DNLI


Line plots across dimensions of each concept
Line plots across concepts
Tables

Table of contents



us-gaap:CommonStockValue

us-gaap:WeightedAverageNumberOfDilutedSharesOutstanding

us-gaap:WeightedAverageNumberOfSharesOutstandingBasic

us-gaap:WeightedAverageNumberOfShareOutstandingBasicAndDiluted

us-gaap:AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount
us-gaap:AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecurities

us-gaap:EarningsPerShareBasic

us-gaap:EarningsPerShareDiluted

us-gaap:EarningsPerShareBasicAndDiluted

us-gaap:AllocatedShareBasedCompensationExpense
us-gaap:IncomeStatementLocation

us-gaap:ComprehensiveIncomeNetOfTax

us-gaap:GeneralAndAdministrativeExpense

us-gaap:IncomeTaxExpenseBenefit

us-gaap:NetIncomeLoss
us-gaap:StatementEquityComponents

us-gaap:NonoperatingIncomeExpense

us-gaap:OperatingExpenses

us-gaap:OperatingIncomeLoss

us-gaap:ResearchAndDevelopmentExpense
us-gaap:CapitalizedCostsOfUnprovedPropertiesExcludedFromAmortizationByPropertyOrProject

us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax
us-gaap:CounterpartyName, us-gaap:ProductOrService, us-gaap:TypeOfArrangement
us-gaap:ProductOrService, us-gaap:TypeOfArrangement
us-gaap:TypeOfArrangement

us-gaap:Revenues
us-gaap:TypeOfArrangement

us-gaap:Assets

us-gaap:Liabilities

us-gaap:LiabilitiesAndStockholdersEquity

us-gaap:StockholdersEquity
us-gaap:StatementEquityComponents

us-gaap:AssetsCurrent

us-gaap:CashAndCashEquivalentsAtCarryingValue

us-gaap:CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents

us-gaap:MarketableSecuritiesCurrent

us-gaap:AccountsReceivableNetCurrent

us-gaap:PrepaidExpenseAndOtherAssetsCurrent

us-gaap:PropertyPlantAndEquipmentGross
us-gaap:PropertyPlantAndEquipmentByType

us-gaap:AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment

us-gaap:PropertyPlantAndEquipmentNet

us-gaap:OperatingLeaseRightOfUseAsset

us-gaap:OtherAssetsNoncurrent

us-gaap:AccountsPayableCurrent

us-gaap:AccruedLiabilitiesCurrent

us-gaap:ContractWithCustomerLiabilityCurrent

us-gaap:LiabilitiesCurrent

us-gaap:OperatingLeaseLiabilityCurrent

us-gaap:OtherLiabilitiesCurrent

us-gaap:OtherLiabilitiesNoncurrent

us-gaap:OperatingLeaseLiabilityNoncurrent

us-gaap:LesseeOperatingLeaseLiabilityPaymentsDueYearTwo

us-gaap:LesseeOperatingLeaseLiabilityPaymentsDueYearThree

us-gaap:LesseeOperatingLeaseLiabilityPaymentsDueYearFour

us-gaap:LesseeOperatingLeaseLiabilityPaymentsDueYearFive

us-gaap:LesseeOperatingLeaseLiabilityPaymentsDueAfterYearFive

us-gaap:OperatingLeaseLiability

us-gaap:LesseeOperatingLeaseLiabilityPaymentsDue

us-gaap:LesseeOperatingLeaseLiabilityUndiscountedExcessAmount

us-gaap:StockholdersEquity
us-gaap:StatementEquityComponents

us-gaap:CommonStockValue

us-gaap:AdditionalPaidInCapital
us-gaap:CounterpartyName, us-gaap:ResearchAndDevelopmentArrangementContractToPerformForOthersByType, us-gaap:TypeOfArrangement
us-gaap:CommonStocksIncludingAdditionalPaidInCapital

us-gaap:RetainedEarningsAccumulatedDeficit

us-gaap:AccumulatedOtherComprehensiveIncomeLossNetOfTax

us-gaap:StockIssuedDuringPeriodValueNewIssues
us-gaap:StatementEquityComponents

us-gaap:AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue
us-gaap:StatementEquityComponents

us-gaap:NetCashProvidedByUsedInOperatingActivities

us-gaap:NetCashProvidedByUsedInInvestingActivities

us-gaap:NetCashProvidedByUsedInFinancingActivities

us-gaap:DepreciationDepletionAndAmortization

us-gaap:IncreaseDecreaseInAccountsPayable

us-gaap:NetCashProvidedByUsedInOperatingActivities

us-gaap:NetIncomeLoss
us-gaap:StatementEquityComponents

us-gaap:ShareBasedCompensation

us-gaap:NetCashProvidedByUsedInInvestingActivities

us-gaap:PaymentsToAcquirePropertyPlantAndEquipment

us-gaap:NetCashProvidedByUsedInFinancingActivities

us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePrice

us-gaap:DeferredTaxAssetsNet

us-gaap:UnrecognizedTaxBenefits

us-gaap:DeferredTaxAssetsValuationAllowance
us-gaap:CounterpartyName, us-gaap:ProductOrService, us-gaap:TypeOfArrangement
dnli:CollaborationAgreementTransactionPriceIncrease
us-gaap:CounterpartyName, us-gaap:TypeOfArrangement
us-gaap:CounterpartyName, us-gaap:TypeOfArrangement
dnli:CollaborativeArrangementUpfrontPaymentToBeReceived

dnli:IncreaseDecreaseInContractWithCustomerLiabilityRelatedParties

dnli:IncreaseDecreaseInNonCashOperatingLeaseExpense
us-gaap:PurchaseCommitmentExcludingLongtermCommitment
dnli:PaymentsForManufacturingCost
us-gaap:CounterpartyName, us-gaap:SubsequentEventType, us-gaap:TypeOfArrangement
dnli:PreclinicalMilestonePaymentReceived
us-gaap:CounterpartyName, us-gaap:TypeOfArrangement

dnli:ProceedsFromIssuanceOfCommonStockInConnectionWithCollaborationAgreement

dnli:ResearchAndDevelopmentExpenseOffsetFromRelatedPartyCostReimbursement
us-gaap:CounterpartyName, us-gaap:TypeOfArrangement
us-gaap:CounterpartyName, us-gaap:ResearchAndDevelopmentArrangementContractToPerformForOthersByType, us-gaap:TypeOfArrangement
dnli:SaleOfStockConsiderationPremiumReceivedOnTransaction

dnli:StockIssuedDuringPeriodValueEquityIncentivePlan
us-gaap:StatementEquityComponents

dnli:StockIssuedDuringPeriodValueStockPurchaseAgreement
us-gaap:StatementEquityComponents
us-gaap:CounterpartyName, us-gaap:SubsequentEventType, us-gaap:TypeOfArrangement
dnli:UpfrontPayments
us-gaap:StatementEquityComponents
us-gaap:AdjustmentsToAdditionalPaidInCapitalStockIssuedIssuanceCosts

us-gaap:CapitalExpendituresIncurredButNotYetPaid

us-gaap:CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseExcludingExchangeRateEffect
us-gaap:CounterpartyName, us-gaap:TypeOfArrangement
us-gaap:ContractWithCustomerLiabilityRevenueRecognized
us-gaap:TypeOfArrangement
us-gaap:PurchaseCommitmentExcludingLongtermCommitment
us-gaap:CostsIncurredDevelopmentCosts

us-gaap:DerivativeGainLossOnDerivativeNet

us-gaap:IncomeLossAttributableToParent

us-gaap:IncreaseDecreaseInAccruedLiabilitiesAndOtherOperatingLiabilities

us-gaap:IncreaseDecreaseInContractWithCustomerLiability

us-gaap:IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets

us-gaap:InvestmentIncomeNetAmortizationOfDiscountAndPremium

us-gaap:LeaseCost

us-gaap:OperatingLeasePayments

us-gaap:OtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentBeforeReclassificationAdjustmentsNetOfTax

us-gaap:OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent
us-gaap:StatementEquityComponents

us-gaap:OtherNoncashIncomeExpense

us-gaap:PaymentsToAcquireMarketableSecurities

us-gaap:ProceedsFromIssuanceOfCommonStock

us-gaap:ProceedsFromIssuanceOfSharesUnderIncentiveAndShareBasedCompensationPlansIncludingStockOptions

us-gaap:ProceedsFromSaleAndMaturityOfMarketableSecurities

us-gaap:RevenueFromCollaborativeArrangementExcludingRevenueFromContractWithCustomer
us-gaap:ProductOrService, us-gaap:TypeOfArrangement

us-gaap:RevenueFromRelatedParties
us-gaap:CounterpartyName, us-gaap:ResearchAndDevelopmentArrangementContractToPerformForOthersByType, us-gaap:TypeOfArrangement
us-gaap:SaleOfStockConsiderationReceivedOnTransaction
us-gaap:AwardType
us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeituresWeightedAverageGrantDateFairValue
us-gaap:AwardType
us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriodWeightedAverageGrantDateFairValue
us-gaap:AwardType
us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriodWeightedAverageGrantDateFairValue
us-gaap:AwardType
us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRateMaximum
us-gaap:AwardType
us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRateMinimum
us-gaap:AwardType
us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRateMaximum
us-gaap:AwardType
us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRateMinimum

us-gaap:ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsExercisesInPeriodWeightedAverageExercisePrice

us-gaap:ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsForfeituresInPeriodWeightedAverageExercisePrice

us-gaap:ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageExercisePrice
us-gaap:StatementEquityComponents
us-gaap:StockIssuedDuringPeriodValueRestrictedStockAwardNetOfForfeitures

us-gaap:SubleaseIncome

dnli:AccruedClinicalAndContractResearchOrganizationCosts

dnli:AccruedClinicalAndOtherResearchAndDevelopmentCostsCurrent

dnli:AccruedClinicalCostsCurrent

dnli:AccruedGeneralAdministrativeAndSharedCosts
us-gaap:CounterpartyName, us-gaap:SubsequentEventType, us-gaap:TypeOfArrangement
dnli:AggregateClinicalRegulatoryAndSalesMilestonePayment
us-gaap:CounterpartyName, us-gaap:TypeOfArrangement
dnli:AggregateDevelopmentFirstCommercialSaleAndNetSalesBasedMilestonePayments
dei:LegalEntity, us-gaap:StatementGeographical, us-gaap:SubsequentEventType, us-gaap:TypeOfArrangement
dnli:CollaborativeAgreementAgreedShareOfCommercialProfitLoss
us-gaap:StatementGeographical, us-gaap:SubsequentEventType, us-gaap:TypeOfArrangement
dei:LegalEntity, us-gaap:SubsequentEventType, us-gaap:TypeOfArrangement
dnli:CollaborativeAgreementFundedPercentage
us-gaap:SubsequentEventType, us-gaap:TypeOfArrangement

dnli:ContractWithCustomerLiabilityFromRelatedPartiesCurrent
us-gaap:CounterpartyName, us-gaap:ResearchAndDevelopmentArrangementContractToPerformForOthersByType, us-gaap:TypeOfArrangement

dnli:ContractWithCustomerLiabilityFromRelatedPartiesNoncurrent

dnli:DeferredTaxAssetsOperatingLeaseLiability

dnli:DeferredTaxLiabilitiesOperatingLeaseRightOfUseAsset
us-gaap:CounterpartyName, us-gaap:TypeOfArrangement
dnli:DevelopmentMilestonePayments
us-gaap:CounterpartyName, us-gaap:TypeOfArrangement
dnli:FirstCommercialSaleMilestonePayments

dnli:LesseeOperatingLeaseLiabilityToBePaidAfterYearFour
us-gaap:CounterpartyName, us-gaap:TypeOfArrangement
dnli:NetSalesBasedMilestonePayments

dnli:OtherAccruedCostsAndOtherLiabilitiesCurrent

dnli:OtherAccruedManufacturingCosts

dnli:OtherAccruedManufacturingCostsCurrent

dnli:OtherAccruedResearchAndDevelopmentCosts
us-gaap:CounterpartyName, us-gaap:SubsequentEventType, us-gaap:TypeOfArrangement
dnli:PreclinicalMilestonePaymentEarnedNotYetReceived
us-gaap:CounterpartyName, us-gaap:TypeOfArrangement
us-gaap:PurchaseCommitmentExcludingLongtermCommitment
dnli:PurchaseOrderExecuted
us-gaap:AwardType
dnli:ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValueExpectedToVest
us-gaap:AwardType
dnli:ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedAndExpectedToVestOutstandingAggregateIntrinsicValue
us-gaap:CounterpartyName, us-gaap:TypeOfArrangement
us-gaap:AccountsReceivableNet

us-gaap:AssetsFairValueDisclosure
us-gaap:FairValueByFairValueHierarchyLevel

us-gaap:AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax
us-gaap:FinancialInstrument, us-gaap:InvestmentType
us-gaap:InvestmentType

us-gaap:AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax
us-gaap:FinancialInstrument, us-gaap:InvestmentType
us-gaap:InvestmentType

us-gaap:AvailableForSaleDebtSecuritiesAmortizedCostBasis
us-gaap:FinancialInstrument, us-gaap:InvestmentType
us-gaap:InvestmentType

us-gaap:AvailableForSaleSecuritiesDebtSecurities
us-gaap:FairValueByFairValueHierarchyLevel, us-gaap:FinancialInstrument, us-gaap:InvestmentType
us-gaap:FinancialInstrument, us-gaap:InvestmentType
us-gaap:InvestmentType
us-gaap:CashAndCashEquivalents
us-gaap:CashAndCashEquivalentsFairValueDisclosure
us-gaap:CashAndCashEquivalents, us-gaap:FairValueByFairValueHierarchyLevel
us-gaap:CounterpartyName
us-gaap:ContractWithCustomerLiability
us-gaap:CounterpartyName, us-gaap:ProductOrService, us-gaap:RelatedPartyTransaction, us-gaap:TypeOfArrangement
us-gaap:CounterpartyName, us-gaap:RelatedPartyTransaction
us-gaap:CounterpartyName, us-gaap:TypeOfArrangement

us-gaap:ContractWithCustomerLiabilityNoncurrent

us-gaap:ContractualObligation
us-gaap:FinancialInstrument, us-gaap:InvestmentType
us-gaap:DebtSecuritiesAvailableForSaleUnrealizedLossPosition

us-gaap:DeferredTaxAssetsDeferredIncome

us-gaap:DeferredTaxAssetsGross

us-gaap:DeferredTaxAssetsOperatingLossCarryforwards

us-gaap:DeferredTaxAssetsOther

us-gaap:DeferredTaxAssetsTaxCreditCarryforwards

us-gaap:DeferredTaxAssetsTaxDeferredExpenseCompensationAndBenefitsShareBasedCompensationCost

us-gaap:DeferredTaxLiabilitiesPropertyPlantAndEquipment

us-gaap:DerivativeAssets
us-gaap:BalanceSheetLocation
us-gaap:FairValueByFairValueHierarchyLevel

us-gaap:DerivativeLiabilities
us-gaap:DerivativeInstrumentRisk
us-gaap:FairValueByFairValueHierarchyLevel
us-gaap:DerivativeInstrumentRisk, us-gaap:HedgingDesignation
us-gaap:DerivativeNotionalAmount

us-gaap:DueFromRelatedPartiesCurrent
us-gaap:CounterpartyName, us-gaap:TypeOfArrangement

us-gaap:EmployeeRelatedLiabilitiesCurrent
us-gaap:AwardType
us-gaap:EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognized

us-gaap:LesseeOperatingLeaseLiabilityPaymentsDueNextTwelveMonths

us-gaap:LesseeOperatingLeaseLiabilityPaymentsRemainderOfFiscalYear

us-gaap:LessorOperatingLeasePaymentsToBeReceived

us-gaap:LessorOperatingLeasePaymentsToBeReceivedNextTwelveMonths

us-gaap:LessorOperatingLeasePaymentsToBeReceivedRemainderOfFiscalYear

us-gaap:LessorOperatingLeasePaymentsToBeReceivedThreeYears

us-gaap:LessorOperatingLeasePaymentsToBeReceivedTwoYears

us-gaap:LiabilitiesFairValueDisclosure
us-gaap:FairValueByFairValueHierarchyLevel

us-gaap:MarketableSecuritiesNoncurrent
us-gaap:IncomeTaxAuthority
us-gaap:OperatingLossCarryforwards
us-gaap:PurchaseCommitmentExcludingLongtermCommitment
us-gaap:PurchaseObligation

us-gaap:RestrictedCashAndCashEquivalentsNoncurrent
us-gaap:ProductOrService
us-gaap:RevenueRemainingPerformanceObligation
us-gaap:CounterpartyName, us-gaap:ResearchAndDevelopmentArrangementContractToPerformForOthersByType, us-gaap:TypeOfArrangement
us-gaap:SaleOfStockPricePerShare
us-gaap:AwardType
us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValue
us-gaap:PlanName
us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAvailableForGrant

us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingIntrinsicValue

us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsVestedAndExpectedToVestExercisableWeightedAverageExercisePrice

us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsVestedAndExpectedToVestOutstandingAggregateIntrinsicValue

us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsVestedAndExpectedToVestOutstandingWeightedAverageExercisePrice

us-gaap:SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsExercisableIntrinsicValue1
us-gaap:IncomeTaxAuthority
us-gaap:TaxCreditCarryforwardAmount
us-gaap:IncomeTaxAuthority, us-gaap:TaxCreditCarryforward

us-gaap:UnrecognizedTaxBenefitsThatWouldImpactEffectiveTaxRate

Plots across concepts


IncomeStatement
Operating Income Loss
Expenses
Income Tax Expense Benefit
Balance Sheet
Operating Lease Right Of Use Asset
Assets
Derivative Assets
Current Assets
Accounts Receivable Net Current
NonCurrent Assets
Other Assets Noncurrent
PropertyPlantAndEquipmentNet
Accumulated Depreciation Depletion And Amortization Property Plant And Equipment
Liabilities
Derivative Liabilities
Current Liabilities
Accounts Payable Current
Stockholders Equity
Retained Earnings Accumulated Deficit
CashFlow
Net Income Loss
NetCashProvidedByUsedInOperatingActivities
Net Income Loss
NetCashProvidedByUsedInInvestingActivities
Payments To Acquire Property Plant And Equipment
Shares
Weighted Average Number Of Share Outstanding Basic And Diluted
OperatingLeaseLiability
Operating Lease Liability Current
LesseeOperatingLeaseLiabilityPaymentsDue
Lessee Operating Lease Liability Payments Remainder Of Fiscal Year

Tables

  2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-31
us-gaap:CommonStockValue ████▄▄▁▁▁▁1.5411.5371.5311.5241.3851.3821.2881.2861.2831.279
us-gaap:WeightedAverageNumberOfDilutedSharesOutstanding █▁121.291435120.884665NANA105.717912102.419718NANANANA
us-gaap:WeightedAverageNumberOfSharesOutstandingBasic █▁121.291435120.884665NANA105.717912102.419718NANANANA
us-gaap:WeightedAverageNumberOfShareOutstandingBasicAndDiluted NANANA107.490702105.717912102.41971896.0789595.85904895.49549794.984503
us-gaap:AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount ▁█16.70362417.022363NA15.95078616.02484716.168362NA12.81805312.86570412.815477
us-gaap:EarningsPerShareBasic █▁-0.5-0.58NANA-0.56-0.55NANANANA
us-gaap:EarningsPerShareDiluted █▁-0.5-0.58NANA-0.56-0.55NANANANA
us-gaap:EarningsPerShareBasicAndDiluted NANANA-0.54-0.56-0.55-0.56-0.48-0.61-0.41
  2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-31
  2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-31
  2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-31
us-gaap:AllocatedShareBasedCompensationExpense ██▄▄▄▃▂▂▄▁21.13621.02813.8313.25212.48410.7858.8898.90113.7146.874
us-gaap:ComprehensiveIncomeNetOfTax ▁▁█▁▁▁▁▂▁▂-60.827-70.028244.629-58.768-59.042-56.278-54.237-46.577-57.79-38.011
us-gaap:GeneralAndAdministrativeExpense ██▇▆▄▃▂▂▅▁19.04518.93617.99415.80513.97212.55510.87911.21515.0769.31
us-gaap:IncomeTaxExpenseBenefit NANANA0.0560.079-0.1350.075-0.113-0.3130.0
us-gaap:NetIncomeLoss ▁▁█▁▁▁▁▂▁▂-60.691-70.041244.885-58.228-58.758-56.763-54.025-46.26-58.337-38.992
 us-gaap:NetIncomeLoss us-gaap:StatementEquityComponents us-gaap:RetainedEarnings▁▁█▁▁▁▁▂▁▂-60.691-70.041244.885-58.228-58.758-56.763-54.025-46.26-58.337-38.992
us-gaap:NonoperatingIncomeExpense ▁▁▂▃▄▆▇▇█▇1.1261.1791.631.9442.5983.0693.8083.7824.1133.516
us-gaap:OperatingExpenses █▇▆▅▅▄▄▄▅▁84.75679.14372.73769.50967.12463.57162.4363.75966.9646.713
us-gaap:OperatingIncomeLoss ▁▁█▁▁▁▁▁▁▂-61.817-71.22244.078-60.116-61.277-59.967-57.758-50.155-62.763-42.508
us-gaap:ResearchAndDevelopmentExpense █▇▅▅▅▄▄▅▅▁65.71160.20754.74353.70453.15251.01651.55152.54451.88437.403
us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax ▁▁█▁▁▁▁▁▁▁22.9367.922316.819.3885.8113.5524.67213.6044.1974.205
us-gaap:Revenues ▁▁█▁▁▁▁▁▁▁22.9397.923316.8159.3935.8473.6044.67213.6044.1974.205
  2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-31
  2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-31
us-gaap:Assets ▇██▄▂▂▁▁▂▂1509.8151547.8581604.281070.306647.337695.865553.231602.978637.604676.596
us-gaap:Liabilities ███▂▁▁▁▁▁▁437.11442.505453.749187.756145.17150.554158.341164.781162.431159.948
us-gaap:LiabilitiesAndStockholdersEquity ▇██▄▂▂▁▁▂▂1509.8151547.8581604.281070.306647.337695.865553.231602.978637.604676.596
us-gaap:StockholdersEquity ▇██▆▂▂▁▁▂▂1072.7051105.3531150.531882.55502.167545.311394.89438.197475.173516.648
  2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-31
us-gaap:AssetsCurrent ▇██▅▂▂▁▁▁▁1341.7451431.6221495.655970.866559.409604.785430.031494.377495.981499.533
us-gaap:CashAndCashEquivalentsAtCarryingValue █▇█▆▂▄▂▂▁▁485.68435.321507.144351.047137.184207.53779.44982.67362.93639.661
us-gaap:CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents █▇█▆▂▄▂▂▁▁487.18436.821508.644352.547138.684209.03780.94984.17364.43641.161
us-gaap:MarketableSecuritiesCurrent ▆██▄▂▁▁▂▂▂823.251977.827962.553610.154412.397379.713335.907396.717415.667445.82
us-gaap:AccountsReceivableNetCurrent 15.218NA8.593NANANANANANANA
us-gaap:PrepaidExpenseAndOtherAssetsCurrent ▅▅█▁▁▆▄▅▆▄16.02915.96320.2849.6659.82817.53514.67514.98717.37814.052
  2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-31
us-gaap:PropertyPlantAndEquipmentGross NANA61.648NANANA59.005NANANA
 us-gaap:PropertyPlantAndEquipmentGross us-gaap:PropertyPlantAndEquipmentByType dnli:ComputerEquipmentAndSoftwareNANA1.254NANANA1.156NANANA
 us-gaap:PropertyPlantAndEquipmentGross us-gaap:PropertyPlantAndEquipmentByType us-gaap:EquipmentNANA24.216NANANA21.846NANANA
 us-gaap:PropertyPlantAndEquipmentGross us-gaap:PropertyPlantAndEquipmentByType us-gaap:FurnitureAndFixturesNANA1.44NANANA1.44NANANA
 us-gaap:PropertyPlantAndEquipmentGross us-gaap:PropertyPlantAndEquipmentByType us-gaap:LeaseholdImprovementsNANA34.738NANANA34.563NANANA
us-gaap:AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment NANA20.802NANANA12.273NANANA
us-gaap:PropertyPlantAndEquipmentNet ▃▄▄▅▅▇███▁40.3541.37640.84642.26543.62245.45246.73247.48147.19536.955
us-gaap:OperatingLeaseRightOfUseAsset ▁▂▃▄▅▆▆▇█▇31.62232.23632.61832.97633.31233.62633.92334.34434.64734.407
us-gaap:OtherAssetsNoncurrent ▃▃▁▃▃▁▁▂▃█3.5763.7392.4623.8583.7652.3182.6593.2423.9498.147
  2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-31
us-gaap:AccountsPayableCurrent █▂▁▅▃▄▄▃▇▇4.2351.6261.0712.8061.8662.3162.592.0223.9313.662
us-gaap:AccruedLiabilitiesCurrent NA8.2998.31511.5318.4247.2656.56915.46713.79312.114
us-gaap:ContractWithCustomerLiabilityCurrent ▁▃▄▆█▆▄▄▅▅5.75512.88619.91428.01534.13424.67418.73918.18522.59823.148
us-gaap:LiabilitiesCurrent ▂▂▄█▃▁▁▁▁▁51.41254.6171.699105.41358.46447.63545.34446.68546.54943.244
us-gaap:OperatingLeaseLiabilityCurrent █▇▆▅▄▃▁5.0554.8764.694.5084.334.1213.665NANANA
us-gaap:OtherLiabilitiesCurrent NANA47.145NANANA24.0153.4832.1351.107
  2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-31
us-gaap:OtherLiabilitiesNoncurrent ███▁▁▁▁▁▂▂0.7010.7010.7010.3790.3790.3790.3790.3860.4080.44
us-gaap:OperatingLeaseLiabilityNoncurrent ▁▂▃▄▅▅▆▇██61.39662.91664.17565.40766.61267.79368.86569.91570.91171.412
us-gaap:LesseeOperatingLeaseLiabilityPaymentsDueYearTwo ▇█▁▁11.05311.08310.73110.731NANANANANANA
us-gaap:LesseeOperatingLeaseLiabilityPaymentsDueYearThree ▇█▁▁11.41711.44711.08311.083NANANANANANA
us-gaap:LesseeOperatingLeaseLiabilityPaymentsDueYearFour ▇█▁▁11.79311.82411.44711.447NANANANANANA
us-gaap:LesseeOperatingLeaseLiabilityPaymentsDueYearFive NANA11.824NANANANANANANA
us-gaap:LesseeOperatingLeaseLiabilityPaymentsDueAfterYearFive NANA42.25NANANANANANANA
  2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-31
us-gaap:StockholdersEquity ▇██▆▂▂▁▁▂▂1072.7051105.3531150.531882.55502.167545.311394.89438.197475.173516.648
us-gaap:CommonStockValue ████▄▄▁▁▁▁1.5411.5371.5311.5241.3851.3821.2881.2861.2831.279
us-gaap:AdditionalPaidInCapital ███▇▃▃▁▁▁▁1556.6791528.5041503.661480.3151041.3031025.408818.803807.875798.277781.966
 us-gaap:CommonStocksIncludingAdditionalPaidInCapital us-gaap:CounterpartyName,us-gaap:ResearchAndDevelopmentArrangementContractToPerformForOthersByType,us-gaap:TypeOfArrangement dnli:Biogen,dnli:SharePurchaseAgreement,dnli:ProvisionalCollaborativeArrangementNANANANANANANANANANA
us-gaap:RetainedEarningsAccumulatedDeficit ▃▅▆▁▂▃▅▆▇█-485.147-424.456-354.415-599.3-541.072-482.314-425.551-371.526-325.266-266.929
us-gaap:AccumulatedOtherComprehensiveIncomeLossNetOfTax ▁▂▂▃▆█▅▆█▅-0.368-0.232-0.2450.0110.5510.8350.350.5620.8790.332
us-gaap:StockIssuedDuringPeriodValueNewIssues NANA0.00.00.0193.948NANANANA
 us-gaap:StockIssuedDuringPeriodValueNewIssues us-gaap:StatementEquityComponents us-gaap:AdditionalPaidInCapitalNANA0.00.00.0193.858NANANANA
 us-gaap:StockIssuedDuringPeriodValueNewIssues us-gaap:StatementEquityComponents us-gaap:CommonStockNANA0.00.00.00.09NANANANA
us-gaap:AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue ██▄▄▄▃▂▂▄▁21.13621.02813.8313.25212.48410.7858.8898.90113.7146.874
  2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-31
us-gaap:NetCashProvidedByUsedInOperatingActivities ▁▁█▂▁▁▁▁▁▁-54.221-50.24513.9150.086-43.357-54.492-47.643-30.435-43.175-30.323
us-gaap:NetCashProvidedByUsedInInvestingActivities █▆▁▃▆▆▇▇▇▆97.537-25.405-367.34-212.122-30.411-13.33342.38549.49363.881-8.047
us-gaap:NetCashProvidedByUsedInFinancingActivities ▁▁▁█▁▄▁▁▁▁7.0433.8229.522425.8993.415195.9132.0340.6792.5690.908
  2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-31
us-gaap:DepreciationDepletionAndAmortization ▆▅▅▆▆▅▅▃▁█2.2042.1082.1212.1562.1452.1092.0551.891.6432.403
us-gaap:IncreaseDecreaseInAccountsPayable █▅▁▅▃▃▅▃▃▇2.3780.623-1.770.891-0.452-0.2920.567-0.837-0.6621.965
us-gaap:NetCashProvidedByUsedInOperatingActivities ▁▁█▂▁▁▁▁▁▁-54.221-50.24513.9150.086-43.357-54.492-47.643-30.435-43.175-30.323
us-gaap:NetIncomeLoss ▁▁█▁▁▁▁▂▁▂-60.691-70.041244.885-58.228-58.758-56.763-54.025-46.26-58.337-38.992
 us-gaap:NetIncomeLoss us-gaap:StatementEquityComponents us-gaap:RetainedEarnings▁▁█▁▁▁▁▂▁▂-60.691-70.041244.885-58.228-58.758-56.763-54.025-46.26-58.337-38.992
us-gaap:ShareBasedCompensation ██▄▄▄▃▂▂▄▁21.13621.02813.8313.25212.48410.7858.8898.90113.7146.874
  2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-31
us-gaap:NetCashProvidedByUsedInInvestingActivities █▆▁▃▆▆▇▇▇▆97.537-25.405-367.34-212.122-30.411-13.33342.38549.49363.881-8.047
us-gaap:PaymentsToAcquirePropertyPlantAndEquipment ▁▃▂▁▁▁▃▃█▂0.7722.81.1950.7060.3150.8792.7732.84710.2712.028
  2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-31
us-gaap:NetCashProvidedByUsedInFinancingActivities ▁▁▁█▁▄▁▁▁▁7.0433.8229.522425.8993.415195.9132.0340.6792.5690.908
  2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-31

Common Stock Value

us-gaap:CommonStockValue

us-gaap:CommonStockValue


Common
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-31
Value1541000.01537000.01531000.01524000.01385000.01382000.01288000.01286000.01283000.01279000.01273000.01266000.01259000.01252000.01201000.0
Percentage of CommonStockValue100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0
Percentage of Assets0.10.10.10.10.20.20.20.20.20.20.20.20.20.20.2

Weighted Average Number Of Diluted Shares Outstanding

us-gaap:WeightedAverageNumberOfDilutedSharesOutstanding

us-gaap:WeightedAverageNumberOfDilutedSharesOutstanding


Weighted
Period End2021-06-302021-03-312020-06-302020-03-31
Value121120105102
Percentage of WeightedAverageNumberOfDilutedSharesOutstanding100.0100.0100.0100.0

Weighted Average Number Of Shares Outstanding Basic

us-gaap:WeightedAverageNumberOfSharesOutstandingBasic

us-gaap:WeightedAverageNumberOfSharesOutstandingBasic


Weighted
Period End2021-06-302021-03-312020-06-302020-03-31
Value121120105102
Percentage of WeightedAverageNumberOfSharesOutstandingBasic100.0100.0100.0100.0

Weighted Average Number Of Share Outstanding Basic And Diluted

us-gaap:WeightedAverageNumberOfShareOutstandingBasicAndDiluted

us-gaap:WeightedAverageNumberOfShareOutstandingBasicAndDiluted


Weighted
Period End2020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-09-302018-06-302018-03-312017-09-302017-06-302017-03-31
Value10710510296959594939289109.6704499.017425
Percentage of WeightedAverageNumberOfShareOutstandingBasicAndDiluted100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0

Antidilutive Securities Excluded From Computation Of Earnings Per Share Amount

us-gaap:AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount

us-gaap:AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount


Antidilutive
Period End2021-06-302021-03-312020-09-302020-06-302020-03-312019-09-302019-06-302019-03-312018-09-302018-06-302018-03-312017-09-302017-06-302017-03-31
Value1617151616121212101011676868
Percentage of AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0

us-gaap:AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount us-gaap:AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecurities

dnli:EmployeeAndNonEmployeeStockOption


Antidilutive
Period End2021-06-302021-03-312020-09-302020-06-302020-03-312019-09-302019-06-302019-03-312018-09-302018-06-302018-03-312017-09-302017-06-302017-03-31
Value14141314141112129.6444449.2646449.2431126.1796875.9540995.877804
Percentage of AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount84.284.185.889.689.993.594.995.289.886.983.39.18.78.6

dnli:RestrictedSharesSubjectToFutureVesting


Antidilutive
Period End2021-06-302021-03-312020-09-302020-06-302020-03-312019-09-302019-06-302019-03-312018-09-302018-06-302018-03-312017-09-302017-06-302017-03-31
Value2.6469012.6991072.2698971.6730521.6379840.8265110.6100030.5243590.9104521.1679971.5752042.7010593.1082013.515405
Percentage of AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount15.815.914.210.410.16.44.74.18.511.014.24.04.65.1

Earnings Per Share Basic

us-gaap:EarningsPerShareBasic

us-gaap:EarningsPerShareBasic


Earnings
Period End2021-06-302021-03-312020-06-302020-03-312018-12-312018-09-302018-06-302018-03-31
Value-0.5-0.58-0.56-0.550.82-0.38-0.59-0.26
Percentage of EarningsPerShareBasic100.0100.0100.0100.0100.0100.0100.0100.0

Earnings Per Share Diluted

us-gaap:EarningsPerShareDiluted

us-gaap:EarningsPerShareDiluted


Earnings
Period End2021-06-302021-03-312020-06-302020-03-312018-12-312018-09-302018-06-302018-03-31
Value-0.5-0.58-0.56-0.550.79-0.38-0.59-0.26
Percentage of EarningsPerShareDiluted100.0100.0100.0100.0100.0100.0100.0100.0

Earnings Per Share Basic And Diluted

us-gaap:EarningsPerShareBasicAndDiluted

us-gaap:EarningsPerShareBasicAndDiluted


Earnings
Period End2020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302017-06-302017-03-31
Value-0.54-0.56-0.55-0.56-0.48-0.61-0.410.85-0.38-0.59-0.26-0.74-2.14-2.29-2.36
Percentage of EarningsPerShareBasicAndDiluted100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0

Allocated Share Based Compensation Expense

us-gaap:AllocatedShareBasedCompensationExpense

us-gaap:AllocatedShareBasedCompensationExpense


Allocated
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302017-06-302017-03-31
Value2121131312108.8898.901136.8745.6465.514.712.9251.4571.1281.0590.765
Percentage of AllocatedShareBasedCompensationExpense100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0
Percentage of RevenueFromCollaborativeArrangementExcludingRevenueFromContractWithCustomer704533.32102800.00.0265040.034677.820740.40.09271.913852.57312.80.00.00.00.00.00.00.00.0

us-gaap:AllocatedShareBasedCompensationExpense us-gaap:IncomeStatementLocation

us-gaap:GeneralAndAdministrativeExpense


Allocated
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302017-06-302017-03-31
Value8.6278.7145.8095.4715.3384.7313.8283.9788.4192.8922.7322.6032.1241.2390.5520.4030.350.252
Percentage of AllocatedShareBasedCompensationExpense40.841.442.041.342.843.943.144.761.442.148.447.245.142.437.935.733.132.9
Percentage of RevenueFromCollaborativeArrangementExcludingRevenueFromContractWithCustomer287566.7871400.00.0109420.014827.89098.10.04143.88504.03076.60.00.00.00.00.00.00.00.0
Percentage of RevenueFromCollaborativeArrangementExcludingRevenueFromContractWithCustomer us-gaap:GeneralAndAdministrativeExpense0.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.0

us-gaap:ResearchAndDevelopmentExpense


Allocated
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302017-06-302017-03-31
Value12128.0217.7817.1466.0545.0614.9235.2953.9822.9142.9072.5861.6860.9050.7250.7090.513
Percentage of AllocatedShareBasedCompensationExpense59.258.658.058.757.256.156.955.338.657.951.652.854.957.662.164.366.967.1
Percentage of RevenueFromCollaborativeArrangementExcludingRevenueFromContractWithCustomer416966.71231400.00.0155620.019850.011642.30.05128.15348.54236.20.00.00.00.00.00.00.00.0
Percentage of RevenueFromCollaborativeArrangementExcludingRevenueFromContractWithCustomer us-gaap:ResearchAndDevelopmentExpense0.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.0

Comprehensive Income Net Of Tax

us-gaap:ComprehensiveIncomeNetOfTax

us-gaap:ComprehensiveIncomeNetOfTax


Comprehensive
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302017-06-302017-03-31
Value-60.827-70.028244-58.768-59.042-56.278-54.237-46.577-57.79-38.01178-35.294-54.93-24.597-23.018-21.704-22.116-21.342
Percentage of ComprehensiveIncomeNetOfTax100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0
Percentage of RevenueFromCollaborativeArrangementExcludingRevenueFromContractWithCustomer-2027566.7-7002800.00.0-1175360.0-164005.6-108226.90.0-48517.7-58373.7-40437.20.00.00.00.00.00.00.00.0

General And Administrative Expense

us-gaap:GeneralAndAdministrativeExpense

us-gaap:GeneralAndAdministrativeExpense


General
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302017-06-302017-03-31
Value1918171513121011159.31118.8386.8965.575.0693.7733.5643.274
Percentage of GeneralAndAdministrativeExpense100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0
Percentage of RevenueFromCollaborativeArrangementExcludingRevenueFromContractWithCustomer634833.31893600.00.0316100.038811.124144.20.011682.315228.39904.30.00.00.00.00.00.00.00.0

Income Tax Expense Benefit

us-gaap:IncomeTaxExpenseBenefit

us-gaap:IncomeTaxExpenseBenefit


Income
Period End2020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-30
Value56000.079000.0-135000.075000.0-113000.0-313000.00000
Percentage of IncomeTaxExpenseBenefit100.0100.0100.0100.0100.0100.00.00.00.00.0
Percentage of RevenueFromCollaborativeArrangementExcludingRevenueFromContractWithCustomer1120.0219.4-259.60.0-117.7-316.20.00.00.00.0

Net Income Loss

us-gaap:NetIncomeLoss

us-gaap:NetIncomeLoss


Net
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302017-06-302017-03-31
Value-60.691-70.041244-58.228-58.758-56.763-54.025-46.26-58.337-38.99277-35.371-54.724-23.678-22.887-21.844-22.134-21.32
Percentage of NetIncomeLoss100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0
Percentage of RevenueFromCollaborativeArrangementExcludingRevenueFromContractWithCustomer-2023033.3-7004100.00.0-1164560.0-163216.7-109159.60.0-48187.5-58926.3-41480.90.00.00.00.00.00.00.00.0

us-gaap:NetIncomeLoss us-gaap:StatementEquityComponents

us-gaap:RetainedEarnings


Net
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-31
Value-60.691-70.041244-58.228-58.758-56.763-54.025-46.26-58.337-38.99277-35.371-54.724-23.678
Percentage of NetIncomeLoss100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0
Percentage of RevenueFromCollaborativeArrangementExcludingRevenueFromContractWithCustomer-2023033.3-7004100.00.0-1164560.0-163216.7-109159.60.0-48187.5-58926.3-41480.90.00.00.00.0
Percentage of RevenueFromCollaborativeArrangementExcludingRevenueFromContractWithCustomer us-gaap:RetainedEarnings0.00.00.00.00.00.00.00.00.00.00.00.00.00.0

Nonoperating Income Expense

us-gaap:NonoperatingIncomeExpense

us-gaap:NonoperatingIncomeExpense


Nonoperating
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302017-06-302017-03-31
Value1.1261.1791.631.9442.5983.0693.8083.7824.1133.5162.8112.5932.6582.070.6530.4440.4340.424
Percentage of NonoperatingIncomeExpense100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0
Percentage of RevenueFromCollaborativeArrangementExcludingRevenueFromContractWithCustomer37533.3117900.00.038880.07216.75901.90.03939.64154.53740.40.00.00.00.00.00.00.00.0

Operating Expenses

us-gaap:OperatingExpenses

us-gaap:OperatingExpenses


Operating
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302017-06-302017-03-31
Value847972696763626366465039592623222221
Percentage of OperatingExpenses100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0
Percentage of RevenueFromCollaborativeArrangementExcludingRevenueFromContractWithCustomer2825200.07914300.00.01390180.0186455.6122251.90.066415.667636.449694.70.00.00.00.00.00.00.00.0

Operating Income Loss

us-gaap:OperatingIncomeLoss

us-gaap:OperatingIncomeLoss


Operating
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302017-06-302017-03-31
Value-61.817-71.22244-60.116-61.277-59.967-57.758-50.155-62.763-42.50874-37.964-57.382-25.748-23.54-22.288-22.568-21.744
Percentage of OperatingIncomeLoss100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0
Percentage of RevenueFromCollaborativeArrangementExcludingRevenueFromContractWithCustomer-2060566.7-7122000.00.0-1202320.0-170213.9-115321.20.0-52244.8-63397.0-45221.30.00.00.00.00.00.00.00.0

Research And Development Expense

us-gaap:ResearchAndDevelopmentExpense

us-gaap:ResearchAndDevelopmentExpense


Research
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302017-06-302017-03-31
Value656054535351515251373930522018181918
Percentage of ResearchAndDevelopmentExpense100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0
Percentage of RevenueFromCollaborativeArrangementExcludingRevenueFromContractWithCustomer2190366.76020700.00.01074080.0147644.498107.70.054733.352408.139790.40.00.00.00.00.00.00.00.0

us-gaap:ResearchAndDevelopmentExpense us-gaap:CapitalizedCostsOfUnprovedPropertiesExcludedFromAmortizationByPropertyOrProject

dnli:CollaborativeArrangementWithFStarAndAcquisitionOfFStarGamma


Research
Period End2020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302017-06-30
Value0.30.30.30.30.30.30.30.2-0.10.30.20.30.30.30.2
Percentage of ResearchAndDevelopmentExpense0.50.60.60.60.60.60.60.5-0.31.00.41.41.61.61.1
Percentage of RevenueFromCollaborativeArrangementExcludingRevenueFromContractWithCustomer0.06000.0833.3576.90.0312.5303.0212.80.00.00.00.00.00.00.0
Percentage of RevenueFromCollaborativeArrangementExcludingRevenueFromContractWithCustomer dnli:CollaborativeArrangementWithFStarAndAcquisitionOfFStarGamma0.00.00.00.00.00.00.00.00.00.00.00.00.00.00.0

Revenue From Contract With Customer Excluding Assessed Tax

us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax

us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax


Revenue
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302017-06-30
Value227.9223169.3885.8113.5524.672134.1974.2051251.1951.6480.6410.00.00.0
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.00.00.00.0
Percentage of RevenueFromCollaborativeArrangementExcludingRevenueFromContractWithCustomer764533.3792200.00.0187760.016141.76830.80.014170.84239.44473.40.00.00.00.00.00.00.0

us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax us-gaap:CounterpartyName, us-gaap:ProductOrService, us-gaap:TypeOfArrangement

dnli:Sanofi, dnli:MilestoneTriggered, us-gaap:CollaborativeArrangement


Revenue
Period End2021-06-302020-09-302020-06-302019-07-31
Value150.00.010.0
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax65.40.00.00.0
Percentage of RevenueFromCollaborativeArrangementExcludingRevenueFromContractWithCustomer0.00.00.00.0
Percentage of RevenueFromCollaborativeArrangementExcludingRevenueFromContractWithCustomer dnli:Sanofi dnli:MilestoneTriggered us-gaap:CollaborativeArrangement0.00.00.00.0

dnli:TakedaPharmaceuticalCompanyLimited, dnli:MilestoneTriggered, us-gaap:CollaborativeArrangement


Revenue
Period End2021-06-30
Value0.0
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax0.0
Percentage of RevenueFromCollaborativeArrangementExcludingRevenueFromContractWithCustomer0.0
Percentage of RevenueFromCollaborativeArrangementExcludingRevenueFromContractWithCustomer dnli:TakedaPharmaceuticalCompanyLimited dnli:MilestoneTriggered us-gaap:CollaborativeArrangement0.0

us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax us-gaap:ProductOrService, us-gaap:TypeOfArrangement

dnli:OptionServices, dnli:Biogen


Revenue
Period End2021-06-302021-03-31
Value0.7940.892
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax3.511.3
Percentage of RevenueFromCollaborativeArrangementExcludingRevenueFromContractWithCustomer26466.789200.0
Percentage of RevenueFromCollaborativeArrangementExcludingRevenueFromContractWithCustomer dnli:OptionServices dnli:Biogen0.00.0

dnli:PeripheralProduct, dnli:SanofiCollaborationAgreement


Revenue
Period End2021-06-302019-12-312019-09-302018-12-312018-09-30
Value150.010.0470.0
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax65.40.073.537.50.0
Percentage of RevenueFromCollaborativeArrangementExcludingRevenueFromContractWithCustomer500000.00.010416.70.00.0
Percentage of RevenueFromCollaborativeArrangementExcludingRevenueFromContractWithCustomer dnli:PeripheralProduct dnli:SanofiCollaborationAgreement0.00.00.00.00.0

dnli:RetainedActivities, dnli:SanofiCollaborationAgreement


Revenue
Period End2020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-31
Value0.0440.1170.2740.5341.1842.4233.3583.4292.3430.00.00.0
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax0.01.24.715.025.317.880.081.51.90.00.00.0
Percentage of RevenueFromCollaborativeArrangementExcludingRevenueFromContractWithCustomer0.02340.0761.11026.90.02524.03391.93647.90.00.00.00.0
Percentage of RevenueFromCollaborativeArrangementExcludingRevenueFromContractWithCustomer dnli:RetainedActivities dnli:SanofiCollaborationAgreement0.00.00.00.00.00.00.00.00.00.00.00.0

us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax us-gaap:TypeOfArrangement

dnli:TakedaCollaborationAgreement


Revenue
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-31
Value7.1427.039.3299.2715.5373.0183.4191.0850.740.6822.1931.1951.6480.641
Percentage of RevenueFromContractWithCustomerExcludingAssessedTax31.188.72.998.895.385.073.28.017.616.21.7100.0100.0100.0
Percentage of RevenueFromCollaborativeArrangementExcludingRevenueFromContractWithCustomer238066.7703000.00.0185420.015380.65803.80.01130.2747.5725.50.00.00.00.0
Percentage of RevenueFromCollaborativeArrangementExcludingRevenueFromContractWithCustomer dnli:TakedaCollaborationAgreement0.00.00.00.00.00.00.00.00.00.00.00.00.00.0

Revenues

us-gaap:Revenues

us-gaap:Revenues


Revenues
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302017-06-30
Value227.9233169.3935.8473.6044.672134.1974.2051251.1951.6480.6410.00.00.0
Percentage of Revenues100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.00.00.00.0
Percentage of RevenueFromCollaborativeArrangementExcludingRevenueFromContractWithCustomer764633.3792300.00.0187860.016241.76930.80.014170.84239.44473.40.00.00.00.00.00.00.0

us-gaap:Revenues us-gaap:TypeOfArrangement

dnli:Biogen


Revenuesus-gaap:
Period End2021-06-30
Value0.794
Percentage of Revenues3.5
Percentage of RevenueFromCollaborativeArrangementExcludingRevenueFromContractWithCustomer26466.7
Percentage of RevenueFromCollaborativeArrangementExcludingRevenueFromContractWithCustomer dnli:Biogen0.0

dnli:SanofiCollaborationAgreement


Revenuesus-gaap:
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-31
Value150.0010.0490.1220.310.5861.253123.4573.5231230.00.00.0
Percentage of Revenues65.40.00.01.35.316.326.892.082.483.898.30.00.00.0
Percentage of RevenueFromCollaborativeArrangementExcludingRevenueFromContractWithCustomer500100.0100.00.02440.0861.11126.90.013040.63491.93747.90.00.00.00.0
Percentage of RevenueFromCollaborativeArrangementExcludingRevenueFromContractWithCustomer dnli:SanofiCollaborationAgreement0.00.00.00.00.00.00.00.00.00.00.00.00.00.0

Assets

us-gaap:Assets

us-gaap:Assets


Assets
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-31
Value1509154716041070647695553602637676661544572613486
Percentage of Assets100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0
Percentage of Assets100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0

Liabilities

us-gaap:Liabilities

us-gaap:Liabilities


Liabilities
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-31
Value43744245318714515015816416215911583817420
Percentage of Liabilities100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0
Percentage of Assets29.028.628.317.522.421.628.627.325.523.617.415.314.312.24.3

Liabilities And Stockholders Equity

us-gaap:LiabilitiesAndStockholdersEquity

us-gaap:LiabilitiesAndStockholdersEquity


Liabilities
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-31
Value1509154716041070647695553602637676661544572613486
Percentage of LiabilitiesAndStockholdersEquity100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0
Percentage of Assets100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0

Stockholders Equity

us-gaap:StockholdersEquity

us-gaap:StockholdersEquity


Stockholders
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312016-12-312015-12-31
Value107211051150882502545394438475516546461490539465-94.154-15.634
Percentage of StockholdersEquity100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0
Percentage of Assets71.071.471.782.577.678.471.472.774.576.482.684.785.787.895.70.00.0

us-gaap:StockholdersEquity us-gaap:StatementEquityComponents

us-gaap:AccumulatedOtherComprehensiveIncome


Stockholders
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312016-12-31
Value-0.368-0.232-0.2450.0110.5510.8350.350.5620.8790.332-0.649-1.416-1.493-1.287-0.368-0.373
Percentage of StockholdersEquity-0.0-0.0-0.00.00.10.20.10.10.20.1-0.1-0.3-0.3-0.2-0.10.4
Percentage of Assets-0.0-0.0-0.00.00.10.10.10.10.10.0-0.1-0.3-0.3-0.2-0.10.0
Percentage of Assets us-gaap:AccumulatedOtherComprehensiveIncome0.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.0

us-gaap:AdditionalPaidInCapital


Stockholders
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312016-12-312015-12-31
Value1556152815031480104110258188077987817747667607546569.3871.056
Percentage of StockholdersEquity145.1138.3130.7167.7207.4188.0207.3184.4168.0151.4141.6166.3155.1140.0141.0-10.0-6.8
Percentage of Assets103.198.793.7138.3160.9147.4148.0134.0125.2115.6116.9140.8133.0122.9134.90.00.0
Percentage of Assets us-gaap:AdditionalPaidInCapital0.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.0

us-gaap:CommonStock


Stockholders
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312016-12-312015-12-31
Value1.5411.5371.5311.5241.3851.3821.2881.2861.2831.2791.2731.2661.2591.2521.2010.3440.17
Percentage of StockholdersEquity0.10.10.10.20.30.30.30.30.30.20.20.30.30.20.3-0.4-1.1
Percentage of Assets0.10.10.10.10.20.20.20.20.20.20.20.20.20.20.20.00.0
Percentage of Assets us-gaap:CommonStock0.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.0

us-gaap:RetainedEarnings


Stockholders
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312016-12-312015-12-31
Value-485.147-424.456-354.415-599.3-541.072-482.314-425.551-371.526-325.266-266.929-227.937-305.47-270.099-215.375-191.697-103.512-16.86
Percentage of StockholdersEquity-45.2-38.4-30.8-67.9-107.7-88.4-107.8-84.8-68.5-51.7-41.7-66.2-55.1-40.0-41.2109.9107.8
Percentage of Assets-32.1-27.4-22.1-56.0-83.6-69.3-76.9-61.6-51.0-39.5-34.4-56.1-47.2-35.1-39.40.00.0
Percentage of Assets us-gaap:RetainedEarnings0.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.0

Assets Current

us-gaap:AssetsCurrent

us-gaap:AssetsCurrent


Assets
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-31
Value134114311495970559604430494495499480383377377409
Percentage of AssetsCurrent100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0
Percentage of Assets88.992.593.290.786.486.977.782.077.873.872.670.466.061.584.2

Cash And Cash Equivalents At Carrying Value

us-gaap:CashAndCashEquivalentsAtCarryingValue

us-gaap:CashAndCashEquivalentsAtCarryingValue


Cash
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302017-06-302017-03-312016-12-31
Value485435507351137207798262397743334421836413639
Percentage of CashAndCashEquivalentsAtCarryingValue100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0
Percentage of Assets32.228.131.632.821.229.814.413.79.95.911.78.05.87.244.90.00.00.00.0

Cash Cash Equivalents Restricted Cash And Restricted Cash Equivalents

us-gaap:CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents

us-gaap:CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents


Cash
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302017-06-302017-03-312016-12-312015-12-31
Value48743650835213820980846441784534442183641374030
Percentage of CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0
Percentage of Assets32.328.231.732.921.430.014.614.010.16.111.98.36.07.245.00.00.00.00.00.0

Marketable Securities Current

us-gaap:MarketableSecuritiesCurrent

us-gaap:MarketableSecuritiesCurrent


Marketable
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-31
Value823977962610412379335396415445387331339329187
Percentage of MarketableSecuritiesCurrent100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0
Percentage of Assets54.563.260.057.063.754.660.765.865.265.958.560.859.353.738.6

Accounts Receivable Net Current

us-gaap:AccountsReceivableNetCurrent

us-gaap:AccountsReceivableNetCurrent


Accounts
Period End2021-06-302020-12-31
Value158.593
Percentage of AccountsReceivableNetCurrent100.0100.0
Percentage of Assets1.00.5

Prepaid Expense And Other Assets Current

us-gaap:PrepaidExpenseAndOtherAssetsCurrent

us-gaap:PrepaidExpenseAndOtherAssetsCurrent


Prepaid
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-31
Value1615209.6659.8281714141714168.4454.8274.023.381
Percentage of PrepaidExpenseAndOtherAssetsCurrent100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0
Percentage of Assets1.11.01.30.91.52.52.72.52.72.12.51.60.80.70.7

Property Plant And Equipment Gross

us-gaap:PropertyPlantAndEquipmentGross

us-gaap:PropertyPlantAndEquipmentGross


Property
Period End2020-12-312019-12-312018-12-312017-12-31
Value61593719
Percentage of PropertyPlantAndEquipmentGross100.0100.0100.0100.0
Percentage of Assets3.810.75.64.0

us-gaap:PropertyPlantAndEquipmentGross us-gaap:PropertyPlantAndEquipmentByType

dnli:ComputerEquipmentAndSoftware


Property
Period End2020-12-312019-12-312018-12-312017-12-31
Value1.2541.1560.4580.439
Percentage of PropertyPlantAndEquipmentGross2.02.01.22.2
Percentage of Assets0.10.20.10.1
Percentage of Assets dnli:ComputerEquipmentAndSoftware0.00.00.00.0

us-gaap:Equipment


Property
Period End2020-12-312019-12-312018-12-312017-12-31
Value24211411
Percentage of PropertyPlantAndEquipmentGross39.337.038.657.9
Percentage of Assets1.53.92.22.3
Percentage of Assets us-gaap:Equipment0.00.00.00.0

us-gaap:FurnitureAndFixtures


Property
Period End2020-12-312019-12-312018-12-312017-12-31
Value1.441.440.0740.065
Percentage of PropertyPlantAndEquipmentGross2.32.40.20.3
Percentage of Assets0.10.30.00.0
Percentage of Assets us-gaap:FurnitureAndFixtures0.00.00.00.0

us-gaap:LeaseholdImprovements


Property
Period End2020-12-312019-12-312018-12-312017-12-31
Value3434227.737
Percentage of PropertyPlantAndEquipmentGross56.358.660.039.5
Percentage of Assets2.26.23.41.6
Percentage of Assets us-gaap:LeaseholdImprovements0.00.00.00.0

Accumulated Depreciation Depletion And Amortization Property Plant And Equipment

us-gaap:AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment

us-gaap:AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment


Accumulated
Period End2020-12-312019-12-312018-12-312017-12-31
Value2012124.669
Percentage of AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment100.0100.0100.0100.0
Percentage of Assets1.32.21.81.0

Property Plant And Equipment Net

us-gaap:PropertyPlantAndEquipmentNet

us-gaap:PropertyPlantAndEquipmentNet


Property
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-31
Value404140424345464747362516131414
Percentage of PropertyPlantAndEquipmentNet100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0
Percentage of Assets2.72.72.53.96.76.58.47.97.45.53.83.02.32.43.1

Operating Lease Right Of Use Asset

us-gaap:OperatingLeaseRightOfUseAsset

us-gaap:OperatingLeaseRightOfUseAsset


Operating
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-31
Value31323232333333343434
Percentage of OperatingLeaseRightOfUseAsset100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0
Percentage of Assets2.12.12.03.15.14.86.15.75.45.1

Other Assets Noncurrent

us-gaap:OtherAssetsNoncurrent

us-gaap:OtherAssetsNoncurrent


Other
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-31
Value3576000.03739000.02462000.03858000.03765000.02318000.02659000.03242000.03949000.08147000.08105000.02654000.02611000.02265000.01441000.0
Percentage of OtherAssetsNoncurrent100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0
Percentage of Assets0.20.20.20.40.60.30.50.50.61.21.20.50.50.40.3

Accounts Payable Current

us-gaap:AccountsPayableCurrent

us-gaap:AccountsPayableCurrent


Accounts
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-31
Value4235000.01626000.01071000.02806000.01866000.02316000.02590000.02022000.03931000.03662000.01891000.03354000.09176000.01377000.02716000.0
Percentage of AccountsPayableCurrent100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0
Percentage of Assets0.30.10.10.30.30.30.50.30.60.50.30.61.60.20.6

Accrued Liabilities Current

us-gaap:AccruedLiabilitiesCurrent

us-gaap:AccruedLiabilitiesCurrent


Accrued
Period End2021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-31
Value8.2998.315118.4247.2656.5691513128.527.3935.5374.4255.364
Percentage of AccruedLiabilitiesCurrent100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0
Percentage of Assets0.50.51.11.31.01.22.62.21.81.31.41.00.71.1

Contract With Customer Liability Current

us-gaap:ContractWithCustomerLiabilityCurrent

us-gaap:ContractWithCustomerLiabilityCurrent


Contract
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-31
Value5.75512192834241818222311128.7158.4340.0
Percentage of ContractWithCustomerLiabilityCurrent100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.00.0
Percentage of Assets0.40.81.22.65.33.53.43.03.53.41.72.31.51.40.0

Liabilities Current

us-gaap:LiabilitiesCurrent

us-gaap:LiabilitiesCurrent


Liabilities
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-31
Value5154711055847454646433231311714
Percentage of LiabilitiesCurrent100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0
Percentage of Assets3.43.54.59.89.06.88.27.77.36.45.05.85.42.82.9

Operating Lease Liability Current

us-gaap:OperatingLeaseLiabilityCurrent

us-gaap:OperatingLeaseLiabilityCurrent


Operating
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-31
Value5055000.04876000.04690000.04508000.04330000.04121000.03665000.0
Percentage of OperatingLeaseLiabilityCurrent100.0100.0100.0100.0100.0100.0100.0
Percentage of Assets0.30.30.30.40.70.60.7

Other Liabilities Current

us-gaap:OtherLiabilitiesCurrent

us-gaap:OtherLiabilitiesCurrent


Other
Period End2020-12-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-31
Value47243.4832.1351.1070.380.1380.0470.0630.063
Percentage of OtherLiabilitiesCurrent100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0
Percentage of Assets2.94.30.60.30.20.10.00.00.00.0

Other Liabilities Noncurrent

us-gaap:OtherLiabilitiesNoncurrent

us-gaap:OtherLiabilitiesNoncurrent


Other
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-31
Value701000.0701000.0701000.0379000.0379000.0379000.0379000.0386000.0408000.0440000.0471000.0124000.0156000.0188000.0467000.0
Percentage of OtherLiabilitiesNoncurrent100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0
Percentage of Assets0.00.00.00.00.10.10.10.10.10.10.10.00.00.00.1

Operating Lease Liability Noncurrent

us-gaap:OperatingLeaseLiabilityNoncurrent

us-gaap:OperatingLeaseLiabilityNoncurrent


Operating
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-31
Value61626465666768697071
Percentage of OperatingLeaseLiabilityNoncurrent100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0
Percentage of Assets4.14.14.06.110.39.712.411.611.110.6

Lessee Operating Lease Liability Payments Due Year Two

us-gaap:LesseeOperatingLeaseLiabilityPaymentsDueYearTwo

us-gaap:LesseeOperatingLeaseLiabilityPaymentsDueYearTwo


Lessee
Period End2021-06-302021-03-312020-12-312020-09-30
Value11111010
Percentage of LesseeOperatingLeaseLiabilityPaymentsDueYearTwo100.0100.0100.0100.0
Percentage of Assets0.70.70.71.0

Lessee Operating Lease Liability Payments Due Year Three

us-gaap:LesseeOperatingLeaseLiabilityPaymentsDueYearThree

us-gaap:LesseeOperatingLeaseLiabilityPaymentsDueYearThree


Lessee
Period End2021-06-302021-03-312020-12-312020-09-30
Value11111111
Percentage of LesseeOperatingLeaseLiabilityPaymentsDueYearThree100.0100.0100.0100.0
Percentage of Assets0.80.70.71.0

Lessee Operating Lease Liability Payments Due Year Four

us-gaap:LesseeOperatingLeaseLiabilityPaymentsDueYearFour

us-gaap:LesseeOperatingLeaseLiabilityPaymentsDueYearFour


Lessee
Period End2021-06-302021-03-312020-12-312020-09-30
Value11111111
Percentage of LesseeOperatingLeaseLiabilityPaymentsDueYearFour100.0100.0100.0100.0
Percentage of Assets0.80.80.71.1

Lessee Operating Lease Liability Payments Due Year Five

us-gaap:LesseeOperatingLeaseLiabilityPaymentsDueYearFive

us-gaap:LesseeOperatingLeaseLiabilityPaymentsDueYearFive


Lessee
Period End2020-12-31
Value11
Percentage of LesseeOperatingLeaseLiabilityPaymentsDueYearFive100.0
Percentage of Assets0.7

Lessee Operating Lease Liability Payments Due After Year Five

us-gaap:LesseeOperatingLeaseLiabilityPaymentsDueAfterYearFive

us-gaap:LesseeOperatingLeaseLiabilityPaymentsDueAfterYearFive


Lessee
Period End2020-12-31
Value42
Percentage of LesseeOperatingLeaseLiabilityPaymentsDueAfterYearFive100.0
Percentage of Assets2.6

Operating Lease Liability

us-gaap:OperatingLeaseLiability

us-gaap:OperatingLeaseLiability


Operating
Period End2021-06-302021-03-312020-12-312020-09-302019-12-312019-09-302019-06-302019-03-31
Value6667686972737272
Percentage of OperatingLeaseLiability100.0100.0100.0100.0100.0100.0100.0100.0
Percentage of Assets4.44.44.36.513.112.111.410.7

Lessee Operating Lease Liability Payments Due

us-gaap:LesseeOperatingLeaseLiabilityPaymentsDue

us-gaap:LesseeOperatingLeaseLiabilityPaymentsDue


Lessee
Period End2021-06-302021-03-312020-12-312020-09-30
Value929597100
Percentage of LesseeOperatingLeaseLiabilityPaymentsDue100.0100.0100.0100.0
Percentage of Assets6.16.16.19.4

Lessee Operating Lease Liability Undiscounted Excess Amount

us-gaap:LesseeOperatingLeaseLiabilityUndiscountedExcessAmount

us-gaap:LesseeOperatingLeaseLiabilityUndiscountedExcessAmount


Lessee
Period End2021-06-302021-03-312020-12-312020-09-30
Value25272830
Percentage of LesseeOperatingLeaseLiabilityUndiscountedExcessAmount100.0100.0100.0100.0
Percentage of Assets1.71.81.82.8

Stockholders Equity

us-gaap:StockholdersEquity

us-gaap:StockholdersEquity


Stockholders
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312016-12-312015-12-31
Value107211051150882502545394438475516546461490539465-94.154-15.634
Percentage of StockholdersEquity100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0
Percentage of Assets71.071.471.782.577.678.471.472.774.576.482.684.785.787.895.70.00.0

us-gaap:StockholdersEquity us-gaap:StatementEquityComponents

us-gaap:AccumulatedOtherComprehensiveIncome


Stockholders
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312016-12-31
Value-0.368-0.232-0.2450.0110.5510.8350.350.5620.8790.332-0.649-1.416-1.493-1.287-0.368-0.373
Percentage of StockholdersEquity-0.0-0.0-0.00.00.10.20.10.10.20.1-0.1-0.3-0.3-0.2-0.10.4
Percentage of Assets-0.0-0.0-0.00.00.10.10.10.10.10.0-0.1-0.3-0.3-0.2-0.10.0
Percentage of Assets us-gaap:AccumulatedOtherComprehensiveIncome0.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.0

us-gaap:AdditionalPaidInCapital


Stockholders
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312016-12-312015-12-31
Value1556152815031480104110258188077987817747667607546569.3871.056
Percentage of StockholdersEquity145.1138.3130.7167.7207.4188.0207.3184.4168.0151.4141.6166.3155.1140.0141.0-10.0-6.8
Percentage of Assets103.198.793.7138.3160.9147.4148.0134.0125.2115.6116.9140.8133.0122.9134.90.00.0
Percentage of Assets us-gaap:AdditionalPaidInCapital0.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.0

us-gaap:CommonStock


Stockholders
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312016-12-312015-12-31
Value1.5411.5371.5311.5241.3851.3821.2881.2861.2831.2791.2731.2661.2591.2521.2010.3440.17
Percentage of StockholdersEquity0.10.10.10.20.30.30.30.30.30.20.20.30.30.20.3-0.4-1.1
Percentage of Assets0.10.10.10.10.20.20.20.20.20.20.20.20.20.20.20.00.0
Percentage of Assets us-gaap:CommonStock0.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.0

us-gaap:RetainedEarnings


Stockholders
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312016-12-312015-12-31
Value-485.147-424.456-354.415-599.3-541.072-482.314-425.551-371.526-325.266-266.929-227.937-305.47-270.099-215.375-191.697-103.512-16.86
Percentage of StockholdersEquity-45.2-38.4-30.8-67.9-107.7-88.4-107.8-84.8-68.5-51.7-41.7-66.2-55.1-40.0-41.2109.9107.8
Percentage of Assets-32.1-27.4-22.1-56.0-83.6-69.3-76.9-61.6-51.0-39.5-34.4-56.1-47.2-35.1-39.40.00.0
Percentage of Assets us-gaap:RetainedEarnings0.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.00.0

Common Stock Value

us-gaap:CommonStockValue

us-gaap:CommonStockValue


Common
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-31
Value1541000.01537000.01531000.01524000.01385000.01382000.01288000.01286000.01283000.01279000.01273000.01266000.01259000.01252000.01201000.0
Percentage of CommonStockValue100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0
Percentage of Assets0.10.10.10.10.20.20.20.20.20.20.20.20.20.20.2

Additional Paid In Capital

us-gaap:AdditionalPaidInCapital

us-gaap:AdditionalPaidInCapital


Additional
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-31
Value155615281503148010411025818807798781774766760754656
Percentage of AdditionalPaidInCapital100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0
Percentage of Assets103.198.793.7138.3160.9147.4148.0134.0125.2115.6116.9140.8133.0122.9134.9

Common Stocks Including Additional Paid In Capital

us-gaap:CommonStocksIncludingAdditionalPaidInCapital us-gaap:CounterpartyName, us-gaap:ResearchAndDevelopmentArrangementContractToPerformForOthersByType, us-gaap:TypeOfArrangement

us-gaap:CommonStocksIncludingAdditionalPaidInCapital

dnli:Biogen, dnli:SharePurchaseAgreement, dnli:ProvisionalCollaborativeArrangement


Common
Period End2020-09-22
Value420
Percentage of CommonStocksIncludingAdditionalPaidInCapital100.0
Percentage of Assets0.0
Percentage of Assets dnli:Biogen dnli:SharePurchaseAgreement dnli:ProvisionalCollaborativeArrangement0.0

Retained Earnings Accumulated Deficit

us-gaap:RetainedEarningsAccumulatedDeficit

us-gaap:RetainedEarningsAccumulatedDeficit


Retained
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-31
Value-485150000.0-424460000.0-354420000.0-599300000.0-541070000.0-482310000.0-425550000.0-371530000.0-325270000.0-266930000.0-227940000.0-305470000.0-270100000.0-215380000.0-191700000.0
Percentage of RetainedEarningsAccumulatedDeficit100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0
Percentage of Assets-32.1-27.4-22.1-56.0-83.6-69.3-76.9-61.6-51.0-39.5-34.4-56.1-47.2-35.1-39.4

Accumulated Other Comprehensive Income Loss Net Of Tax

us-gaap:AccumulatedOtherComprehensiveIncomeLossNetOfTax

us-gaap:AccumulatedOtherComprehensiveIncomeLossNetOfTax


Accumulated
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-31
Value-368000.0-232000.0-245000.011000.0551000.0835000.0350000.0562000.0879000.0332000.0-649000.0-1416000.0-1493000.0-1287000.0-368000.0
Percentage of AccumulatedOtherComprehensiveIncomeLossNetOfTax100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0
Percentage of Assets-0.0-0.0-0.00.00.10.10.10.10.10.0-0.1-0.3-0.3-0.2-0.1

Stock Issued During Period Value New Issues

us-gaap:StockIssuedDuringPeriodValueNewIssues

us-gaap:StockIssuedDuringPeriodValueNewIssues


Stock
Period End2020-12-312020-09-302020-06-302020-03-31
Value0.00.00.0193
Percentage of StockIssuedDuringPeriodValueNewIssues0.00.00.0100.0
Percentage of Assets0.00.00.00.0

us-gaap:StockIssuedDuringPeriodValueNewIssues us-gaap:StatementEquityComponents

us-gaap:AdditionalPaidInCapital


Stock
Period End2020-12-312020-09-302020-06-302020-03-31
Value0.00.00.0193
Percentage of StockIssuedDuringPeriodValueNewIssues0.00.00.0100.0
Percentage of Assets0.00.00.00.0
Percentage of Assets us-gaap:AdditionalPaidInCapital0.00.00.00.0

us-gaap:CommonStock


Stock
Period End2020-12-312020-09-302020-06-302020-03-31
Value0.00.00.00.09
Percentage of StockIssuedDuringPeriodValueNewIssues0.00.00.00.0
Percentage of Assets0.00.00.00.0
Percentage of Assets us-gaap:CommonStock0.00.00.00.0

Adjustments To Additional Paid In Capital Sharebased Compensation Requisite Service Period Recognition Value

us-gaap:AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue

us-gaap:AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue


Adjustments
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-31
Value2121131312108.8898.901136.8745.6465.514.712.925
Percentage of AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0
Percentage of Assets0.00.00.00.00.00.00.00.00.00.00.00.00.00.0

us-gaap:AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue us-gaap:StatementEquityComponents

us-gaap:AdditionalPaidInCapital


Adjustments
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-31
Value2121131312108.8898.901136.8745.6465.514.712.925
Percentage of AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0
Percentage of Assets0.00.00.00.00.00.00.00.00.00.00.00.00.00.0
Percentage of Assets us-gaap:AdditionalPaidInCapital0.00.00.00.00.00.00.00.00.00.00.00.00.00.0

Net Cash Provided By Used In Operating Activities

us-gaap:NetCashProvidedByUsedInOperatingActivities

us-gaap:NetCashProvidedByUsedInOperatingActivities


Net
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-31
Value-54.221-50.245130.086-43.357-54.492-47.643-30.435-43.175-30.32393-34.822-41.82433-18.336
Percentage of NetCashProvidedByUsedInOperatingActivities100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0
Percentage of RevenueFromCollaborativeArrangementExcludingRevenueFromContractWithCustomer-1807366.7-5024000.00.01720.0-120436.1-104792.30.0-31703.1-43611.1-32258.50.00.00.00.00.0

Net Cash Provided By Used In Investing Activities

us-gaap:NetCashProvidedByUsedInInvestingActivities

us-gaap:NetCashProvidedByUsedInInvestingActivities


Net
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302017-06-302017-03-31
Value97-25.405-367.34-212.122-30.411-13.333424963-8.047-61.4034430-301.274-95.149162215
Percentage of NetCashProvidedByUsedInInvestingActivities100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0
Percentage of RevenueFromCollaborativeArrangementExcludingRevenueFromContractWithCustomer3251233.3-2540500.00.0-4242440.0-84475.0-25640.40.051555.264526.3-8560.60.00.00.00.00.00.00.00.0

Net Cash Provided By Used In Financing Activities

us-gaap:NetCashProvidedByUsedInFinancingActivities

us-gaap:NetCashProvidedByUsedInFinancingActivities


Net
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-31
Value7.0433.8229.5224253.4151952.0340.6792.5690.9081.690.6581.43293295
Percentage of NetCashProvidedByUsedInFinancingActivities100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0
Percentage of RevenueFromCollaborativeArrangementExcludingRevenueFromContractWithCustomer234766.7382200.00.08517980.09486.1376755.80.0707.32594.9966.00.00.00.00.00.0

Depreciation Depletion And Amortization

us-gaap:DepreciationDepletionAndAmortization

us-gaap:DepreciationDepletionAndAmortization


Depreciation
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-31
Value2204000.02108000.02121000.02156000.02145000.02109000.02055000.01890000.01643000.02403000.02379000.02327000.01855000.0854000.0
Percentage of DepreciationDepletionAndAmortization100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0

Increase Decrease In Accounts Payable

us-gaap:IncreaseDecreaseInAccountsPayable

us-gaap:IncreaseDecreaseInAccountsPayable


Increase
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302017-06-302017-03-31
Value2378000.0623000.0-1770000.0891000.0-452000.0-292000.0567000.0-837000.0-662000.01965000.0-1761000.0-5859000.08045000.0-951000.0-111000.0764000.0272000.0-718000.0
Percentage of IncreaseDecreaseInAccountsPayable100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0

Net Cash Provided By Used In Operating Activities

us-gaap:NetCashProvidedByUsedInOperatingActivities

us-gaap:NetCashProvidedByUsedInOperatingActivities


Net
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-31
Value-54.221-50.245130.086-43.357-54.492-47.643-30.435-43.175-30.32393-34.822-41.82433-18.336
Percentage of NetCashProvidedByUsedInOperatingActivities100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0
Percentage of RevenueFromCollaborativeArrangementExcludingRevenueFromContractWithCustomer-1807366.7-5024000.00.01720.0-120436.1-104792.30.0-31703.1-43611.1-32258.50.00.00.00.00.0

Net Income Loss

us-gaap:NetIncomeLoss

us-gaap:NetIncomeLoss


Net
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302017-06-302017-03-31
Value-60.691-70.041244-58.228-58.758-56.763-54.025-46.26-58.337-38.99277-35.371-54.724-23.678-22.887-21.844-22.134-21.32
Percentage of NetIncomeLoss100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0
Percentage of RevenueFromCollaborativeArrangementExcludingRevenueFromContractWithCustomer-2023033.3-7004100.00.0-1164560.0-163216.7-109159.60.0-48187.5-58926.3-41480.90.00.00.00.00.00.00.00.0

us-gaap:NetIncomeLoss us-gaap:StatementEquityComponents

us-gaap:RetainedEarnings


Net
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-31
Value-60.691-70.041244-58.228-58.758-56.763-54.025-46.26-58.337-38.99277-35.371-54.724-23.678
Percentage of NetIncomeLoss100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0
Percentage of RevenueFromCollaborativeArrangementExcludingRevenueFromContractWithCustomer-2023033.3-7004100.00.0-1164560.0-163216.7-109159.60.0-48187.5-58926.3-41480.90.00.00.00.0
Percentage of RevenueFromCollaborativeArrangementExcludingRevenueFromContractWithCustomer us-gaap:RetainedEarnings0.00.00.00.00.00.00.00.00.00.00.00.00.00.0

Share Based Compensation

us-gaap:ShareBasedCompensation

us-gaap:ShareBasedCompensation


Share
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302017-06-302017-03-31
Value2121131312108.8898.901136.8745.6465.514.712.9251.4571.1281.0590.765
Percentage of ShareBasedCompensation100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0

Net Cash Provided By Used In Investing Activities

us-gaap:NetCashProvidedByUsedInInvestingActivities

us-gaap:NetCashProvidedByUsedInInvestingActivities


Net
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302017-06-302017-03-31
Value97-25.405-367.34-212.122-30.411-13.333424963-8.047-61.4034430-301.274-95.149162215
Percentage of NetCashProvidedByUsedInInvestingActivities100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0
Percentage of RevenueFromCollaborativeArrangementExcludingRevenueFromContractWithCustomer3251233.3-2540500.00.0-4242440.0-84475.0-25640.40.051555.264526.3-8560.60.00.00.00.00.00.00.00.0

Payments To Acquire Property Plant And Equipment

us-gaap:PaymentsToAcquirePropertyPlantAndEquipment

us-gaap:PaymentsToAcquirePropertyPlantAndEquipment


Payments
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302017-06-302017-03-31
Value0.7722.81.1950.7060.3150.8792.7732.847102.0281.4370.8470.5720.5371.0710.3670.5690.868
Percentage of PaymentsToAcquirePropertyPlantAndEquipment100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0

Net Cash Provided By Used In Financing Activities

us-gaap:NetCashProvidedByUsedInFinancingActivities

us-gaap:NetCashProvidedByUsedInFinancingActivities


Net
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-31
Value7.0433.8229.5224253.4151952.0340.6792.5690.9081.690.6581.43293295
Percentage of NetCashProvidedByUsedInFinancingActivities100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0
Percentage of RevenueFromCollaborativeArrangementExcludingRevenueFromContractWithCustomer234766.7382200.00.08517980.09486.1376755.80.0707.32594.9966.00.00.00.00.00.0

Share Based Compensation Arrangement By Share Based Payment Award Options Outstanding Weighted Average Exercise Price

us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePrice

us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePrice


Share
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312016-12-31
Value23.623.2216.3115.7715.7415.4712.9612.9512.7212.2910.4910.189.729.164.081.77
Percentage of ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePrice100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0

Deferred Tax Assets Net

us-gaap:DeferredTaxAssetsNet

us-gaap:DeferredTaxAssetsNet


Deferred
Period End2020-12-312019-12-312018-12-312017-12-31
Value17134.1592.644
Percentage of DeferredTaxAssetsNet100.0100.0100.0100.0

Unrecognized Tax Benefits

us-gaap:UnrecognizedTaxBenefits

us-gaap:UnrecognizedTaxBenefits


Unrecognized
Period End2020-12-312019-12-312018-12-312017-12-312016-12-312015-12-31
Value8139000.05299000.02642000.01146000.0531000.0122000.0
Percentage of UnrecognizedTaxBenefits100.0100.0100.0100.0100.0100.0

Deferred Tax Assets Valuation Allowance

us-gaap:DeferredTaxAssetsValuationAllowance

us-gaap:DeferredTaxAssetsValuationAllowance


Deferred
Period End2020-12-312019-12-312018-12-312017-12-31
Value1331126054
Percentage of DeferredTaxAssetsValuationAllowance100.0100.0100.0100.0

dnli:CollaborationAgreementTransactionPriceIncrease us-gaap:CounterpartyName, us-gaap:ProductOrService, us-gaap:TypeOfArrangement

dnli:CollaborationAgreementTransactionPriceIncrease

dnli:Sanofi, dnli:MilestoneTriggered, us-gaap:CollaborativeArrangement


Collaboration
Period End2021-06-302019-12-31
Value150.0
Percentage of CollaborationAgreementTransactionPriceIncrease100.00.0

dnli:Sanofi, dnli:RetainedActivities, us-gaap:CollaborativeArrangement


Collaboration
Period End2020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-31
Value0.10.10.30.51.22.43.43.4
Percentage of CollaborationAgreementTransactionPriceIncrease0.00.00.00.00.00.00.00.0

dnli:CollaborationAgreementTransactionPriceIncrease us-gaap:CounterpartyName, us-gaap:TypeOfArrangement

dnli:Sanofi, us-gaap:CollaborativeArrangement


Collaboration
Period End2020-09-302020-06-30
Value-2.20.2
Percentage of CollaborationAgreementTransactionPriceIncrease0.00.0

dnli:CollaborativeArrangementUpfrontPaymentToBeReceived us-gaap:CounterpartyName, us-gaap:TypeOfArrangement

dnli:CollaborativeArrangementUpfrontPaymentToBeReceived

dnli:Biogen, dnli:ProvisionalCollaborativeArrangement


Collaborative
Period End2020-08-05
Value560
Percentage of CollaborativeArrangementUpfrontPaymentToBeReceived100.0

dnli:IncreaseDecreaseInContractWithCustomerLiabilityRelatedParties

dnli:IncreaseDecreaseInContractWithCustomerLiabilityRelatedParties


Increase
Period End2021-06-302021-03-312020-12-31
Value-0.794-0.892252
Percentage of IncreaseDecreaseInContractWithCustomerLiabilityRelatedParties100.0100.0100.0

dnli:IncreaseDecreaseInNonCashOperatingLeaseExpense

dnli:IncreaseDecreaseInNonCashOperatingLeaseExpense


Increase
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-31
Value728000.0691000.0691000.0691000.01299000.0-321000.0216000.0-593000.0-475000.0-1265000.0
Percentage of IncreaseDecreaseInNonCashOperatingLeaseExpense100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0

dnli:PaymentsForManufacturingCost us-gaap:PurchaseCommitmentExcludingLongtermCommitment

dnli:PaymentsForManufacturingCost

dnli:DMSA


Payments
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-31
Value5.70.71.30.82.03.23.52.53.92.61.41.30.60.1
Percentage of PaymentsForManufacturingCost100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0

dnli:PreclinicalMilestonePaymentReceived us-gaap:CounterpartyName, us-gaap:SubsequentEventType, us-gaap:TypeOfArrangement

dnli:PreclinicalMilestonePaymentReceived

dnli:TakedaPharmaceuticalCompanyLimited, us-gaap:SubsequentEvent, dnli:CollaborativeArrangementPTVPGRN


Preclinical
Period End2021-01-31
Value8000000.0
Percentage of PreclinicalMilestonePaymentReceived100.0

dnli:PreclinicalMilestonePaymentReceived us-gaap:CounterpartyName, us-gaap:TypeOfArrangement

dnli:TakedaPharmaceuticalCompanyLimited, dnli:CollaborativeArrangementATVTREM2


Preclinical
Period End2021-03-31
Value8000000.0
Percentage of PreclinicalMilestonePaymentReceived0.0

dnli:TakedaPharmaceuticalCompanyLimited, dnli:CollaborativeArrangementPTVPGRN


Preclinical
Period End2021-01-31
Value8000000.0
Percentage of PreclinicalMilestonePaymentReceived100.0

dnli:ProceedsFromIssuanceOfCommonStockInConnectionWithCollaborationAgreement

dnli:ProceedsFromIssuanceOfCommonStockInConnectionWithCollaborationAgreement


Proceeds
Period End2020-12-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-31
Value0.00.00.00.00.00.00.00.094
Percentage of ProceedsFromIssuanceOfCommonStockInConnectionWithCollaborationAgreement0.00.00.00.00.00.00.00.0100.0

dnli:ResearchAndDevelopmentExpenseOffsetFromRelatedPartyCostReimbursement

dnli:ResearchAndDevelopmentExpenseOffsetFromRelatedPartyCostReimbursement


Research
Period End2021-06-302021-03-31
Value1600000.02500000.0
Percentage of ResearchAndDevelopmentExpenseOffsetFromRelatedPartyCostReimbursement100.0100.0

dnli:ResearchAndDevelopmentExpenseOffsetFromRelatedPartyCostReimbursement us-gaap:CounterpartyName, us-gaap:TypeOfArrangement

dnli:Biogen, dnli:BiogenCollaborativeArrangement


Research
Period End2021-06-302021-03-31
Value1600000.02500000.0
Percentage of ResearchAndDevelopmentExpenseOffsetFromRelatedPartyCostReimbursement100.0100.0

dnli:SaleOfStockConsiderationPremiumReceivedOnTransaction us-gaap:CounterpartyName, us-gaap:ResearchAndDevelopmentArrangementContractToPerformForOthersByType, us-gaap:TypeOfArrangement

dnli:SaleOfStockConsiderationPremiumReceivedOnTransaction

dnli:Biogen, dnli:SharePurchaseAgreement, dnli:ProvisionalCollaborativeArrangement


Sale
Period End2020-09-22
Value44
Percentage of SaleOfStockConsiderationPremiumReceivedOnTransaction100.0

dnli:StockIssuedDuringPeriodValueEquityIncentivePlan

dnli:StockIssuedDuringPeriodValueEquityIncentivePlan


Stock
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-31
Value7.0433.8229.5225.7533.4141.9662.0340.6792.5690.9081.6880.6591.4330.219
Percentage of StockIssuedDuringPeriodValueEquityIncentivePlan100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0

dnli:StockIssuedDuringPeriodValueEquityIncentivePlan us-gaap:StatementEquityComponents

us-gaap:AdditionalPaidInCapital


Stock
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-31
Value7.043.8199.5155.7493.4111.9632.0320.6772.5660.9061.6850.6571.4310.218
Percentage of StockIssuedDuringPeriodValueEquityIncentivePlan100.099.999.999.999.999.899.999.799.999.899.899.799.999.5

us-gaap:CommonStock


Stock
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-31
Value0.0030.0030.0070.0040.0030.0030.0020.0020.0030.0020.0030.0020.0020.001
Percentage of StockIssuedDuringPeriodValueEquityIncentivePlan0.00.10.10.10.10.20.10.30.10.20.20.30.10.5

dnli:StockIssuedDuringPeriodValueStockPurchaseAgreement

dnli:StockIssuedDuringPeriodValueStockPurchaseAgreement


Stock
Period End2020-12-312020-09-30
Value0.0420
Percentage of StockIssuedDuringPeriodValueStockPurchaseAgreement0.0100.0

dnli:StockIssuedDuringPeriodValueStockPurchaseAgreement us-gaap:StatementEquityComponents

us-gaap:AdditionalPaidInCapital


Stock
Period End2020-12-312020-09-30
Value0.0420
Percentage of StockIssuedDuringPeriodValueStockPurchaseAgreement0.0100.0

us-gaap:CommonStock


Stock
Period End2020-12-312020-09-30
Value0.00.133
Percentage of StockIssuedDuringPeriodValueStockPurchaseAgreement0.00.0

dnli:UpfrontPayments us-gaap:CounterpartyName, us-gaap:SubsequentEventType, us-gaap:TypeOfArrangement

dnli:UpfrontPayments

dnli:Biogen, us-gaap:SubsequentEvent, dnli:DefinitiveCollaborativeArrangement


Upfront
Period End2020-10-31
Value560
Percentage of UpfrontPayments100.0

us-gaap:AdjustmentsToAdditionalPaidInCapitalStockIssuedIssuanceCosts us-gaap:StatementEquityComponents

us-gaap:AdjustmentsToAdditionalPaidInCapitalStockIssuedIssuanceCosts

us-gaap:CommonStock


Adjustments
Period End2020-12-312020-09-302020-06-302020-03-31
Value000632000.0
Percentage of AdjustmentsToAdditionalPaidInCapitalStockIssuedIssuanceCosts0.00.00.0100.0

us-gaap:CapitalExpendituresIncurredButNotYetPaid

us-gaap:CapitalExpendituresIncurredButNotYetPaid


Capital
Period End2020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-03-31
Value35000.030000.02000.00-1500000.0-662000.0593000.01569000.0298000.037000.0-246000.0246000.025000.098000.0
Percentage of CapitalExpendituresIncurredButNotYetPaid100.0100.0100.00.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0

us-gaap:CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseExcludingExchangeRateEffect

us-gaap:CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseExcludingExchangeRateEffect


Cash
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302017-06-302017-03-31
Value50-71.823156213-70.353128-3.2241923-37.4623310-9.864-174.458182-5.0384.556-3.102
Percentage of CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseExcludingExchangeRateEffect100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0

us-gaap:ContractWithCustomerLiabilityRevenueRecognized us-gaap:CounterpartyName, us-gaap:TypeOfArrangement

us-gaap:ContractWithCustomerLiabilityRevenueRecognized

dnli:TakedaPharmaceuticalCompanyLimited, us-gaap:CollaborativeArrangement


Contract
Period End2020-12-312020-09-302020-06-302020-03-31
Value-2.92.61.63.3
Percentage of ContractWithCustomerLiabilityRevenueRecognized100.0100.0100.0100.0

us-gaap:ContractWithCustomerLiabilityRevenueRecognized us-gaap:TypeOfArrangement

dnli:TakedaCollaborationAgreement


Contract
Period End2021-06-302021-03-31
Value6.15.7
Percentage of ContractWithCustomerLiabilityRevenueRecognized0.00.0

us-gaap:CostsIncurredDevelopmentCosts us-gaap:PurchaseCommitmentExcludingLongtermCommitment

us-gaap:CostsIncurredDevelopmentCosts

dnli:DMSA


Costs
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-31
Value3.25.24.61.43.81.03.03.03.13.61.31.41.10.1
Percentage of CostsIncurredDevelopmentCosts100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0

us-gaap:DerivativeGainLossOnDerivativeNet

us-gaap:DerivativeGainLossOnDerivativeNet


Derivative
Period End2021-03-312020-03-312019-12-312019-09-302019-06-302018-12-312018-09-302018-06-30
Value-200000.0-200000.0300000.0-100000.0-7320.0-100000.0-100000.0-31952.0
Percentage of DerivativeGainLossOnDerivativeNet100.0100.0100.0100.0100.0100.0100.0100.0

us-gaap:IncomeLossAttributableToParent

us-gaap:IncomeLossAttributableToParent


Income
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-30
Value-60.691-70.041245-58.172-58.679-56.898-53.95-46.373-58.65-38.99277-35.371-54.724
Percentage of IncomeLossAttributableToParent100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0

us-gaap:IncreaseDecreaseInAccruedLiabilitiesAndOtherOperatingLiabilities

us-gaap:IncreaseDecreaseInAccruedLiabilitiesAndOtherOperatingLiabilities


Increase
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302017-06-302017-03-31
Value1.277-10.804177.0951.612-3.827-1.3764.7632.706-4.5936.4744.0421.854-3.2572.694-1.5393.366-0.943
Percentage of IncreaseDecreaseInAccruedLiabilitiesAndOtherOperatingLiabilities100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0

us-gaap:IncreaseDecreaseInContractWithCustomerLiability

us-gaap:IncreaseDecreaseInContractWithCustomerLiability


Increase
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-30
Value-7.1440.969-1.333-9.276-5.575-3.069-3.489-1.181-0.839-0.77711-1.195-1.648590.00.0
Percentage of IncreaseDecreaseInContractWithCustomerLiability100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.00.00.0

us-gaap:IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets

us-gaap:IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets


Increase
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302017-06-302017-03-31
Value14-6.30114-0.025-6.2482.454-0.863-3.1080.145-2.849123.6610.1051.613-0.0761.2690.693-1.959
Percentage of IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0

us-gaap:InvestmentIncomeNetAmortizationOfDiscountAndPremium

us-gaap:InvestmentIncomeNetAmortizationOfDiscountAndPremium


Investment
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302017-06-302017-03-31
Value-2495000.0-1161000.0-1129000.049000.0418000.0607000.0987000.01298000.01417000.01317000.0841000.0772000.0705000.0387000.0146000.0-214000.0-458000.0-227000.0
Percentage of InvestmentIncomeNetAmortizationOfDiscountAndPremium100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0

us-gaap:LeaseCost

us-gaap:LeaseCost


Lease
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-31
Value2.82.82.7999999999999992.82.92.62.82.62.52.3
Percentage of LeaseCost100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0

us-gaap:OperatingLeasePayments

us-gaap:OperatingLeasePayments


Operating
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-09-302019-06-302019-03-31
Value2600000.02500000.02500000.02500000.02500000.02200000.01500000.01200000.0700000.0
Percentage of OperatingLeasePayments100.0100.0100.0100.0100.0100.0100.0100.0100.0

us-gaap:OtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentBeforeReclassificationAdjustmentsNetOfTax

us-gaap:OtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentBeforeReclassificationAdjustmentsNetOfTax


Other
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302017-06-302017-03-31
Value-136000.013000.0-256000.0-540000.0-284000.0485000.0-212000.0-317000.0547000.0981000.0767000.077000.0-206000.0-919000.0-131000.0140000.018000.0-22000.0
Percentage of OtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentBeforeReclassificationAdjustmentsNetOfTax100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0

us-gaap:OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent

us-gaap:OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent


Other
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-31
Value-136000.013000.0-256000.0-540000.0-284000.0485000.0-212000.0-317000.0547000.0981000.0767000.077000.0-206000.0-919000.0
Percentage of OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0

us-gaap:OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent us-gaap:StatementEquityComponents

us-gaap:AccumulatedOtherComprehensiveIncome


Other
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-31
Value-136000.013000.0-256000.0-540000.0-284000.0485000.0-212000.0-317000.0547000.0981000.0767000.077000.0-206000.0-919000.0
Percentage of OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0

us-gaap:OtherNoncashIncomeExpense

us-gaap:OtherNoncashIncomeExpense


Other
Period End2021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-30
Value2000.0-20000.0-57000.0-14000.053000.0-76000.0114000.0313000.0036000.00
Percentage of OtherNoncashIncomeExpense100.0100.0100.0100.0100.0100.0100.0100.00.0100.00.0

us-gaap:PaymentsToAcquireMarketableSecurities

us-gaap:PaymentsToAcquireMarketableSecurities


Payments
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302017-06-302017-03-31
Value38446359736317015315075341091573833328133181116
Percentage of PaymentsToAcquireMarketableSecurities100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0

us-gaap:ProceedsFromIssuanceOfCommonStock

us-gaap:ProceedsFromIssuanceOfCommonStock


Proceeds
Period End2020-12-312020-09-302020-06-302020-03-312019-06-302019-03-312018-12-312018-09-302017-12-312017-09-30
Value0.00.00.01930.00.0-94.4060.02650.0
Percentage of ProceedsFromIssuanceOfCommonStock0.00.00.0100.00.00.0100.00.0100.00.0

us-gaap:ProceedsFromIssuanceOfSharesUnderIncentiveAndShareBasedCompensationPlansIncludingStockOptions

us-gaap:ProceedsFromIssuanceOfSharesUnderIncentiveAndShareBasedCompensationPlansIncludingStockOptions


Proceeds
Period End2021-06-302021-03-312020-09-302020-06-302020-03-312019-09-302019-06-302019-03-312018-09-302018-06-302018-03-312017-09-30
Value7.0433.8225.7533.4151.9650.6792.5690.9080.6581.4320.2190.357
Percentage of ProceedsFromIssuanceOfSharesUnderIncentiveAndShareBasedCompensationPlansIncludingStockOptions100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0

us-gaap:ProceedsFromSaleAndMaturityOfMarketableSecurities

us-gaap:ProceedsFromSaleAndMaturityOfMarketableSecurities


Proceeds
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302017-06-302017-03-31
Value4824402311521401401951271081039784642739353333
Percentage of ProceedsFromSaleAndMaturityOfMarketableSecurities100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0

us-gaap:RevenueFromCollaborativeArrangementExcludingRevenueFromContractWithCustomer

us-gaap:RevenueFromCollaborativeArrangementExcludingRevenueFromContractWithCustomer


Revenue
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-31
Value3000.01000.05000.05000.036000.052000.069000.096000.099000.094000.0
Percentage of RevenueFromCollaborativeArrangementExcludingRevenueFromContractWithCustomer100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0

us-gaap:RevenueFromCollaborativeArrangementExcludingRevenueFromContractWithCustomer us-gaap:ProductOrService, us-gaap:TypeOfArrangement

dnli:AlzheimersDiseaseServices, dnli:SanofiCollaborationAgreement


Revenue
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-31
Value3000.01000.05000.05000.036000.052000.069000.096000.099000.094000.060000.0000
Percentage of RevenueFromCollaborativeArrangementExcludingRevenueFromContractWithCustomer100.0100.0100.0100.0100.0100.0100.0100.0100.0100.00.00.00.00.0

us-gaap:RevenueFromRelatedParties

us-gaap:RevenueFromRelatedParties


Revenue
Period End2021-06-302021-03-31
Value0.80.9
Percentage of RevenueFromRelatedParties100.0100.0

us-gaap:SaleOfStockConsiderationReceivedOnTransaction us-gaap:CounterpartyName, us-gaap:ResearchAndDevelopmentArrangementContractToPerformForOthersByType, us-gaap:TypeOfArrangement

us-gaap:SaleOfStockConsiderationReceivedOnTransaction

dnli:Biogen, dnli:SharePurchaseAgreement, dnli:ProvisionalCollaborativeArrangement


Sale
Period End2020-09-22
Value465
Percentage of SaleOfStockConsiderationReceivedOnTransaction100.0

us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeituresWeightedAverageGrantDateFairValue us-gaap:AwardType

us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeituresWeightedAverageGrantDateFairValue

us-gaap:RestrictedStockUnitsRSU


Share
Period End2021-06-302021-03-31
Value-26.9461.97
Percentage of ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeituresWeightedAverageGrantDateFairValue100.0100.0

us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriodWeightedAverageGrantDateFairValue us-gaap:AwardType

us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriodWeightedAverageGrantDateFairValue

us-gaap:RestrictedStockUnitsRSU


Share
Period End2021-06-302021-03-31
Value-1.2576.33
Percentage of ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriodWeightedAverageGrantDateFairValue100.0100.0

us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriodWeightedAverageGrantDateFairValue us-gaap:AwardType

us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriodWeightedAverageGrantDateFairValue

us-gaap:RestrictedStockUnitsRSU


Share
Period End2021-06-302021-03-31
Value0.4122.73
Percentage of ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriodWeightedAverageGrantDateFairValue100.0100.0

us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRateMaximum us-gaap:AwardType

us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRateMaximum

us-gaap:EmployeeStockOption


Share
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-31
Value0.363.4066.4290.0150.656-77.02277.0220.0840.694
Percentage of ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRateMaximum100.0100.00.0100.0100.0100.0100.0100.0100.0100.0

us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRateMinimum us-gaap:AwardType

us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRateMinimum

us-gaap:EmployeeStockOption


Share
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-31
Value062.2064.54800.652-64.84564.831-0.0240.693
Percentage of ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRateMinimum0.0100.00.0100.00.0100.0100.0100.0100.0100.0

us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRateMaximum us-gaap:AwardType

us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRateMaximum

us-gaap:EmployeeStockOption


Share
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-31
Value0.11.001.68300.017-2.5742.57400.026
Percentage of ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRateMaximum100.0100.00.0100.00.0100.0100.0100.00.0100.0

us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRateMinimum us-gaap:AwardType

us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRateMinimum

us-gaap:EmployeeStockOption


Share
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-31
Value00.500.296-0.0030.007-1.5851.58-0.0050.025
Percentage of ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRateMinimum0.0100.00.0100.0100.0100.0100.0100.0100.0100.0

us-gaap:ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsExercisesInPeriodWeightedAverageExercisePrice

us-gaap:ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsExercisesInPeriodWeightedAverageExercisePrice


Share
Period End2021-06-302021-03-312020-12-312020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-31
Value2.7511.420.927.570.22-0.570.074.550.210.4-0.52.67
Percentage of ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsExercisesInPeriodWeightedAverageExercisePrice100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0

us-gaap:ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsForfeituresInPeriodWeightedAverageExercisePrice

us-gaap:ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsForfeituresInPeriodWeightedAverageExercisePrice


Share
Period End2021-06-302021-03-312020-12-31
Value5.9926.77-0.03
Percentage of ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsForfeituresInPeriodWeightedAverageExercisePrice100.0100.0100.0

us-gaap:ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageExercisePrice

us-gaap:ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageExercisePrice


Share
Period End2021-06-302021-03-312020-12-31
Value-1.0275.521.24
Percentage of ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageExercisePrice100.0100.0100.0

us-gaap:StockIssuedDuringPeriodValueRestrictedStockAwardNetOfForfeitures us-gaap:StatementEquityComponents

us-gaap:StockIssuedDuringPeriodValueRestrictedStockAwardNetOfForfeitures

us-gaap:AdditionalPaidInCapital


Stock
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-31
Value-1000.0-3000.00-2000.00-1000.00-1000.00-3000.0-4000.0-4000.0-4000.0-7000.0
Percentage of StockIssuedDuringPeriodValueRestrictedStockAwardNetOfForfeitures100.0100.00.0100.00.0100.00.0100.00.0100.0100.0100.0100.0100.0

us-gaap:CommonStock


Stock
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-31
Value1000.03000.002000.001000.001000.003000.04000.04000.04000.07000.0
Percentage of StockIssuedDuringPeriodValueRestrictedStockAwardNetOfForfeitures-100.0-100.00.0-100.00.0-100.00.0-100.00.0-100.0-100.0-100.0-100.0-100.0

us-gaap:SubleaseIncome

us-gaap:SubleaseIncome


Sublease
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-31
Value1000000.0900000.0800000.0900000.01000000.0900000.0900000.0900000.0800000.00
Percentage of SubleaseIncome100.0100.0100.0100.0100.0100.0100.0100.0100.00.0

dnli:AccruedClinicalAndContractResearchOrganizationCosts

dnli:AccruedClinicalAndContractResearchOrganizationCosts


Accrued
Period End2020-12-312019-12-312018-12-31
Value6497000.05042000.02091000.0
Percentage of AccruedClinicalAndContractResearchOrganizationCosts100.0100.0100.0

dnli:AccruedClinicalAndOtherResearchAndDevelopmentCostsCurrent

dnli:AccruedClinicalAndOtherResearchAndDevelopmentCostsCurrent


Accrued
Period End2021-06-302020-12-31
Value1111
Percentage of AccruedClinicalAndOtherResearchAndDevelopmentCostsCurrent100.0100.0

dnli:AccruedClinicalCostsCurrent

dnli:AccruedClinicalCostsCurrent


Accrued
Period End2021-03-312020-12-312020-09-302020-06-302020-03-312019-12-31
Value5049000.06497000.04689000.04179000.05349000.05042000.0
Percentage of AccruedClinicalCostsCurrent100.0100.0100.0100.0100.0100.0

dnli:AccruedGeneralAdministrativeAndSharedCosts

dnli:AccruedGeneralAdministrativeAndSharedCosts


Accrued
Period End2020-12-312019-12-312018-12-31
Value3037000.01310000.02250000.0
Percentage of AccruedGeneralAdministrativeAndSharedCosts100.0100.0100.0

dnli:AggregateClinicalRegulatoryAndSalesMilestonePayment us-gaap:CounterpartyName, us-gaap:SubsequentEventType, us-gaap:TypeOfArrangement

dnli:AggregateClinicalRegulatoryAndSalesMilestonePayment

dnli:Biogen, us-gaap:SubsequentEvent, dnli:ProvisionalCollaborativeArrangement


Aggregate
Period End2020-08-05
Value1100
Percentage of AggregateClinicalRegulatoryAndSalesMilestonePayment100.0

dnli:AggregateDevelopmentFirstCommercialSaleAndNetSalesBasedMilestonePayments us-gaap:CounterpartyName, us-gaap:TypeOfArrangement

dnli:AggregateDevelopmentFirstCommercialSaleAndNetSalesBasedMilestonePayments

dnli:Biogen, dnli:ProvisionalCollaborativeArrangement


Aggregate
Period End2020-08-05
Value1100
Percentage of AggregateDevelopmentFirstCommercialSaleAndNetSalesBasedMilestonePayments100.0

dnli:CollaborativeAgreementAgreedShareOfCommercialProfitLoss dei:LegalEntity, us-gaap:StatementGeographical, us-gaap:SubsequentEventType, us-gaap:TypeOfArrangement

dnli:CollaborativeAgreementAgreedShareOfCommercialProfitLoss

dnli:Biogen, country:CN, us-gaap:SubsequentEvent, dnli:ProvisionalCollaborativeArrangement


Collaborative
Period End2020-08-05
Value0.6
Percentage of CollaborativeAgreementAgreedShareOfCommercialProfitLoss100.0

dnli:Biogen, country:US, us-gaap:SubsequentEvent, dnli:ProvisionalCollaborativeArrangement


Collaborative
Period End2020-08-05
Value0.5
Percentage of CollaborativeAgreementAgreedShareOfCommercialProfitLoss83.3

dnli:CollaborativeAgreementAgreedShareOfCommercialProfitLoss us-gaap:StatementGeographical, us-gaap:SubsequentEventType, us-gaap:TypeOfArrangement

country:CN, us-gaap:SubsequentEvent, dnli:ProvisionalCollaborativeArrangement


Collaborative
Period End2020-08-05
Value0.4
Percentage of CollaborativeAgreementAgreedShareOfCommercialProfitLoss66.7

country:US, us-gaap:SubsequentEvent, dnli:ProvisionalCollaborativeArrangement


Collaborative
Period End2020-08-05
Value0.5
Percentage of CollaborativeAgreementAgreedShareOfCommercialProfitLoss83.3

dnli:CollaborativeAgreementFundedPercentage dei:LegalEntity, us-gaap:SubsequentEventType, us-gaap:TypeOfArrangement

dnli:CollaborativeAgreementFundedPercentage

dnli:Biogen, us-gaap:SubsequentEvent, dnli:ProvisionalCollaborativeArrangement


Collaborative
Period End2020-08-05
Value0.6
Percentage of CollaborativeAgreementFundedPercentage100.0

dnli:CollaborativeAgreementFundedPercentage us-gaap:SubsequentEventType, us-gaap:TypeOfArrangement

us-gaap:SubsequentEvent, dnli:ProvisionalCollaborativeArrangement


Collaborative
Period End2020-08-05
Value0.4
Percentage of CollaborativeAgreementFundedPercentage66.7

dnli:ContractWithCustomerLiabilityFromRelatedPartiesCurrent

dnli:ContractWithCustomerLiabilityFromRelatedPartiesCurrent


Contract
Period End2021-06-302021-03-312020-12-312020-09-30
Value3.4383.5693.56944
Percentage of ContractWithCustomerLiabilityFromRelatedPartiesCurrent100.0100.0100.0100.0

dnli:ContractWithCustomerLiabilityFromRelatedPartiesCurrent us-gaap:CounterpartyName, us-gaap:ResearchAndDevelopmentArrangementContractToPerformForOthersByType, us-gaap:TypeOfArrangement

dnli:Biogen, dnli:SharePurchaseAgreement, dnli:ProvisionalCollaborativeArrangement


Contract
Period End2020-09-30
Value44
Percentage of ContractWithCustomerLiabilityFromRelatedPartiesCurrent100.1

dnli:ContractWithCustomerLiabilityFromRelatedPartiesNoncurrent

dnli:ContractWithCustomerLiabilityFromRelatedPartiesNoncurrent


Contract
Period End2021-06-302021-03-312020-12-31
Value292292293
Percentage of ContractWithCustomerLiabilityFromRelatedPartiesNoncurrent100.0100.0100.0

dnli:DeferredTaxAssetsOperatingLeaseLiability

dnli:DeferredTaxAssetsOperatingLeaseLiability


Deferred
Period End2020-12-312019-12-312018-12-31
Value17150.0
Percentage of DeferredTaxAssetsOperatingLeaseLiability100.0100.00.0

dnli:DeferredTaxLiabilitiesOperatingLeaseRightOfUseAsset

dnli:DeferredTaxLiabilitiesOperatingLeaseRightOfUseAsset


Deferred
Period End2020-12-312019-12-312018-12-31
Value8137000.07337000.00
Percentage of DeferredTaxLiabilitiesOperatingLeaseRightOfUseAsset100.0100.00.0

dnli:DevelopmentMilestonePayments us-gaap:CounterpartyName, us-gaap:TypeOfArrangement

dnli:DevelopmentMilestonePayments

dnli:Biogen, dnli:ProvisionalCollaborativeArrangement


Development
Period End2020-08-05
Value375
Percentage of DevelopmentMilestonePayments100.0

dnli:FirstCommercialSaleMilestonePayments us-gaap:CounterpartyName, us-gaap:TypeOfArrangement

dnli:FirstCommercialSaleMilestonePayments

dnli:Biogen, dnli:ProvisionalCollaborativeArrangement


First
Period End2020-08-05
Value375
Percentage of FirstCommercialSaleMilestonePayments100.0

dnli:LesseeOperatingLeaseLiabilityToBePaidAfterYearFour

dnli:LesseeOperatingLeaseLiabilityToBePaidAfterYearFour


Lessee
Period End2021-06-302021-03-312020-09-30
Value424254
Percentage of LesseeOperatingLeaseLiabilityToBePaidAfterYearFour100.0100.0100.0

dnli:NetSalesBasedMilestonePayments us-gaap:CounterpartyName, us-gaap:TypeOfArrangement

dnli:NetSalesBasedMilestonePayments

dnli:Biogen, dnli:ProvisionalCollaborativeArrangement


Net
Period End2020-08-05
Value375
Percentage of NetSalesBasedMilestonePayments100.0

dnli:OtherAccruedCostsAndOtherLiabilitiesCurrent

dnli:OtherAccruedCostsAndOtherLiabilitiesCurrent


Other
Period End2021-06-302020-12-31
Value2148000.03037000.0
Percentage of OtherAccruedCostsAndOtherLiabilitiesCurrent100.0100.0

dnli:OtherAccruedManufacturingCosts

dnli:OtherAccruedManufacturingCosts


Other
Period End2020-12-312019-12-31
Value7140000.02027000.0
Percentage of OtherAccruedManufacturingCosts100.0100.0

dnli:OtherAccruedManufacturingCostsCurrent

dnli:OtherAccruedManufacturingCostsCurrent


Other
Period End2021-06-302021-03-312020-12-31
Value13137.14
Percentage of OtherAccruedManufacturingCostsCurrent100.0100.0100.0

dnli:OtherAccruedResearchAndDevelopmentCosts

dnli:OtherAccruedResearchAndDevelopmentCosts


Other
Period End2020-12-312019-12-312018-12-31
Value5278000.05251000.04179000.0
Percentage of OtherAccruedResearchAndDevelopmentCosts100.0100.0100.0

dnli:PreclinicalMilestonePaymentEarnedNotYetReceived us-gaap:CounterpartyName, us-gaap:SubsequentEventType, us-gaap:TypeOfArrangement

dnli:PreclinicalMilestonePaymentEarnedNotYetReceived

dnli:TakedaPharmaceuticalCompanyLimited, us-gaap:SubsequentEvent, dnli:CollaborativeArrangementATVTREM2


Preclinical
Period End2021-01-31
Value8000000.0
Percentage of PreclinicalMilestonePaymentEarnedNotYetReceived100.0

dnli:PreclinicalMilestonePaymentEarnedNotYetReceived us-gaap:CounterpartyName, us-gaap:TypeOfArrangement

dnli:TakedaPharmaceuticalCompanyLimited, dnli:CollaborativeArrangementPTVPGRN


Preclinical
Period End2020-12-31
Value8000000.0
Percentage of PreclinicalMilestonePaymentEarnedNotYetReceived0.0

dnli:PurchaseOrderExecuted us-gaap:PurchaseCommitmentExcludingLongtermCommitment

dnli:PurchaseOrderExecuted

dnli:DMSA


Purchase
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302017-12-31
Value3233331718142122252524130.7
Percentage of PurchaseOrderExecuted100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0

dnli:ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValueExpectedToVest us-gaap:AwardType

dnli:ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValueExpectedToVest

us-gaap:RestrictedStock


Share
Period End2020-09-30
Value25.82
Percentage of ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValueExpectedToVest100.0

us-gaap:RestrictedStockUnitsRSU


Share
Period End2021-06-302021-03-312020-12-31
Value41.1340.2427.08
Percentage of ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValueExpectedToVest0.00.00.0

dnli:ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedAndExpectedToVestOutstandingAggregateIntrinsicValue us-gaap:AwardType

dnli:ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedAndExpectedToVestOutstandingAggregateIntrinsicValue

us-gaap:RestrictedStockUnitsRSU


Share
Period End2020-12-31
Value192
Percentage of ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedAndExpectedToVestOutstandingAggregateIntrinsicValue100.0

us-gaap:AccountsReceivableNet us-gaap:CounterpartyName, us-gaap:TypeOfArrangement

us-gaap:AccountsReceivableNet

dnli:Sanofi, us-gaap:CollaborativeArrangement


Accounts
Period End2021-06-302020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-31
Value150.0443030.10.30.51.22.43.43.42.3
Percentage of AccountsReceivableNet100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0

us-gaap:AssetsFairValueDisclosure

us-gaap:AssetsFairValueDisclosure


Assets
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-31
Value137914431480957530569446473507568588501534585461
Percentage of AssetsFairValueDisclosure100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0

us-gaap:AssetsFairValueDisclosure us-gaap:FairValueByFairValueHierarchyLevel

us-gaap:FairValueInputsLevel1


Assets
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-31
Value116013011366874444453334358355394380284279286295
Percentage of AssetsFairValueDisclosure84.190.292.391.383.779.674.975.769.969.464.656.852.248.964.0

us-gaap:FairValueInputsLevel2


Assets
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-31
Value2181411138286116111115152174208216255298166
Percentage of AssetsFairValueDisclosure15.99.87.78.716.320.425.124.330.130.635.443.247.851.136.0

us-gaap:AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax

us-gaap:AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax


Available
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302017-12-31
Value49000.0149000.0130000.0377000.0958000.01470000.0729000.0990000.01222000.0661000.0369000.0000
Percentage of AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.00.00.00.0

us-gaap:AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax us-gaap:FinancialInstrument, us-gaap:InvestmentType

us-gaap:CorporateDebtSecurities, dnli:LongTermMarketableSecurities


Available
Period End2021-06-302020-12-312020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302017-12-31
Value1000.02000.0102000.0034000.039000.070000.057000.08000.0000
Percentage of AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax2.01.510.60.04.73.95.78.62.20.00.00.0

us-gaap:CorporateDebtSecurities, dnli:ShortTermMarketableSecurities


Available
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302017-12-31
Value25000.048000.079000.0216000.0303000.039000.094000.0136000.0122000.07000.01000.0000
Percentage of AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax51.032.260.857.331.62.712.913.710.01.10.30.00.00.0

us-gaap:USGovernmentAgenciesDebtSecurities, dnli:ShortTermMarketableSecurities


Available
Period End2021-06-302021-03-312020-12-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302017-12-31
Value3000.010000.05000.01000.04000.07000.04000.00000
Percentage of AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax6.16.73.80.10.40.60.60.00.00.00.0

us-gaap:USTreasurySecurities, dnli:LongTermMarketableSecurities


Available
Period End2021-06-302021-03-312020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302017-12-31
Value2000.01000.040000.06000.0156000.0455000.0421000.0329000.0000
Percentage of AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax4.10.72.70.815.837.263.789.20.00.00.0

us-gaap:USTreasurySecurities, dnli:ShortTermMarketableSecurities


Available
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302017-12-31
Value18000.090000.044000.0161000.0553000.01391000.0594000.0655000.0568000.0172000.029000.0000
Percentage of AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax36.760.433.842.757.794.681.566.246.526.07.90.00.00.0

us-gaap:AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax us-gaap:InvestmentType

dnli:LongTermMarketableSecurities


Available
Period End2021-06-302021-03-312020-12-312020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302017-12-31
Value3000.01000.02000.0102000.040000.040000.0195000.0525000.0478000.0339000.0000
Percentage of AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax6.10.71.510.62.75.519.743.072.391.90.00.00.0

dnli:ShortTermMarketableSecurities


Available
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302017-12-31
Value46000.0148000.0128000.0377000.0856000.01430000.0689000.0795000.0697000.0183000.030000.0000
Percentage of AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax93.999.398.5100.089.497.394.580.357.027.78.10.00.00.0

us-gaap:AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax

us-gaap:AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax


Available
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302017-12-31
Value66000.030000.025000.015000.00227000.030000.02000.029000.0329000.01019000.01415000.01493000.0368000.0
Percentage of AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax100.0100.0100.0100.00.0100.0100.0100.0100.0100.0100.0100.0100.0100.0

us-gaap:AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax us-gaap:FinancialInstrument, us-gaap:InvestmentType

us-gaap:CorporateDebtSecurities, dnli:LongTermMarketableSecurities


Available
Period End2021-06-302021-03-312020-12-312020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302017-12-31
Value7000.019000.011000.0034000.015000.000099000.0220000.0331000.00
Percentage of AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax10.663.344.00.015.050.00.00.00.09.715.522.20.0

us-gaap:CorporateDebtSecurities, dnli:ShortTermMarketableSecurities


Available
Period End2021-06-302021-03-312020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302017-12-31
Value4000.03000.00193000.011000.0014000.093000.0266000.0124000.0162000.072000.0
Percentage of AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax6.110.00.085.036.70.048.328.326.18.810.919.6

us-gaap:USGovernmentAgenciesDebtSecurities, dnli:LongTermMarketableSecurities


Available
Period End2020-09-302018-12-312018-09-302018-06-302017-12-31
Value1000.0078000.0164000.020000.0
Percentage of AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax6.70.05.511.05.4

us-gaap:USGovernmentAgenciesDebtSecurities, dnli:ShortTermMarketableSecurities


Available
Period End2020-12-312020-09-302019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302017-12-31
Value2000.011000.00010000.080000.0222000.0234000.0230000.0229000.0
Percentage of AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax8.073.30.00.034.524.321.816.515.462.2

us-gaap:USTreasurySecurities, dnli:LongTermMarketableSecurities


Available
Period End2021-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302017-12-31
Value6000.002000.01000.00076000.0397000.0320000.020000.0
Percentage of AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax9.10.06.750.00.00.07.528.121.45.4

us-gaap:USTreasurySecurities, dnli:ShortTermMarketableSecurities


Available
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302017-12-31
Value49000.08000.012000.03000.0002000.01000.05000.0156000.0356000.0362000.0286000.027000.0
Percentage of AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax74.226.748.020.00.00.06.750.017.247.434.925.619.27.3

us-gaap:AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax us-gaap:InvestmentType

dnli:LongTermMarketableSecurities


Available
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302017-12-31
Value13000.019000.011000.01000.0034000.017000.01000.000175000.0695000.0815000.040000.0
Percentage of AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax19.763.344.06.70.015.056.750.00.00.017.249.154.610.9

dnli:ShortTermMarketableSecurities


Available
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302017-12-31
Value53000.011000.014000.014000.00193000.013000.01000.029000.0329000.0844000.0720000.0678000.0328000.0
Percentage of AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax80.336.756.093.30.085.043.350.0100.0100.082.850.945.489.1

us-gaap:AvailableForSaleDebtSecuritiesAmortizedCostBasis

us-gaap:AvailableForSaleDebtSecuritiesAmortizedCostBasis


Available
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302017-12-31
Value9151016995630418388375419470543535474519248
Percentage of AvailableForSaleDebtSecuritiesAmortizedCostBasis100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0

us-gaap:AvailableForSaleDebtSecuritiesAmortizedCostBasis us-gaap:FinancialInstrument, us-gaap:InvestmentType

us-gaap:CommercialPaperNotIncludedWithCashAndCashEquivalents, dnli:ShortTermMarketableSecurities


Available
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-30
Value101713113294430333437222.95110
Percentage of AvailableForSaleDebtSecuritiesAmortizedCostBasis11.17.03.12.17.011.48.17.97.46.84.20.62.1

us-gaap:CorporateDebtSecurities, dnli:LongTermMarketableSecurities


Available
Period End2021-06-302021-03-312020-12-312020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302017-12-31
Value2534307.1277.153255.7519.968152854620.991
Percentage of AvailableForSaleDebtSecuritiesAmortizedCostBasis2.83.43.01.71.86.91.42.12.95.411.512.00.4

us-gaap:CorporateDebtSecurities, dnli:ShortTermMarketableSecurities


Available
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302017-12-31
Value4615274349615364786971554539
Percentage of AvailableForSaleDebtSecuritiesAmortizedCostBasis5.11.52.76.911.816.014.215.316.812.813.411.68.715.7

us-gaap:USGovernmentAgenciesDebtSecurities, dnli:LongTermMarketableSecurities


Available
Period End2020-09-302018-12-312018-09-302018-06-302017-12-31
Value151.975112619
Percentage of AvailableForSaleDebtSecuritiesAmortizedCostBasis2.40.42.55.28.0

us-gaap:USGovernmentAgenciesDebtSecurities, dnli:ShortTermMarketableSecurities


Available
Period End2021-06-302021-03-312020-12-312020-09-302019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302017-12-31
Value152025101.9991128517392111106
Percentage of AvailableForSaleDebtSecuritiesAmortizedCostBasis1.62.02.51.60.52.96.29.513.719.421.442.7

us-gaap:USTreasurySecurities, dnli:LongTermMarketableSecurities


Available
Period End2021-06-302021-03-312020-12-312020-09-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302017-12-31
Value664.0492.5615.1532.52513174581116769039
Percentage of AvailableForSaleDebtSecuritiesAmortizedCostBasis7.30.40.30.80.73.74.29.614.921.816.117.316.0

us-gaap:USTreasurySecurities, dnli:ShortTermMarketableSecurities


Available
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302017-12-31
Value66087087854233227224928627228722018117342
Percentage of AvailableForSaleDebtSecuritiesAmortizedCostBasis72.185.688.386.179.570.166.568.457.953.041.138.233.317.1

us-gaap:AvailableForSaleDebtSecuritiesAmortizedCostBasis us-gaap:InvestmentType

dnli:LongTermMarketableSecurities


Available
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302017-12-31
Value923832207.1279.6783923559714714217960
Percentage of AvailableForSaleDebtSecuritiesAmortizedCostBasis10.13.83.33.21.72.510.65.611.817.927.630.134.524.4

dnli:ShortTermMarketableSecurities


Available
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302017-12-31
Value823977962609411378335395414445387332340188
Percentage of AvailableForSaleDebtSecuritiesAmortizedCostBasis89.996.296.796.898.397.589.494.488.282.172.469.965.575.6

us-gaap:AvailableForSaleSecuritiesDebtSecurities

us-gaap:AvailableForSaleSecuritiesDebtSecurities


Available
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302017-12-31
Value9151016995630419389375420471543535473518248
Percentage of AvailableForSaleSecuritiesDebtSecurities100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0

us-gaap:AvailableForSaleSecuritiesDebtSecurities us-gaap:FairValueByFairValueHierarchyLevel, us-gaap:FinancialInstrument, us-gaap:InvestmentType

us-gaap:FairValueInputsLevel1, us-gaap:USTreasurySecurities, dnli:LongTermInvestments


Available
Period End2021-06-302021-03-312020-12-312020-09-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302017-12-31
Value664.052.5615.1532.56513174581117758939
Percentage of AvailableForSaleSecuritiesDebtSecurities7.30.40.30.80.73.74.29.715.021.916.017.316.0

us-gaap:FairValueInputsLevel1, us-gaap:USTreasurySecurities, us-gaap:ShortTermInvestments


Available
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302017-12-31
Value66087087854233327325028727328721918117242
Percentage of AvailableForSaleSecuritiesDebtSecurities72.185.688.386.179.470.366.568.457.952.941.138.333.317.1

us-gaap:FairValueInputsLevel2, us-gaap:CommercialPaper, us-gaap:ShortTermInvestments


Available
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-31
Value10171311329443033343722
Percentage of AvailableForSaleSecuritiesDebtSecurities11.17.03.12.17.011.48.17.97.46.84.2

us-gaap:FairValueInputsLevel2, us-gaap:CorporateDebtSecurities, dnli:LongTermInvestments


Available
Period End2021-06-302021-03-312020-12-312020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302017-12-31
Value2534307.2297.119265.7910162854620.991
Percentage of AvailableForSaleSecuritiesDebtSecurities2.83.43.01.71.86.91.42.12.95.411.512.00.4

us-gaap:FairValueInputsLevel2, us-gaap:CorporateDebtSecurities, us-gaap:ShortTermInvestments


Available
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302017-12-31
Value4615274349615364786971554539
Percentage of AvailableForSaleSecuritiesDebtSecurities5.11.52.77.011.915.914.215.316.712.813.411.68.715.7

us-gaap:FairValueInputsLevel2, us-gaap:USGovernmentAgenciesDebtSecurities, dnli:LongTermInvestments


Available
Period End2020-09-302018-12-312018-09-302018-06-302017-12-31
Value151.977112619
Percentage of AvailableForSaleSecuritiesDebtSecurities2.40.42.55.18.0

us-gaap:FairValueInputsLevel2, us-gaap:USGovernmentAgenciesDebtSecurities, us-gaap:ShortTermInvestments


Available
Period End2021-06-302021-03-312020-12-312020-09-302019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302017-12-31
Value152025102.01128517392110106
Percentage of AvailableForSaleSecuritiesDebtSecurities1.62.02.51.60.52.96.19.413.719.521.442.7

us-gaap:AvailableForSaleSecuritiesDebtSecurities us-gaap:FinancialInstrument, us-gaap:InvestmentType

us-gaap:CommercialPaper, us-gaap:ShortTermInvestments


Available
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-31
Value10171311329443033343722
Percentage of AvailableForSaleSecuritiesDebtSecurities11.17.03.12.17.011.48.17.97.46.84.2

us-gaap:CommercialPaperNotIncludedWithCashAndCashEquivalents, dnli:ShortTermMarketableSecurities


Available
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-30
Value101713113294430333437222.95110
Percentage of AvailableForSaleSecuritiesDebtSecurities11.17.03.12.17.011.48.17.97.46.84.20.62.1

us-gaap:CorporateDebtSecurities, dnli:LongTermInvestments


Available
Period End2021-06-302021-03-312020-12-312020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302017-12-31
Value2534307.2297.119265.7910162854620.991
Percentage of AvailableForSaleSecuritiesDebtSecurities2.83.43.01.71.86.91.42.12.95.411.512.00.4

us-gaap:CorporateDebtSecurities, dnli:LongTermMarketableSecurities


Available
Period End2021-06-302021-03-312020-12-312020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302017-12-31
Value2534307.2297.119265.7910162854620.991
Percentage of AvailableForSaleSecuritiesDebtSecurities2.83.43.01.71.86.91.42.12.95.411.512.00.4

us-gaap:CorporateDebtSecurities, dnli:ShortTermMarketableSecurities


Available
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302017-12-31
Value4615274349615364786971554539
Percentage of AvailableForSaleSecuritiesDebtSecurities5.11.52.77.011.915.914.215.316.712.813.411.68.715.7

us-gaap:CorporateDebtSecurities, us-gaap:ShortTermInvestments


Available
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302017-12-31
Value4615274349615364786971554539
Percentage of AvailableForSaleSecuritiesDebtSecurities5.11.52.77.011.915.914.215.316.712.813.411.68.715.7

us-gaap:USGovernmentAgenciesDebtSecurities, dnli:LongTermInvestments


Available
Period End2020-09-302018-12-312018-09-302018-06-302017-12-31
Value151.977112619
Percentage of AvailableForSaleSecuritiesDebtSecurities2.40.42.55.18.0

us-gaap:USGovernmentAgenciesDebtSecurities, dnli:LongTermMarketableSecurities


Available
Period End2020-09-302018-12-312018-09-302018-06-302017-12-31
Value151.977112619
Percentage of AvailableForSaleSecuritiesDebtSecurities2.40.42.55.18.0

us-gaap:USGovernmentAgenciesDebtSecurities, dnli:ShortTermMarketableSecurities


Available
Period End2021-06-302021-03-312020-12-312020-09-302019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302017-12-31
Value152025102.01128517392110106
Percentage of AvailableForSaleSecuritiesDebtSecurities1.62.02.51.60.52.96.19.413.719.521.442.7

us-gaap:USGovernmentAgenciesDebtSecurities, us-gaap:ShortTermInvestments


Available
Period End2021-06-302021-03-312020-12-312020-09-302019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302017-12-31
Value152025102.01128517392110106
Percentage of AvailableForSaleSecuritiesDebtSecurities1.62.02.51.60.52.96.19.413.719.521.442.7

us-gaap:USTreasurySecurities, dnli:LongTermInvestments


Available
Period End2021-06-302021-03-312020-12-312020-09-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302017-12-31
Value664.052.5615.1532.56513174581117758939
Percentage of AvailableForSaleSecuritiesDebtSecurities7.30.40.30.80.73.74.29.715.021.916.017.316.0

us-gaap:USTreasurySecurities, dnli:LongTermMarketableSecurities


Available
Period End2021-06-302021-03-312020-12-312020-09-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302017-12-31
Value664.052.5615.1532.56513174581117758939
Percentage of AvailableForSaleSecuritiesDebtSecurities7.30.40.30.80.73.74.29.715.021.916.017.316.0

us-gaap:USTreasurySecurities, dnli:ShortTermMarketableSecurities


Available
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302017-12-31
Value66087087854233327325028727328721918117242
Percentage of AvailableForSaleSecuritiesDebtSecurities72.185.688.386.179.470.366.568.457.952.941.138.333.317.1

us-gaap:USTreasurySecurities, us-gaap:ShortTermInvestments


Available
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302017-12-31
Value66087087854233327325028727328721918117242
Percentage of AvailableForSaleSecuritiesDebtSecurities72.185.688.386.179.470.366.568.457.952.941.138.333.317.1

us-gaap:AvailableForSaleSecuritiesDebtSecurities us-gaap:InvestmentType

dnli:LongTermMarketableSecurities


Available
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302017-12-31
Value923832207.2299.6843923559714714217860
Percentage of AvailableForSaleSecuritiesDebtSecurities10.13.83.33.21.72.510.65.611.818.027.630.034.524.4

dnli:ShortTermMarketableSecurities


Available
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302017-12-31
Value823977962610412379335396415445387331339187
Percentage of AvailableForSaleSecuritiesDebtSecurities89.996.296.796.898.397.589.494.488.282.072.470.065.575.6

us-gaap:CashAndCashEquivalentsFairValueDisclosure us-gaap:CashAndCashEquivalents

us-gaap:CashAndCashEquivalentsFairValueDisclosure

us-gaap:CommercialPaper


Cash
Period End2021-06-302020-03-312018-12-31
Value292.9969.979
Percentage of CashAndCashEquivalentsFairValueDisclosure100.0100.0100.0

us-gaap:MoneyMarketFunds


Cash
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302017-12-31
Value3834263353261119254533624422716212
Percentage of CashAndCashEquivalentsFairValueDisclosure1278.30.00.00.00.03076.10.00.00.00.0423.10.00.00.0

us-gaap:USTreasurySecurities


Cash
Period End2021-06-302020-12-312020-03-312019-12-312018-12-31
Value4914984151.499
Percentage of CashAndCashEquivalentsFairValueDisclosure166.70.02837.00.015.0

us-gaap:CashAndCashEquivalentsFairValueDisclosure us-gaap:CashAndCashEquivalents, us-gaap:FairValueByFairValueHierarchyLevel

us-gaap:CommercialPaper, us-gaap:FairValueInputsLevel2


Cash
Period End2021-06-302020-03-312018-12-31
Value292.9969.979
Percentage of CashAndCashEquivalentsFairValueDisclosure100.0100.0100.0

us-gaap:MoneyMarketFunds, us-gaap:FairValueInputsLevel1


Cash
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302017-12-31
Value3834263353261119254533624422716212
Percentage of CashAndCashEquivalentsFairValueDisclosure1278.30.00.00.00.03076.10.00.00.00.0423.10.00.00.0

us-gaap:USTreasurySecurities, us-gaap:FairValueInputsLevel1


Cash
Period End2021-06-302020-12-312020-03-312019-12-312018-12-31
Value4914984151.499
Percentage of CashAndCashEquivalentsFairValueDisclosure166.70.02837.00.015.0

us-gaap:ContractWithCustomerLiability us-gaap:CounterpartyName

us-gaap:ContractWithCustomerLiability

dnli:Biogen


Contract
Period End2020-12-31
Value297
Percentage of ContractWithCustomerLiability100.0

us-gaap:ContractWithCustomerLiability us-gaap:CounterpartyName, us-gaap:ProductOrService, us-gaap:RelatedPartyTransaction, us-gaap:TypeOfArrangement

dnli:Biogen, dnli:OptionResearchServices, srt:AffiliatedEntity, dnli:BiogenCollaborativeArrangement


Contract
Period End2021-06-302021-03-312020-12-31
Value6.87.68.5
Percentage of ContractWithCustomerLiability0.00.02.9

us-gaap:ContractWithCustomerLiability us-gaap:CounterpartyName, us-gaap:RelatedPartyTransaction

dnli:Biogen, srt:AffiliatedEntity


Contract
Period End2021-06-302021-03-31
Value295296
Percentage of ContractWithCustomerLiability0.00.0

us-gaap:ContractWithCustomerLiability us-gaap:CounterpartyName, us-gaap:TypeOfArrangement

dnli:Biogen, dnli:ROFNAndOptionAgreementCollaborativeArrangement


Contract
Period End2020-12-31
Value288
Percentage of ContractWithCustomerLiability97.1

dnli:TakedaPharmaceuticalCompanyLimited, us-gaap:CollaborativeArrangement


Contract
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302017-12-31
Value334039415056596263646457580.0
Percentage of ContractWithCustomerLiability0.00.013.40.00.00.00.00.00.00.00.00.00.00.0

us-gaap:ContractWithCustomerLiabilityNoncurrent

us-gaap:ContractWithCustomerLiabilityNoncurrent


Contract
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302017-12-31
Value313123161934434744445744490.0
Percentage of ContractWithCustomerLiabilityNoncurrent100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.00.0

us-gaap:ContractualObligation

us-gaap:ContractualObligation


Contractual
Period End2020-12-312019-12-312018-12-312017-12-31
Value4800000.01100000.01200000.01600000.0
Percentage of ContractualObligation100.0100.0100.0100.0

us-gaap:DebtSecuritiesAvailableForSaleUnrealizedLossPosition us-gaap:FinancialInstrument, us-gaap:InvestmentType

us-gaap:DebtSecuritiesAvailableForSaleUnrealizedLossPosition

us-gaap:CorporateDebtSecurities, dnli:LongTermMarketableSecurities


Debt
Period End2021-06-302021-03-312020-12-312020-03-312019-12-31
Value2234207.117
Percentage of DebtSecuritiesAvailableForSaleUnrealizedLossPosition100.0100.0100.0100.0100.0

us-gaap:CorporateDebtSecurities, dnli:ShortTermMarketableSecurities


Debt
Period End2021-06-302021-03-312020-03-312019-12-31
Value117.13525
Percentage of DebtSecuritiesAvailableForSaleUnrealizedLossPosition51.820.4502.8150.6

us-gaap:USGovernmentAgenciesDebtSecurities, dnli:LongTermMarketableSecurities


Debt
Period End2020-09-30
Value15
Percentage of DebtSecuritiesAvailableForSaleUnrealizedLossPosition0.0

us-gaap:USTreasurySecurities, dnli:LongTermMarketableSecurities


Debt
Period End2021-06-302019-12-31
Value4710
Percentage of DebtSecuritiesAvailableForSaleUnrealizedLossPosition210.658.7

us-gaap:USTreasurySecurities, dnli:ShortTermMarketableSecurities


Debt
Period End2021-06-302021-03-312020-12-312020-09-302019-12-31
Value319126369739.3
Percentage of DebtSecuritiesAvailableForSaleUnrealizedLossPosition1411.5363.21840.30.054.1

us-gaap:DeferredTaxAssetsDeferredIncome

us-gaap:DeferredTaxAssetsDeferredIncome


Deferred
Period End2020-12-312019-12-312018-12-31
Value15130.0
Percentage of DeferredTaxAssetsDeferredIncome100.0100.00.0

us-gaap:DeferredTaxAssetsGross

us-gaap:DeferredTaxAssetsGross


Deferred
Period End2020-12-312019-12-312018-12-312017-12-31
Value1501266557
Percentage of DeferredTaxAssetsGross100.0100.0100.0100.0

us-gaap:DeferredTaxAssetsOperatingLossCarryforwards

us-gaap:DeferredTaxAssetsOperatingLossCarryforwards


Deferred
Period End2020-12-312019-12-312018-12-312017-12-31
Value54563537
Percentage of DeferredTaxAssetsOperatingLossCarryforwards100.0100.0100.0100.0

us-gaap:DeferredTaxAssetsOther

us-gaap:DeferredTaxAssetsOther


Deferred
Period End2020-12-312019-12-312018-12-312017-12-31
Value17110.0070.007
Percentage of DeferredTaxAssetsOther100.0100.0100.0100.0

us-gaap:DeferredTaxAssetsTaxCreditCarryforwards

us-gaap:DeferredTaxAssetsTaxCreditCarryforwards


Deferred
Period End2020-12-312019-12-312018-12-312017-12-31
Value27199.5654.072
Percentage of DeferredTaxAssetsTaxCreditCarryforwards100.0100.0100.0100.0

us-gaap:DeferredTaxAssetsTaxDeferredExpenseCompensationAndBenefitsShareBasedCompensationCost

us-gaap:DeferredTaxAssetsTaxDeferredExpenseCompensationAndBenefitsShareBasedCompensationCost


Deferred
Period End2020-12-312019-12-312018-12-312017-12-31
Value189.5133.3050.733
Percentage of DeferredTaxAssetsTaxDeferredExpenseCompensationAndBenefitsShareBasedCompensationCost100.0100.0100.0100.0

us-gaap:DeferredTaxLiabilitiesPropertyPlantAndEquipment

us-gaap:DeferredTaxLiabilitiesPropertyPlantAndEquipment


Deferred
Period End2020-12-312019-12-312018-12-312017-12-31
Value9329000.06225000.04159000.02618000.0
Percentage of DeferredTaxLiabilitiesPropertyPlantAndEquipment100.0100.0100.0100.0

us-gaap:DerivativeAssets

us-gaap:DerivativeAssets


Derivative
Period End2021-06-302021-03-312020-12-312020-09-302019-12-312019-09-302019-06-302019-03-312018-12-312018-09-30
Value7000.045000.0185000.0109000.085000.014000.016000.026000.014000.04000.0
Percentage of DerivativeAssets100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0

us-gaap:DerivativeAssets us-gaap:BalanceSheetLocation

us-gaap:PrepaidExpensesAndOtherCurrentAssets


Derivative
Period End2021-03-312020-12-312019-12-31
Value0200000.00
Percentage of DerivativeAssets0.0108.10.0

us-gaap:DerivativeAssets us-gaap:FairValueByFairValueHierarchyLevel

us-gaap:FairValueInputsLevel2


Derivative
Period End2021-06-302021-03-312020-12-312020-09-302019-12-312019-09-302019-06-302019-03-312018-12-312018-09-30
Value7000.045000.0185000.0109000.085000.014000.016000.026000.014000.04000.0
Percentage of DerivativeAssets100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0

us-gaap:DerivativeLiabilities

us-gaap:DerivativeLiabilities


Derivative
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-30
Value164000.0176000.011000.0173000.0108000.0141000.08000.0229000.0155000.0159000.0182000.0100000.032000.0
Percentage of DerivativeLiabilities100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0

us-gaap:DerivativeLiabilities us-gaap:DerivativeInstrumentRisk

us-gaap:ForeignExchangeContract


Derivative
Period End2021-03-312020-12-312019-12-31
Value200000.000
Percentage of DerivativeLiabilities113.60.00.0

us-gaap:DerivativeLiabilities us-gaap:FairValueByFairValueHierarchyLevel

us-gaap:FairValueInputsLevel2


Derivative
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-30
Value164000.0176000.011000.0173000.0108000.0141000.08000.0229000.0155000.0159000.0182000.0123000.032000.0
Percentage of DerivativeLiabilities100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0123.0100.0

us-gaap:DerivativeNotionalAmount us-gaap:DerivativeInstrumentRisk, us-gaap:HedgingDesignation

us-gaap:DerivativeNotionalAmount

dnli:ForeignExchangeForwardBritishPounds, us-gaap:DesignatedAsHedgingInstrument


Derivative
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-30
Value3120000.0963000.02658000.03736000.02868000.02482000.02285000.02944000.0
Percentage of DerivativeNotionalAmount100.0100.0100.0100.0100.0100.0100.0100.0

dnli:ForeignExchangeForwardEuros, us-gaap:DesignatedAsHedgingInstrument


Derivative
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-30
Value3050000.04305000.03855000.03630000.03535000.02746000.01500000.02976000.0
Percentage of DerivativeNotionalAmount97.8447.0145.097.2123.3110.665.6101.1

us-gaap:DueFromRelatedPartiesCurrent

us-gaap:DueFromRelatedPartiesCurrent


Due
Period End2021-06-302021-03-312020-12-31
Value1567000.02511000.05674000.0
Percentage of DueFromRelatedPartiesCurrent100.0100.0100.0

us-gaap:DueFromRelatedPartiesCurrent us-gaap:CounterpartyName, us-gaap:TypeOfArrangement

dnli:Biogen, dnli:BiogenCollaborativeArrangement


Due
Period End2021-06-302021-03-312020-12-31
Value1600000.02500000.05700000.0
Percentage of DueFromRelatedPartiesCurrent102.199.6100.5

us-gaap:EmployeeRelatedLiabilitiesCurrent

us-gaap:EmployeeRelatedLiabilitiesCurrent


Employee
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-31
Value6.2954.963209.015.5313.918.7397.5284.0923.2139.9524.8472.7511.9945.166
Percentage of EmployeeRelatedLiabilitiesCurrent100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0

us-gaap:EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognized us-gaap:AwardType

us-gaap:EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognized

us-gaap:EmployeeStockOption


Employee
Period End2020-12-312019-12-312018-12-312018-09-302018-06-302018-03-312017-12-31
Value125765760565617
Percentage of EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognized100.0100.0100.0100.0100.0100.0100.0

us-gaap:LesseeOperatingLeaseLiabilityPaymentsDueNextTwelveMonths

us-gaap:LesseeOperatingLeaseLiabilityPaymentsDueNextTwelveMonths


Lessee
Period End2021-06-302021-03-312020-12-312020-09-30
Value10101010
Percentage of LesseeOperatingLeaseLiabilityPaymentsDueNextTwelveMonths100.0100.0100.0100.0

us-gaap:LesseeOperatingLeaseLiabilityPaymentsRemainderOfFiscalYear

us-gaap:LesseeOperatingLeaseLiabilityPaymentsRemainderOfFiscalYear


Lessee
Period End2021-06-302021-03-312020-09-30
Value5237000.07855000.02536000.0
Percentage of LesseeOperatingLeaseLiabilityPaymentsRemainderOfFiscalYear100.0100.0100.0

us-gaap:LessorOperatingLeasePaymentsToBeReceived

us-gaap:LessorOperatingLeasePaymentsToBeReceived


Lessor
Period End2021-06-302021-03-312020-12-312020-09-30
Value8.4559.199.90610
Percentage of LessorOperatingLeasePaymentsToBeReceived100.0100.0100.0100.0

us-gaap:LessorOperatingLeasePaymentsToBeReceivedNextTwelveMonths

us-gaap:LessorOperatingLeasePaymentsToBeReceivedNextTwelveMonths


Lessor
Period End2021-06-302021-03-312020-12-312020-09-30
Value3009000.03009000.02925000.02925000.0
Percentage of LessorOperatingLeasePaymentsToBeReceivedNextTwelveMonths100.0100.0100.0100.0

us-gaap:LessorOperatingLeasePaymentsToBeReceivedRemainderOfFiscalYear

us-gaap:LessorOperatingLeasePaymentsToBeReceivedRemainderOfFiscalYear


Lessor
Period End2021-06-302021-03-312020-09-30
Value1474000.02209000.0715000.0
Percentage of LessorOperatingLeasePaymentsToBeReceivedRemainderOfFiscalYear100.0100.0100.0

us-gaap:LessorOperatingLeasePaymentsToBeReceivedThreeYears

us-gaap:LessorOperatingLeasePaymentsToBeReceivedThreeYears


Lessor
Period End2021-06-302021-03-312020-12-312020-09-30
Value876000.0876000.03096000.03096000.0
Percentage of LessorOperatingLeasePaymentsToBeReceivedThreeYears100.0100.0100.0100.0

us-gaap:LessorOperatingLeasePaymentsToBeReceivedTwoYears

us-gaap:LessorOperatingLeasePaymentsToBeReceivedTwoYears


Lessor
Period End2021-06-302021-03-312020-12-312020-09-30
Value3096000.03096000.03009000.03009000.0
Percentage of LessorOperatingLeasePaymentsToBeReceivedTwoYears100.0100.0100.0100.0

us-gaap:LiabilitiesFairValueDisclosure

us-gaap:LiabilitiesFairValueDisclosure


Liabilities
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-30
Value164000.0176000.011000.0173000.0108000.0141000.08000.0229000.0155000.0159000.0182000.0123000.032000.0
Percentage of LiabilitiesFairValueDisclosure100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0

us-gaap:LiabilitiesFairValueDisclosure us-gaap:FairValueByFairValueHierarchyLevel

us-gaap:FairValueInputsLevel2


Liabilities
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-30
Value164000.0176000.011000.0173000.0108000.0141000.08000.0229000.0155000.0159000.0182000.0123000.032000.0
Percentage of LiabilitiesFairValueDisclosure100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0

us-gaap:MarketableSecuritiesNoncurrent

us-gaap:MarketableSecuritiesNoncurrent


Marketable
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-31
Value923832207.2299.6843923559714714217821960
Percentage of MarketableSecuritiesNoncurrent100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0

us-gaap:OperatingLossCarryforwards us-gaap:IncomeTaxAuthority

us-gaap:OperatingLossCarryforwards

us-gaap:DomesticCountry


Operating
Period End2020-12-312019-12-312018-12-31
Value212221118
Percentage of OperatingLossCarryforwards100.0100.0100.0

us-gaap:StateAndLocalJurisdiction


Operating
Period End2020-12-312019-12-312018-12-31
Value133144134
Percentage of OperatingLossCarryforwards63.065.1113.0

us-gaap:PurchaseObligation us-gaap:PurchaseCommitmentExcludingLongtermCommitment

us-gaap:PurchaseObligation

dnli:DMSA


Purchase
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-31
Value28282712127.6118.8101214
Percentage of PurchaseObligation100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0

dnli:NonCancellablePurchaseCommitments


Purchase
Period End2020-12-312019-12-312018-12-312017-12-31
Value2711140.4
Percentage of PurchaseObligation100.0100.0100.00.0

us-gaap:RestrictedCashAndCashEquivalentsNoncurrent

us-gaap:RestrictedCashAndCashEquivalentsNoncurrent


Restricted
Period End2021-06-302020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312017-09-302017-06-302017-03-312016-12-31
Value1500000.01500000.01500000.01500000.01500000.01500000.01500000.01500000.01500000.01500000.01500000.01500000.0451000.0451000.0451000.0451000.0451000.0535000.0
Percentage of RestrictedCashAndCashEquivalentsNoncurrent100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0

us-gaap:RevenueRemainingPerformanceObligation us-gaap:ProductOrService

us-gaap:RevenueRemainingPerformanceObligation

dnli:AlzheimersDiseaseServices


Revenue
Period End2021-06-302021-03-312020-12-312020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-31
Value3400000.03400000.03400000.03400000.03400000.03400000.03500000.03600000.03700000.03800000.03900000.0
Percentage of RevenueRemainingPerformanceObligation100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0

us-gaap:SaleOfStockPricePerShare us-gaap:CounterpartyName, us-gaap:ResearchAndDevelopmentArrangementContractToPerformForOthersByType, us-gaap:TypeOfArrangement

us-gaap:SaleOfStockPricePerShare

dnli:Biogen, dnli:SharePurchaseAgreement, dnli:ProvisionalCollaborativeArrangement


Sale
Period End2020-09-22
Value35.87
Percentage of SaleOfStockPricePerShare100.0

us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValue us-gaap:AwardType

us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValue

us-gaap:RestrictedStock


Share
Period End2020-09-302020-06-302020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312016-12-31
Value25.8221.9821.7518.6718.9418.4417.474.862.760.180.180.180.18
Percentage of ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValue100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0

us-gaap:RestrictedStockUnitsRSU


Share
Period End2021-06-302021-03-312020-12-312019-12-31
Value41.1340.2427.0818.67
Percentage of ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValue0.00.00.0100.0

us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAvailableForGrant us-gaap:PlanName

us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAvailableForGrant

dnli:TwoThousandSeventeenEquityIncentivePlan


Share
Period End2020-12-312020-03-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-31
Value3700000.04500000.03400000.03500000.03700000.04100000.02289200.02659300.03237000.03523000.06012500.0
Percentage of ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAvailableForGrant100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0

us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingIntrinsicValue

us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingIntrinsicValue


Share
Period End2020-12-312019-12-312019-09-302019-06-302019-03-312018-12-312018-09-302018-06-302018-03-312017-12-312016-12-31
Value8745127961319711050957718
Percentage of ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingIntrinsicValue100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0100.0

us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsVestedAndExpectedToVestExercisableWeightedAverageExercisePrice

us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsVestedAndExpectedToVestExercisableWeightedAverageExercisePrice


Share
Period End2021-06-302021-03-312020-12-312020-09-30
Value14.6714.0114.2813.8
Percentage of ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsVestedAndExpectedToVestExercisableWeightedAverageExercisePrice100.0100.0100.0100.0

us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsVestedAndExpectedToVestOutstandingAggregateIntrinsicValue

us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsVestedAndExpectedToVestOutstandingAggregateIntrinsicValue


Share
Period End2020-12-31
Value717
Percentage of ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsVestedAndExpectedToVestOutstandingAggregateIntrinsicValue100.0

us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsVestedAndExpectedToVestOutstandingWeightedAverageExercisePrice

us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsVestedAndExpectedToVestOutstandingWeightedAverageExercisePrice


Share
Period End2021-06-302021-03-312020-12-312020-09-30
Value25.1324.6918.7518.0
Percentage of ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsVestedAndExpectedToVestOutstandingWeightedAverageExercisePrice100.0100.0100.0100.0

us-gaap:SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsExercisableIntrinsicValue1

us-gaap:SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsExercisableIntrinsicValue1


Sharebased
Period End2020-12-31
Value368
Percentage of SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsExercisableIntrinsicValue1100.0

us-gaap:TaxCreditCarryforwardAmount us-gaap:IncomeTaxAuthority

us-gaap:TaxCreditCarryforwardAmount

us-gaap:StateAndLocalJurisdiction


Tax
Period End2020-12-312019-12-312018-12-31
Value139.85.7
Percentage of TaxCreditCarryforwardAmount100.0100.0100.0

us-gaap:TaxCreditCarryforwardAmount us-gaap:IncomeTaxAuthority, us-gaap:TaxCreditCarryforward

us-gaap:DomesticCountry, dnli:OrphanDrugTaxCreditCarryforward


Tax
Period End2020-12-312019-12-31
Value3.31.7
Percentage of TaxCreditCarryforwardAmount24.317.3

us-gaap:DomesticCountry, us-gaap:Research


Tax
Period End2020-12-312019-12-31
Value2014
Percentage of TaxCreditCarryforwardAmount150.0148.0

us-gaap:UnrecognizedTaxBenefitsThatWouldImpactEffectiveTaxRate

us-gaap:UnrecognizedTaxBenefitsThatWouldImpactEffectiveTaxRate


Unrecognized
Period End2020-12-31
Value300000.0
Percentage of UnrecognizedTaxBenefitsThatWouldImpactEffectiveTaxRate100.0

Line plots across dimensions of each concept


us-gaap:AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount
us-gaap:AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecurities
(None,)
Antidilutive Securities Excluded From Computation Of Earnings Per Share Amountus-gaap: Antidilutive Securities Excluded From Computation Of Earnings Per Share By Antidilutive Securities
TTM Greenblatt ROC
_
(None,)
T T M  Greenblatt  R O C_
us-gaap:AllocatedShareBasedCompensationExpense
us-gaap:IncomeStatementLocation
(None,)
Allocated Share Based Compensation Expenseus-gaap: Income Statement Location
us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax
us-gaap:ProductOrService, us-gaap:TypeOfArrangement
(None, 'dnli:SanofiCollaborationAgreement')
Revenue From Contract With Customer Excluding Assessed Taxus-gaap: Product Or Service, us-gaap: Type Of Arrangement
us-gaap:StockholdersEquity
us-gaap:StatementEquityComponents
(None,)
Stockholders Equityus-gaap: Statement Equity Components
us-gaap:PropertyPlantAndEquipmentGross
us-gaap:PropertyPlantAndEquipmentByType
(None,)
Property Plant And Equipment Grossus-gaap: Property Plant And Equipment By Type
us-gaap:StockholdersEquity
us-gaap:StatementEquityComponents
(None,)
Stockholders Equityus-gaap: Statement Equity Components
us-gaap:StockIssuedDuringPeriodValueNewIssues
us-gaap:StatementEquityComponents
(None,)
Stock Issued During Period Value New Issuesus-gaap: Statement Equity Components