringReserveNetExpense28.00.0

ions:RestructuringReserveRestructuringChargesNetOfReserveAdjustments us-gaap:IncomeStatementLocation, us-gaap:RestructuringCostAndReserve

ions:RestructuringReserveRestructuringChargesNetOfReserveAdjustments

ions:ResearchDevelopmentAndPatentExpenses, ions:AkceaAcquisition


Restructuring
Period End2021-06-30
Value1300000.0
Percentage of RestructuringReserveRestructuringChargesNetOfReserveAdjustments100.0

us-gaap:SellingGeneralAndAdministrativeExpenses, ions:AkceaAcquisition


Restructuring
Period End2021-06-30
Value3100000.0
Percentage of RestructuringReserveRestructuringChargesNetOfReserveAdjustments238.5

us-gaap:SellingGeneralAndAdministrativeExpenses, ions:RestructuredEuropeanOperations


Restructuring
Period End2021-06-30
Value400000.0
Percentage of RestructuringReserveRestructuringChargesNetOfReserveAdjustments30.8

ions:RestructuringReserveRestructuringChargesNetOfReserveAdjustments us-gaap:RestructuringCostAndReserve

ions:AkceaAcquisition


Restructuring
Period End2021-06-30
Value4400000.0
Percentage of RestructuringReserveRestructuringChargesNetOfReserveAdjustments338.5

ions:RestructuredEuropeanOperations


Restructuring
Period End2021-06-30
Value400000.0
Percentage of RestructuringReserveRestructuringChargesNetOfReserveAdjustments30.8

ions:RevenueFromContractWithCustomerTransactionPriceAdditions us-gaap:TypeOfArrangement

ions:RevenueFromContractWithCustomerTransactionPriceAdditions

ions:CollaborativeArrangementAndLicensingAgreementEnteredIntoInApril2018WithBiogen


Revenue
Period End2020-12-312018-12-31
Value7.515
Percentage of RevenueFromContractWithCustomerTransactionPriceAdditions100.0100.0

ions:CollaborativeArrangementAndLicensingAgreementEnteredIntoInDecember2012WithBiogen


Revenue
Period End2020-09-302017-09-30
Value1210.0
Percentage of RevenueFromContractWithCustomerTransactionPriceAdditions0.00.0

ions:ShareBasedCompensationArrangementByShareBasedPaymentAwardPercentageOfUnitsGuaranteedToVest us-gaap:Range, us-gaap:AwardType, us-gaap:GranteeStatus

ions:ShareBasedCompensationArrangementByShareBasedPaymentAwardPercentageOfUnitsGuaranteedToVest

srt:Maximum, us-gaap:PerformanceShares, srt:ChiefExecutiveOfficer


Share
Period End2021-06-302021-03-31
Value0150.0
Percentage of ShareBasedCompensationArrangementByShareBasedPaymentAwardPercentageOfUnitsGuaranteedToVest0.0100.0

ions:WeightedAverageNumberOfSharesOwnedInSubsidiary us-gaap:Ownership

ions:WeightedAverageNumberOfSharesOwnedInSubsidiary

ions:AkceaTherapeuticsInc


Weighted
Period End2020-12-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-31
Value777170706867656045
Percentage of WeightedAverageNumberOfSharesOwnedInSubsidiary100.0100.0100.0100.0100.0100.0100.0100.0100.0

ions:WeightedAverageNumberOfSharesOwnedInSubsidiary us-gaap:Ownership, us-gaap:StatementClassOfStock

ions:AkceaTherapeuticsInc, us-gaap:CommonStock


Weighted
Period End2020-09-302020-06-302020-03-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-30
Value777777707068676560454536
Percentage of WeightedAverageNumberOfSharesOwnedInSubsidiary0.00.00.0100.0100.0100.0100.0100.0100.0100.00.00.0

us-gaap:AccretionAmortizationOfDiscountsAndPremiumsInvestments

us-gaap:AccretionAmortizationOfDiscountsAndPremiumsInvestments


Accretion
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302017-06-302017-03-312016-12-312016-09-302016-06-302016-03-312015-12-312015-09-302015-06-302015-03-312014-12-312014-09-30
Value-4801000.0-4023000.0-3709000.0-3970000.0-2780000.0-1062000.0421000.01901000.02730000.02433000.01804000.01054000.0-653000.0-1192000.0-1525000.0-1669000.0-1950000.0-1608000.0-1499000.0-1521000.0-1754000.0-2039000.0-2317000.0-2118000.0-1628000.0-1749000.0-1821000.0-1802000.0
Percentage of AccretionAmortizationOfDiscountsAndPremiumsInvestments100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0

us-gaap:AdjustmentsRelatedToTaxWithholdingForShareBasedCompensation

us-gaap:AdjustmentsRelatedToTaxWithholdingForShareBasedCompensation


Adjustments
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-31
Value0.458150.450.990.367110.401100.4387.597
Percentage of AdjustmentsRelatedToTaxWithholdingForShareBasedCompensation100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0

us-gaap:AdjustmentsRelatedToTaxWithholdingForShareBasedCompensation us-gaap:StatementEquityComponents

us-gaap:AdditionalPaidInCapital


Adjustments
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-31
Value0.458150.450.990.367110.401100.4387.597
Percentage of AdjustmentsRelatedToTaxWithholdingForShareBasedCompensation100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0

us-gaap:Parent


Adjustments
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-31
Value0.458150.450.990.367110.401100.4387.597
Percentage of AdjustmentsRelatedToTaxWithholdingForShareBasedCompensation100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0

us-gaap:AdjustmentsToAdditionalPaidInCapitalOther

us-gaap:AdjustmentsToAdditionalPaidInCapitalOther


Adjustments
Period End2021-06-30
Value-136620000.0
Percentage of AdjustmentsToAdditionalPaidInCapitalOther100.0

us-gaap:AdjustmentsToAdditionalPaidInCapitalOther us-gaap:StatementEquityComponents

us-gaap:AdditionalPaidInCapital


Adjustments
Period End2021-06-30
Value-136620000.0
Percentage of AdjustmentsToAdditionalPaidInCapitalOther100.0

us-gaap:Parent


Adjustments
Period End2021-06-30
Value-136620000.0
Percentage of AdjustmentsToAdditionalPaidInCapitalOther100.0

us-gaap:AdjustmentsToAdditionalPaidInCapitalWarrantIssued

us-gaap:AdjustmentsToAdditionalPaidInCapitalWarrantIssued


Adjustments
Period End2021-06-30
Value89
Percentage of AdjustmentsToAdditionalPaidInCapitalWarrantIssued100.0

us-gaap:AdjustmentsToAdditionalPaidInCapitalWarrantIssued us-gaap:StatementEquityComponents

us-gaap:AdditionalPaidInCapital


Adjustments
Period End2021-06-30
Value89
Percentage of AdjustmentsToAdditionalPaidInCapitalWarrantIssued100.0

us-gaap:Parent


Adjustments
Period End2021-06-30
Value89
Percentage of AdjustmentsToAdditionalPaidInCapitalWarrantIssued100.0

us-gaap:AmortizationOfDebtDiscountPremium

us-gaap:AmortizationOfDebtDiscountPremium


Amortization
Period End2020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302017-06-302017-03-312016-12-312016-09-302016-06-302016-03-31
Value9.2459.1058.9738.834109.0868.9358.7268.5828.4178.2818.0837.9577.87.6577.5066.1526.0295.9145.795
Percentage of AmortizationOfDebtDiscountPremium100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0

us-gaap:ConcentrationRiskPercentage1 us-gaap:ConcentrationRiskByBenchmark, us-gaap:ConcentrationRiskByType, us-gaap:TypeOfArrangement

us-gaap:ConcentrationRiskPercentage1

us-gaap:RevenueFromContractWithCustomer, us-gaap:CustomerConcentrationRisk, ions:CollaborativeArrangementAndLicensingAgreementEnteredIntoInDecember2014WithJanssenBiotechInc


Concentration
Period End2020-09-30
Value3.0
Percentage of ConcentrationRiskPercentage1100.0

us-gaap:RevenueFromContractWithCustomer, us-gaap:CustomerConcentrationRisk, ions:CollaborativeArrangementsAndLicensingAgreementsAstrazeneca


Concentration
Period End2020-09-302020-06-302019-09-302019-06-30
Value2.00.124.00.02
Percentage of ConcentrationRiskPercentage166.70.00.00.0

us-gaap:RevenueFromContractWithCustomer, us-gaap:CustomerConcentrationRisk, ions:CollaborativeArrangementsAndLicensingAgreementsBiogen


Concentration
Period End2021-06-302021-03-312020-09-302020-06-302020-03-312019-09-302019-06-302019-03-312018-09-30
Value80.070.078.00.670.660.640.630.280.72
Percentage of ConcentrationRiskPercentage10.00.02600.00.00.00.00.00.00.0

us-gaap:ConcentrationRiskPercentage1 us-gaap:MajorCustomers, us-gaap:ConcentrationRiskByBenchmark, us-gaap:ConcentrationRiskByType

ions:ThreeSignificantCustomers, us-gaap:AccountsReceivable, us-gaap:CreditConcentrationRisk


Concentration
Period End2021-03-31
Value46.8
Percentage of ConcentrationRiskPercentage10.0

us-gaap:ConsolidationLessThanWhollyOwnedSubsidiaryParentOwnershipInterestChangesPurchaseOfInterestByParent us-gaap:Ownership

us-gaap:ConsolidationLessThanWhollyOwnedSubsidiaryParentOwnershipInterestChangesPurchaseOfInterestByParent

ions:AkceaTherapeuticsInc


Consolidation
Period End2020-10-31
Value450
Percentage of ConsolidationLessThanWhollyOwnedSubsidiaryParentOwnershipInterestChangesPurchaseOfInterestByParent100.0

us-gaap:ContractWithCustomerLiabilityRevenueRecognized

us-gaap:ContractWithCustomerLiabilityRevenueRecognized


Contract
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302017-06-302017-03-31
Value262616223928563046402437333410313526
Percentage of ContractWithCustomerLiabilityRevenueRecognized100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0

us-gaap:Depreciation

us-gaap:Depreciation


Depreciation
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302017-06-302017-03-312016-12-312016-09-302016-06-302016-03-312015-12-312015-09-302015-06-302015-03-312014-12-312014-09-302014-06-302014-03-312013-12-312013-09-302013-06-302013-03-31
Value4.0343.9173.6523.3533.1273.2333.1953.0923.183.0733.0562.7922.4952.3630.572.1482.011.981.8891.8771.8741.8411.7941.7841.8351.5711.5891.651.581.5611.5961.621.6681.707
Percentage of Depreciation100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0

us-gaap:EffectOfExchangeRateOnCashAndCashEquivalents

us-gaap:EffectOfExchangeRateOnCashAndCashEquivalents


Effect
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-31
Value104000.0-126000.0259000.0276000.074000.08000.0
Percentage of EffectOfExchangeRateOnCashAndCashEquivalents100.0100.0100.0100.0100.0100.0

us-gaap:EffectiveIncomeTaxRateReconciliationAtFederalStatutoryIncomeTaxRate

us-gaap:EffectiveIncomeTaxRateReconciliationAtFederalStatutoryIncomeTaxRate


Effective
Period End2020-12-31
Value0
Percentage of EffectiveIncomeTaxRateReconciliationAtFederalStatutoryIncomeTaxRate0.0

us-gaap:EquitySecuritiesFvNiUnrealizedGain us-gaap:InvestmentType

us-gaap:EquitySecuritiesFvNiUnrealizedGain

ions:EquitySecuritiesPrivateCompanies


Equity
Period End2021-03-312020-12-312020-09-30
Value156.620.0
Percentage of EquitySecuritiesFvNiUnrealizedGain100.0100.00.0

us-gaap:EquitySecurities


Equity
Period End2021-03-312020-12-312020-09-302020-06-302020-03-31
Value156.620.09.3180.0
Percentage of EquitySecuritiesFvNiUnrealizedGain100.0100.00.00.00.0

us-gaap:EquitySecuritiesFvNiUnrealizedLoss us-gaap:InvestmentType

us-gaap:EquitySecuritiesFvNiUnrealizedLoss

ions:EquitySecuritiesPublicCompanies


Equity
Period End2020-09-30
Value243000.0
Percentage of EquitySecuritiesFvNiUnrealizedLoss100.0

ions:EquitySecuritiesPubliclyTradedCompanies


Equity
Period End2021-03-31
Value1514000.0
Percentage of EquitySecuritiesFvNiUnrealizedLoss0.0

us-gaap:EquitySecurities


Equity
Period End2021-03-312020-12-312020-09-302020-06-302020-03-31
Value1514000.0116000.0243000.0-301000.02623000.0
Percentage of EquitySecuritiesFvNiUnrealizedLoss0.00.0100.00.00.0

us-gaap:ImpairmentOfIntangibleAssetsFinitelived

us-gaap:ImpairmentOfIntangibleAssetsFinitelived


Impairment
Period End2021-06-302021-03-312020-06-302020-03-312013-12-312013-09-302012-09-30
Value606000.0221000.033000.0159000.05959000.0166000.0376000.0
Percentage of ImpairmentOfIntangibleAssetsFinitelived100.0100.0100.0100.0100.0100.0100.0

us-gaap:IncreaseDecreaseInAccruedIncomeTaxesPayable

us-gaap:IncreaseDecreaseInAccruedIncomeTaxesPayable


Increase
Period End2021-06-302021-03-312020-09-302020-06-302020-03-31
Value549000.02000.0-19103000.0-4039000.0-532000.0
Percentage of IncreaseDecreaseInAccruedIncomeTaxesPayable100.0100.0100.0100.0100.0

us-gaap:IncreaseDecreaseInContractWithCustomerAsset

us-gaap:IncreaseDecreaseInContractWithCustomerAsset


Increase
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-30
Value0.607-52.8073711-0.771-34.429131721-4.9080.628-2.03-20.096-26.09720-7.691
Percentage of IncreaseDecreaseInContractWithCustomerAsset100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0

us-gaap:IncreaseDecreaseInContractWithCustomerLiability

us-gaap:IncreaseDecreaseInContractWithCustomerLiability


Increase
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-30
Value-26.759-23.717-1.94-14.615-39.676-19.679-22.254-23.386-33.29-40.35347-36.646511-27.788-0.889-24.517
Percentage of IncreaseDecreaseInContractWithCustomerLiability100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0

us-gaap:IncreaseDecreaseInOtherCurrentLiabilities

us-gaap:IncreaseDecreaseInOtherCurrentLiabilities


Increase
Period End2021-06-302021-03-312020-09-302020-06-302020-03-312019-09-302019-06-302019-03-31
Value-3.009-11.905150.597-2.5650.626-10.47313
Percentage of IncreaseDecreaseInOtherCurrentLiabilities100.0100.0100.0100.0100.0100.0100.0100.0

us-gaap:IncreaseDecreaseInOtherEmployeeRelatedLiabilities

us-gaap:IncreaseDecreaseInOtherEmployeeRelatedLiabilities


Increase
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302017-06-302017-03-312016-12-312016-09-302016-06-302016-03-312015-12-312015-09-302015-06-302015-03-312014-12-312014-09-302014-06-302014-03-312013-12-312013-09-302013-06-302013-03-31
Value0.959-36.465375.5686.385-20.92124.3553.785-13.0045.0099.172.923-12.9859.9644.8892.031-15.919133.5671.104-9.7286.5571.5932.504-6.8915.1380.7342.102-7.845.515-0.3783.213-4.06
Percentage of IncreaseDecreaseInOtherEmployeeRelatedLiabilities100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0

us-gaap:IncreaseDecreaseInOtherOperatingAssets

us-gaap:IncreaseDecreaseInOtherOperatingAssets


Increase
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302017-06-302017-03-312016-12-312016-09-302016-06-302016-03-312015-12-312015-09-302015-06-302015-03-312014-12-312014-09-302014-06-302014-03-312013-12-312013-09-302013-06-302013-03-31
Value7.302-16.4814.3286.7118.468-9.53221178.174-1.8022.7752116-11.42223-4.5052514-1.686-2.549-0.1712.747-8.938-1.371122.4510.5110.545-0.2020.896-0.4441.043-1.1091.601
Percentage of IncreaseDecreaseInOtherOperatingAssets100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0

us-gaap:InvestmentIncomeNet

us-gaap:InvestmentIncomeNet


Investment
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302017-06-302017-03-312016-12-312016-09-302016-06-302016-03-312015-12-312015-09-302015-06-302015-03-312014-12-312014-09-302014-06-302014-03-312013-12-312013-09-302013-06-302013-03-312012-12-312012-09-302012-06-302012-03-312011-12-312011-09-302011-06-302011-03-312010-12-312010-09-302010-06-302010-03-31
Value2.7344.6434.6496.4549.2431013131312119.9635.1343.610.3012.8112.4652.281.5040.9891.4661.4571.3561.1850.9170.8450.6790.6750.6710.6570.6850.4340.5890.3760.3590.4080.4770.60.5180.5750.6160.7050.780.7760.8590.955
Percentage of InvestmentIncomeNet100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0

us-gaap:LitigationSettlementAmountAwardedFromOtherParty us-gaap:TypeOfArrangement

us-gaap:LitigationSettlementAmountAwardedFromOtherParty

ions:CollaborativeArrangementAndLicensingAgreementEnteredIntoInMarch2004WithAlnylamPharmaceuticalsInc


Litigation
Period End2020-12-31
Value41
Percentage of LitigationSettlementAmountAwardedFromOtherParty100.0

us-gaap:MinorityInterestPeriodIncreaseDecrease

us-gaap:MinorityInterestPeriodIncreaseDecrease


Minority
Period End2020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-31
Value-1.155-12.147-11.924-10.25419-7.729-9.1366.442-20.776-13.943-14.663-9.399
Percentage of MinorityInterestPeriodIncreaseDecrease100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0

us-gaap:MinorityInterestPeriodIncreaseDecrease us-gaap:StatementEquityComponents

us-gaap:AccumulatedOtherComprehensiveIncome


Minority
Period End2020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-31
Value0.0140.041-0.4830.00.00.00.00.00.00.00.00.0
Percentage of MinorityInterestPeriodIncreaseDecrease-1.2-0.34.1-0.00.0-0.0-0.00.0-0.0-0.0-0.0-0.0

us-gaap:AdditionalPaidInCapital


Minority
Period End2020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-31
Value1.101-17.803-18.889-6.973-32.23918-17.185-34.246-30.263-22.356-50.134-10.842
Percentage of MinorityInterestPeriodIncreaseDecrease-95.3146.6158.468.0-165.0-238.3188.1-531.6145.7160.3341.9115.4

us-gaap:NoncontrollingInterest


Minority
Period End2020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-31
Value-2.275.6157.448-3.28151-26.1458.049409.4878.413351.443
Percentage of MinorityInterestPeriodIncreaseDecrease196.5-46.2-62.532.0265.0338.3-88.1631.6-45.7-60.3-241.9-15.4

us-gaap:Parent


Minority
Period End2020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-31
Value1.115-17.762-19.372-6.973-32.23918-17.185-34.246-30.263-22.356-50.134-10.842
Percentage of MinorityInterestPeriodIncreaseDecrease-96.5146.2162.568.0-165.0-238.3188.1-531.6145.7160.3341.9115.4

us-gaap:OperatingLeaseRightOfUseAssetAmortizationExpense

us-gaap:OperatingLeaseRightOfUseAssetAmortizationExpense


Operating
Period End2021-06-302021-03-312020-06-302020-03-31
Value387000.0394000.0391000.0393000.0
Percentage of OperatingLeaseRightOfUseAssetAmortizationExpense100.0100.0100.0100.0

us-gaap:OtherComprehensiveIncomeAvailableforsaleSecuritiesAdjustmentNetOfTaxPortionAttributableToParent

us-gaap:OtherComprehensiveIncomeAvailableforsaleSecuritiesAdjustmentNetOfTaxPortionAttributableToParent


Other
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-31
Value-1.697-3.006-2.074-3.44811-1.954-0.033-1.113.4524.3240.5540.1330.563-1.53
Percentage of OtherComprehensiveIncomeAvailableforsaleSecuritiesAdjustmentNetOfTaxPortionAttributableToParent100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0

us-gaap:OtherComprehensiveIncomeAvailableforsaleSecuritiesAdjustmentNetOfTaxPortionAttributableToParent us-gaap:StatementEquityComponents

us-gaap:AccumulatedOtherComprehensiveIncome


Other
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-31
Value-1.697-3.006-2.074-3.44811-1.954-0.033-1.113.4524.3240.5540.1330.563-1.53
Percentage of OtherComprehensiveIncomeAvailableforsaleSecuritiesAdjustmentNetOfTaxPortionAttributableToParent100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0

us-gaap:Parent


Other
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-31
Value-1.697-3.006-2.074-3.44811-1.954-0.033-1.113.4524.3240.5540.1330.563-1.53
Percentage of OtherComprehensiveIncomeAvailableforsaleSecuritiesAdjustmentNetOfTaxPortionAttributableToParent100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0

us-gaap:OtherComprehensiveIncomeForeignCurrencyTransactionAndTranslationGainLossArisingDuringPeriodNetOfTax

us-gaap:OtherComprehensiveIncomeForeignCurrencyTransactionAndTranslationGainLossArisingDuringPeriodNetOfTax


Other
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302017-06-302017-03-312016-12-312016-09-302016-06-302016-03-31
Value104000.0-126000.0260000.0275000.074000.09000.0118000.0-13000.0-96000.084000.0-38000.0-28000.037000.055000.019000.037000.0-42000.0-6000.0-21000.0000
Percentage of OtherComprehensiveIncomeForeignCurrencyTransactionAndTranslationGainLossArisingDuringPeriodNetOfTax100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.00.00.00.0

us-gaap:OtherComprehensiveIncomeForeignCurrencyTransactionAndTranslationGainLossArisingDuringPeriodNetOfTax us-gaap:StatementEquityComponents

us-gaap:AccumulatedOtherComprehensiveIncome


Other
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-31
Value104000.0-126000.0260000.0275000.074000.09000.0118000.0-13000.0-96000.084000.0-38000.0-31000.037000.055000.0
Percentage of OtherComprehensiveIncomeForeignCurrencyTransactionAndTranslationGainLossArisingDuringPeriodNetOfTax100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0110.7100.0100.0

us-gaap:Parent


Other
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-31
Value104000.0-126000.0260000.0275000.074000.09000.0118000.0-13000.0-96000.084000.0-38000.0-31000.037000.055000.0
Percentage of OtherComprehensiveIncomeForeignCurrencyTransactionAndTranslationGainLossArisingDuringPeriodNetOfTax100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0110.7100.0100.0

us-gaap:OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax

us-gaap:OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax


Other
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302017-06-302017-03-312016-12-312016-09-302016-06-302016-03-312015-12-312015-09-302015-06-302015-03-312014-12-312014-09-302014-06-302014-03-312013-12-312013-09-302013-06-302013-03-312012-12-312012-09-302012-06-302012-03-312011-12-312011-09-302011-06-302011-03-312010-12-312010-09-302010-06-30
Value-1.697-3.006-2.074-3.44811-1.954-0.033-1.113.4524.3240.5540.1330.563-1.53-1.5470.1920.130.266-3.761-0.17-10.738-2.554.392-16.157-28.7037.36743-6.994-4.4568.261-7.6232.2079.2026.46711-0.1221.210.5280.383-1.552-0.29-0.26-1.2760.221-0.437
Percentage of OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0

us-gaap:PaymentsForHedgeFinancingActivities

us-gaap:PaymentsForHedgeFinancingActivities


Payments
Period End2021-04-302019-12-31
Value136108
Percentage of PaymentsForHedgeFinancingActivities100.0100.0

us-gaap:PaymentsForHedgeFinancingActivities us-gaap:SubsequentEventType

us-gaap:SubsequentEvent


Payments
Period End2021-04-30
Value136
Percentage of PaymentsForHedgeFinancingActivities100.0

us-gaap:PaymentsForRestructuring us-gaap:RestructuringCostAndReserve

us-gaap:PaymentsForRestructuring

ions:AkceaAcquisition


Payments
Period End2021-06-302021-03-31
Value9.19.0
Percentage of PaymentsForRestructuring100.0100.0

ions:AkceaAcquisitionEmployeeSeveranceAndRetention


Payments
Period End2020-12-31
Value0.6
Percentage of PaymentsForRestructuring0.0

ions:RestructuredEuropeanOperations


Payments
Period End2021-06-302021-03-31
Value1.011
Percentage of PaymentsForRestructuring11.0132.2

ions:RestructuredNorthAmericanTegsediOperations


Payments
Period End2021-06-30
Value7.6
Percentage of PaymentsForRestructuring83.5

ions:UpdatedEuropeanDistributionModelEmployeeSeveranceAndRetention


Payments
Period End2020-12-31
Value0.1
Percentage of PaymentsForRestructuring0.0

us-gaap:PaymentsRelatedToTaxWithholdingForShareBasedCompensation

us-gaap:PaymentsRelatedToTaxWithholdingForShareBasedCompensation


Payments
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-31
Value0.458150.4510.9890.368110.401100.4377.5970.00.00.00.0
Percentage of PaymentsRelatedToTaxWithholdingForShareBasedCompensation100.0100.0100.0100.0100.0100.0100.0100.0100.0100.00.00.00.00.0

us-gaap:PaymentsToAcquireAvailableForSaleSecuritiesDebt

us-gaap:PaymentsToAcquireAvailableForSaleSecuritiesDebt


Payments
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302017-06-302017-03-312016-12-312016-09-302016-06-302016-03-312015-12-312015-09-302015-06-302015-03-312014-12-312014-09-302014-06-302014-03-312013-12-312013-09-302013-06-302013-03-312012-12-312012-09-302012-06-302012-03-312011-12-312011-09-302011-06-302011-03-312010-12-312010-09-30
Value410330193400431544329568556492638507557912882418126666152404195157200401417111069121159796445555461867598110100103
Percentage of PaymentsToAcquireAvailableForSaleSecuritiesDebt100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0

us-gaap:PaymentsToAcquireOtherProductiveAssets

us-gaap:PaymentsToAcquireOtherProductiveAssets


Payments
Period End2021-06-302021-03-312020-06-302020-03-31
Value1954000.01228000.02119000.0904000.0
Percentage of PaymentsToAcquireOtherProductiveAssets100.0100.0100.0100.0

us-gaap:ProceedsFromIssuanceOfSharesUnderIncentiveAndShareBasedCompensationPlansIncludingStockOptions

us-gaap:ProceedsFromIssuanceOfSharesUnderIncentiveAndShareBasedCompensationPlansIncludingStockOptions


Proceeds
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302017-06-302017-03-312016-12-312016-09-302016-06-302016-03-312015-12-312015-09-302015-06-302015-03-312014-12-312014-09-302014-06-302014-03-312013-12-312013-09-302013-06-302013-03-312012-12-312012-09-302012-06-302012-03-312011-12-312011-09-302011-06-302011-03-312010-12-312010-09-302010-06-302010-03-31
Value1.8827.7622128.8017.6527.521034679.6468.0764.5035.6755.2597.7453.6036.3246.1633.1341.3842.7364.6132.243.919145.3624.2931.413126.062025111.6816.1720.9790.6382.0130.6780.1930.6832.320.7540.2511.031
Percentage of ProceedsFromIssuanceOfSharesUnderIncentiveAndShareBasedCompensationPlansIncludingStockOptions100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0

us-gaap:ProceedsFromIssuanceOfWarrants

us-gaap:ProceedsFromIssuanceOfWarrants


Proceeds
Period End2021-04-302019-12-31
Value8956
Percentage of ProceedsFromIssuanceOfWarrants100.0100.0

us-gaap:ProceedsFromIssuanceOfWarrants us-gaap:SubsequentEventType

us-gaap:SubsequentEvent


Proceeds
Period End2021-04-30
Value89
Percentage of ProceedsFromIssuanceOfWarrants100.0

us-gaap:ProceedsFromSaleAndMaturityOfAvailableForSaleSecurities

us-gaap:ProceedsFromSaleAndMaturityOfAvailableForSaleSecurities


Proceeds
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302017-06-302017-03-312016-12-312016-09-302016-06-302016-03-312015-12-312015-09-302015-06-302015-03-312014-12-312014-09-302014-06-302014-03-312013-12-312013-09-302013-06-302013-03-312012-12-312012-09-302012-06-302012-03-312011-12-312011-09-302011-06-302011-03-312010-12-312010-09-30
Value3154113885155224594865874514263142041901732431111039986979881126105109787147809537384749534680611177312717094181
Percentage of ProceedsFromSaleAndMaturityOfAvailableForSaleSecurities100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0

us-gaap:RepaymentsOfConvertibleDebt us-gaap:DebtInstrument

us-gaap:RepaymentsOfConvertibleDebt

ions:ConvertibleSeniorNotes1Percent


Repayments
Period End2021-04-30
Value257
Percentage of RepaymentsOfConvertibleDebt100.0

us-gaap:RepaymentsOfConvertibleDebt us-gaap:DebtInstrument, us-gaap:SubsequentEventType

ions:ConvertibleSeniorNotes1Percent, us-gaap:SubsequentEvent


Repayments
Period End2021-04-30
Value257
Percentage of RepaymentsOfConvertibleDebt100.0

us-gaap:RestructuringCharges us-gaap:IncomeStatementLocation, us-gaap:RestructuringCostAndReserve

us-gaap:RestructuringCharges

ions:ResearchAndDevelopmentExpenses, ions:AkceaAcquisitionEmployeeSeveranceAndRetention


Restructuring
Period End2020-12-31
Value3.9
Percentage of RestructuringCharges100.0

ions:ResearchAndDevelopmentExpenses, ions:UpdatedEuropeanDistributionModelEmployeeSeveranceAndRetention


Restructuring
Period End2020-12-31
Value4.2
Percentage of RestructuringCharges107.7

ions:ResearchDevelopmentAndPatentExpenses, ions:RestructuredNorthAmericanTegsediOperations


Restructuring
Period End2021-06-30
Value2.3
Percentage of RestructuringCharges0.0

us-gaap:SellingGeneralAndAdministrativeExpenses, ions:AkceaAcquisitionEmployeeSeveranceAndRetention


Restructuring
Period End2020-12-31
Value11
Percentage of RestructuringCharges292.3

us-gaap:SellingGeneralAndAdministrativeExpenses, ions:RestructuredNorthAmericanTegsediOperations


Restructuring
Period End2021-06-30
Value7.1
Percentage of RestructuringCharges0.0

us-gaap:SellingGeneralAndAdministrativeExpenses, ions:UpdatedEuropeanDistributionModelEmployeeSeveranceAndRetention


Restructuring
Period End2020-12-31
Value8.3
Percentage of RestructuringCharges212.8

us-gaap:RestructuringCharges us-gaap:RestructuringCostAndReserve

ions:AkceaAcquisition


Restructuring
Period End2021-06-302021-03-31
Value5.16.1
Percentage of RestructuringCharges0.00.0

ions:AkceaAcquisitionEmployeeSeveranceAndRetention


Restructuring
Period End2020-12-31
Value15
Percentage of RestructuringCharges392.3

ions:RestructuredEuropeanOperations


Restructuring
Period End2021-06-302021-03-31
Value0.22.2
Percentage of RestructuringCharges0.00.0

ions:RestructuredNorthAmericanTegsediOperations


Restructuring
Period End2021-06-30
Value9.4
Percentage of RestructuringCharges0.0

ions:UpdatedEuropeanDistributionModelEmployeeSeveranceAndRetention


Restructuring
Period End2020-12-31
Value12
Percentage of RestructuringCharges320.5

us-gaap:RestructuringReserveAccrualAdjustment1 us-gaap:RestructuringCostAndReserve

us-gaap:RestructuringReserveAccrualAdjustment1

ions:RestructuredEuropeanOperations


Restructuring
Period End2021-06-302021-03-31
Value200000.0-1500000.0
Percentage of RestructuringReserveAccrualAdjustment1100.0100.0

us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRate us-gaap:AwardType

us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRate

ions:BoardOfDirectorStockOption


Share
Period End2020-12-312019-12-312019-09-302018-12-312018-03-312017-12-312017-03-312016-12-312015-12-31
Value00-0.00100.02200.01300
Percentage of ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRate0.00.0100.00.0100.00.0100.00.00.0

us-gaap:EmployeeStock


Share
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302017-06-302017-03-312016-12-312016-09-302016-06-302016-03-312015-12-312015-09-302015-06-302015-03-312014-12-312014-09-302014-06-302014-03-312013-12-312013-09-302013-06-302013-03-312012-12-312012-09-302012-06-302012-03-312011-12-31
Value00.100.78900.0110-0.00100.02500.00200.01600.00100.0070-0.00100.0050000.0010000.001-0.0090.00900.001-0.0010.00100.0010
Percentage of ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRate0.00.00.00.00.00.00.0100.00.00.00.00.00.072.70.00.00.053.80.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.0

us-gaap:EmployeeStockOption


Share
Period End2020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302017-06-302017-03-312016-12-312016-09-302016-06-302016-03-312015-12-312015-09-302015-06-302015-03-312014-12-312014-09-302014-06-302014-03-312013-12-312013-09-302013-06-302013-03-312012-12-312012-09-302012-06-302012-03-312011-12-31
Value01.48400.0160-0.00100.0240.00100.0010.0220000.0180000.0150000.0150.001000.0160.001000.010.0010.002-0.0030.0110
Percentage of ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRate0.00.00.00.00.0100.00.00.00.00.00.0100.00.00.00.0138.50.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.0

us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRate us-gaap:AwardType, us-gaap:GranteeStatus

us-gaap:EmployeeStockOption, us-gaap:ShareBasedPaymentArrangementEmployee


Share
Period End2021-06-302021-03-312020-06-302020-03-31
Value00.501.6
Percentage of ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRate0.00.00.00.0

us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRate us-gaap:ConsolidatedEntities, us-gaap:AwardType

ions:AkceaTherapeuticsInc, ions:BoardOfDirectorStockOption


Share
Period End2020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302018-12-312018-09-30
Value00.792-0.0070.0150-0.00100
Percentage of ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRate0.00.00.00.00.0100.00.00.0

ions:AkceaTherapeuticsInc, us-gaap:EmployeeStock


Share
Period End2020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-31
Value00.9900.010-0.00100.02500.00300.016
Percentage of ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRate0.00.00.00.00.0100.00.00.00.00.00.072.7

ions:AkceaTherapeuticsInc, us-gaap:EmployeeStockOption


Share
Period End2020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-31
Value01.087-0.0020.015-0.001-0.00200.0250.001-0.0010.0020.026
Percentage of ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRate0.00.00.00.00.0200.00.00.00.00.00.0118.2

us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsWeightedAverageVolatilityRate us-gaap:AwardType

us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsWeightedAverageVolatilityRate

ions:BoardOfDirectorStockOption


Share
Period End2020-12-312019-12-312019-09-302018-12-312018-03-312017-12-312017-03-312016-12-312015-12-31
Value000.00100.61200.53100
Percentage of ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsWeightedAverageVolatilityRate0.00.0100.00.0100.00.0100.00.00.0

us-gaap:EmployeeStock


Share
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302017-06-302017-03-312016-12-312016-09-302016-06-302016-03-312015-12-312015-09-302015-06-302015-03-312014-12-312014-09-302014-06-302014-03-312013-12-312013-09-302013-06-302013-03-312012-12-312012-09-302012-06-302012-03-312011-12-31
Value039.1047.42800.47200.00100.45500.02900.4440-0.06600.66500.1700.6940-0.04500.562-0.0050.01600.5900.01500.614-0.0510.073-0.0110.4340
Percentage of ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsWeightedAverageVolatilityRate0.00.00.00.00.00.00.0100.00.00.00.00.00.072.50.00.00.0125.20.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.0

us-gaap:EmployeeStockOption


Share
Period End2020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302017-06-302017-03-312016-12-312016-09-302016-06-302016-03-312015-12-312015-09-302015-06-302015-03-312014-12-312014-09-302014-06-302014-03-312013-12-312013-09-302013-06-302013-03-312012-12-312012-09-302012-06-302012-03-312011-12-31
Value-0.258.21100.5890000.603-0.0010-0.0010.632-0.0020-0.0020.6630.0020.0010.0050.5790.0010.0010.0010.535-0.0060.0010.0010.505-0.003-0.00100.5150.0005-0.00450.0050.5060
Percentage of ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsWeightedAverageVolatilityRate0.00.00.00.00.00.00.00.00.00.00.0103.30.00.00.0124.90.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.0

us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsWeightedAverageVolatilityRate us-gaap:AwardType, us-gaap:GranteeStatus

us-gaap:EmployeeStockOption, us-gaap:ShareBasedPaymentArrangementEmployee


Share
Period End2021-06-302021-03-312020-06-302020-03-31
Value-0.355.1058.9
Percentage of ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsWeightedAverageVolatilityRate0.00.00.00.0

us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsWeightedAverageVolatilityRate us-gaap:ConsolidatedEntities, us-gaap:AwardType

ions:AkceaTherapeuticsInc, ions:BoardOfDirectorStockOption


Share
Period End2020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302018-12-312018-09-30
Value074.5470.020.7330-0.00500
Percentage of ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsWeightedAverageVolatilityRate0.00.00.00.00.0-500.00.00.0

ions:AkceaTherapeuticsInc, us-gaap:EmployeeStock


Share
Period End2020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-31
Value071.18100.7190-0.04100.64100.01900.623
Percentage of ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsWeightedAverageVolatilityRate0.00.00.00.00.0-4100.00.00.00.00.00.0101.8

ions:AkceaTherapeuticsInc, us-gaap:EmployeeStockOption


Share
Period End2020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-31
Value074.2550.0090.736-0.002-0.007-0.0010.7640-0.0060.0060.771
Percentage of ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsWeightedAverageVolatilityRate0.00.00.00.00.0-700.00.00.00.00.00.0126.0

us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageGrantDateFairValue us-gaap:AwardType, us-gaap:GranteeStatus

us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageGrantDateFairValue

us-gaap:PerformanceShares, srt:ChiefExecutiveOfficer


Share
Period End2021-06-302021-03-31
Value077.17
Percentage of ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageGrantDateFairValue0.0100.0

us-gaap:RestrictedStockUnitsRSU, us-gaap:ShareBasedPaymentArrangementEmployee


Share
Period End2021-06-302021-03-31
Value-0.6162.02
Percentage of ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageGrantDateFairValue0.080.4

us-gaap:SharebasedCompensationArrangementBySharebasedPaymentAwardAwardVestingRightsPercentage us-gaap:AwardType, us-gaap:GranteeStatus, us-gaap:Vesting

us-gaap:SharebasedCompensationArrangementBySharebasedPaymentAwardAwardVestingRightsPercentage

us-gaap:PerformanceShares, srt:ChiefExecutiveOfficer, us-gaap:ShareBasedCompensationAwardTrancheOne


Sharebased
Period End2021-06-302021-03-31
Value00.333
Percentage of SharebasedCompensationArrangementBySharebasedPaymentAwardAwardVestingRightsPercentage0.0100.0

us-gaap:PerformanceShares, srt:ChiefExecutiveOfficer, us-gaap:ShareBasedCompensationAwardTrancheThree


Sharebased
Period End2021-06-302021-03-31
Value00.333
Percentage of SharebasedCompensationArrangementBySharebasedPaymentAwardAwardVestingRightsPercentage0.0100.0

us-gaap:PerformanceShares, srt:ChiefExecutiveOfficer, us-gaap:ShareBasedCompensationAwardTrancheTwo


Sharebased
Period End2021-06-302021-03-31
Value00.333
Percentage of SharebasedCompensationArrangementBySharebasedPaymentAwardAwardVestingRightsPercentage0.0100.0

us-gaap:SharesPaidForTaxWithholdingForShareBasedCompensation us-gaap:StatementEquityComponents

us-gaap:SharesPaidForTaxWithholdingForShareBasedCompensation

us-gaap:CommonStock


Shares
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-31
Value10000.0251000.08000.016000.07000.0186000.07000.011000.05000.0130000.0
Percentage of SharesPaidForTaxWithholdingForShareBasedCompensation100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0

us-gaap:StockIssuedDuringPeriodSharesShareBasedCompensation us-gaap:StatementEquityComponents

us-gaap:StockIssuedDuringPeriodSharesShareBasedCompensation

us-gaap:CommonStock


Stock
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-31
Value108000.0809000.0580000.0321000.0214000.0606000.0245000.0255000.0774000.01825000.0422000.0350000.0206000.0473000.0
Percentage of StockIssuedDuringPeriodSharesShareBasedCompensation100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0

us-gaap:StockIssuedDuringPeriodValueShareBasedCompensationGross

us-gaap:StockIssuedDuringPeriodValueShareBasedCompensationGross


Stock
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-31
Value1.8827.75922128.87.6527.522103467136.2262.9125.664
Percentage of StockIssuedDuringPeriodValueShareBasedCompensationGross100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0

us-gaap:StockIssuedDuringPeriodValueShareBasedCompensationGross us-gaap:StatementEquityComponents

us-gaap:AdditionalPaidInCapital


Stock
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-31
Value1.8827.75822128.87.6527.522103467136.2252.9115.664
Percentage of StockIssuedDuringPeriodValueShareBasedCompensationGross100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0

us-gaap:CommonStock


Stock
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-31
Value0.00.0010.00.0010.00.00.00.0010.00.0020.00.0010.0010.0
Percentage of StockIssuedDuringPeriodValueShareBasedCompensationGross0.00.00.00.00.00.00.00.00.00.00.00.00.00.0

us-gaap:Parent


Stock
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-31
Value1.8827.75922128.87.6527.522103467136.2262.9125.664
Percentage of StockIssuedDuringPeriodValueShareBasedCompensationGross100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0

us-gaap:StockRepurchasedAndRetiredDuringPeriodShares us-gaap:StatementEquityComponents

us-gaap:StockRepurchasedAndRetiredDuringPeriodShares

us-gaap:CommonStock


Stock
Period End2020-12-312020-09-302020-06-302020-03-31
Value0001478000.0
Percentage of StockRepurchasedAndRetiredDuringPeriodShares0.00.00.0100.0

us-gaap:StockRepurchasedAndRetiredDuringPeriodValue

us-gaap:StockRepurchasedAndRetiredDuringPeriodValue


Stock
Period End2020-12-312020-09-302020-06-302020-03-31
Value-0.0010.00.090
Percentage of StockRepurchasedAndRetiredDuringPeriodValue100.00.00.0100.0

us-gaap:StockRepurchasedAndRetiredDuringPeriodValue us-gaap:StatementEquityComponents

us-gaap:CommonStock


Stock
Period End2020-12-312020-09-302020-06-302020-03-31
Value0.00.00.00.001
Percentage of StockRepurchasedAndRetiredDuringPeriodValue-0.00.00.00.0

us-gaap:Parent


Stock
Period End2020-12-312020-09-302020-06-302020-03-31
Value-0.0010.00.090
Percentage of StockRepurchasedAndRetiredDuringPeriodValue100.00.00.0100.0

us-gaap:RetainedEarnings


Stock
Period End2020-12-312020-09-302020-06-302020-03-31
Value-0.0010.00.090
Percentage of StockRepurchasedAndRetiredDuringPeriodValue100.00.00.0100.0

us-gaap:ValuationAllowancesAndReservesPeriodIncreaseDecrease

us-gaap:ValuationAllowancesAndReservesPeriodIncreaseDecrease


Valuation
Period End2020-12-31
Value313
Percentage of ValuationAllowancesAndReservesPeriodIncreaseDecrease100.0

ions:AccruedClinicalExpenses

ions:AccruedClinicalExpenses


Accrued
Period End2020-12-312019-12-312018-12-312017-12-312016-12-31
Value3924221623
Percentage of AccruedClinicalExpenses100.0100.0100.0100.0100.0

ions:AccruedCommercialExpensesCurrent

ions:AccruedCommercialExpensesCurrent


Accrued
Period End2020-12-312019-12-31
Value116.02
Percentage of AccruedCommercialExpensesCurrent100.0100.0

ions:AccruedInLicensingFeesCurrent

ions:AccruedInLicensingFeesCurrent


Accrued
Period End2020-12-312019-12-312018-12-312017-12-312016-12-31
Value8.2641012336.43
Percentage of AccruedInLicensingFeesCurrent100.0100.0100.0100.0100.0

ions:AvailableForSaleSecuritiesDebtMaturitiesAfterOneThroughTwoYearsPercentage

ions:AvailableForSaleSecuritiesDebtMaturitiesAfterOneThroughTwoYearsPercentage


Available
Period End2021-06-302021-03-312020-12-312020-09-30
Value27.020.018.020.0
Percentage of AvailableForSaleSecuritiesDebtMaturitiesAfterOneThroughTwoYearsPercentage100.0100.0100.0100.0

ions:AvailableForSaleSecuritiesDebtMaturitiesAfterTwoThroughThreeAndOneHalfYearsPercentage

ions:AvailableForSaleSecuritiesDebtMaturitiesAfterTwoThroughThreeAndOneHalfYearsPercentage


Available
Period End2021-06-302021-03-312020-12-31
Value13.013.09.0
Percentage of AvailableForSaleSecuritiesDebtMaturitiesAfterTwoThroughThreeAndOneHalfYearsPercentage100.0100.0100.0

ions:AvailableForSaleSecuritiesDebtMaturitiesAfterTwoThroughThreeYearsPercentage

ions:AvailableForSaleSecuritiesDebtMaturitiesAfterTwoThroughThreeYearsPercentage


Available
Period End2020-09-30
Value9.0
Percentage of AvailableForSaleSecuritiesDebtMaturitiesAfterTwoThroughThreeYearsPercentage100.0

ions:AvailableForSaleSecuritiesDebtMaturitiesWithinOneYearPercentage

ions:AvailableForSaleSecuritiesDebtMaturitiesWithinOneYearPercentage


Available
Period End2021-06-302021-03-312020-12-312020-09-30
Value60.067.073.071.0
Percentage of AvailableForSaleSecuritiesDebtMaturitiesWithinOneYearPercentage100.0100.0100.0100.0

ions:AvailableForSaleSecuritiesDebtMaturitiesWithinTwoYearsPercentage

ions:AvailableForSaleSecuritiesDebtMaturitiesWithinTwoYearsPercentage


Available
Period End2021-06-302021-03-312020-12-312020-09-30
Value87.087.091.091.0
Percentage of AvailableForSaleSecuritiesDebtMaturitiesWithinTwoYearsPercentage100.0100.0100.0100.0

ions:CumulativePaymentsIncludedInTransactionPriceForPerformanceObligation us-gaap:ProductOrService, us-gaap:TypeOfArrangement

ions:CumulativePaymentsIncludedInTransactionPriceForPerformanceObligation

ions:ResearchAndDevelopmentRevenueUnderCollaborativeAgreements, ions:CollaborativeArrangementAndLicensingAgreementEnteredIntoInJuly2015WithAstrazeneca


Cumulative
Period End2020-12-31
Value90
Percentage of CumulativePaymentsIncludedInTransactionPriceForPerformanceObligation100.0

ions:CumulativePaymentsIncludedInTransactionPriceForPerformanceObligation us-gaap:TypeOfArrangement

ions:CollaborativeArrangementAndLicensingAgreementEnteredIntoInApril2018WithBiogen


Cumulative
Period End2020-12-312019-12-31
Value608597
Percentage of CumulativePaymentsIncludedInTransactionPriceForPerformanceObligation675.60.0

ions:CumulativePaymentsReceived us-gaap:Range, us-gaap:TypeOfArrangement

ions:CumulativePaymentsReceived

srt:Maximum, ions:CollaborativeArrangementAndLicensingAgreementEnteredIntoInJanuary2017WithNovartis


Cumulative
Period End2021-06-30
Value400
Percentage of CumulativePaymentsReceived100.0

srt:Minimum, ions:CollaborativeArrangementAndLicensingAgreementEnteredIntoInDecember2012WithAstrazeneca


Cumulative
Period End2020-12-31
Value140
Percentage of CumulativePaymentsReceived0.0

srt:Minimum, ions:CollaborativeArrangementAndLicensingAgreementEnteredIntoInDecember2014WithJanssenBiotechInc


Cumulative
Period End2020-12-312019-12-31
Value8075
Percentage of CumulativePaymentsReceived0.00.0

srt:Minimum, ions:CollaborativeArrangementAndLicensingAgreementEnteredIntoInJuly2015WithAstrazeneca


Cumulative
Period End2020-12-31
Value235
Percentage of CumulativePaymentsReceived0.0

srt:Minimum, ions:CollaborativeArrangementAndLicensingAgreementEnteredIntoInMarch2010WithGlaxoSmithKline


Cumulative
Period End2020-12-31
Value190
Percentage of CumulativePaymentsReceived0.0

srt:Minimum, ions:CollaborativeArrangementAndLicensingAgreementEnteredIntoInMay2015WithBayer


Cumulative
Period End2020-12-31
Value185
Percentage of CumulativePaymentsReceived0.0

srt:Minimum, ions:CollaborativeArrangementAndLicensingAgreementEnteredIntoInOctober2019WithPfizer


Cumulative
Period End2020-12-312020-09-30
Value330255
Percentage of CumulativePaymentsReceived0.00.0

srt:Minimum, ions:CollaborativeArrangementAndLicensingAgreementEnteredIntoInSeptember2013WithBiogen


Cumulative
Period End2020-12-31
Value270
Percentage of CumulativePaymentsReceived0.0

srt:Minimum, ions:CollaborativeArrangementsAndLicensingAgreementsAstrazeneca


Cumulative
Period End2020-12-31
Value380
Percentage of CumulativePaymentsReceived0.0

srt:Minimum, ions:CollaborativeArrangementsAndLicensingAgreementsBiogen


Cumulative
Period End2020-12-312020-09-30
Value28002700
Percentage of CumulativePaymentsReceived0.00.0

ions:CumulativePaymentsReceived us-gaap:TypeOfArrangement

ions:CollaborativeArrangementAndLicensingAgreementEnteredIntoInApril2013WithRoche


Cumulative
Period End2020-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312016-12-31
Value1502202202201121101071056053
Percentage of CumulativePaymentsReceived0.00.00.00.00.00.00.00.00.00.0

ions:CollaborativeArrangementAndLicensingAgreementEnteredIntoInApril2018WithBiogen


Cumulative
Period End2020-12-312019-12-312018-12-31
Value105010001000
Percentage of CumulativePaymentsReceived0.00.00.0

ions:CollaborativeArrangementAndLicensingAgreementEnteredIntoInAugust2018WithPtcTherapeutics


Cumulative
Period End2020-12-31
Value22
Percentage of CumulativePaymentsReceived0.0

ions:CollaborativeArrangementAndLicensingAgreementEnteredIntoInDecember2012WithBiogen


Cumulative
Period End2020-12-312019-12-312018-12-312018-09-302018-06-302018-03-31
Value15413058585858
Percentage of CumulativePaymentsReceived0.00.00.00.00.00.0

ions:CollaborativeArrangementAndLicensingAgreementEnteredIntoInDecember2014WithJanssenBiotechInc


Cumulative
Period End2020-09-302018-12-312018-09-302018-06-302018-03-312017-12-312016-12-31
Value80757572726147
Percentage of CumulativePaymentsReceived0.00.00.00.00.00.00.0

ions:CollaborativeArrangementAndLicensingAgreementEnteredIntoInJanuary2017WithNovartis


Cumulative
Period End2020-12-31
Value249
Percentage of CumulativePaymentsReceived0.0

ions:CollaborativeArrangementsAndLicensingAgreementsAstrazeneca


Cumulative
Period End2020-09-302020-06-30
Value330300
Percentage of CumulativePaymentsReceived0.00.0

ions:CollaborativeArrangementsAndLicensingAgreementsBiogen


Cumulative
Period End2021-06-302021-03-312020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312016-12-31
Value30002900260025002400230022002100200019001800800745500
Percentage of CumulativePaymentsReceived750.00.00.00.00.00.00.00.00.00.00.00.00.00.0

ions:CumulativeRevenueFromContractWithCustomerExcludingAssessedTax us-gaap:ProductOrService, us-gaap:Range, us-gaap:TypeOfArrangement

ions:CumulativeRevenueFromContractWithCustomerExcludingAssessedTax

ions:ResearchAndDevelopmentRevenueUnderCollaborativeAgreements, srt:Minimum, ions:CollaborativeArrangementAndLicensingAgreementEnteredIntoInJanuary2012WithBiogen


Cumulative
Period End2020-12-31
Value435
Percentage of CumulativeRevenueFromContractWithCustomerExcludingAssessedTax100.0

ions:SpinrazaRoyalties, srt:Minimum, ions:CollaborativeArrangementAndLicensingAgreementEnteredIntoInJanuary2012WithBiogen


Cumulative
Period End2020-12-31
Value930
Percentage of CumulativeRevenueFromContractWithCustomerExcludingAssessedTax213.8

ions:CumulativeRevenueFromContractWithCustomerExcludingAssessedTax us-gaap:Range, us-gaap:TypeOfArrangement

srt:Minimum, ions:CollaborativeArrangementAndLicensingAgreementEnteredIntoInJanuary2012WithBiogen


Cumulative
Period End2020-12-312019-12-31
Value13001000
Percentage of CumulativeRevenueFromContractWithCustomerExcludingAssessedTax298.90.0

ions:DebtInstrumentConvertibleConversionPriceIncludingCallSpread us-gaap:DebtInstrument

ions:DebtInstrumentConvertibleConversionPriceIncludingCallSpread

ions:ConvertibleSeniorNotes0Percent


Debt
Period End2021-06-30
Value76.39
Percentage of DebtInstrumentConvertibleConversionPriceIncludingCallSpread100.0

ions:DebtInstrumentConvertibleConversionPriceIncludingCallSpread us-gaap:DebtInstrument, us-gaap:SubsequentEventType

ions:ConvertibleSeniorNotes0Percent, us-gaap:SubsequentEvent


Debt
Period End2021-04-30
Value76.39
Percentage of DebtInstrumentConvertibleConversionPriceIncludingCallSpread0.0

ions:DebtInstrumentConvertibleSharesSubjectToConversion us-gaap:DebtInstrument

ions:DebtInstrumentConvertibleSharesSubjectToConversion

ions:ConvertibleSeniorNotes0Percent


Debt
Period End2021-06-30
Value10
Percentage of DebtInstrumentConvertibleSharesSubjectToConversion100.0

ions:ConvertibleSeniorNotes1Percent


Debt
Period End2021-06-302021-03-31
Value0.94.6
Percentage of DebtInstrumentConvertibleSharesSubjectToConversion8.30.0

ions:DebtInstrumentConvertibleSharesSubjectToConversion us-gaap:DebtInstrument, us-gaap:SubsequentEventType

ions:ConvertibleSeniorNotes0Percent, us-gaap:SubsequentEvent


Debt
Period End2021-04-30
Value10
Percentage of DebtInstrumentConvertibleSharesSubjectToConversion0.0

ions:ConvertibleSeniorNotes1Percent, us-gaap:SubsequentEvent


Debt
Period End2021-04-30
Value0.9
Percentage of DebtInstrumentConvertibleSharesSubjectToConversion0.0

ions:DebtSecuritiesAvailableForSaleAndEquitySecuritiesFvNi

ions:DebtSecuritiesAvailableForSaleAndEquitySecuritiesFvNi


Debt
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302018-12-31
Value1535145015551745194320231849199320151871
Percentage of DebtSecuritiesAvailableForSaleAndEquitySecuritiesFvNi100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0

ions:DebtSecuritiesAvailableForSaleAndEquitySecuritiesFvNiCost

ions:DebtSecuritiesAvailableForSaleAndEquitySecuritiesFvNiCost


Debt
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302018-12-31
Value1516143015331727192020231846198820121874
Percentage of DebtSecuritiesAvailableForSaleAndEquitySecuritiesFvNiCost100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0

ions:DebtSecuritiesAvailableForSaleAndEquitySecuritiesFvNiGrossUnrealizedGain

ions:DebtSecuritiesAvailableForSaleAndEquitySecuritiesFvNiGrossUnrealizedGain


Debt
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302018-12-31
Value21212421257.0075.0075.3074.8680.556
Percentage of DebtSecuritiesAvailableForSaleAndEquitySecuritiesFvNiGrossUnrealizedGain100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0

ions:DebtSecuritiesAvailableForSaleAndEquitySecuritiesFvNiGrossUnrealizedLoss

ions:DebtSecuritiesAvailableForSaleAndEquitySecuritiesFvNiGrossUnrealizedLoss


Debt
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302018-12-31
Value2080000.02110000.02821000.02735000.02514000.07463000.01166000.01185000.01028000.04068000.0
Percentage of DebtSecuritiesAvailableForSaleAndEquitySecuritiesFvNiGrossUnrealizedLoss100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0

ions:DeferredTaxAssetsLiabilitiesNetBeforeValuationAllowance

ions:DeferredTaxAssetsLiabilitiesNetBeforeValuationAllowance


Deferred
Period End2020-12-312019-12-312018-12-312017-12-312016-12-312015-12-312014-12-31
Value633502525456452404315
Percentage of DeferredTaxAssetsLiabilitiesNetBeforeValuationAllowance100.0100.0100.0100.0100.0100.0100.0

ions:EmployeeStockPurchasePlanSharesAvailableForPurchase us-gaap:PlanName

ions:EmployeeStockPurchasePlanSharesAvailableForPurchase

ions:EmployeeStockPurchasePlan


Employee
Period End2020-12-31
Value700000.0
Percentage of EmployeeStockPurchasePlanSharesAvailableForPurchase100.0

ions:IncreaseDecreaseInFungibleShareReserveForEachShareIssuedPursuantToFullValueAward us-gaap:PlanName

ions:IncreaseDecreaseInFungibleShareReserveForEachShareIssuedPursuantToFullValueAward

ions:EquityIncentivePlan2011


Increase
Period End2021-06-30
Value-1.7
Percentage of IncreaseDecreaseInFungibleShareReserveForEachShareIssuedPursuantToFullValueAward100.0

ions:IncreaseDecreaseInFungibleShareReserveForEachShareReturningFromFullValueAward us-gaap:PlanName

ions:IncreaseDecreaseInFungibleShareReserveForEachShareReturningFromFullValueAward

ions:EquityIncentivePlan2011


Increase
Period End2021-06-30
Value1.7
Percentage of IncreaseDecreaseInFungibleShareReserveForEachShareReturningFromFullValueAward100.0

ions:LeasesAndOtherObligations

ions:LeasesAndOtherObligations


Leases
Period End2020-12-312019-12-31
Value3017
Percentage of LeasesAndOtherObligations100.0100.0

ions:LesseeOperatingLeaseAllowanceForTenantImprovements us-gaap:ConsolidatedEntities, us-gaap:GeographicDistribution

ions:LesseeOperatingLeaseAllowanceForTenantImprovements

ions:AkceaTherapeuticsInc, ions:BostonOfficeSpace


Lessee
Period End2020-12-31
Value3800000.0
Percentage of LesseeOperatingLeaseAllowanceForTenantImprovements100.0

ions:LesseeOperatingLeaseInitialLetterOfCreditToSecureLeaseObligation us-gaap:ConsolidatedEntities, us-gaap:GeographicDistribution

ions:LesseeOperatingLeaseInitialLetterOfCreditToSecureLeaseObligation

ions:AkceaTherapeuticsInc, ions:BostonOfficeSpace


Lessee
Period End2020-12-31
Value2400000.0
Percentage of LesseeOperatingLeaseInitialLetterOfCreditToSecureLeaseObligation100.0

ions:LesseeOperatingLeaseLetterOfCreditToSecureLeaseObligationOnFifthAnniversaryOfRentCommencementDate us-gaap:ConsolidatedEntities, us-gaap:GeographicDistribution

ions:LesseeOperatingLeaseLetterOfCreditToSecureLeaseObligationOnFifthAnniversaryOfRentCommencementDate

ions:AkceaTherapeuticsInc, ions:BostonOfficeSpace


Lessee
Period End2020-12-31
Value1200000.0
Percentage of LesseeOperatingLeaseLetterOfCreditToSecureLeaseObligationOnFifthAnniversaryOfRentCommencementDate100.0

ions:LesseeOperatingLeaseLetterOfCreditToSecureLeaseObligationOnThirdAnniversaryOfRentCommencementDate us-gaap:ConsolidatedEntities, us-gaap:GeographicDistribution

ions:LesseeOperatingLeaseLetterOfCreditToSecureLeaseObligationOnThirdAnniversaryOfRentCommencementDate

ions:AkceaTherapeuticsInc, ions:BostonOfficeSpace


Lessee
Period End2020-12-31
Value1800000.0
Percentage of LesseeOperatingLeaseLetterOfCreditToSecureLeaseObligationOnThirdAnniversaryOfRentCommencementDate100.0

ions:LongTermDebtAndLeaseObligationCurrentAndOtherCurrentLiabilities

ions:LongTermDebtAndLeaseObligationCurrentAndOtherCurrentLiabilities


Long
Period End2020-09-302020-06-302020-03-312019-12-31
Value5849000.04966000.04150000.02026000.0
Percentage of LongTermDebtAndLeaseObligationCurrentAndOtherCurrentLiabilities100.0100.0100.0100.0

ions:LongTermObligationsCurrent

ions:LongTermObligationsCurrent


Long
Period End2021-06-302021-03-312020-12-312019-12-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302017-06-302017-03-312016-12-312015-12-312014-12-31
Value7.9727.6887.3012.02613141.1640.0471.6210.06210.0561.1859.0292.882
Percentage of LongTermObligationsCurrent100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0

ions:LongTermObligationsNoncurrent

ions:LongTermObligationsNoncurrent


Long
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302017-06-302017-03-312016-12-312016-09-302016-06-302016-03-312015-12-312014-12-31
Value222223151515151616164.9145.13814121213151514142.422.3722.3417.669
Percentage of LongTermObligationsNoncurrent100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0

ions:MaximumAmountOfPaymentReceivableForEachAdditionalDrugDeveloped us-gaap:TypeOfArrangement

ions:MaximumAmountOfPaymentReceivableForEachAdditionalDrugDeveloped

ions:CollaborativeArrangementAndLicensingAgreementEnteredIntoInApril2013WithRoche


Maximum
Period End2020-12-31
Value136
Percentage of MaximumAmountOfPaymentReceivableForEachAdditionalDrugDeveloped100.0

ions:MaximumAmountOfPaymentsReceivableForCommercializationMilestones us-gaap:TypeOfArrangement

ions:MaximumAmountOfPaymentsReceivableForCommercializationMilestones

ions:CollaborativeArrangementAndLicensingAgreementEnteredIntoInDecember2014WithJanssenBiotechInc


Maximum
Period End2020-12-312019-12-312018-12-312018-09-302018-06-302018-03-312017-12-312016-12-31
Value6060180180180180180180
Percentage of MaximumAmountOfPaymentsReceivableForCommercializationMilestones100.0100.0100.0100.0100.0100.0100.0100.0

ions:CollaborativeArrangementAndLicensingAgreementEnteredIntoInJanuary2017WithNovartis


Maximum
Period End2020-12-31
Value360
Percentage of MaximumAmountOfPaymentsReceivableForCommercializationMilestones600.0

ions:CollaborativeArrangementAndLicensingAgreementEnteredIntoInJuly2015WithAstrazeneca


Maximum
Period End2020-12-31
Value1500
Percentage of MaximumAmountOfPaymentsReceivableForCommercializationMilestones2500.0

ions:CollaborativeArrangementAndLicensingAgreementEnteredIntoInMarch2010WithGlaxoSmithKline


Maximum
Period End2020-12-31
Value70
Percentage of MaximumAmountOfPaymentsReceivableForCommercializationMilestones116.7

ions:CollaborativeArrangementAndLicensingAgreementEnteredIntoInOctober2019WithPfizer


Maximum
Period End2020-12-31
Value850
Percentage of MaximumAmountOfPaymentsReceivableForCommercializationMilestones1416.7

ions:MaximumAmountOfPaymentsReceivableForDevelopmentMilestones us-gaap:TypeOfArrangement

ions:MaximumAmountOfPaymentsReceivableForDevelopmentMilestones

ions:CollaborativeArrangementAndLicensingAgreementEnteredIntoInDecember2012WithAstrazeneca


Maximum
Period End2020-12-31
Value107
Percentage of MaximumAmountOfPaymentsReceivableForDevelopmentMilestones100.0

ions:CollaborativeArrangementAndLicensingAgreementEnteredIntoInDecember2014WithJanssenBiotechInc


Maximum
Period End2020-12-312019-12-312018-12-312018-09-302018-06-302018-03-312017-12-312016-12-31
Value6565175175175175175175
Percentage of MaximumAmountOfPaymentsReceivableForDevelopmentMilestones60.70.00.00.00.00.00.00.0

ions:CollaborativeArrangementAndLicensingAgreementEnteredIntoInJanuary2017WithNovartis


Maximum
Period End2020-12-31
Value25
Percentage of MaximumAmountOfPaymentsReceivableForDevelopmentMilestones23.4

ions:CollaborativeArrangementAndLicensingAgreementEnteredIntoInJuly2015WithAstrazeneca


Maximum
Period End2020-12-31
Value1100
Percentage of MaximumAmountOfPaymentsReceivableForDevelopmentMilestones1028.0

ions:CollaborativeArrangementAndLicensingAgreementEnteredIntoInMarch2010WithGlaxoSmithKline


Maximum
Period End2020-12-31
Value47
Percentage of MaximumAmountOfPaymentsReceivableForDevelopmentMilestones44.4

ions:CollaborativeArrangementAndLicensingAgreementEnteredIntoInOctober2019WithPfizer


Maximum
Period End2020-12-31
Value205
Percentage of MaximumAmountOfPaymentsReceivableForDevelopmentMilestones191.6

ions:MaximumAmountOfPaymentsReceivableForDevelopmentRegulatoryAndSalesMilestones us-gaap:TypeOfArrangement

ions:MaximumAmountOfPaymentsReceivableForDevelopmentRegulatoryAndSalesMilestones

ions:CollaborativeArrangementAndLicensingAgreementEnteredIntoInOctober2019WithPfizer


Maximum
Period End2020-12-31
Value1300
Percentage of MaximumAmountOfPaymentsReceivableForDevelopmentRegulatoryAndSalesMilestones100.0

ions:MaximumAmountOfPaymentsReceivableForLicenseFeesAndMilestones us-gaap:TypeOfArrangement

ions:MaximumAmountOfPaymentsReceivableForLicenseFeesAndMilestones

ions:CollaborativeArrangementAndLicensingAgreementEnteredIntoInApril2013WithRoche


Maximum
Period End2020-12-31
Value365
Percentage of MaximumAmountOfPaymentsReceivableForLicenseFeesAndMilestones100.0

ions:CollaborativeArrangementAndLicensingAgreementEnteredIntoInDecember2017WithBiogen


Maximum
Period End2020-12-31
Value1200
Percentage of MaximumAmountOfPaymentsReceivableForLicenseFeesAndMilestones328.8

ions:CollaborativeArrangementAndLicensingAgreementEnteredIntoInMarch2010WithGlaxoSmithKline


Maximum
Period End2020-12-31
Value262
Percentage of MaximumAmountOfPaymentsReceivableForLicenseFeesAndMilestones71.8

ions:CollaborativeArrangementAndLicensingAgreementEnteredIntoInMay2015WithBayer


Maximum
Period End2020-12-31
Value385
Percentage of MaximumAmountOfPaymentsReceivableForLicenseFeesAndMilestones105.5

ions:CollaborativeArrangementAndLicensingAgreementEnteredIntoInOctober2018WithRoche


Maximum
Period End2020-12-31
Value684
Percentage of MaximumAmountOfPaymentsReceivableForLicenseFeesAndMilestones187.4

ions:MaximumAmountOfPaymentsReceivableForMilestones us-gaap:TypeOfArrangement

ions:MaximumAmountOfPaymentsReceivableForMilestones

ions:CollaborativeArrangementAndLicensingAgreementEnteredIntoInJanuary2017WithNovartis


Maximum
Period End2020-12-31
Value675
Percentage of MaximumAmountOfPaymentsReceivableForMilestones100.0

ions:MaximumAmountOfPaymentsReceivableForRegulatoryMilestones us-gaap:TypeOfArrangement

ions:MaximumAmountOfPaymentsReceivableForRegulatoryMilestones

ions:CollaborativeArrangementAndLicensingAgreementEnteredIntoInDecember2012WithAstrazeneca


Maximum
Period End2020-12-31
Value105
Percentage of MaximumAmountOfPaymentsReceivableForRegulatoryMilestones100.0

ions:CollaborativeArrangementAndLicensingAgreementEnteredIntoInDecember2014WithJanssenBiotechInc


Maximum
Period End2020-12-312019-12-312018-12-312018-09-302018-06-302018-03-312017-12-312016-12-31
Value160160440440440440440420
Percentage of MaximumAmountOfPaymentsReceivableForRegulatoryMilestones152.40.00.00.00.00.00.00.0

ions:CollaborativeArrangementAndLicensingAgreementEnteredIntoInJanuary2017WithNovartis


Maximum
Period End2020-12-31
Value290
Percentage of MaximumAmountOfPaymentsReceivableForRegulatoryMilestones276.2

ions:CollaborativeArrangementAndLicensingAgreementEnteredIntoInJuly2015WithAstrazeneca


Maximum
Period End2020-12-31
Value2900
Percentage of MaximumAmountOfPaymentsReceivableForRegulatoryMilestones2761.9

ions:CollaborativeArrangementAndLicensingAgreementEnteredIntoInMarch2010WithGlaxoSmithKline


Maximum
Period End2020-12-31
Value120
Percentage of MaximumAmountOfPaymentsReceivableForRegulatoryMilestones114.3

ions:CollaborativeArrangementAndLicensingAgreementEnteredIntoInOctober2019WithPfizer


Maximum
Period End2020-12-31
Value250
Percentage of MaximumAmountOfPaymentsReceivableForRegulatoryMilestones238.1

ions:MaximumAmountOfPaymentsReceivableForSalesMilestones us-gaap:TypeOfArrangement

ions:MaximumAmountOfPaymentsReceivableForSalesMilestones

ions:CollaborativeArrangementAndLicensingAgreementEnteredIntoInDecember2017WithBiogen


Maximum
Period End2020-12-31
Value800
Percentage of MaximumAmountOfPaymentsReceivableForSalesMilestones100.0

ions:MaximumAmountOfPaymentsReceivablePerDrugForSubstantiveMilestonePayments us-gaap:TypeOfArrangement

ions:MaximumAmountOfPaymentsReceivablePerDrugForSubstantiveMilestonePayments

ions:CollaborativeArrangementAndLicensingAgreementEnteredIntoInApril2018WithBiogen


Maximum
Period End2020-12-31
Value270
Percentage of MaximumAmountOfPaymentsReceivablePerDrugForSubstantiveMilestonePayments100.0

ions:MaximumPaymentReceivableUnderLicenseAgreement us-gaap:TypeOfArrangement

ions:MaximumPaymentReceivableUnderLicenseAgreement

ions:CollaborativeArrangementAndLicensingAgreementEnteredIntoInAugust2018WithPtcTherapeutics


Maximum
Period End2020-12-31
Value26
Percentage of MaximumPaymentReceivableUnderLicenseAgreement100.0

ions:MinimumAmountOfPaymentsReceivableForLicenseFeesAndSubstantiveMilestones us-gaap:TypeOfArrangement

ions:MinimumAmountOfPaymentsReceivableForLicenseFeesAndSubstantiveMilestones

ions:CollaborativeArrangementAndLicensingAgreementEnteredIntoInDecember2012WithAstrazeneca


Minimum
Period End2020-12-31
Value265
Percentage of MinimumAmountOfPaymentsReceivableForLicenseFeesAndSubstantiveMilestones100.0

ions:CollaborativeArrangementAndLicensingAgreementEnteredIntoInDecember2014WithJanssenBiotechInc


Minimum
Period End2020-12-312019-12-312018-12-312018-09-302018-06-302018-03-31
Value285285800800800800
Percentage of MinimumAmountOfPaymentsReceivableForLicenseFeesAndSubstantiveMilestones107.50.00.00.00.00.0

ions:CollaborativeArrangementAndLicensingAgreementEnteredIntoInJuly2015WithAstrazeneca


Minimum
Period End2020-12-31
Value5500
Percentage of MinimumAmountOfPaymentsReceivableForLicenseFeesAndSubstantiveMilestones2075.5

ions:NextPotentialMilestonePayment us-gaap:Range, us-gaap:StatementScenario, us-gaap:TypeOfArrangement

ions:NextPotentialMilestonePayment

srt:Maximum, us-gaap:ScenarioPlan, ions:CollaborativeArrangementAndLicensingAgreementEnteredIntoInJanuary2017WithNovartis


Next
Period End2021-08-04
Value75
Percentage of NextPotentialMilestonePayment100.0

ions:NextPotentialMilestonePayment us-gaap:SubsequentEventType, us-gaap:TypeOfArrangement

us-gaap:SubsequentEvent, ions:CollaborativeArrangementAndLicensingAgreementEnteredIntoInOctober2019WithPfizer


Next
Period End2020-10-31
Value50
Percentage of NextPotentialMilestonePayment0.0

ions:NextPotentialPayment us-gaap:ProductOrService, us-gaap:Range, us-gaap:SubsequentEventType, us-gaap:TypeOfArrangement

ions:NextPotentialPayment

ions:IonisMapt, srt:Maximum, us-gaap:SubsequentEvent, ions:CollaborativeArrangementAndLicensingAgreementEnteredIntoInDecember2012WithBiogen


Next
Period End2020-08-05
Value25
Percentage of NextPotentialPayment100.0

ions:NextPotentialPayment us-gaap:Range, us-gaap:SubsequentEventType, us-gaap:TypeOfArrangement

srt:Maximum, us-gaap:SubsequentEvent, ions:CollaborativeArrangementAndLicensingAgreementEnteredIntoInSeptember2013WithBiogen


Next
Period End2020-07-31
Value10.0
Percentage of NextPotentialPayment0.0

ions:NextPotentialPayment us-gaap:Range, us-gaap:TypeOfArrangement

srt:Maximum, ions:CollaborativeArrangementAndLicensingAgreementEnteredIntoInDecember2012WithBiogen


Next
Period End2020-09-30
Value25
Percentage of NextPotentialPayment0.0

srt:Maximum, ions:CollaborativeArrangementAndLicensingAgreementEnteredIntoInSeptember2013WithBiogen


Next
Period End2020-09-30
Value10.0
Percentage of NextPotentialPayment0.0

ions:NextPotentialPayment us-gaap:StatementScenario, us-gaap:TypeOfArrangement

us-gaap:ScenarioPlan, ions:CollaborativeArrangementAndLicensingAgreementEnteredIntoInSeptember2013WithBiogen


Next
Period End2021-04-30
Value8.0
Percentage of NextPotentialPayment0.0

ions:NextPotentialPayment us-gaap:SubsequentEventType, us-gaap:TypeOfArrangement

us-gaap:SubsequentEvent, ions:CollaborativeArrangementAndLicensingAgreementEnteredIntoInDecember2014WithJanssenBiotechInc


Next
Period End2020-07-31
Value5.0
Percentage of NextPotentialPayment0.0

ions:NextPotentialPayment us-gaap:TypeOfArrangement

ions:CollaborativeArrangementAndLicensingAgreementEnteredIntoInApril2013WithRoche


Next
Period End2020-12-31
Value15
Percentage of NextPotentialPayment0.0

ions:CollaborativeArrangementAndLicensingAgreementEnteredIntoInDecember2012WithBiogen


Next
Period End2020-12-312019-12-312018-12-312018-09-302018-06-302018-03-31
Value25127.57.57.57.5
Percentage of NextPotentialPayment0.00.00.00.00.00.0

ions:CollaborativeArrangementAndLicensingAgreementEnteredIntoInJanuary2017WithNovartis


Next
Period End2020-12-31
Value25
Percentage of NextPotentialPayment0.0

ions:CollaborativeArrangementAndLicensingAgreementEnteredIntoInJuly2015WithAstrazeneca


Next
Period End2020-12-31
Value30
Percentage of NextPotentialPayment0.0

ions:CollaborativeArrangementAndLicensingAgreementEnteredIntoInMarch2010WithGlaxoSmithKline


Next
Period End2020-12-31
Value15
Percentage of NextPotentialPayment0.0

ions:CollaborativeArrangementAndLicensingAgreementEnteredIntoInMay2015WithBayer


Next
Period End2020-12-31
Value20
Percentage of NextPotentialPayment0.0

ions:CollaborativeArrangementAndLicensingAgreementEnteredIntoInOctober2018WithRoche


Next
Period End2020-12-31
Value20
Percentage of NextPotentialPayment0.0

ions:CollaborativeArrangementAndLicensingAgreementEnteredIntoInOctober2019WithPfizer


Next
Period End2020-12-31
Value50
Percentage of NextPotentialPayment0.0

ions:CollaborativeArrangementAndLicensingAgreementEnteredIntoInSeptember2013WithBiogen


Next
Period End2021-06-302020-12-312019-12-312018-12-312018-09-302018-06-302018-03-31
Value8.010.010.010.010.010.010.0
Percentage of NextPotentialPayment0.00.00.00.00.00.00.0

ions:NumberOfCountriesWhereDrugIsApprovedForUse us-gaap:Range, us-gaap:TypeOfArrangement

ions:NumberOfCountriesWhereDrugIsApprovedForUse

srt:Minimum, ions:CollaborativeArrangementAndLicensingAgreementEnteredIntoInJanuary2012WithBiogen


Number
Period End2020-12-31
Value50.0
Percentage of NumberOfCountriesWhereDrugIsApprovedForUse100.0

ions:PercentageOfTaxableIncomeThatCanBeOffsetWithFederalNetOperatingLosses us-gaap:StatementScenario

ions:PercentageOfTaxableIncomeThatCanBeOffsetWithFederalNetOperatingLosses

us-gaap:ScenarioPlan


Percentage
Period End2021-01-01
Value0.8
Percentage of PercentageOfTaxableIncomeThatCanBeOffsetWithFederalNetOperatingLosses100.0

ions:RemainingPortionOfAvailableEquitySharePool us-gaap:ConsolidatedEntities

ions:RemainingPortionOfAvailableEquitySharePool

ions:AkceaTherapeuticsInc


Remaining
Period End2020-10-31
Value2800000.0
Percentage of RemainingPortionOfAvailableEquitySharePool100.0

ions:UpfrontPayments us-gaap:SubsequentEventType, us-gaap:TypeOfArrangement

ions:UpfrontPayments

us-gaap:SubsequentEvent, ions:CollaborationAgreementEnteredIntoInDecember2020WithBicycle


Upfront
Period End2021-07-31
Value45
Percentage of UpfrontPayments100.0

us-gaap:AssetsFairValueDisclosure us-gaap:FairValueByFairValueHierarchyLevel, us-gaap:FairValueByMeasurementFrequency

us-gaap:AssetsFairValueDisclosure

us-gaap:FairValueInputsLevel1, us-gaap:FairValueMeasurementsRecurring


Assets
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302017-06-302017-03-312016-12-312016-09-302016-06-302016-03-312015-12-312015-09-302015-06-302015-03-312014-12-312014-09-302014-06-302014-03-312013-12-312013-09-302013-06-302013-03-312012-12-312012-09-302012-06-302012-03-312011-12-312011-09-302011-06-302010-12-31
Value72666858190274975778256950650840655977419211715714112785979910611613314921212310213922020125729210711989885659538076
Percentage of AssetsFairValueDisclosure100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0

us-gaap:FairValueInputsLevel2, us-gaap:FairValueMeasurementsRecurring


Assets
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302017-06-302017-03-312016-12-312016-09-302016-06-302016-03-312015-12-312015-09-302015-06-302015-03-312014-12-312014-09-302014-06-302014-03-312013-12-312013-09-302013-06-302013-03-312012-12-312012-09-302012-06-302012-03-312011-12-312011-09-302011-06-302010-12-31
Value1238112211631328153115851472162616761558160913341162790877834705729560592565602655693654549586524504463494399291255240255241278278312315396
Percentage of AssetsFairValueDisclosure170.4167.8200.1147.2204.3209.4188.3285.7331.3306.4396.0238.5150.1410.7749.7529.0498.0574.2653.0607.6571.2564.0563.5520.4437.1259.0474.5514.1362.5209.7244.9155.299.7238.8202.0284.5274.2492.3468.4580.7389.7518.8

us-gaap:FairValueInputsLevel3, us-gaap:FairValueMeasurementsRecurring


Assets
Period End2020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312017-12-312016-12-312016-09-302015-12-312015-09-302015-06-302015-03-312014-12-312014-09-302014-06-302014-03-312013-12-312013-09-302013-06-302013-03-312012-12-31
Value1.6081.7061.4724.5060.6060.8960.9681.3490.00.00.00.00.00.00.0810.01.8561.9180.065624434
Percentage of AssetsFairValueDisclosure0.20.20.20.60.10.20.20.30.00.00.00.00.00.00.066.20.01.30.90.025.221.341.928.8

us-gaap:AssetsFairValueDisclosure us-gaap:FairValueByMeasurementFrequency

us-gaap:FairValueMeasurementsRecurring


Assets
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302017-06-302017-03-312016-12-312016-09-302016-06-302016-03-312015-12-312015-09-302015-06-302015-03-312014-12-312014-09-302014-06-302014-03-312013-12-31
Value1965179117452232228223442258219521832067201718941937982994992847856646690664709771826803761792626645685696
Percentage of AssetsFairValueDisclosure270.4267.8300.1247.4304.6309.6288.8385.8431.5406.6496.3338.5250.1510.7849.7629.0598.0674.2753.0707.6671.2664.0663.5620.4537.1359.0640.7614.1463.8310.5344.9

us-gaap:AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax us-gaap:FinancialInstrument

us-gaap:AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax

us-gaap:DebtSecurities


Available
Period End2021-06-302020-12-31
Value4.3668.577
Percentage of AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax100.0100.0

us-gaap:AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax us-gaap:FinancialInstrument, us-gaap:InvestmentSecondaryCategorization

us-gaap:CorporateDebtSecurities, ions:SecuritiesWithMaturityOfMoreThanOneYear


Available
Period End2021-06-302020-12-31
Value2.0914.941
Percentage of AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax47.957.6

us-gaap:CorporateDebtSecurities, ions:SecuritiesWithMaturityOfOneYearOrLess


Available
Period End2021-06-302020-12-31
Value1.5772.194
Percentage of AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax36.125.6

us-gaap:DebtSecurities, ions:SecuritiesWithMaturityOfMoreThanOneYear


Available
Period End2021-06-302020-12-31
Value2.3875.6
Percentage of AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax54.765.3

us-gaap:DebtSecurities, ions:SecuritiesWithMaturityOfOneYearOrLess


Available
Period End2021-06-302020-12-31
Value1.9792.977
Percentage of AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax45.334.7

us-gaap:USGovernmentAgenciesDebtSecurities, ions:SecuritiesWithMaturityOfMoreThanOneYear


Available
Period End2021-06-302020-12-31
Value0.0010.185
Percentage of AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax0.02.2

us-gaap:USGovernmentAgenciesDebtSecurities, ions:SecuritiesWithMaturityOfOneYearOrLess


Available
Period End2021-06-302020-12-31
Value0.1640.354
Percentage of AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax3.84.1

us-gaap:USStatesAndPoliticalSubdivisions, ions:SecuritiesWithMaturityOfMoreThanOneYear


Available
Period End2021-06-302020-12-31
Value0.020.091
Percentage of AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax0.51.1

us-gaap:USStatesAndPoliticalSubdivisions, ions:SecuritiesWithMaturityOfOneYearOrLess


Available
Period End2021-06-302020-12-31
Value0.1910.196
Percentage of AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax4.42.3

us-gaap:USTreasurySecurities, ions:SecuritiesWithMaturityOfMoreThanOneYear


Available
Period End2021-06-302020-12-31
Value0.2750.383
Percentage of AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax6.34.5

us-gaap:USTreasurySecurities, ions:SecuritiesWithMaturityOfOneYearOrLess


Available
Period End2021-06-302020-12-31
Value0.0470.233
Percentage of AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax1.12.7

us-gaap:AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax us-gaap:InvestmentSecondaryCategorization, us-gaap:InvestmentType

ions:SecuritiesWithMaturityOfMoreThanOneYear, us-gaap:CorporateDebtSecurities


Available
Period End2021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302017-06-302017-03-312016-12-312016-09-302016-06-302016-03-312015-12-312014-12-31
Value3.1084.9416.3158.782.3182.9113.1082.6861.2360.1940.0160.0280.0050.0080.0320.0420.0490.0360.4570.9450.6080.0030.016
Percentage of AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax0.057.60.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.0

ions:SecuritiesWithMaturityOfMoreThanOneYear, us-gaap:DebtSecurities


Available
Period End2021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302017-06-302017-03-312016-12-312016-09-302016-06-302016-03-312015-12-31
Value3.5515.67.416104.2262.9953.2343.1791.5270.3880.0160.0280.0050.0080.0390.0420.0650.0380.4821.0420.6360.006
Percentage of AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax0.065.30.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.0

ions:SecuritiesWithMaturityOfMoreThanOneYear, us-gaap:USGovernmentAgenciesDebtSecurities


Available
Period End2021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302017-06-302017-03-312016-12-312016-09-302016-06-302016-03-312015-12-312014-12-31
Value0.0360.1850.440.5210.9940.0570.1010.4280.2790.1940.00.00.00.00.0010.00.00.0010.0010.0050.0020.00.0
Percentage of AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax0.02.20.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.0

ions:SecuritiesWithMaturityOfMoreThanOneYear, us-gaap:USStatesAndPoliticalSubdivisions


Available
Period End2021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302017-06-302017-03-312016-12-312016-09-302016-06-302016-03-312015-12-312014-12-31
Value0.0810.0910.2370.3710.10.0180.0250.0190.00.00.00.00.00.00.0060.00.0160.0010.0240.0780.0260.0030.032
Percentage of AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax0.01.10.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.0

ions:SecuritiesWithMaturityOfMoreThanOneYear, us-gaap:USTreasurySecurities


Available
Period End2021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302017-12-312017-06-302017-03-312016-06-30
Value0.3260.3830.4240.5880.810.0090.00.0460.0120.00.00.00.00.00.014
Percentage of AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax0.04.50.00.00.00.00.00.00.00.00.00.00.00.00.0

ions:SecuritiesWithMaturityOfOneYearOrLess, us-gaap:CorporateDebtSecurities


Available
Period End2021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302017-06-302017-03-312016-12-312016-09-302016-06-302016-03-312015-12-312014-12-31
Value1.8382.1943.4434.2750.5451.4511.4841.1860.3260.0130.0230.0020.0010.0020.0610.0270.0180.0250.0360.0520.0290.0050.089
Percentage of AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax0.025.60.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.0

ions:SecuritiesWithMaturityOfOneYearOrLess, us-gaap:DebtSecurities


Available
Period End2021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302017-06-302017-03-312016-12-312016-09-302016-06-302016-03-312015-12-31
Value2.4762.9774.5635.9842.7812.0122.0731.6890.5180.0310.0250.0140.0030.0060.0720.0390.0220.0290.0630.090.0490.024
Percentage of AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax0.034.70.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.0

ions:SecuritiesWithMaturityOfOneYearOrLess, us-gaap:OtherDebtSecurities


Available
Period End2020-09-302020-06-302019-09-302019-06-302019-03-31
Value0.0060.0070.00.0030.001
Percentage of AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax0.00.00.00.00.0

ions:SecuritiesWithMaturityOfOneYearOrLess, us-gaap:USGovernmentAgenciesDebtSecurities


Available
Period End2021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302017-06-302017-03-312016-12-312016-09-302016-06-302016-03-312015-12-312014-12-31
Value0.2920.3540.3910.6730.5720.3030.3210.1520.0710.0030.0020.0050.00.00.0020.00.0020.00.0110.0150.0030.0010.007
Percentage of AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax0.04.10.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.0

ions:SecuritiesWithMaturityOfOneYearOrLess, us-gaap:USStatesAndPoliticalSubdivisions


Available
Period End2021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302017-06-302017-03-312016-12-312016-09-302016-06-302016-03-312015-12-312014-12-31
Value0.220.1960.2380.2140.0430.0260.0040.0160.010.00.00.00.0010.0040.0090.0120.0020.0020.0020.0120.0140.0180.019
Percentage of AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax0.02.30.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.0

ions:SecuritiesWithMaturityOfOneYearOrLess, us-gaap:USTreasurySecurities


Available
Period End2021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302017-06-302017-03-312016-12-312016-09-302016-06-302016-03-312015-12-312014-12-31
Value0.1260.2330.4850.8151.6210.2320.2640.3320.110.0150.00.0070.0010.00.00.00.00.0020.0140.0110.0030.00.009
Percentage of AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax0.02.70.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.0

us-gaap:AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax us-gaap:InvestmentType

us-gaap:DebtSecurities


Available
Period End2021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302017-06-302017-03-312016-12-312016-09-302016-06-302016-03-312015-12-312015-09-302014-12-31
Value6.0278.57711167.0075.0075.3074.8682.0450.4190.0410.0420.0080.0140.1110.0810.0870.0670.5451.1320.6850.030.260.172
Percentage of AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax0.0100.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.0

us-gaap:AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax us-gaap:FinancialInstrument

us-gaap:AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax

us-gaap:DebtSecurities


Available
Period End2021-06-302020-12-31
Value629000.0140000.0
Percentage of AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax100.0100.0

us-gaap:AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax us-gaap:FinancialInstrument, us-gaap:InvestmentSecondaryCategorization

us-gaap:CorporateDebtSecurities, ions:SecuritiesWithMaturityOfMoreThanOneYear


Available
Period End2021-06-302020-12-31
Value294000.040000.0
Percentage of AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax46.728.6

us-gaap:CorporateDebtSecurities, ions:SecuritiesWithMaturityOfOneYearOrLess


Available
Period End2021-06-302020-12-31
Value38000.041000.0
Percentage of AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax6.029.3

us-gaap:DebtSecurities, ions:SecuritiesWithMaturityOfMoreThanOneYear


Available
Period End2021-06-302020-12-31
Value567000.069000.0
Percentage of AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax90.149.3

us-gaap:DebtSecurities, ions:SecuritiesWithMaturityOfOneYearOrLess


Available
Period End2021-06-302020-12-31
Value62000.071000.0
Percentage of AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax9.950.7

us-gaap:OtherDebtSecurities, ions:SecuritiesWithMaturityOfMoreThanOneYear


Available
Period End2021-06-30
Value22000.0
Percentage of AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax3.5

us-gaap:OtherDebtSecurities, ions:SecuritiesWithMaturityOfOneYearOrLess


Available
Period End2021-06-302020-12-31
Value4000.07000.0
Percentage of AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax0.65.0

us-gaap:USGovernmentAgenciesDebtSecurities, ions:SecuritiesWithMaturityOfMoreThanOneYear


Available
Period End2021-06-302020-12-31
Value127000.09000.0
Percentage of AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax20.26.4

us-gaap:USStatesAndPoliticalSubdivisions, ions:SecuritiesWithMaturityOfMoreThanOneYear


Available
Period End2021-06-302020-12-31
Value52000.016000.0
Percentage of AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax8.311.4

us-gaap:USStatesAndPoliticalSubdivisions, ions:SecuritiesWithMaturityOfOneYearOrLess


Available
Period End2021-06-302020-12-31
Value13000.012000.0
Percentage of AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax2.18.6

us-gaap:USTreasurySecurities, ions:SecuritiesWithMaturityOfMoreThanOneYear


Available
Period End2021-06-302020-12-31
Value72000.04000.0
Percentage of AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax11.42.9

us-gaap:USTreasurySecurities, ions:SecuritiesWithMaturityOfOneYearOrLess


Available
Period End2021-06-302020-12-31
Value5000.09000.0
Percentage of AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax0.86.4

us-gaap:AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax us-gaap:InvestmentSecondaryCategorization, us-gaap:InvestmentType

ions:SecuritiesWithMaturityOfMoreThanOneYear, us-gaap:CorporateDebtSecurities


Available
Period End2021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302017-06-302017-03-312016-12-312016-09-302016-06-302016-03-312015-12-312014-12-31
Value245000.040000.087000.0121000.02903000.043000.0161000.0179000.0336000.01286000.01420000.01607000.01807000.01059000.0554000.0674000.0833000.01174000.0713000.0165000.0416000.01705000.0600000.0
Percentage of AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax0.028.60.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.0

ions:SecuritiesWithMaturityOfMoreThanOneYear, us-gaap:DebtSecurities


Available
Period End2021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302017-06-302017-03-312016-12-312016-09-302016-06-302016-03-312015-12-31
Value489000.069000.0148000.0156000.02918000.0178000.0342000.0320000.0595000.01706000.02090000.02428000.02754000.01969000.01066000.01118000.01249000.01690000.0846000.0192000.0510000.02192000.0
Percentage of AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax0.049.30.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.0

ions:SecuritiesWithMaturityOfMoreThanOneYear, us-gaap:OtherDebtSecurities


Available
Period End2021-03-312020-03-31
Value20000.00
Percentage of AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax0.00.0

ions:SecuritiesWithMaturityOfMoreThanOneYear, us-gaap:USGovernmentAgenciesDebtSecurities


Available
Period End2021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302017-06-302017-03-312016-12-312016-09-302016-06-302016-03-312015-12-312014-12-31
Value164000.09000.031000.028000.015000.0117000.0137000.0106000.0112000.0109000.0109000.072000.0162000.0168000.083000.0108000.0124000.0167000.033000.01000.012000.0244000.0151000.0
Percentage of AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax0.06.40.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.0

ions:SecuritiesWithMaturityOfMoreThanOneYear, us-gaap:USStatesAndPoliticalSubdivisions


Available
Period End2021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302017-06-302017-03-312016-12-312016-09-302016-06-302016-03-312015-12-312014-12-31
Value25000.016000.01000.03000.006000.06000.012000.0125000.0287000.0551000.0749000.0785000.0740000.0429000.0336000.0291000.0349000.0100000.026000.082000.0243000.0234000.0
Percentage of AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax0.011.40.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.0

ions:SecuritiesWithMaturityOfMoreThanOneYear, us-gaap:USTreasurySecurities


Available
Period End2021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302017-12-312017-06-302017-03-312016-06-30
Value35000.04000.06000.04000.0012000.038000.023000.022000.024000.010000.02000.001000.00
Percentage of AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax0.02.90.00.00.00.00.00.00.00.00.00.00.00.00.0

ions:SecuritiesWithMaturityOfOneYearOrLess, us-gaap:CorporateDebtSecurities


Available
Period End2021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302017-06-302017-03-312016-12-312016-09-302016-06-302016-03-312015-12-312014-12-31
Value76000.041000.012000.017000.01890000.043000.0148000.0280000.0531000.01858000.01264000.01210000.01286000.0752000.0328000.0360000.0405000.0161000.0152000.082000.059000.0250000.089000.0
Percentage of AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax0.029.30.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.0

ions:SecuritiesWithMaturityOfOneYearOrLess, us-gaap:DebtSecurities


Available
Period End2021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302017-06-302017-03-312016-12-312016-09-302016-06-302016-03-312015-12-31
Value107000.071000.022000.036000.01922000.0118000.0237000.0392000.0761000.02362000.01852000.01667000.01846000.01103000.0494000.0607000.0612000.0319000.0271000.0174000.0160000.0360000.0
Percentage of AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax0.050.70.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.0

ions:SecuritiesWithMaturityOfOneYearOrLess, us-gaap:OtherDebtSecurities


Available
Period End2021-03-312020-12-312020-06-302019-09-302019-06-302019-03-31
Value7000.07000.00000
Percentage of AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax0.05.00.00.00.00.0

ions:SecuritiesWithMaturityOfOneYearOrLess, us-gaap:USGovernmentAgenciesDebtSecurities


Available
Period End2021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302017-06-302017-03-312016-12-312016-09-302016-06-302016-03-312015-12-312014-12-31
Value2000.02000.01000.09000.028000.043000.045000.017000.015000.0104000.0169000.0233000.0323000.0212000.073000.098000.072000.010000.0001000.019000.027000.0
Percentage of AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax0.01.40.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.0

ions:SecuritiesWithMaturityOfOneYearOrLess, us-gaap:USStatesAndPoliticalSubdivisions


Available
Period End2021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302017-06-302017-03-312016-12-312016-09-302016-06-302016-03-312015-12-312014-12-31
Value22000.012000.02000.03000.02000.05000.027000.091000.0203000.0323000.0330000.0190000.0194000.0122000.085000.0122000.0116000.0134000.0119000.092000.097000.088000.053000.0
Percentage of AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax0.08.60.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.0

ions:SecuritiesWithMaturityOfOneYearOrLess, us-gaap:USTreasurySecurities


Available
Period End2020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302017-06-302017-03-312016-12-312016-09-302016-06-302016-03-312015-12-312014-12-31
Value9000.07000.07000.02000.027000.017000.04000.012000.077000.089000.034000.043000.017000.08000.025000.019000.014000.0003000.03000.00
Percentage of AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax6.40.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.0

us-gaap:AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax us-gaap:InvestmentType

us-gaap:DebtSecurities


Available
Period End2021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302017-06-302017-03-312016-12-312016-09-302016-06-302016-03-312015-12-312015-09-302014-12-31
Value596000.0140000.0170000.0192000.04840000.0296000.0579000.0712000.01356000.04068000.03942000.04095000.04600000.03072000.01560000.01725000.01861000.02009000.01117000.0366000.0670000.02552000.0977000.01154000.0
Percentage of AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax0.0100.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.0

us-gaap:AvailableForSaleDebtSecuritiesAmortizedCostBasis us-gaap:FinancialInstrument

us-gaap:AvailableForSaleDebtSecuritiesAmortizedCostBasis

us-gaap:DebtSecurities


Available
Period End2021-06-302020-12-31
Value14961513
Percentage of AvailableForSaleDebtSecuritiesAmortizedCostBasis100.0100.0

us-gaap:AvailableForSaleDebtSecuritiesAmortizedCostBasis us-gaap:FinancialInstrument, us-gaap:InvestmentSecondaryCategorization

us-gaap:CorporateDebtSecurities, ions:SecuritiesWithMaturityOfMoreThanOneYear


Available
Period End2021-06-302020-12-31
Value390325
Percentage of AvailableForSaleDebtSecuritiesAmortizedCostBasis26.121.5

us-gaap:CorporateDebtSecurities, ions:SecuritiesWithMaturityOfOneYearOrLess


Available
Period End2021-06-302020-12-31
Value463514
Percentage of AvailableForSaleDebtSecuritiesAmortizedCostBasis31.034.0

us-gaap:DebtSecurities, ions:SecuritiesWithMaturityOfMoreThanOneYear


Available
Period End2021-06-302020-12-31
Value622488
Percentage of AvailableForSaleDebtSecuritiesAmortizedCostBasis41.632.3

us-gaap:DebtSecurities, ions:SecuritiesWithMaturityOfOneYearOrLess


Available
Period End2021-06-302020-12-31
Value8741025
Percentage of AvailableForSaleDebtSecuritiesAmortizedCostBasis58.467.7

us-gaap:OtherDebtSecurities, ions:SecuritiesWithMaturityOfMoreThanOneYear


Available
Period End2021-06-302020-12-31
Value6.2011.041
Percentage of AvailableForSaleDebtSecuritiesAmortizedCostBasis0.40.1

us-gaap:OtherDebtSecurities, ions:SecuritiesWithMaturityOfOneYearOrLess


Available
Period End2021-06-302020-12-31
Value5.0835.191
Percentage of AvailableForSaleDebtSecuritiesAmortizedCostBasis0.30.3

us-gaap:USGovernmentAgenciesDebtSecurities, ions:SecuritiesWithMaturityOfMoreThanOneYear


Available
Period End2021-06-302020-12-31
Value7180
Percentage of AvailableForSaleDebtSecuritiesAmortizedCostBasis4.85.3

us-gaap:USGovernmentAgenciesDebtSecurities, ions:SecuritiesWithMaturityOfOneYearOrLess


Available
Period End2021-06-302020-12-31
Value6594
Percentage of AvailableForSaleDebtSecuritiesAmortizedCostBasis4.46.2

us-gaap:USStatesAndPoliticalSubdivisions, ions:SecuritiesWithMaturityOfMoreThanOneYear


Available
Period End2021-06-302020-12-31
Value6531
Percentage of AvailableForSaleDebtSecuritiesAmortizedCostBasis4.42.1

us-gaap:USStatesAndPoliticalSubdivisions, ions:SecuritiesWithMaturityOfOneYearOrLess


Available
Period End2021-06-302020-12-31
Value167104
Percentage of AvailableForSaleDebtSecuritiesAmortizedCostBasis11.26.9

us-gaap:USTreasurySecurities, ions:SecuritiesWithMaturityOfMoreThanOneYear


Available
Period End2021-06-302020-12-31
Value8850
Percentage of AvailableForSaleDebtSecuritiesAmortizedCostBasis5.93.3

us-gaap:USTreasurySecurities, ions:SecuritiesWithMaturityOfOneYearOrLess


Available
Period End2021-06-302020-12-31
Value173307
Percentage of AvailableForSaleDebtSecuritiesAmortizedCostBasis11.620.3

us-gaap:AvailableForSaleDebtSecuritiesAmortizedCostBasis us-gaap:InvestmentSecondaryCategorization, us-gaap:InvestmentType

ions:SecuritiesWithMaturityOfMoreThanOneYear, us-gaap:CorporateDebtSecurities


Available
Period End2021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302017-06-302017-03-312016-12-312016-09-302016-06-302016-03-312015-12-312014-12-31
Value325325392485500428539395360299240199126148144159189202217191242258152
Percentage of AvailableForSaleDebtSecuritiesAmortizedCostBasis0.021.50.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.0

ions:SecuritiesWithMaturityOfMoreThanOneYear, us-gaap:DebtSecurities


Available
Period End2021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302017-06-302017-03-312016-12-312016-09-302016-06-302016-03-312015-12-31
Value521488578712747624690559530439314252200268234228273268288262320346
Percentage of AvailableForSaleDebtSecuritiesAmortizedCostBasis0.032.30.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.0

ions:SecuritiesWithMaturityOfMoreThanOneYear, us-gaap:OtherDebtSecurities


Available
Period End2021-03-312020-12-312020-03-31
Value6.2331.0410.903
Percentage of AvailableForSaleDebtSecuritiesAmortizedCostBasis0.00.10.0

ions:SecuritiesWithMaturityOfMoreThanOneYear, us-gaap:USGovernmentAgenciesDebtSecurities


Available
Period End2021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302017-06-302017-03-312016-12-312016-09-302016-06-302016-03-312015-12-312014-12-31
Value9680120118165140106129120107323.9862152271925283331363862
Percentage of AvailableForSaleDebtSecuritiesAmortizedCostBasis0.05.30.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.0

ions:SecuritiesWithMaturityOfMoreThanOneYear, us-gaap:USStatesAndPoliticalSubdivisions


Available
Period End2021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302017-06-302017-03-312016-12-312016-09-302016-06-302016-03-312015-12-312014-12-31
Value3431275018199.2838.817151631485265634955363629404860
Percentage of AvailableForSaleDebtSecuritiesAmortizedCostBasis0.02.10.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.0

ions:SecuritiesWithMaturityOfMoreThanOneYear, us-gaap:USTreasurySecurities


Available
Period End2021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302017-12-312017-06-302017-03-312016-06-30
Value595031586235342533159.8721.4090.03.4978.983
Percentage of AvailableForSaleDebtSecuritiesAmortizedCostBasis0.03.30.00.00.00.00.00.00.00.00.00.00.00.00.0

ions:SecuritiesWithMaturityOfOneYearOrLess, us-gaap:CorporateDebtSecurities


Available
Period End2021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302017-06-302017-03-312016-12-312016-09-302016-06-302016-03-312015-12-312014-12-31
Value446514568652717669752938869956841747433500496369341195195179161181219
Percentage of AvailableForSaleDebtSecuritiesAmortizedCostBasis0.034.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.0

ions:SecuritiesWithMaturityOfOneYearOrLess, us-gaap:DebtSecurities


Available
Period End2021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302017-06-302017-03-312016-12-312016-09-302016-06-302016-03-312015-12-31
Value88810251129118712561206129714511388143311881053648643618507484323333324295314
Percentage of AvailableForSaleDebtSecuritiesAmortizedCostBasis0.067.70.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.0

ions:SecuritiesWithMaturityOfOneYearOrLess, us-gaap:OtherDebtSecurities


Available
Period End2021-03-312020-12-312020-09-302020-06-302019-09-302019-06-302019-03-31
Value5.1375.1910.9010.9022.9482.9392.931
Percentage of AvailableForSaleDebtSecuritiesAmortizedCostBasis0.00.30.00.00.00.00.0

ions:SecuritiesWithMaturityOfOneYearOrLess, us-gaap:USGovernmentAgenciesDebtSecurities


Available
Period End2021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302017-06-302017-03-312016-12-312016-09-302016-06-302016-03-312015-12-312014-12-31
Value809410413916718817613512416814313712983726364262944425047
Percentage of AvailableForSaleDebtSecuritiesAmortizedCostBasis0.06.20.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.0

ions:SecuritiesWithMaturityOfOneYearOrLess, us-gaap:USStatesAndPoliticalSubdivisions


Available
Period End2021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302017-06-302017-03-312016-12-312016-09-302016-06-302016-03-312015-12-312014-12-31
Value121104966815213361636349293129294355727988787945
Percentage of AvailableForSaleDebtSecuritiesAmortizedCostBasis0.06.90.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.0

ions:SecuritiesWithMaturityOfOneYearOrLess, us-gaap:USTreasurySecurities


Available
Period End2021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302017-06-302017-03-312016-12-312016-09-302016-06-302016-03-312015-12-312014-12-31
Value2343073583253553273313123282441541385429162823292813132.60419
Percentage of AvailableForSaleDebtSecuritiesAmortizedCostBasis0.020.30.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.0

us-gaap:AvailableForSaleDebtSecuritiesAmortizedCostBasis us-gaap:InvestmentType

us-gaap:DebtSecurities


Available
Period End2021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302017-06-302017-03-312016-12-312016-09-302016-06-302016-03-312015-12-312015-09-302015-06-302015-03-312014-12-312014-09-302014-06-302014-03-312013-12-312013-09-302013-06-302013-03-312012-12-312012-09-302012-06-302012-03-312011-12-312011-09-302011-06-302010-12-31
Value141015131707190020041831198720101919187315021305848911853735758591621586616660693655555606534515478510416305264249258250277278310309401
Percentage of AvailableForSaleDebtSecuritiesAmortizedCostBasis0.0100.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.0

us-gaap:AvailableForSaleSecurities us-gaap:BalanceSheetLocation, us-gaap:FairValueByMeasurementFrequency, us-gaap:FinancialInstrument

us-gaap:AvailableForSaleSecurities

us-gaap:CashAndCashEquivalents, us-gaap:FairValueMeasurementsRecurring, us-gaap:CorporateDebtSecurities